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OncoImmunology Volume 5, 2016 - Issue 6
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Original Research

Epigenetic modification augments the immunogenicity of human leukocyte antigen G serving as a tumor antigen for T cell-based immunotherapy

Kei IshibashiDepartment of Pathology, Asahikawa Medical University, Asahikawa, Japan;Respiratory and Breast Center, Asahikawa Medical University Hospital, Asahikawa, Japan
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Takumi KumaiDepartment of Pathology, Asahikawa Medical University, Asahikawa, Japan;Department of Otolaryngology, Head and Neck Surgery, Asahikawa Medical University, Asahikawa, Japan;Cancer Immunology, Inflammation and Tolerance Program, Augusta University Cancer Center, Augusta, GA, USACorrespondence[email protected] [email protected]
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Takayuki OhkuriDepartment of Pathology, Asahikawa Medical University, Asahikawa, JapanCorrespondence[email protected] [email protected]
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Akemi KosakaDepartment of Pathology, Asahikawa Medical University, Asahikawa, Japan
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Toshihiro NagatoDepartment of Otolaryngology, Head and Neck Surgery, Asahikawa Medical University, Asahikawa, Japan
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Yui HirataDepartment of Pathology, Asahikawa Medical University, Asahikawa, Japan;Department of Otolaryngology, Head and Neck Surgery, Asahikawa Medical University, Asahikawa, Japan
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Kenzo OharaDepartment of Pathology, Asahikawa Medical University, Asahikawa, Japan;Department of Otolaryngology, Head and Neck Surgery, Asahikawa Medical University, Asahikawa, Japan
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Kensuke OikawaDepartment of Pathology, Asahikawa Medical University, Asahikawa, Japan
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Naoko AokiDepartment of Pathology, Asahikawa Medical University, Asahikawa, Japan
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Naoko AkiyamaDepartment of Surgical Pathology, Asahikawa Medical University Hospital, Asahikawa, Japan
,
Masatoshi SadoDepartment of Surgical Pathology, Asahikawa Medical University Hospital, Asahikawa, Japan
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Masahiro KitadaRespiratory and Breast Center, Asahikawa Medical University Hospital, Asahikawa, Japan
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Yasuaki HarabuchiDepartment of Otolaryngology, Head and Neck Surgery, Asahikawa Medical University, Asahikawa, Japan
,
Esteban CelisCancer Immunology, Inflammation and Tolerance Program, Augusta University Cancer Center, Augusta, GA, USA
&
Hiroya KobayashiDepartment of Pathology, Asahikawa Medical University, Asahikawa, Japan
 show all
Article: e1169356 | Received 25 Jan 2016, Accepted 17 Mar 2016, Published online: 09 Jun 2016

