OncoImmunology, Volume 5, Issue 6 (2016)

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OncoImmunology, Volume 5, Issue 6 (2016)

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Author's View

Opinion
Positive impact of autophagy in human breast cancer cells on local immunosurveillance
Sylvain Ladoire, David Enot, Laura Senovilla, Marie Chaix, Laurence Zitvogel & Guido Kroemer
Article: e1174801
Published online: 08 Jun 2016
AbstractforPositive impact of autophagy in human breast cancer cells on local immunosurveillance | Full Text | References | PDF (464.9 KB)
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Opinion
DC vaccine generated by ALA-PDT-induced immunogenic apoptotic cells for skin squamous cell carcinoma
Jie Ji, Yunfeng Zhang, Wei R. Chen & Xiuli Wang
Article: e1072674
Published online: 10 Jun 2016
AbstractforDC vaccine generated by ALA-PDT-induced immunogenic apoptotic cells for skin squamous cell carcinoma | Full Text | References | PDF (321.2 KB)
  • 1134 Views
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Opinion
Predictive immune markers in advanced melanoma patients treated with ipilimumab
Viktor Umansky, Jochen Utikal & Christoffer Gebhardt
Article: e1158901
Published online: 28 Jun 2016
AbstractforPredictive immune markers in advanced melanoma patients treated with ipilimumab | Full Text | References | PDF (324.9 KB)
  • 972 Views
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Brief Report

Brief Report
A Tec kinase BTK inhibitor ibrutinib promotes maturation and activation of dendritic cells
Gayathri Natarajan, Steve Oghumu, Cesar Terrazas, Sanjay Varikuti, John C. Byrd & Abhay R. Satoskar
Article: e1151592
Published online: 26 May 2016
AbstractforA Tec kinase BTK inhibitor ibrutinib promotes maturation and activation of dendritic cells | Full Text | References | PDF (971.5 KB)
  • 1700 Views
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Brief Report
Anti-TNF-refractory colitis after checkpoint inhibitor therapy: Possible role of CMV-mediated immunopathogenesis
Katharina Lankes, Gheorghe Hundorfean, Thomas Harrer, Ansgar J. Pommer, Abbas Agaimy, Irena Angelovska, Azadeh Tajmir-Riahi, Jonas Göhl, Gerold Schuler, Markus F. Neurath, Werner Hohenberger & Lucie Heinzerling
Article: e1128611
Published online: 31 May 2016
AbstractforAnti-TNF-refractory colitis after checkpoint inhibitor therapy: Possible role of CMV-mediated immunopathogenesis | Full Text | References | PDF (752.4 KB)
  • 2173 Views
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Brief Report
Tumor relapse prevented by combining adoptive T cell therapy with Salmonella typhimurium
David C. Binder, Ainhoa Arina, Frank Wen, Tony Tu, Ming Zhao, Robert M. Hoffman, Derek A. Wainwright & Hans Schreiber
Article: e1130207
Published online: 31 May 2016
AbstractforTumor relapse prevented by combining adoptive T cell therapy with Salmonella typhimurium | Full Text | References | PDF (706.4 KB)
  • 944 Views
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Brief Report
CD137 signaling in Hodgkin and Reed-Sternberg cell lines induces IL-13 secretion, immune deviation and enhanced growth
Sakthi Rajendran, Weng Tong Ho & Herbert Schwarz
Article: e1160188
Published online: 31 May 2016
AbstractforCD137 signaling in Hodgkin and Reed-Sternberg cell lines induces IL-13 secretion, immune deviation and enhanced growth | Full Text | References | PDF (713.6 KB) | Supplemental
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Brief Report
