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Original Research

PD-L1 expression as a predictive biomarker for cytokine-induced killer cell immunotherapy in patients with hepatocellular carcinoma

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Article: e1176653 | Received 09 Oct 2015, Accepted 04 Apr 2016, Published online: 29 Jun 2016

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Chae Eun Lee, Jeong Hwan Lee, Hyun Joo Chung, Da Won Lee, Jong Seok Lim, Kibum Kim, Jin Wook Kim, Yong Seong Lee, Kyung Soo Kim, Hyun Jin Min, Kisung Ko & Soon Chul Myung. (2023) Expression and in vitro function of anti-PD-L1 human antibody expressed in plant. Plant Biotechnology Reports 17:4, pages 531-539.
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Hongjie Xin, Qianwei Lai, Yuchen Zhou, Jian He, Yangda Song, Minjun Liao, Jiarun Sun, Meng Li, Mingxia Zhang, Weifang Liang, Yang Bai, Yongyuan Zhang & Yuanping Zhou. (2023) Noninvasive evaluation of neutrophil extracellular traps signature predicts clinical outcomes and immunotherapy response in hepatocellular carcinoma. Frontiers in Immunology 14.
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Xue-Qin Gong, Ning Liu, Yun-Yun Tao, Li Li, Zu-Mao Li, Lin Yang & Xiao-Ming Zhang. (2023) Radiomics models based on multisequence MRI for predicting PD-1/PD-L1 expression in hepatocellular carcinoma. Scientific Reports 13:1.
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Xiaoqiang Gao & Shi Zuo. (2023) Immune landscape and immunotherapy of hepatocellular carcinoma: focus on innate and adaptive immune cells. Clinical and Experimental Medicine.
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Xiaoqiang Yin, Tongchui Wu, Yadong Lan & Wulin Yang. (2022) Current progress of immune checkpoint inhibitors in the treatment of advanced hepatocellular carcinoma. Bioscience Reports 42:2.
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Caecilia H C Sukowati, Korri Elvanita El-Khobar & Claudio Tiribelli. (2021) Immunotherapy against programmed death-1/programmed death ligand 1 in hepatocellular carcinoma: Importance of molecular variations, cellular heterogeneity, and cancer stem cells. World Journal of Stem Cells 13:7, pages 795-824.
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Wei Jiang, Tao Li, Jiaojiao Guo, Jingjing Wang, Lizhou Jia, Xiao shi, Tingting Yang, Ruonan Jiao, Xin Wei, Zhenqing Feng, Qi Tang & Guozhong Ji. (2021) Bispecific c-Met/PD-L1 CAR-T Cells Have Enhanced Therapeutic Effects on Hepatocellular Carcinoma. Frontiers in Oncology 11.
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Li-Li Liu, Shi-Wen Zhang, Xue Chao, Chun-Hua Wang, Xia Yang, Xin-Ke Zhang, Yan-lin Wen, Jing-Ping Yun & Rong-Zhen Luo. (2020) Coexpression of CMTM6 and PD-L1 as a predictor of poor prognosis in macrotrabecular-massive hepatocellular carcinoma. Cancer Immunology, Immunotherapy 70:2, pages 417-429.
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Guosheng Yuan, Yangda Song, Qi Li, Xiaoyun Hu, Mengya Zang, Wencong Dai, Xiao Cheng, Wei Huang, Wenxuan Yu, Mian Chen, Yabing Guo, Qifan Zhang & Jinzhang Chen. (2021) Development and Validation of a Contrast-Enhanced CT-Based Radiomics Nomogram for Prediction of Therapeutic Efficacy of Anti-PD-1 Antibodies in Advanced HCC Patients. Frontiers in Immunology 11.
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Svetlana Bornschlegl, Michael P Gustafson, Danae A Delivanis, Mabel Ryder, Minetta C Liu, George Vasmatzis, Chris L Hallemeier, Sean S Park, Lewis R Roberts, Ian F Parney, Diane F Jelinek & Allan B Dietz. (2021) Categorisation of patients based on immune profiles: a new approach to identifying candidates for response to checkpoint inhibitors. Clinical & Translational Immunology 10:4.
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Morvarid Golrokh Mofrad, Donya Taghizadeh Maleki & Ebrahim Faghihloo. (2020) The roles of programmed death ligand 1 in virus-associated cancers. Infection, Genetics and Evolution 84, pages 104368.
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Xing Huang, Xiaozhen Zhang, Jian Xu, Xun Wang, Gang Zhang, Tianyu Tang, Xiaochao Shen, Tingbo Liang & Xueli Bai. (2020) Deubiquitinating Enzyme: A Potential Secondary Checkpoint of Cancer Immunity. Frontiers in Oncology 10.
