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OncoImmunology Volume 5, 2016 - Issue 10
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Original Research

Natural killer cell recognition of in vivo drug-induced senescent multiple myeloma cells

Fabrizio AntonangeliDepartment of Molecular Medicine, Pasteur Institute-Cenci Bolognetti Foundation, Sapienza University of Rome, Rome, Italy
,
Alessandra SorianiDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy
,
Biancamaria RicciDepartment of Molecular Medicine, Pasteur Institute-Cenci Bolognetti Foundation, Sapienza University of Rome, Rome, Italy
,
Andrea PonzettaDepartment of Molecular Medicine, Pasteur Institute-Cenci Bolognetti Foundation, Sapienza University of Rome, Rome, Italy
,
Giorgia BenigniDepartment of Molecular Medicine, Pasteur Institute-Cenci Bolognetti Foundation, Sapienza University of Rome, Rome, Italy
,
Stefania MorroneDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy
,
Giovanni BernardiniDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy;IRCCS Neuromed, Pozzilli IS, Italy
&
Angela SantoniDepartment of Molecular Medicine, Pasteur Institute-Cenci Bolognetti Foundation, Sapienza University of Rome, Rome, Italy;IRCCS Neuromed, Pozzilli IS, ItalyCorrespondence[email protected]
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Article: e1218105 | Received 26 Feb 2016, Accepted 22 Jul 2016, Published online: 27 Sep 2016

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Rohit Sharma & Yogendra Padwad. (2020) Probiotic bacteria as modulators of cellular senescence: emerging concepts and opportunities. Gut Microbes 11:3, pages 335-349.
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Elisabetta Vulpis, Francesca Cecere, Rosa Molfetta, Alessandra Soriani, Cinzia Fionda, Giovanna Peruzzi, Giulio Caracciolo, Sara Palchetti, Laura Masuelli, Lucilla Simonelli, Ugo D'Oro, Maria Pia Abruzzese, Maria Teresa Petrucci, Maria Rosaria Ricciardi, Rossella Paolini, Marco Cippitelli, Angela Santoni & Alessandra Zingoni. (2017) Genotoxic stress modulates the release of exosomes from multiple myeloma cells capable of activating NK cell cytokine production: Role of HSP70/TLR2/NF-kB axis. OncoImmunology 6:3.
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Articles from other publishers (35)

Tareq Saleh, Sarah Bloukh, Mira Hasan & Sofian Al Shboul. (2023) Therapy-induced senescence as a component of tumor biology: Evidence from clinical cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1878:6, pages 188994.
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Luisa Salvatori, Silvia Malatesta, Barbara Illi, Maria Patrizia Somma, Cinzia Fionda, Helena Stabile, Rosaria Anna Fontanella & Carlo Gaetano. (2023) Nitric Oxide Prevents Glioblastoma Stem Cells’ Expansion and Induces Temozolomide Sensitization. International Journal of Molecular Sciences 24:14, pages 11286.
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Elisabetta Vulpis, Lorenzo Cuollo, Cristiana Borrelli, Fabrizio Antonangeli, Laura Masuelli, Marco Cippitelli, Cinzia Fionda, Giulio Caracciolo, Maria Teresa Petrucci, Angela Santoni, Alessandra Zingoni & Alessandra Soriani. (2023) Doxorubicin–Mediated miR–433 Expression on Exosomes Promotes Bystander Senescence in Multiple Myeloma Cells in a DDR–Independent Manner. International Journal of Molecular Sciences 24:7, pages 6862.
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Rohit Sharma & Bhawna Diwan. (2023) A Cellular Senescence-Centric Integrated Approach to Understanding Organismal Aging. Current Aging Science 16:1, pages 12-24.
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Rohit Sharma, Bhawna Diwan, Anamika Sharma & Jacek M. Witkowski. (2022) Emerging cellular senescence-centric understanding of immunological aging and its potential modulation through dietary bioactive components. Biogerontology 23:6, pages 699-729.
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Lina Alhaddad, Andreyan N. Osipov & Sergey Leonov. (2022) The Molecular and Cellular Strategies of Glioblastoma and Non-Small-Cell Lung Cancer Cells Conferring Radioresistance. International Journal of Molecular Sciences 23:21, pages 13577.
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Loretah Chibaya, Jarin Snyder & Marcus Ruscetti. (2022) Senescence and the tumor-immune landscape: Implications for cancer immunotherapy. Seminars in Cancer Biology 86, pages 827-845.