Inhibition of formyl peptide receptor 1 reduces the efficacy of anticancer chemotherapy against carcinogen-induced breast cancer
Elisa E. Baracco, Federico Pietrocola, Aitziber Buqué, Norma Bloy, Laura Senovilla, Laurence Zitvogel, Erika Vacchelli & Guido Kroemer
Article: e1139275
Published online: 16 Jun 2016
AbstractforInhibition of formyl peptide receptor 1 reduces the efficacy of anticancer chemotherapy against carcinogen-induced breast cancer | Full Text | References | PDF (503.9 KB)
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Original Research

Article
CD8+ Tregs promote GVHD prevention and overcome the impaired GVL effect mediated by CD4+ Tregs in mice
Jessica Heinrichs, Jun Li, Hung Nguyen, Yongxia Wu, David Bastian, Anusara Daethanasanmak, M-Hanief Sofi, Steven Schutt, Chen Liu, Junfei Jin, Brian Betts, Claudio Anasetti & Xue-Zhong Yu
Article: e1146842
Published online: 23 May 2016
AbstractforCD8+ Tregs promote GVHD prevention and overcome the impaired GVL effect mediated by CD4+ Tregs in mice | Full Text | References | PDF (1.4 MB) | Supplemental
  • 1963 Views
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Article
A novel dendritic cell targeting HPV16 E7 synthetic vaccine in combination with PD-L1 blockade elicits therapeutic antitumor immunity in mice
Zhida Liu, Hang Zhou, Wenjun Wang, Yang-Xin Fu & Mingzhao Zhu
Article: e1147641
Published online: 23 May 2016
AbstractforA novel dendritic cell targeting HPV16 E7 synthetic vaccine in combination with PD-L1 blockade elicits therapeutic antitumor immunity in mice | Full Text | References | PDF (813.4 KB) | Supplemental
  • 2263 Views
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Article
Maraviroc decreases CCL8-mediated migration of CCR5+ regulatory T cells and reduces metastatic tumor growth in the lungs
E. C. Halvorsen, M. J. Hamilton, A. Young, B. J. Wadsworth, N. E. LePard, H. N. Lee, N. Firmino, J. L. Collier & K. L. Bennewith
Article: e1150398
Published online: 23 May 2016
AbstractforMaraviroc decreases CCL8-mediated migration of CCR5+ regulatory T cells and reduces metastatic tumor growth in the lungs | Full Text | References | PDF (1.7 MB) | Supplemental
  • 2562 Views
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Article
Efficacy of antineoplastic treatment is associated with the use of antibiotics that modulate intestinal microbiota
Natali Pflug, Sandra Kluth, Jörg J. Vehreschild, Jasmin Bahlo, Daniela Tacke, Lena Biehl, Barbara Eichhorst, Kirsten Fischer, Paula Cramer, Anna-Maria Fink, Michael von Bergwelt-Baildon, Stephan Stilgenbauer, Michael Hallek, Oliver A. Cornely & Maria J. G. T. Vehreschild
Article: e1150399
Published online: 26 May 2016
AbstractforEfficacy of antineoplastic treatment is associated with the use of antibiotics that modulate intestinal microbiota | Full Text | References | PDF (531.5 KB) | Supplemental
  • 2109 Views
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Article
NLRC5 elicits antitumor immunity by enhancing processing and presentation of tumor antigens to CD8+ T lymphocytes
Galaxia M. Rodriguez, Diwakar Bobbala, Daniel Serrano, Marian Mayhue, Audrey Champagne, Caroline Saucier, Viktor Steimle, Thomas A. Kufer, Alfredo Menendez, Sheela Ramanathan & Subburaj Ilangumaran
Article: e1151593
Published online: 26 May 2016
AbstractforNLRC5 elicits antitumor immunity by enhancing processing and presentation of tumor antigens to CD8+ T lymphocytes | Full Text | References | PDF (1.4 MB) | Supplemental
  • 3040 Views
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Open Access
Article