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Ryusuke Hayashi, Toshihiro Nagato, Takumi Kumai, Kenzo Ohara, Mizuho Ohara, Takayuki Ohkuri, Yui Hirata-Nozaki, Shohei Harabuchi, Akemi Kosaka, Marino Nagata, Yuki Yajima, Syunsuke Yasuda, Kensuke Oikawa, Michihisa Kono, Kan Kishibe, Miki Takahara, Akihiro Katada, Tatsuya Hayashi, Esteban Celis, Yasuaki Harabuchi & Hiroya Kobayashi. (2021) Expression of placenta-specific 1 and its potential for eliciting anti-tumor helper T-cell responses in head and neck squamous cell carcinoma. OncoImmunology 10:1.
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Kenzo Ohara, Takayuki Ohkuri, Takumi Kumai, Toshihiro Nagato, Yui Nozaki, Kei Ishibashi, Akemi Kosaka, Marino Nagata, Shohei Harabuchi, Mizuho Ohara, Kensuke Oikawa, Naoko Aoki, Yasuaki Harabuchi, Esteban Celis & Hiroya Kobayashi. (2018) Targeting phosphorylated p53 to elicit tumor-reactive T helper responses against head and neck squamous cell carcinoma. OncoImmunology 7:9.
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Mozhi Wang, Changwang Zhang, Yongxi Song, Zhenning Wang, Yaojia Wang, Fang Luo, Yujie Xu, Yi Zhao, Zhonghua Wu & Yingying Xu. (2017) Mechanism of immune evasion in breast cancer. OncoTargets and Therapy 10, pages 1561-1573.
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Peilong Li, Nan Wang, Yi Zhang, Chuanxin Wang & Lutao Du. (2021) HLA-G/sHLA-G and HLA-G-Bearing Extracellular Vesicles in Cancers: Potential Role as Biomarkers. Frontiers in Immunology 12.
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Akemi Kosaka, Kei Ishibashi, Toshihiro Nagato, Hidemitsu Kitamura, Yukio Fujiwara, Syunsuke Yasuda, Marino Nagata, Shohei Harabuchi, Ryusuke Hayashi, Yuki Yajima, Kenzo Ohara, Takumi Kumai, Naoko Aoki, Yoshihiro Komohara, Kensuke Oikawa, Yasuaki Harabuchi, Masahiro Kitada, Hiroya Kobayashi & Takayuki Ohkuri. (2021) CD47 blockade enhances the efficacy of intratumoral STING-targeting therapy by activating phagocytes. Journal of Experimental Medicine 218:11.
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Nanna Jørgensen, Anne-Vibeke Lænkholm, Susanne Gjørup Sækmose, Lone Bak Hansen & Thomas Vauvert F. Hviid. (2021) Peripheral blood immune markers in breast cancer: Differences in regulatory T cell abundance are related to clinical parameters. Clinical Immunology 232, pages 108847.
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Aifen Lin & Wei-Hua Yan. (2021) HLA-G/ILTs Targeted Solid Cancer Immunotherapy: Opportunities and Challenges. Frontiers in Immunology 12.
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Maria Loustau, François Anna, Raphaelle Dréan, Martin Lecomte, Pierre Langlade-Demoyen & Julien Caumartin. (2020) HLA-G Neo-Expression on Tumors. Frontiers in Immunology 11.
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Nanna Jørgensen, Abid Sayed, Helene Bjerregaard Jeppesen, Gry Persson, Iben Weisdorf, Tina Funck & Thomas Vauvert Faurschou Hviid. (2020) Characterization of HLA-G Regulation and HLA Expression in Breast Cancer and Malignant Melanoma Cell Lines upon IFN-γ Stimulation and Inhibition of DNA Methylation. International Journal of Molecular Sciences 21:12, pages 4307.
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Dan J. Raz. 2019. Targeted Therapies for Lung Cancer. Targeted Therapies for Lung Cancer 217 232 .
Aifen Lin & Wei‐Hua Yan. (2019) Intercellular transfer of HLA‐G: its potential in cancer immunology. Clinical & Translational Immunology 8:9.
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Aifen Lin & Wei-Hua Yan. (2018) Heterogeneity of HLA-G Expression in Cancers: Facing the Challenges. Frontiers in Immunology 9.
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Toshihiro Nagato, Takumi Kumai, Miki Takahara, Takayuki Ohkuri, Hiroya Kobayashi, Esteban Celis & Yasuaki Harabuchi. (2018) Innovative immunotherapy for nasal NK/T-cell lymphoma鼻性NK/T細胞リンパ腫に対する革新的免疫療法の開発. Journal of Japan Society of Immunology & Allergology in Otolaryngology 36:1, pages 15-22.
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Rui-Li Zhang, Xia Zhang, Shan-Shan Dong, Bing Hu, Qiu-Yue Han, Jian-Gang Zhang, Wen-Jun Zhou, Aifen Lin & Wei-Hua Yan. (2017) Predictive value of different proportion of lesion HLA-G expression in colorectal cancer. Oncotarget 8:64, pages 107441-107451.
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Rosaria Benedetti, Carmela Dell’Aversana, Cristina Giorgio, Roberta Astorri & Lucia Altucci. (2017) Breast Cancer Vaccines: New Insights. Frontiers in Endocrinology 8.
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Jennifer Dunn & Sudha Rao. (2017) Epigenetics and immunotherapy: The current state of play. Molecular Immunology 87, pages 227-239.
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Lasse Lindholm Johansen, Jørgen Lock-Andersen & Thomas Vauvert F. Hviid. (2016) The Pathophysiological Impact of HLA Class Ia and HLA-G Expression and Regulatory T Cells in Malignant Melanoma: A Review. Journal of Immunology Research 2016, pages 1-11.
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