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Tareq Saleh, Valerie J. Carpenter, Sarah Bloukh & David A. Gewirtz. (2022) Targeting tumor cell senescence and polyploidy as potential therapeutic strategies. Seminars in Cancer Biology 81, pages 37-47.
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Rohit Sharma & Bhawna Diwan. (2022) An update on healthspan and lifespan enhancing attributes of tea amidst the emerging understanding of aging biology. Human Nutrition & Metabolism 28, pages 200149.
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Jonas Schwestermann, Andrej Besse, Christoph Driessen & Lenka Besse. (2022) Contribution of the Tumor Microenvironment to Metabolic Changes Triggering Resistance of Multiple Myeloma to Proteasome Inhibitors. Frontiers in Oncology 12.
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Muhammed Iraqi, Avishay Edri, Yariv Greenshpan, Oron Goldstein, Noa Ofir, Priyanka Bolel, Muhammad Abu Ahmad, Miri Zektser, Kerry S. Campbell, Ory Rouvio, Roi Gazit & Angel Porgador. (2022) Blocking the PCNA/NKp44 Checkpoint to Stimulate NK Cell Responses to Multiple Myeloma. International Journal of Molecular Sciences 23:9, pages 4717.
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Jacques Ferreira & Alex Deamer. 2022. Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging. Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging 291 306 .
Elisabetta Vulpis, Luisa Loconte, Agnese Peri, Rosa Molfetta, Giulio Caracciolo, Laura Masuelli, Luana Tomaipitinca, Giovanna Peruzzi, Sara Petillo, Maria Teresa Petrucci, Francesca Fazio, Lucilla Simonelli, Cinzia Fionda, Alessandra Soriani, Cristina Cerboni, Marco Cippitelli, Rossella Paolini, Giovanni Bernardini, Gabriella Palmieri, Angela Santoni & Alessandra Zingoni. (2022) Impact on NK cell functions of acute versus chronic exposure to extracellular vesicle‐associated MICA: Dual role in cancer immunosurveillance. Journal of Extracellular Vesicles 11:1.
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Hadrien De Blander, Anne-Pierre Morel, Aruni P. Senaratne, Maria Ouzounova & Alain Puisieux. (2021) Cellular Plasticity: A Route to Senescence Exit and Tumorigenesis. Cancers 13:18, pages 4561.
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Shaojie Wu, Huixian Kuang, Jin Ke, Manfei Pi & Dong-Hua Yang. (2021) Metabolic Reprogramming Induces Immune Cell Dysfunction in the Tumor Microenvironment of Multiple Myeloma. Frontiers in Oncology 10.
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Lorenzo Cuollo, Fabrizio Antonangeli, Angela Santoni & Alessandra Soriani. (2020) The Senescence-Associated Secretory Phenotype (SASP) in the Challenging Future of Cancer Therapy and Age-Related Diseases. Biology 9:12, pages 485.
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Abhijit Kale, Amit Sharma, Alexandra Stolzing, Pierre-Yves Desprez & Judith Campisi. (2020) Role of immune cells in the removal of deleterious senescent cells. Immunity & Ageing 17:1.
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Enrico Lattuada, Manuela Leo, Debora Caprara, Luisa Salvatori, Antonella Stoppacciaro, Francesco Sciortino & Patrizia Filetici. (2020) DNA-GEL, Novel Nanomaterial for Biomedical Applications and Delivery of Bioactive Molecules. Frontiers in Pharmacology 11.
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Eleonora Russo, Angela Santoni & Giovanni Bernardini. (2020) Tumor inhibition or tumor promotion? The duplicity of CXCR3 in cancer. Journal of Leukocyte Biology 108:2, pages 673-685.
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Giuseppina D'Alessandro, Fabrizio Antonangeli, Francesco Marrocco, Alessandra Porzia, Clotilde Lauro, Angela Santoni & Cristina Limatola. (2020) Gut microbiota alterations affect glioma growth and innate immune cells involved in tumor immunosurveillance in mice. European Journal of Immunology 50:5, pages 705-711.
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Tareq Saleh, Sarah Bloukh, Valerie J. Carpenter, Enas Alwohoush, Jomana Bakeer, Sarah Darwish, Belal Azab & David A. Gewirtz. (2020) Therapy-Induced Senescence: An “Old” Friend Becomes the Enemy. Cancers 12:4, pages 822.