An oncofetal antigen, IMP-3-derived long peptides induce immune responses of both helper T cells and CTLs
Masatoshi Hirayama, Yusuke Tomita, Akira Yuno, Hirotake Tsukamoto, Satoru Senju, Yuya Imamura, Mohammad Abu Sayem, Atsushi Irie, Yoshihiro Yoshitake, Daiki Fukuma, Masanori Shinohara, Akinobu Hamada, Hirofumi Jono, Eiji Yuba, Kenji Kono, Koji Yoshida, Takuya Tsunoda, Hideki Nakayama & Yasuharu Nishimura
Article: e1123368
Published online: 31 May 2016
AbstractforAn oncofetal antigen, IMP-3-derived long peptides induce immune responses of both helper T cells and CTLs | Full Text | References | PDF (1.6 MB) | Supplemental
  • 1536 Views
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Article
Tasquinimod modulates tumor-infiltrating myeloid cells and improves the antitumor immune response to PD-L1 blockade in bladder cancer
Jessica Nakhlé, Valérie Pierron, Anne-Laure Bauchet, Pascale Plas, Amath Thiongane, Florence Meyer-Losic & Fabien Schmidlin
Article: e1145333
Published online: 04 Jun 2016
AbstractforTasquinimod modulates tumor-infiltrating myeloid cells and improves the antitumor immune response to PD-L1 blockade in bladder cancer | Full Text | References | PDF (1.6 MB) | Supplemental
  • 1947 Views
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Article
Tumor-infiltrating HLA-matched CD4+ T cells retargeted against Hodgkin and Reed–Sternberg cells
Benjamin Rengstl, Frederike Schmid, Christian Weiser, Claudia Döring, Tim Heinrich, Kathrin Warner, Petra S. A. Becker, Robin Wistinghausen, Sima Kameh-Var, Eva Werling, Arne Billmeier, Christian Seidl, Sylvia Hartmann, Hinrich Abken, Ralf Küppers, Martin-Leo Hansmann & Sebastian Newrzela
Article: e1160186
Published online: 31 May 2016
AbstractforTumor-infiltrating HLA-matched CD4+ T cells retargeted against Hodgkin and Reed–Sternberg cells | Full Text | References | PDF (1.3 MB) | Supplemental
  • 1144 Views
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Article
Natural killer cells require monocytic Gr-1+/CD11b+ myeloid cells to eradicate orthotopically engrafted glioma cells
Gregory J. Baker, Peter Chockley, Daniel Zamler, Maria G. Castro & Pedro R. Lowenstein
Article: e1163461
Published online: 31 May 2016
AbstractforNatural killer cells require monocytic Gr-1+/CD11b+ myeloid cells to eradicate orthotopically engrafted glioma cells | Full Text | References | PDF (1.6 MB) | Supplemental
  • 1361 Views
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Article
Intratumoral delivery of mTORC2-deficient dendritic cells inhibits B16 melanoma growth by promoting CD8+ effector T cell responses
Dàlia Raïch-Regué, Kellsye P. Fabian, Alicia R. Watson, Ronald J. Fecek, Walter J. Storkus & Angus W. Thomson
Article: e1146841
Published online: 07 Jun 2016
AbstractforIntratumoral delivery of mTORC2-deficient dendritic cells inhibits B16 melanoma growth by promoting CD8+ effector T cell responses | Full Text | References | PDF (959.8 KB)
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Article
Contribution of RIP3 and MLKL to immunogenic cell death signaling in cancer chemotherapy
Heng Yang, Yuting Ma, Guo Chen, Heng Zhou, Takahiro Yamazaki, Christophe Klein, Federico Pietrocola, Erika Vacchelli, Sylvie Souquere, Allan Sauvat, Laurence Zitvogel, Oliver Kepp & Guido Kroemer
Article: e1149673
Published online: 07 Jun 2016
AbstractforContribution of RIP3 and MLKL to immunogenic cell death signaling in cancer chemotherapy | Full Text | References | PDF (1.9 MB) | Supplemental
  • 4507 Views
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Article
