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OncoImmunology Volume 5, 2016 - Issue 6
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Original Research

Epithelial NF-κB signaling promotes EGFR-driven lung carcinogenesis via macrophage recruitment

Jamie A. SaxonDepartment of Cancer Biology, Vanderbilt University, Nashville, TN, USACorrespondence[email protected]
,
Taylor P. SherrillDepartment of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
,
Vasiliy V. PolosukhinDepartment of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
,
Jiqing SaiDepartment of Cancer Biology, Vanderbilt University, Nashville, TN, USA
,
Rinat ZaynagetdinovDepartment of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
,
Allyson G. McLoedDepartment of Cancer Biology, Vanderbilt University, Nashville, TN, USA
,
Peter M. GullemanDepartment of Pediatrics, Division of Pulmonary Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
,
Whitney BarhamDepartment of Cancer Biology, Vanderbilt University, Nashville, TN, USA
,
Dong-Sheng ChengDepartment of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
,
Raphael P. HuntDepartment of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
,
Linda A. GleavesDepartment of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
,
Ann RichmondDepartment of Cancer Biology, Vanderbilt University, Nashville, TN, USA;Department of Veterans Affairs Medical Center, Nashville, TN, USA
,
Lisa R. YoungDepartment of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA;Department of Pediatrics, Division of Pulmonary Medicine, Vanderbilt University Medical Center, Nashville, TN, USA;Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA
,
Fiona E. YullDepartment of Cancer Biology, Vanderbilt University, Nashville, TN, USA
&
Timothy S. BlackwellDepartment of Cancer Biology, Vanderbilt University, Nashville, TN, USA;Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA;Department of Veterans Affairs Medical Center, Nashville, TN, USA;Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA
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Article: e1168549 | Received 23 Nov 2015, Accepted 16 Mar 2016, Published online: 08 Jun 2016

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Golnaz Vaseghi, Ahmad Ghasemi, Ismail Laher, HojjatAllah Alaei, Nasim Dana, Hajar Naji esfahani & Shaghayegh Haghjooy Javanmard. (2023) Morphine upregulates Toll-like receptor 4 expression and promotes melanomas in mice. Immunopharmacology and Immunotoxicology 45:3, pages 347-354.
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Mariona Cabo, Rienk Offringa, Laurence Zitvogel, Guido Kroemer, Aura Muntasell & Lorenzo Galluzzi. (2017) Trial Watch: Immunostimulatory monoclonal antibodies for oncological indications. OncoImmunology 6:12.
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Yingqi Qiu, Tong Chen, Rong Hu, Ruiyi Zhu, Chujun Li, Yingchen Ruan, Xiaoling Xie & Yuhua Li. (2021) Next frontier in tumor immunotherapy: macrophage-mediated immune evasion. Biomarker Research 9:1.
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Sze Wah Samuel Chan, Elliot Smith, Reenika Aggarwal, Karmugi Balaratnam, RuiQi Chen, Katrina Hueniken, Rouhi Fazelzad, Jessica Weiss, Shirley Jiang, Frances A. Shepherd, Penelope A. Bradbury, Adrian G. Sacher, Natasha B. Leighl, Wei Xu, M. Catherine Brown, Lawson Eng & Geoffrey Liu. (2021) Systemic Inflammatory Markers of Survival in Epidermal Growth Factor–Mutated Non–Small-Cell Lung Cancer: Single-Institution Analysis, Systematic Review, and Meta-analysis. Clinical Lung Cancer 22:5, pages 390-407.
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M. S. Sinto, Shaji Thomas & S. Kannan. (2021) Combinatorial treatment with Gefitinib and Bay11-7085 sensitizes primary Gefitinib-resistant OSCC cells by influencing the EGFR- NFκB signaling axis. Medical Oncology 38:9.
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Jian-Zhao Xu, Chen Gong, Zheng-Fu Xie & Hua Zhao. (2021) Development of an Oncogenic Driver Alteration Associated Immune-Related Prognostic Model for Stage I-II Lung Adenocarcinoma. Frontiers in Oncology 10.
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Neng Wang, Shengqi Wang, Xuan Wang, Yifeng Zheng, Bowen Yang, Juping Zhang, Bo Pan, Jianli Gao & Zhiyu Wang. (2021) Research trends in pharmacological modulation of tumor‐associated macrophages. Clinical and Translational Medicine 11:1.
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Foteinos-Ioannis D. Dimitrakopoulos, Anastasia E. Kottorou, Melpomeni Kalofonou & Haralabos P. Kalofonos. (2020) The Fire Within: NF-κB Involvement in Non–Small Cell Lung Cancer. Cancer Research 80:19, pages 4025-4036.
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Anqi Lin, Ting Wei, Hui Meng, Peng Luo & Jian Zhang. (2019) Role of the dynamic tumor microenvironment in controversies regarding immune checkpoint inhibitors for the treatment of non-small cell lung cancer (NSCLC) with EGFR mutations. Molecular Cancer 18:1.
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Yijun Jia, Xuefei Li, Tao Jiang, Sha Zhao, Chao Zhao, Limin Zhang, Xiaozhen Liu, Jinpeng Shi, Meng Qiao, Jiawei Luo, Sangtian Liu, Ruoshuang Han, Chunxia Su, Shengxiang Ren & Caicun Zhou. (2019) EGFR‐targeted therapy alters the tumor microenvironment in EGFR‐driven lung tumors: Implications for combination therapies. International Journal of Cancer 145:5, pages 1432-1444.
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Spiros Vlahopoulos, Maria Adamaki, Nikolas Khoury, Vassilis Zoumpourlis & Istvan Boldogh. (2019) Roles of DNA repair enzyme OGG1 in innate immunity and its significance for lung cancer. Pharmacology & Therapeutics 194, pages 59-72.
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Jinming Yang, Amrendra Kumar, Anna E. Vilgelm, Sheau-Chiann Chen, Gregory D. Ayers, Sergey V. Novitskiy, Sebastian Joyce & Ann Richmond. (2018) Loss of CXCR4 in Myeloid Cells Enhances Antitumor Immunity and Reduces Melanoma Growth through NK Cell and FASL Mechanisms. Cancer Immunology Research 6:10, pages 1186-1198.
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Allyson G. McLoed, Taylor P. Sherrill, Dong-Sheng Cheng, Wei Han, Jamie A. Saxon, Linda A. Gleaves, Pingsheng Wu, Vasiliy V. Polosukhin, Michael Karin, Fiona E. Yull, Georgios T. Stathopoulos, Vassilis Georgoulias, Rinat Zaynagetdinov & Timothy S. Blackwell. (2016) Neutrophil-Derived IL-1β Impairs the Efficacy of NF-κB Inhibitors against Lung Cancer. Cell Reports 16:1, pages 120-132.
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