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Original Research

Programmed death ligand 1 as an indicator of pre-existing adaptive immune responses in human hepatocellular carcinoma

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Article: e1181252 | Received 03 Feb 2016, Accepted 15 Apr 2016, Published online: 30 Jun 2016

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Read on this site (3)

Dina Omar Helmy, Fatma Khattab, Azza Elsayed Hegazy & Rania Mohamed Sabry. (2023) Immunohistochemical expression of immune check point protein PDL-1 in hepatocellular carcinoma denotes its prognostic significance and association with survival. Journal of Immunoassay and Immunochemistry 44:3, pages 213-228.
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Ying Zhu, Xiang-Yu Wang, Yu Zhang, Da Xu, Jian Dong, Ze Zhang, Chen-He Yi, Hu-Liang Jia & Xin Yang. (2018) Programmed death ligand 1 expression in human intrahepatic cholangiocarcinoma and its association with prognosis and CD8+ T-cell immune responses. Cancer Management and Research 10, pages 4113-4123.
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Yu-Jie Zhao, Wei-Peng Sun, Jian-Hong Peng, Yu-Xiang Deng, Yu-Jing Fang, Jun Huang, Hui-Zhong Zhang, De-Sen Wan, Jun-Zhong Lin & Zhi-Zhong Pan. (2018) Programmed death-ligand 1 expression correlates with diminished CD8+ T cell infiltration and predicts poor prognosis in anal squamous cell carcinoma patients. Cancer Management and Research 10, pages 1-11.
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Articles from other publishers (41)