Investigating the association between allergen-specific immunoglobulin E, cancer risk and survival
Wahyu Wulaningsih, Lars Holmberg, Hans Garmo, Sophia N. Karagiannis, Staffan Ahlstedt, Håkan Malmstrom, Mats Lambe, Niklas Hammar, Göran Walldius, Ingmar Jungner, Tony Ng & Mieke Van Hemelrijck
Article: e1154250
Published online: 08 Jun 2016
AbstractforInvestigating the association between allergen-specific immunoglobulin E, cancer risk and survival | Full Text | References | PDF (439.3 KB) | Supplemental
  • 1606 Views
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Open Access
Article
Evaluation of innate and adaptive immunity contributing to the antitumor effects of PD1 blockade in an orthotopic murine model of pancreatic cancer
Marcela D'Alincourt Salazar, Edwin R. Manuel, Weimin Tsai, Massimo D'Apuzzo, Leanne Goldstein, Bruce R. Blazar & Don J. Diamond
Article: e1160184
Published online: 07 Jun 2016
AbstractforEvaluation of innate and adaptive immunity contributing to the antitumor effects of PD1 blockade in an orthotopic murine model of pancreatic cancer | Full Text | References | PDF (662.2 KB) | Supplemental
  • 1464 Views
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Article
Chemotherapy of colorectal liver metastases induces a rapid rise in intermediate blood monocytes which predicts treatment response
Dominic Schauer, Patrick Starlinger, Lejla Alidzanovic, Philipp Zajc, Thomas Maier, Alexandra Feldman, Robin Padickakudy, Elisabeth Buchberger, Vanessa Elleder, Andreas Spittler, Judith Stift, Lorand Pop, Birgit Gruenberger, Thomas Gruenberger & Christine Brostjan
Article: e1160185
Published online: 07 Jun 2016
AbstractforChemotherapy of colorectal liver metastases induces a rapid rise in intermediate blood monocytes which predicts treatment response | Full Text | References | PDF (1.1 MB) | Supplemental
  • 1153 Views
  • 11 CrossRef citations
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Article
Analysis of the hippo transducers TAZ and YAP in cervical cancer and its microenvironment
Simonetta Buglioni, Patrizia Vici, Domenico Sergi, Laura Pizzuti, Luigi Di Lauro, Barbara Antoniani, Francesca Sperati, Irene Terrenato, Mariantonia Carosi, Teresa Gamucci, Cristina Vincenzoni, Luciano Mariani, Enrico Vizza, Aldo Venuti, Giuseppe Sanguineti, Angiolo Gadducci, Maddalena Barba, Clara Natoli, Ilio Vitale, Marcella Mottolese, Ruggero De Maria & Marcello Maugeri-Saccà
Article: e1160187
Published online: 09 Jun 2016
AbstractforAnalysis of the hippo transducers TAZ and YAP in cervical cancer and its microenvironment | Full Text | References | PDF (669 KB) | Supplemental
  • 1646 Views
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Article
Biomarkers of immunogenic stress in metastases from melanoma patients: Correlations with the immune infiltrate
Sylvain Ladoire, Laura Senovilla, David Enot, François Ghiringhelli, Vichnou Poirier-Colame, Kariman Chaba, Gulsun Erdag, Jochen T. Schaefer, Donna H. Deacon, Laurence Zitvogel, Craig L. Slingluff Jr. & Guido Kroemer
Article: e1160193
Published online: 09 Jun 2016
AbstractforBiomarkers of immunogenic stress in metastases from melanoma patients: Correlations with the immune infiltrate | Full Text | References | PDF (1.2 MB) | Supplemental
  • 1216 Views
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Article
CXCL16-positive dendritic cells enhance invariant natural killer T cell-dependent IFNγ production and tumor control
Linnea Veinotte, Simon Gebremeskel & Brent Johnston
Article: e1160979
Published online: 09 Jun 2016
