Advanced search
Publication Cover
OncoImmunology Volume 5, 2016 - Issue 7
Submit an article Journal homepage
2,359
Views
57
CrossRef citations to date
0
Altmetric
Original Research

Regulatory T cells with multiple suppressive and potentially pro-tumor activities accumulate in human colorectal cancer

Eleonora TimperiDipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy
,
Ilenia PacellaDipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy
,
Valeria SchinzariDipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy
,
Chiara FocaccettiDipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy
,
Luca SaccoSezione di Chirurgia Interdisciplinare “F. Durante”, Sapienza Università di Roma, Rome, Italy
,
Francesco FarelliSezione di Chirurgia Interdisciplinare “F. Durante”, Sapienza Università di Roma, Rome, Italy
,
Roberto CaronnaSezione di Chirurgia Interdisciplinare “F. Durante”, Sapienza Università di Roma, Rome, Italy
,
Gabriella Del BeneDipartimento di Medicina Molecolare, Sapienza Università di Roma, Rome, Italy
,
Flavia LongoDipartimento di Medicina Molecolare, Sapienza Università di Roma, Rome, Italy
,
Antonio CiardiDipartimento di Scienze Radiologiche, Oncologiche e Anatomo-Patologiche, Sapienza Università di Roma, Rome, Italy
,
Sergio MorelliDipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy
,
Anna Rita VestriDipartimento di Sanità Pubblica e Malattie Infettive, Sapienza Università di Roma, Rome, Italy
,
Piero ChirlettiSezione di Chirurgia Interdisciplinare “F. Durante”, Sapienza Università di Roma, Rome, Italy
,
Vincenzo BarnabaDipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy;Istituto Pasteur-Fondazione Cenci Bolognetti, Rome, Italy;Center for Life Nano Science, Istituto Italiano di Tecnologia, Rome, ItalyCorrespondence[email protected]
&
Silvia PiconeseDipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy;Istituto Pasteur-Fondazione Cenci Bolognetti, Rome, Italy
 show all
Article: e1175800 | Received 12 Feb 2016, Accepted 01 Apr 2016, Published online: 29 Jun 2016

Citations (57)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Wenqing Yu, Ningfei Ji, Chengjing Gu, Juan Yao, Mingdong Ding, Daming Zhou, Mao Huang & Mingshun Zhang. (2021) IRF4 is Correlated with the Conversion to a Th17-Like Phenotype in Regulatory T Cells from the Malignant Pleural Effusion. International Journal of General Medicine 14, pages 6009-6019.
Read now
Cristina M Quintella, Heitor M Quintella, Mayla Rohweder & Guilherme M Quintella. (2020) Advances in patent applications related to cancer vaccine using CpG-ODN and OX40 association. Expert Opinion on Therapeutic Patents 30:4, pages 287-301.
Read now
Mariona Cabo, Rienk Offringa, Laurence Zitvogel, Guido Kroemer, Aura Muntasell & Lorenzo Galluzzi. (2017) Trial Watch: Immunostimulatory monoclonal antibodies for oncological indications. OncoImmunology 6:12.
Read now

Articles from other publishers (54)

Yejin Cao, Yueru Hou, Longhao Zhao, Yijin Huang & Guangwei Liu. (2023) New insights into follicular regulatory T cells in the intestinal and tumor microenvironments. Journal of Cellular Physiology 238:7, pages 1465-1477.
Crossref
Ming-Ming Shao, Xue-Bin Pei, Qing-Yu Chen, Feng Wang, Zhen Wang & Kan Zhai. (2023) Macrophage-derived exosome promotes regulatory T cell differentiation in malignant pleural effusion. Frontiers in Immunology 14.
Crossref
Julie Bonnereau, Tristan Courau, Nicolas Asesio, Delphine Salfati, Fatiha Bouhidel, Hélène Corte, Sarah Hamoudi, Nassim Hammoudi, Julie Lavolé, Justine Vivier-Chicoteau, Victor Chardiny, Leon Maggiori, Mathieu Blery, Romain Remark, Cécile Bonnafous, Pierre Cattan, Antoine Toubert, Purnima Bhat, Matthieu Allez, Thomas Aparicio & Lionel Le Bourhis. (2023) Autologous T cell responses to primary human colorectal cancer spheroids are enhanced by ectonucleotidase inhibition. Gut 72:4, pages 699-709.