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Jin-Zhi Zhang, Yu-Zhu Ma, Jia-Lin Gu & Jie-Ge Huo. (2020) Clinical research progress of immune checkpoint inhibitors in treatment of primary liver cancer. World Chinese Journal of Digestology 28:14, pages 605-616.
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Xing Huang, Xiaozhen Zhang, Xueli Bai & Tingbo Liang. (2019) Blocking PD-L1 for anti-liver cancer immunity: USP22 represents a critical cotarget. Cellular & Molecular Immunology 17:7, pages 677-679.
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Sukeshi Patel Arora, Gabor Liposits, Susan Caird, Richard F. Dunne, Gordon Taylor Moffat, David Okonji, Maria Grazia Rodriquenz, Divyanshu Dua & Efrat Dotan. (2020) Hepatocellular carcinoma in older adults: A comprehensive review by Young International Society of Geriatric Oncology. Journal of Geriatric Oncology 11:4, pages 557-565.
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Xiao-Song Li, Jun-Wei Li, Hui Li & Tao Jiang. (2020) Prognostic value of programmed cell death ligand 1 (PD-L1) for hepatocellular carcinoma: a meta-analysis. Bioscience Reports 40:4.
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Ji Hye Kim, Kyungbin Kim, Misung Kim, Young Min Kim, Jae Hee Suh, Hee Jeong Cha & Hye Jeong Choi. (2020) Programmed death-ligand 1 expression and its correlation with clinicopathological parameters in gallbladder cancer. Journal of Pathology and Translational Medicine 54:2, pages 154-164.
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Zi-Qi Zhou, Jing-Jing Zhao, Qiu-Zhong Pan, Chang-Long Chen, Yuan Liu, Yan Tang, Qian Zhu, De-Sheng Weng & Jian-Chuan Xia. (2019) PD-L1 expression is a predictive biomarker for CIK cell-based immunotherapy in postoperative patients with breast cancer. Journal for ImmunoTherapy of Cancer 7:1.
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Yanhui Chen, Quanxing Liu, Zhiming Chen, Yating Wang, Wanning Yang, Ying Hu, Wenbo Han, Hui Zeng, Haitao Ma, Jigang Dai & Henghui Zhang. (2019) PD-L1 expression and tumor mutational burden status for prediction of response to chemotherapy and targeted therapy in non-small cell lung cancer. Journal of Experimental & Clinical Cancer Research 38:1.
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Gao-Min Liu, Xu-Gang Li & Yao-Min Zhang. (2019) Prognostic role of PD-L1 for HCC patients after potentially curative resection: a meta-analysis. Cancer Cell International 19:1.
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Hye Won Lee, Kyung Joo Cho, Soon Young Shin, Ha Yan Kim, Eun Ju Lee, Beom Kyung Kim, Seung Up Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn & Kwang-Hyub Han. (2019) Serum PD-1 Levels Change with Immunotherapy Response but Do Not Predict Prognosis in Patients with Hepatocellular Carcinoma. Journal of Liver Cancer 19:2, pages 108-116.
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Mengxin Tian, Yinghong Shi, Weiren Liu & Jia Fan. (2019) Immunotherapy of hepatocellular carcinoma: strategies for combinatorial intervention. Science China Life Sciences 62:9, pages 1138-1143.
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Jing Cao, Fan-Hua Kong, Xi Liu & Xiao-Bo Wang. (2019) Immunotherapy with dendritic cells and cytokine-induced killer cells for hepatocellular carcinoma: A meta-analysis. World Journal of Gastroenterology 25:27, pages 3649-3663.
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T. Mocan, Z. Sparchez, R. Craciun, C. N. Bora & D. C. Leucuta. (2018) Programmed cell death protein-1 (PD-1)/programmed death-ligand-1 (PD-L1) axis in hepatocellular carcinoma: prognostic and therapeutic perspectives. Clinical and Translational Oncology 21:6, pages 702-712.
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Shixia Bu, Boning Li, Qian Wang, Tingting Gu, Qianggang Dong, Xiaofei Miao & Dongmei Lai. (2019) Epithelial ovarian cancer stem‑like cells are resistant to the cellular lysis of cytokine‑induced killer cells via HIF1A‑mediated downregulation of ICAM‑1. International Journal of Oncology.
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Christian Ihling, Bartholomew Naughton, Yue Zhang, P. Alexander Rolfe, Eveline Frick-Krieger, Luigi M. Terracciano & Isabelle Dussault. (2019) Observational Study of PD-L1, TGF-β, and Immune Cell Infiltrates in Hepatocellular Carcinoma. Frontiers in Medicine 6.