AbstractforCXCL16-positive dendritic cells enhance invariant natural killer T cell-dependent IFNγ production and tumor control | Full Text | References | PDF (1 MB)
  • 2084 Views
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Open Access
Article
Anti-GD2 mAb and Vorinostat synergize in the treatment of neuroblastoma
Michiel Kroesen, Christian Büll, Paul R. Gielen, Ingrid C. Brok, Inna Armandari, Melissa Wassink, Maaike W. G. Looman, Louis Boon, Martijn H. den Brok, Peter M. Hoogerbrugge & Gosse J. Adema
Article: e1164919
Published online: 08 Jun 2016
AbstractforAnti-GD2 mAb and Vorinostat synergize in the treatment of neuroblastoma | Full Text | References | PDF (1.1 MB) | Supplemental
  • 2258 Views
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Article
Identification of a novel human memory T-cell population with the characteristics of stem-like chemo-resistance
Kenji Murata, Tomohide Tsukahara, Makoto Emori, Yuji Shibayama, Emi Mizushima, Hiroshi Matsumiya, Keiji Yamashita, Mitsunori Kaya, Yoshihiko Hirohashi, Takayuki Kanaseki, Terufumi Kubo, Tetsuo Himi, Shingo Ichimiya, Toshihiko Yamashita, Noriyuki Sato & Toshihiko Torigoe
Article: e1165376
Published online: 08 Jun 2016
AbstractforIdentification of a novel human memory T-cell population with the characteristics of stem-like chemo-resistance | Full Text | References | PDF (1.5 MB) | Supplemental
  • 1927 Views
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Article
Antitumor vaccination of prostate cancer patients elicits PD-1/PD-L1 regulated antigen-specific immune responses
Brian T. Rekoske, Brian M. Olson & Douglas G. McNeel
Article: e1165377
Published online: 08 Jun 2016
AbstractforAntitumor vaccination of prostate cancer patients elicits PD-1/PD-L1 regulated antigen-specific immune responses | Full Text | References | PDF (796.2 KB) | Supplemental
  • 1329 Views
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Article
A plant-expressed conjugate vaccine breaks CD4+ tolerance and induces potent immunity against metastatic Her2+ breast cancer
Warayut Chotprakaikiat, Alex Allen, Duc Bui-Minh, Elena Harden, Jantipa Jobsri, Federica Cavallo, Yuri Gleba, Freda K. Stevenson, Christian Ottensmeier, Victor Klimyuk & Natalia Savelyeva
Article: e1166323
Published online: 09 Jun 2016
AbstractforA plant-expressed conjugate vaccine breaks CD4+ tolerance and induces potent immunity against metastatic Her2+ breast cancer | Full Text | References | PDF (980.8 KB) | Supplemental
  • 1597 Views
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Article
Epithelial NF-κB signaling promotes EGFR-driven lung carcinogenesis via macrophage recruitment
Jamie A. Saxon, Taylor P. Sherrill, Vasiliy V. Polosukhin, Jiqing Sai, Rinat Zaynagetdinov, Allyson G. McLoed, Peter M. Gulleman, Whitney Barham, Dong-Sheng Cheng, Raphael P. Hunt, Linda A. Gleaves, Ann Richmond, Lisa R. Young, Fiona E. Yull & Timothy S. Blackwell
Article: e1168549
Published online: 08 Jun 2016
AbstractforEpithelial NF-κB signaling promotes EGFR-driven lung carcinogenesis via macrophage recruitment | Full Text | References | PDF (1.4 MB)
  • 1514 Views
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Article
Stereotaxic administrations of allogeneic human Vγ9Vδ2 T cells efficiently control the development of human glioblastoma brain tumors
Ulrich Jarry, Cynthia Chauvin, Noémie Joalland, Alexandra Léger, Sandrine Minault, Myriam Robard, Marc Bonneville, Lisa Oliver, François M. Vallette, Henri Vié, Claire Pecqueur & Emmanuel Scotet
Article: e1168554
Published online: 08 Jun 2016