Crossref
Mi-Ae Lyu, Meixian Huang, Ke Zeng, Li Li, Joseph D. Khoury, Mitsutaka Nishimoto, Hongbing Ma, Tara Sadeghi, Siddhartha Mukherjee, Arthur S. Slutsky, Christopher R. Flowers & Simrit Parmar. (2023) Allogeneic cord blood regulatory T cells can resolve lung inflammation. Cytotherapy 25:3, pages 245-253.
Crossref
Céline M. Laumont & Brad H. Nelson. (2023) B cells in the tumor microenvironment: Multi-faceted organizers, regulators, and effectors of anti-tumor immunity. Cancer Cell 41:3, pages 466-489.
Crossref
Gabriela Sampaio-Ribeiro, Ana Ruivo, Ana Silva, Ana Lúcia Santos, Rui Caetano Oliveira, Paula Laranjeira, João Gama, Maria Augusta Cipriano, José Guilherme Tralhão & Artur Paiva. (2022) Extensive Phenotypic Characterization of T Cells Infiltrating Liver Metastasis from Colorectal Cancer: A Potential Role in Precision Medicine. Cancers 14:24, pages 6069.
Crossref
Jinxiang Wu, Lei Wang & Jianwei Xu. (2022) The role of pyroptosis in modulating the tumor immune microenvironment. Biomarker Research 10:1.
Crossref
Mohammad A. Al-Mterin, Khaled Murshed, Alhasan Alsalman, Ala Abu-Dayeh & Eyad Elkord. (2022) Associations of different immune checkpoints-expressing CD4+ Treg/ T cell subsets with disease-free survival in colorectal cancer patients. BMC Cancer 22:1.
Crossref
Gregório Guilherme Almeida, Inga Rimkute, Isabela Natália Pascoal Campos do Vale, Thomas Liechti, Priscilla Miranda Henriques, Ester Roffe, Fernanda Fortes de Araújo, Manoel Otávio da Costa Rocha, Silvana Maria Elói Santos, Olindo Assis Martins-Filho, Dragana Jankovic, Alan Sher, Andrea Teixeira-Carvalho, Mario Roederer & Lis Ribeiro do Valle Antonelli. (2022) Chagasic cardiomyopathy is marked by a unique signature of activated CD4+ T cells. Journal of Translational Medicine 20:1.
Crossref
Gabriela Roliano, Juliana Azambuja, Veronica Brunetto, Hannah Butterfield, Antonio Kalil & Elizandra Braganhol. (2022) Colorectal Cancer and Purinergic Signalling: An Overview. Cancers 14:19, pages 4887.
Crossref
Mohammad A. Al-Mterin, Khaled Murshed & Eyad Elkord. (2022) Correlations between Circulating and Tumor-Infiltrating CD4+ Treg Subsets with Immune Checkpoints in Colorectal Cancer Patients with Early and Advanced Stages. Vaccines 10:9, pages 1471.
Crossref
Yifang Hu, Ni Zeng, Yaoqi Ge, Dan Wang, Xiaoxuan Qin, Wensong Zhang, Feng Jiang & Yun Liu. (2022) Identification of the Shared Gene Signatures and Biological Mechanism in Type 2 Diabetes and Pancreatic Cancer. Frontiers in Endocrinology 13.
Crossref
Mohammad A. Al-Mterin, Khaled Murshed & Eyad Elkord. (2022) Correlations between Circulating and Tumor-Infiltrating CD4+ T Cell Subsets with Immune Checkpoints in Colorectal Cancer. Vaccines 10:4, pages 538.
Crossref
Galina Zhulai & Eugenia Oleinik. (2022) Targeting regulatory T cells in anti‐PD‐1/PD‐L1 cancer immunotherapy. Scandinavian Journal of Immunology 95:3.
Crossref
Shaokun Wang, Li Pang, Zuolong Liu & Xiangwei Meng. (2021) SERPINE1 associated with remodeling of the tumor microenvironment in colon cancer progression: a novel therapeutic target. BMC Cancer 21:1.
Crossref
Louis Szeponik, Filip Ahlmanner, Patrik Sundström, William Rodin, Bengt Gustavsson, Elinor Bexe Lindskog, Yvonne Wettergren & Marianne Quiding-Järbrink. (2021) Intratumoral regulatory T cells from colon cancer patients comprise several activated effector populations. BMC Immunology 22:1.
Crossref
Yan-Jie Xu, Jie-Min Zhao, Cao Gao, Xue-Feng Ni, Wei Wang, Wen-Wei Hu & Chang-Ping Wu. (2021) Hsa_circ_0136666 activates Treg-mediated immune escape of colorectal cancer via miR-497/PD-L1 pathway. Cellular Signalling 86, pages 110095.