Seogsong Jeong, Woo-Young Shin & Yun Hwan Oh. (2023) Immunotherapy for NAFLD and NAFLD-related hepatocellular carcinoma. Frontiers in Endocrinology 14.
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Kazuki Maesaka, Ryotaro Sakamori, Ryoko Yamada, Akira Doi, Yuki Tahata, Kazuyoshi Ohkawa, Masahide Oshita, Masanori Miyazaki, Takayuki Yakushijin, Yasutoshi Nozaki, Kengo Matsumoto, Satoshi Tanaka, Akira Kaneko, Sadaharu Iio, Takatoshi Nawa, Yukinori Yamada, Naoki Morishita, Takeo Usui, Naoki Hiramatsu, Yoshinori Doi, Mitsuru Sakakibara, Kazuho Imanaka, Yuichi Yoshida, Takahiro Kodama, Hayato Hikita, Tomohide Tatsumi & Tetsuo Takehara. (2023) Pretreatment with antibiotics is associated with reduced therapeutic response to atezolizumab plus bevacizumab in patients with hepatocellular carcinoma. PLOS ONE 18:2, pages e0281459.
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Yang Zhang, Zongjuan Li, Yixing Chen, Ping Yang, Yong Hu, Zhaochong Zeng & Shisuo Du. (2022) Higher serum sPD-L1 levels after radiotherapy indicate poor outcome in hepatocellular carcinoma patients. Translational Oncology 26, pages 101537.
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Ulrich Sommer, Celina Ebersbach, Alicia-Marie K. Beier, Gustavo B. Baretton, Christian Thomas, Angelika Borkowetz & Holger H. H. Erb. (2022) Influence of Androgen Deprivation Therapy on the PD-L1 Expression and Immune Activity in Prostate Cancer Tissue. Frontiers in Molecular Biosciences 9.
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Rosa Lombardi, Roberto Piciotti, Paola Dongiovanni, Marica Meroni, Silvia Fargion & Anna Ludovica Fracanzani. (2022) PD-1/PD-L1 Immuno-Mediated Therapy in NAFLD: Advantages and Obstacles in the Treatment of Advanced Disease. International Journal of Molecular Sciences 23:5, pages 2707.
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Guoying Zhou, Patrick P. C. Boor, Marco J. Bruno, Dave Sprengers & Jaap Kwekkeboom. (2021) Immune suppressive checkpoint interactions in the tumour microenvironment of primary liver cancers. British Journal of Cancer 126:1, pages 10-23.
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Venkata Prasuja Nakka. 2022. Theranostics and Precision Medicine for the Management of Hepatocellular Carcinoma, Volume 3. Theranostics and Precision Medicine for the Management of Hepatocellular Carcinoma, Volume 3 215 223 .
Lin Sun, Luwen Mu, Jing Zhou, Wenjie Tang, Linqi Zhang, Sidong Xie, Jingbiao Chen & Jin Wang. (2021) Imaging features of gadoxetic acid-enhanced MR imaging for evaluation of tumor-infiltrating CD8 cells and PD-L1 expression in hepatocellular carcinoma. Cancer Immunology, Immunotherapy 71:1, pages 25-38.
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Min Deng, Shao-Hua Li, Xu Fu, Xiao-Peng Yan, Jun Chen, Yu-Dong Qiu & Rong-Ping Guo. (2021) Relationship between PD-L1 expression, CD8+ T-cell infiltration and prognosis in intrahepatic cholangiocarcinoma patients. Cancer Cell International 21:1.
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Xiaopei Hao, Guangshun Sun, Yao Zhang, Xiangyi Kong, Dawei Rong, Jinhua Song, Weiwei Tang & Xuehao Wang. (2021) Targeting Immune Cells in the Tumor Microenvironment of HCC: New Opportunities and Challenges. Frontiers in Cell and Developmental Biology 9.
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Thuzar Hla Shwe, Peraphan Pothacharoen, Thanyaluck Phitak, Benjawan Wudtiwai & Prachya Kongtawelert. (2021) Atorvastatin Attenuates Programmed Death Ligand-1 (PD-L1) Induction in Human Hepatocellular Carcinoma Cells. International Journal of Molecular Sciences 22:16, pages 8755.
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Man Wu, Xueqing Xia, Jiemiao Hu, Natalie Wall Fowlkes & Shulin Li. (2021) WSX1 act as a tumor suppressor in hepatocellular carcinoma by downregulating neoplastic PD-L1 expression. Nature Communications 12:1.
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Wei Jiang, Tao Li, Jiaojiao Guo, Jingjing Wang, Lizhou Jia, Xiao shi, Tingting Yang, Ruonan Jiao, Xin Wei, Zhenqing Feng, Qi Tang & Guozhong Ji. (2021) Bispecific c-Met/PD-L1 CAR-T Cells Have Enhanced Therapeutic Effects on Hepatocellular Carcinoma. Frontiers in Oncology 11.
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Tomoko Aoki, Naoshi Nishida, Kazuomi Ueshima, Masahiro Morita, Hirokazu Chishina, Masahiro Takita, Satoru Hagiwara, Hiroshi Ida, Yasunori Minami, Akira Yamada, Keitaro Sofue, Masakatsu Tsurusaki & Masatoshi Kudo. (2021) Higher Enhancement Intrahepatic Nodules on the Hepatobiliary Phase of Gd-EOB-DTPA-Enhanced MRI as a Poor Responsive Marker of Anti-PD-1/PD-L1 Monotherapy for Unresectable Hepatocellular Carcinoma. Liver Cancer 10:6, pages 615-628.
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Hatem A. Elmezayen, Hirohisa Okabe, Yoshifumi Baba, Toshihiko Yusa, Rumi Itoyama, Yosuke Nakao, Takanobu Yamao, Naoki Umzaki, Masayo Tsukamoto, Yuki Kitano, Tatsunori Miyata, Kota Arima, Hiromitsu Hayashi, Katsunori Imai, Akira Chikamoto, Yo-ichi Yamashita & Hideo Baba. (2019) Clinical role of serum programmed death ligand 1 in patients with hepatocellular carcinoma: Where does it come from?. Surgery Today 50:6, pages 569-576.
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Xiao-Song Li, Jun-Wei Li, Hui Li & Tao Jiang. (2020) Prognostic value of programmed cell death ligand 1 (PD-L1) for hepatocellular carcinoma: a meta-analysis. Bioscience Reports 40:4.
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Yi-Ming Li, Jing-Min Yu, Zhen-Yu Liu, Hai-Jiao Yang, Juan Tang & Zhi-Nan Chen. (2019) Programmed Death Ligand 1 Indicates Pre-Existing Adaptive Immune Response by Tumor-Infiltrating CD8+ T Cells in Non-Small Cell Lung Cancer. International Journal of Molecular Sciences 20:20, pages 5138.
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Zhaoyun Zong, Jiahuan Zou, Rudi Mao, Chao Ma, Na Li, Jianing Wang, Xiaoyan Wang, Huaiyu Zhou, Lining Zhang & Yongyu Shi. (2019) M1 Macrophages Induce PD-L1 Expression in Hepatocellular Carcinoma Cells Through IL-1β Signaling. Frontiers in Immunology 10.
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