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Alessandra Zingoni, Elisabetta Vulpis, Luisa Loconte & Angela Santoni. (2020) NKG2D Ligand Shedding in Response to Stress: Role of ADAM10. Frontiers in Immunology 11.
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Alessandra Soriani, Elisabetta Vulpis, Lorenzo Cuollo, Angela Santoni & Alessandra Zingoni. (2020) Cancer extracellular vesicles as novel regulators of NK cell response. Cytokine & Growth Factor Reviews 51, pages 19-26.
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Valentina Bonanni, Fabrizio Antonangeli, Angela Santoni & Giovanni Bernardini. (2019) Targeting of CXCR3 improves anti-myeloma efficacy of adoptively transferred activated natural killer cells. Journal for ImmunoTherapy of Cancer 7:1.
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Maria Teresa Bilotta, Maria Pia Abruzzese, Rosa Molfetta, Gianluca Scarno, Cinzia Fionda, Alessandra Zingoni, Alessandra Soriani, Tina Garofalo, Maria Teresa Petrucci, Maria Rosaria Ricciardi, Rossella Paolini, Angela Santoni & Marco Cippitelli. (2019) Activation of liver X receptor up‐regulates the expression of the NKG2D ligands MICA and MICB in multiple myeloma through different molecular mechanisms. The FASEB Journal 33:8, pages 9489-9504.
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Fabrizio Antonangeli, Alessandra Zingoni, Alessandra Soriani & Angela Santoni. (2019) Senescent cells: Living or dying is a matter of NK cells. Journal of Leukocyte Biology 105:6, pages 1275-1283.
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Elisabetta Vulpis, Alessandra Soriani, Cristina Cerboni, Angela Santoni & Alessandra Zingoni. (2019) Cancer Exosomes as Conveyors of Stress-Induced Molecules: New Players in the Modulation of NK Cell Response. International Journal of Molecular Sciences 20:3, pages 611.
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Kerry S. Campbell, Adam D. Cohen & Tatiana Pazina. (2018) Mechanisms of NK Cell Activation and Clinical Activity of the Therapeutic SLAMF7 Antibody, Elotuzumab in Multiple Myeloma. Frontiers in Immunology 9.
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Cristiana Borrelli, Biancamaria Ricci, Elisabetta Vulpis, Cinzia Fionda, Maria Rosaria Ricciardi, Maria Teresa Petrucci, Laura Masuelli, Agnese Peri, Marco Cippitelli, Alessandra Zingoni, Angela Santoni & Alessandra Soriani. (2018) Drug-Induced Senescent Multiple Myeloma Cells Elicit NK Cell Proliferation by Direct or Exosome-Mediated IL15 Trans -Presentation . Cancer Immunology Research 6:7, pages 860-869.
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Dominick G.A. Burton & Alexandra Stolzing. (2018) Cellular senescence: Immunosurveillance and future immunotherapy. Ageing Research Reviews 43, pages 17-25.
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Alessandra Zingoni, Rosa Molfetta, Cinzia Fionda, Alessandra Soriani, Rossella Paolini, Marco Cippitelli, Cristina Cerboni & Angela Santoni. (2018) NKG2D and Its Ligands: “One for All, All for One”. Frontiers in Immunology 9.
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Irene Veneziani, Elisa Brandetti, Marzia Ognibene, Annalisa Pezzolo, Vito Pistoia & Loredana Cifaldi. (2018) Neuroblastoma Cell Lines Are Refractory to Genotoxic Drug-Mediated Induction of Ligands for NK Cell-Activating Receptors. Journal of Immunology Research 2018, pages 1-10.
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Loredana Cifaldi, Franco Locatelli, Emiliano Marasco, Lorenzo Moretta & Vito Pistoia. (2017) Boosting Natural Killer Cell-Based Immunotherapy with Anticancer Drugs: a Perspective. Trends in Molecular Medicine 23:12, pages 1156-1175.
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Fabrizio Antonangeli, Alessandra Soriani, Cristina Cerboni, Giuseppe Sciumè & Angela Santoni. (2017) How Mucosal Epithelia Deal with Stress: Role of NKG2D/NKG2D Ligands during Inflammation. Frontiers in Immunology 8.
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Jiacheng Bi & Zhigang Tian. (2017) NK Cell Exhaustion. Frontiers in Immunology 8.
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