Crossref
Daniel DiToro & Rajatava Basu. (2021) Emerging Complexity in CD4+T Lineage Programming and Its Implications in Colorectal Cancer. Frontiers in Immunology 12.
Crossref
Eleonora Timperi & Vincenzo Barnaba. (2021) CD39 Regulation and Functions in T Cells. International Journal of Molecular Sciences 22:15, pages 8068.
Crossref
Alessandra Rossi, Ilenia Pacella & Silvia Piconese. (2021) RNA Flow Cytometry for the Study of T Cell Metabolism. International Journal of Molecular Sciences 22:8, pages 3906.
Crossref
Mario Galgani, Sara Bruzzaniti, Claudia La Rocca, Teresa Micillo, Paola de Candia, Maurizio Bifulco & Giuseppe Matarese. (2021) Immunometabolism of regulatory T cells in cancer. Molecular Aspects of Medicine 77, pages 100936.
Crossref
Martin Gutierrez, Victor Moreno, Kimberley M. Heinhuis, Anthony J. Olszanski, Anna Spreafico, Michael Ong, Quincy Chu, Richard D. Carvajal, José Trigo, Maria Ochoa de Olza, Mariano Provencio, Filip Yves De Vos, Filippo De Braud, Stephen Leong, Deanne Lathers, Rui Wang, Palani Ravindran, Yan Feng, Praveen Aanur & Ignacio Melero. (2021) OX40 Agonist BMS-986178 Alone or in Combination With Nivolumab and/or Ipilimumab in Patients With Advanced Solid Tumors. Clinical Cancer Research 27:2, pages 460-472.
Crossref
E. A. Galliamov, M. A. Agapov, P. G. Mal’kov, D. R. Markaryan, N. V. Danilova, V. V. Kakotkin, E. A. Kazachenko, A. M. Lukyanov, N. A. Oleynikova & V. A. Kubyshkin. (2020) PARASITIC ABSCESS AS AN INCIDENTAL HISTOLOGICAL FINDING IN THE TREATMENT OF SIGMOID COLON CANCER. Surgical practice:3, pages 53-58.
Crossref
Ketao Jin, Chengcheng Ren, Yuyao Liu, Huanrong Lan & Zhen Wang. (2020) An update on colorectal cancer microenvironment, epigenetic and immunotherapy. International Immunopharmacology 89, pages 107041.
Crossref
Ioannis Karagiannidis, Stephanie J. Jerman, Damian Jacenik, Brandon B. Phinney, Ruoxin Yao, Eric R. Prossnitz & Ellen J. Beswick. (2020) G-CSF and G-CSFR Modulate CD4 and CD8 T Cell Responses to Promote Colon Tumor Growth and Are Potential Therapeutic Targets. Frontiers in Immunology 11.
Crossref
Bin Hu, Xiaohua Shi, Xiaohui Du, Mingxin Xu, Qi Wang & Hui Zhao. (2020) Pattern of immune infiltration in lung cancer and its clinical implication. Clinica Chimica Acta 508, pages 47-53.
Crossref
Meilan Xue, Hui Liang, Xinqiang Ji, Zhitong Zhou, Ying Liu, Ting Sun & Li Zhang. (2020) Effects of fucoidan on gut flora and tumor prevention in 1,2-dimethylhydrazine-induced colorectal carcinogenesis. The Journal of Nutritional Biochemistry 82, pages 108396.
Crossref
Louis Szeponik, Paulina Akeus, William Rodin, Sukanya Raghavan & Marianne Quiding-Järbrink. (2020) Regulatory T cells specifically suppress conventional CD8αβ T cells in intestinal tumors of APCMin/+ mice. Cancer Immunology, Immunotherapy 69:7, pages 1279-1292.
Crossref
Haider Rasheed Alrafas, Philip Brandon Busbee, Kumaraswamy Naidu Chitrala, Mitzi Nagarkatti & Prakash Nagarkatti. (2020) Alterations in the Gut Microbiome and Suppression of Histone Deacetylases by Resveratrol Are Associated with Attenuation of Colonic Inflammation and Protection Against Colorectal Cancer. Journal of Clinical Medicine 9:6, pages 1796.
Crossref
Xiaodong ChenFen TianPeng LunYugong Feng. (2020) Profiles of immune infiltration and its relevance to survival outcome in meningiomas. Bioscience Reports 40:5.
Crossref
Sam R Adhikary, Peter Cuthbertson, Ross J Turner, Ronald Sluyter & Debbie Watson. (2020) A single‐nucleotide polymorphism in the human ENTPD1 gene encoding CD39 is associated with worsened graft‐ versus ‐host disease in a humanized mouse model . Immunology & Cell Biology 98:5, pages 397-410.