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Xingliang Guo, Hua Jiang, Bizhi Shi, Min Zhou, Honghong Zhang, Zhimin Shi, Guoxiu Du, Hong Luo, Xiuqi Wu, Yi Wang, Ruixin Sun & Zonghai Li. (2018) Disruption of PD-1 Enhanced the Anti-tumor Activity of Chimeric Antigen Receptor T Cells Against Hepatocellular Carcinoma. Frontiers in Pharmacology 9.
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Jing-Hua Li, Wei-Jie Ma, Gang-Gang Wang, Xiang Jiang, Xi Chen, Long Wu, Zhi-Su Liu, Xian-Tao Zeng, Fu-Ling Zhou & Yu-Feng Yuan. (2018) Clinicopathologic Significance and Prognostic Value of Programmed Cell Death Ligand 1 (PD-L1) in Patients With Hepatocellular Carcinoma: A Meta-Analysis. Frontiers in Immunology 9.
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Boyang Chang, Lujun Shen, Kefeng Wang, Jietian Jin, Tao Huang, Qifeng Chen, Wang Li & Peihong Wu. (2018) High number of PD ‐1 positive intratumoural lymphocytes predicts survival benefit of cytokine‐induced killer cells for hepatocellular carcinoma patients . Liver International 38:8, pages 1449-1458.
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Ritu Shrestha, Prashanth Prithviraj, Matthew Anaka, Kim R. Bridle, Darrell H. G. Crawford, Bijay Dhungel, Jason C. Steel & Aparna Jayachandran. (2018) Monitoring Immune Checkpoint Regulators as Predictive Biomarkers in Hepatocellular Carcinoma. Frontiers in Oncology 8.
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Albert J. Czaja. (2018) Under-Evaluated or Unassessed Pathogenic Pathways in Autoimmune Hepatitis and Implications for Future Management. Digestive Diseases and Sciences 63:7, pages 1706-1725.
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Yating Tang, Guang Li, Shan Wu, Lingrong Tang, Ning Zhang, Jinzhao Liu, Shuo Zhang & Lei Yao. (2018) Programmed death ligand 1 expression in esophageal cancer following definitive chemoradiotherapy: Prognostic significance and association with inflammatory biomarkers. Oncology Letters.
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Janis M Taube, Jérôme Galon, Lynette M Sholl, Scott J Rodig, Tricia R Cottrell, Nicolas A Giraldo, Alexander S Baras, Sanjay S Patel, Robert A Anders, David L Rimm & Ashley Cimino-Mathews. (2017) Implications of the tumor immune microenvironment for staging and therapeutics. Modern Pathology 31:2, pages 214-234.
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Peter Dietrich, Kim Freese, Abdo Mahli, Wolfgang Erwin Thasler, Claus Hellerbrand & Anja Katrin Bosserhoff. (2017) Combined effects of PLK1 and RAS in hepatocellular carcinoma reveal rigosertib as promising novel therapeutic “dual-hit” option. Oncotarget 9:3, pages 3605-3618.
Crossref
Li-Wei Liu, Ming-Ya Yang, Min Zhou, Jia-Jia Li, Bo Liu & Yue-Yin Pan. (2017) Improvement of cytotoxicity of autologous CIKs from patients with breast cancer to MCF-7 cells by suppressed PD-1 expression. Cancer Biomarkers 20:4, pages 609-615.
Crossref
Chun-yu Huang, Ying Wang, Guang-yu Luo, Feng Han, Yong-qiang Li, Zhong-guo Zhou & Guo-liang Xu. (2017) Relationship Between PD-L1 Expression and CD8+ T-cell Immune Responses in Hepatocellular Carcinoma. Journal of Immunotherapy 40:9, pages 323-333.
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Elisa Cappuzzello, Roberta Sommaggio, Paola Zanovello & Antonio Rosato. (2017) Cytokines for the induction of antitumor effectors: The paradigm of Cytokine-Induced Killer (CIK) cells. Cytokine & Growth Factor Reviews 36, pages 99-105.
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Yu-Feng Yang, Ying-Hua Pan, Yun Cao, Jia Fu, Xia Yang, Mei-Fang Zhang & Qiu-Hong Tian. (2017) PDZ binding kinase, regulated by FoxM1, enhances malignant phenotype via activation of β-Catenin signaling in hepatocellular carcinoma. Oncotarget 8:29, pages 47195-47205.
Crossref
Mohammad Reza Zamani, Saeed Aslani, Arash Salmaninejad, Mohammad Reza Javan & Nima Rezaei. (2016) PD-1/PD-L and autoimmunity: A growing relationship. Cellular Immunology 310, pages 27-41.
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