AbstractforStereotaxic administrations of allogeneic human Vγ9Vδ2 T cells efficiently control the development of human glioblastoma brain tumors | Full Text | References | PDF (993.4 KB) | Supplemental
  • 1290 Views
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Article
CMRF-56+ blood dendritic cells loaded with mRNA induce effective antigen-specific cytotoxic T-lymphocyte responses
Phillip D. Fromm, Michael S. Papadimitrious, Jennifer L. Hsu, Nicolas Van Kooten Losio, Nirupama D. Verma, Tsun Ho Lo, Pablo A. Silveira, Christian E. Bryant, Cameron J. Turtle, Rebecca L. Prue, Peter Vukovic, David J. Munster, Tomoko Nagasaki, Ross T. Barnard, Stephen M. Mahler, Sébastien A. Anguille, Zwi Berneman, Lisa G. Horvath, Kenneth F. Bradstock, Douglas E. Joshua, Georgina J. Clark & Derek N. J. Hart
Article: e1168555
Published online: 08 Jun 2016
AbstractforCMRF-56+ blood dendritic cells loaded with mRNA induce effective antigen-specific cytotoxic T-lymphocyte responses | Full Text | References | PDF (1.4 MB) | Supplemental
  • 1284 Views
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Article
Epigenetic modification augments the immunogenicity of human leukocyte antigen G serving as a tumor antigen for T cell-based immunotherapy
Kei Ishibashi, Takumi Kumai, Takayuki Ohkuri, Akemi Kosaka, Toshihiro Nagato, Yui Hirata, Kenzo Ohara, Kensuke Oikawa, Naoko Aoki, Naoko Akiyama, Masatoshi Sado, Masahiro Kitada, Yasuaki Harabuchi, Esteban Celis & Hiroya Kobayashi
Article: e1169356
Published online: 09 Jun 2016
AbstractforEpigenetic modification augments the immunogenicity of human leukocyte antigen G serving as a tumor antigen for T cell-based immunotherapy | Full Text | References | PDF (964.2 KB) | Supplemental
  • 1250 Views
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Article
IL-7 signaling imparts polyfunctionality and stemness potential to CD4+ T cells
Zhi-Chun Ding, Chufeng Liu, Yang Cao, Tsadik Habtetsion, Michal Kuczma, Wenhu Pi, Heng Kong, Ercan Cacan, Susanna F. Greer, Yan Cui, Bruce R. Blazar, David H. Munn & Gang Zhou
Article: e1171445
Published online: 08 Jun 2016
AbstractforIL-7 signaling imparts polyfunctionality and stemness potential to CD4+ T cells | Full Text | References | PDF (1.1 MB) | Supplemental
  • 2171 Views
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Article
Successful engineering of a highly potent single-chain variable-fragment (scFv) bispecific antibody to target disialoganglioside (GD2) positive tumors
Ming Cheng, Brian H. Santich, Hong Xu, Mahiuddin Ahmed, Morgan Huse & Nai-Kong V. Cheung
Article: e1168557
Published online: 15 Jun 2016
AbstractforSuccessful engineering of a highly potent single-chain variable-fragment (scFv) bispecific antibody to target disialoganglioside (GD2) positive tumors | Full Text | References | PDF (1 MB) | Supplemental
  • 2889 Views
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Article
SCIB2, an antibody DNA vaccine encoding NY-ESO-1 epitopes, induces potent antitumor immunity which is further enhanced by checkpoint blockade
Wei Xue, Rachael L. Metheringham, Victoria A. Brentville, Barbara Gunn, Peter Symonds, Hideo Yagita, Judith M. Ramage & Lindy G. Durrant
Article: e1169353
Published online: 15 Jun 2016
AbstractforSCIB2, an antibody DNA vaccine encoding NY-ESO-1 epitopes, induces potent antitumor immunity which is further enhanced by checkpoint blockade | Full Text | References | PDF (1.1 MB) | Supplemental
  • 1864 Views
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Article
A novel role of breast cancer-derived hyaluronan on inducement of M2-like tumor-associated macrophages formation