Crossref
Helal F. Hetta, Azza Elkady, Ramadan Yahia, Ahmed Kh. Meshall, Mahmoud M. Saad, Mohamed A. Mekky & Israa M.S. Al-Kadmy. (2020) T follicular helper and T follicular regulatory cells in colorectal cancer: A complex interplay. Journal of Immunological Methods 480, pages 112753.
Crossref
Liuxue Sheng, Xiang Chen, Qh Wang, Sali Lyu & Pengping Li. (2020) Interferon-α2b enhances survival and modulates transcriptional profiles and the immune response in melanoma patients treated with dendritic cell vaccines. Biomedicine & Pharmacotherapy 125, pages 109966.
Crossref
Bobin Mi, Qiushi Li, Tong Li, Guohui Liu & Jiayang Sai. (2020) High miR-31-5p expression promotes colon adenocarcinoma progression by targeting TNS1. Aging 12:8, pages 7480-7490.
Crossref
Emilie Picard, Chris P. Verschoor, Grace W. Ma & Graham Pawelec. (2020) Relationships Between Immune Landscapes, Genetic Subtypes and Responses to Immunotherapy in Colorectal Cancer. Frontiers in Immunology 11.
Crossref
Simone Ragusa, Borja Prat-Luri, Alejandra González-Loyola, Sina Nassiri, Mario Leonardo Squadrito, Alan Guichard, Sabrina Cavin, Nikolce Gjorevski, David Barras, Giancarlo Marra, Matthias P. Lutolf, Jean Perentes, Emily Corse, Roberta Bianchi, Laureline Wetterwald, Jaeryung Kim, Guillermo Oliver, Mauro Delorenzi, Michele De Palma & Tatiana V. Petrova. (2020) Antiangiogenic immunotherapy suppresses desmoplastic and chemoresistant intestinal tumors in mice. Journal of Clinical Investigation 130:3, pages 1199-1216.
Crossref
Eleonora Timperi, Elena Vissio, Caterina Marchiò & Emanuela Romano. 2020. Tumor Microenvironment. Tumor Microenvironment 215 249 .
Wen-Qing Yu, Ning-Fei Ji, Cheng-Jing Gu, Zhi-Xiao Sun, Zheng-Xia Wang, Zhong-Qi Chen, Yuan Ma, Zhen-Zhen Wu, Yan-Li Wang, Chao-Jie Wu, Ming-Dong Ding, Gui-Hong Dai, Juan Yao, Rong-Rong Jin, Mao Huang & Ming-Shun Zhang. (2019) Downregulation of miR-4772-3p promotes enhanced regulatory T cell capacity in malignant pleural effusion by elevating Helios levels. Chinese Medical Journal 132:22, pages 2705-2715.
Crossref
Lele Ye, Teming Zhang, Zhengchun Kang, Gangqiang Guo, Yongji Sun, Kangming Lin, Qunjia Huang, Xinyu Shi, Zhonglin Ni, Ning Ding, Kong-Nan Zhao, Wenjun Chang, Junjie Wang, Feng Lin & Xiangyang Xue. (2019) Tumor-Infiltrating Immune Cells Act as a Marker for Prognosis in Colorectal Cancer. Frontiers in Immunology 10.
Crossref
Leire Pedrosa, Francis Esposito, Timothy M. Thomson & Joan Maurel. (2019) The Tumor Microenvironment in Colorectal Cancer Therapy. Cancers 11:8, pages 1172.
Crossref
Klaus G. Schmetterer, Katrin Goldhahn, Liesa S. Ziegler, Marlene C. Gerner, Ralf L. J. Schmidt, Madeleine Themanns, Eva Zebedin-Brandl, Doris Trapin, Judith Leitner, Winfried F. Pickl, Peter Steinberger, Ilse Schwarzinger & Rodrig Marculescu. (2019) Overexpression of PDE4A Acts as Checkpoint Inhibitor Against cAMP-Mediated Immunosuppression in vitro. Frontiers in Immunology 10.
Crossref
Julie Stockis, Rahul Roychoudhuri & Timotheus Y. F. Halim. (2019) Regulation of regulatory T cells in cancer. Immunology 157:3, pages 219-231.
Crossref
Hytham K. S. Hamid. (2019) Schistosoma japonicum–Associated Colorectal Cancer: A Review. The American Journal of Tropical Medicine and Hygiene 100:3, pages 501-505.
Crossref
Aras Toker & Pamela S. Ohashi. 2019. 193 261 .
Edward S. Taylor, John L. McCall, Shirley Shen, Adam Girardin, Fran M. Munro, Michael A. Black, Kirsten A. Ward‐Hartstonge & Roslyn A. Kemp. (2018) Prognostic roles for IL ‐2‐producing and CD 69 + T cell subsets in colorectal cancer patients . International Journal of Cancer 143:8, pages 2008-2016.
Crossref
Lorenzo Galluzzi, Timothy A. Chan, Guido Kroemer, Jedd D. Wolchok & Alejandro López-Soto. (2018) The hallmarks of successful anticancer immunotherapy. Science Translational Medicine 10:459.
Crossref
Valeria Schinzari, Eleonora Timperi, Giulia Pecora, Francesco Palmucci, Daniela Gallerano, Alessio Grimaldi, Daniela Angela Covino, Nicola Guglielmo, Fabio Melandro, Emy Manzi, Andrea Sagnotta, Francesco Lancellotti, Luca Sacco, Piero Chirletti, Gian Luca Grazi, Massimo Rossi & Vincenzo Barnaba. (2018) Wnt3a/β-Catenin Signaling Conditions Differentiation of Partially Exhausted T-effector Cells in Human Cancers. Cancer Immunology Research 6:8, pages 941-952.
Crossref
Paul A. Moore, Kalpana Shah, Yinhua Yang, Ralph Alderson, Penny Roberts, Vatana Long, Daorong Liu, Jonathan C. Li, Steve Burke, Valentina Ciccarone, Hua Li, Claudia B. Fieger, Jeff Hooley, Ann Easton, Monica Licea, Sergey Gorlatov, Kathy L. King, Peter Young, Arash Adami, Deryk Loo, Gurunadh R. Chichili, Liqin Liu, Douglas H. Smith, Jennifer G. Brown, Francine Z. Chen, Scott Koenig, Jennie Mather, Ezio Bonvini & Syd Johnson. (2018) Development of MGD007, a gpA33 x CD3-Bispecific DART Protein for T-Cell Immunotherapy of Metastatic Colorectal Cancer. Molecular Cancer Therapeutics 17:8, pages 1761-1772.
Crossref
Ilenia PacellaClaudio ProcacciniChiara FocaccettiStefano MiacciEleonora TimperiDeriggio FaicchiaMartina SeveraFabiana RizzoEliana Marina CocciaFabrizia BonacinaNico MitroGiuseppe Danilo NorataGrazisa Rossetti, Valeria RanzaniMassimiliano PaganiEzio GiordaYu WeiGiuseppe Matarese, Vincenzo Barnaba & Silvia Piconese. (2018) Fatty acid metabolism complements glycolysis in the selective regulatory T cell expansion during tumor growth. Proceedings of the National Academy of Sciences 115:28.
Crossref
Sarah L. Buchan, Anne Rogel & Aymen Al-Shamkhani. (2018) The immunobiology of CD27 and OX40 and their potential as targets for cancer immunotherapy. Blood 131:1, pages 39-48.
Crossref
Xinyan Liu, Shucai Wu, Yonghui Yang, Min Zhao, Guiyun Zhu & Zhihua Hou. (2017) The prognostic landscape of tumor-infiltrating immune cell and immunomodulators in lung cancer. Biomedicine & Pharmacotherapy 95, pages 55-61.
Crossref
Gloria Donninelli, Manuela Del Cornò, Marina Pierdominici, Beatrice Scazzocchio, Rosaria Varì, Barbara Varano, Ilenia Pacella, Silvia Piconese, Vincenzo Barnaba, Massimo D’Archivio, Roberta Masella, Lucia Conti & Sandra Gessani. (2017) Distinct Blood and Visceral Adipose Tissue Regulatory T Cell and Innate Lymphocyte Profiles Characterize Obesity and Colorectal Cancer. Frontiers in Immunology 8.
Crossref
Veronica De Rosa, Francesca Di Rella, Antonio Di Giacomo & Giuseppe Matarese. (2017) Regulatory T cells as suppressors of anti-tumor immunity: Role of metabolism. Cytokine & Growth Factor Reviews 35, pages 15-25.
Crossref
Azharuddin Sajid Syed Khaja, Salman M. Toor, Haytham El Salhat, Bassam R. Ali & Eyad Elkord. (2017) Intratumoral FoxP3+Helios+ Regulatory T Cells Upregulating Immunosuppressive Molecules Are Expanded in Human Colorectal Cancer. Frontiers in Immunology 8.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.