Guoliang Zhang, Lin Guo, Cuixia Yang, Yiwen Liu, Yiqing He, Yan Du, Wenjuan Wang & Feng Gao
Article: e1172154
Published online: 15 Jun 2016
AbstractforA novel role of breast cancer-derived hyaluronan on inducement of M2-like tumor-associated macrophages formation | Full Text | References | PDF (1.5 MB) | Supplemental
  • 1829 Views
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Article
Transgenic antigen-specific, HLA-A*02:01-allo-restricted cytotoxic T cells recognize tumor-associated target antigen STEAP1 with high specificity
David Schirmer, Thomas G. P. Grünewald, Richard Klar, Oxana Schmidt, Dirk Wohlleber, Rebeca Alba Rubío, Wolfgang Uckert, Uwe Thiel, Felix Bohne, Dirk H. Busch, Angela M. Krackhardt, Stefan Burdach & Günther H. S. Richter
Article: e1175795
Published online: 16 Jun 2016
AbstractforTransgenic antigen-specific, HLA-A*02:01-allo-restricted cytotoxic T cells recognize tumor-associated target antigen STEAP1 with high specificity | Full Text | References | PDF (936.6 KB) | Supplemental
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Article
CTLA4 blockade reduces immature myeloid cells in head and neck squamous cell carcinoma
Guang-Tao Yu, Lin-Lin Bu, Yu-Yue Zhao, Liang Mao, Wei-Wei Deng, Tian-Fu Wu, Wen-Feng Zhang & Zhi-Jun Sun
Article: e1151594
Published online: 28 Jun 2016
AbstractforCTLA4 blockade reduces immature myeloid cells in head and neck squamous cell carcinoma | Full Text | References | PDF (1.9 MB) | Supplemental
  • 1930 Views
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Article
Similar lymphocytic infiltration pattern in primary breast cancer and their corresponding distant metastases
Bettina Sobottka, Bernhard Pestalozzi, Daniel Fink, Holger Moch & Zsuzsanna Varga
Article: e1153208
Published online: 28 Jun 2016
AbstractforSimilar lymphocytic infiltration pattern in primary breast cancer and their corresponding distant metastases | Full Text | References | PDF (1.1 MB)
  • 1418 Views
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Article
miRNA dynamics in tumor-infiltrating myeloid cells modulating tumor progression in pancreatic cancer
Leonie Mühlberg, Benjamin Kühnemuth, Eithne Costello, Victoria Shaw, Bence Sipos, Magdalena Huber, Heidi Griesmann, Sebastian Krug, Marvin Schober, Thomas M. Gress & Patrick Michl
Article: e1160181
Published online: 28 Jun 2016
AbstractformiRNA dynamics in tumor-infiltrating myeloid cells modulating tumor progression in pancreatic cancer | Full Text | References | PDF (1.3 MB) | Supplemental
  • 1193 Views
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Article
AIM2 inflammasome mediates Arsenic-induced secretion of IL-1 β and IL-18
Mingfang Zhang, Yuanlin Qi, Hui Li, Jiajun Cui, Lu Dai, Jacqueline A. Frank, Jian Chen, Wenhua Xu & Gang Chen
Article: e1160182
Published online: 28 Jun 2016
AbstractforAIM2 inflammasome mediates Arsenic-induced secretion of IL-1 β and IL-18 | Full Text | References | PDF (884.8 KB)
  • 1709 Views
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Article
mRNA-based dendritic cell immunization improves survival in ret transgenic mouse melanoma model
Adi Sharbi-Yunger, Mareike Grees, Esther Tzehoval, Jochen Utikal, Viktor Umansky & Lea Eisenbach
Article: e1160183
Published online: 28 Jun 2016
AbstractformRNA-based dendritic cell immunization improves survival in ret transgenic mouse melanoma model | Full Text | References | PDF (723.3 KB)
  • 866 Views
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Article
Murine mesothelioma induces locally-proliferating IL-10+TNF-α+CD206−CX3CR1+ M3 macrophages that can be selectively depleted by chemotherapy or immunotherapy
Connie Jackaman, Teong L. Yeoh, Manyual L. Acuil, Joanne K. Gardner & Delia J. Nelson
Article: e1173299
Published online: 15 Jun 2016
AbstractforMurine mesothelioma induces locally-proliferating IL-10+TNF-α+CD206−CX3CR1+ M3 macrophages that can be selectively depleted by chemotherapy or immunotherapy | Full Text | References | PDF (1.4 MB) | Supplemental
  • 1553 Views
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Article
The dual role of NK cells in antitumor reactions triggered by ionizing radiation in combination with hyperthermia
Patrick Finkel, Benjamin Frey, Friederike Mayer, Karina Bösl, Nina Werthmöller, Andreas Mackensen, Udo S. Gaipl & Evelyn Ullrich
Article: e1101206
Published online: 16 Jun 2016
AbstractforThe dual role of NK cells in antitumor reactions triggered by ionizing radiation in combination with hyperthermia | Full Text | References | PDF (1 MB) | Supplemental
  • 1866 Views
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Point of View

Article
Macrophages and c-Myc cross paths
Oscar M. Pello
Article: e1151991
Published online: 28 Jun 2016
AbstractforMacrophages and c-Myc cross paths | Full Text | References | PDF (186.6 KB)
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Review

Review
Role of IL-2 in cancer immunotherapy
Tao Jiang, Caicun Zhou & Shengxiang Ren
Article: e1163462
Published online: 31 May 2016
AbstractforRole of IL-2 in cancer immunotherapy | Full Text | References | PDF (689.1 KB)
  • 12204 Views
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Review
Prioritization schema for immunotherapy clinical trials in glioblastoma
Tiffany R. Hodges, Sherise D. Ferguson, Hillary G. Caruso, Gary Kohanbash, Shouhao Zhou, Timothy F. Cloughesy, Mitchel S. Berger, George H. Poste, Mustafa Khasraw, Sujuan Ba, Tao Jiang, Tom Mikkelson, W.K. Alfred Yung, John F. de Groot, Howard Fine, Lewis C. Cantley, Ingo K. Mellinghoff, Duane A. Mitchell, Hideho Okada & Amy B. Heimberger
Article: e1145332
Published online: 23 May 2016
AbstractforPrioritization schema for immunotherapy clinical trials in glioblastoma | Full Text | References | PDF (586 KB) | Supplemental
  • 2286 Views
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Review
Trial Watch—Small molecules targeting the immunological tumor microenvironment for cancer therapy
Aitziber Buqué, Norma Bloy, Fernando Aranda, Isabelle Cremer, Alexander Eggermont, Wolf Hervé Fridman, Jitka Fucikova, Jérôme Galon, Radek Spisek, Eric Tartour, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi
Article: e1149674
Published online: 23 May 2016
AbstractforTrial Watch—Small molecules targeting the immunological tumor microenvironment for cancer therapy | Full Text | References | PDF (707.3 KB)
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Review
The immune network in thyroid cancer
Maria Rosaria Galdiero, Gilda Varricchi & Gianni Marone
Article: e1168556
Published online: 15 Jun 2016
AbstractforThe immune network in thyroid cancer | Full Text | References | PDF (855.7 KB)
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Corrigenda

Correction
Corrigendum
Article: e1193395
Published online: 16 Jun 2016
CitationforCorrigendum | Full Text | PDF (80.8 KB)
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Erratum

Correction
Erratum
Article: e1179503
Published online: 08 Jun 2016
CitationforErratum | Full Text | PDF (80.2 KB)
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