OncoImmunology, Volume 5, Issue 10 (2016)

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OncoImmunology, Volume 5, Issue 10 (2016)

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Original Research

Article
Dynamic alterations of bone marrow cytokine landscape of myelodysplastic syndromes patients treated with 5-azacytidine
Alena Moudra, Sona Hubackova, Veronika Machalova, Marketa Vancurova, Jiri Bartek, Milan Reinis, Zdenek Hodny & Anna Jonasova
Article: e1183860
Published online: 27 Sep 2016
AbstractforDynamic alterations of bone marrow cytokine landscape of myelodysplastic syndromes patients treated with 5-azacytidine | Full Text | References | PDF (1.1 MB) | Supplemental
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Article
Macrophage-derived nitric oxide initiates T-cell diapedesis and tumor rejection
Ibrahim M. Sektioglu, Rafael Carretero, Noemi Bender, Christian Bogdan, Natalio Garbi, Viktor Umansky, Ludmila Umansky, Katharina Urban, Magnus von Knebel-Döberitz, Veena Somasundaram, David Wink, Philipp Beckhove & Günter J. Hämmerling
Article: e1204506
Published online: 27 Sep 2016
AbstractforMacrophage-derived nitric oxide initiates T-cell diapedesis and tumor rejection | Full Text | References | PDF (1.6 MB) | Supplemental
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Article
Vaccination of stage III/IV melanoma patients with long NY-ESO-1 peptide and CpG-B elicits robust CD8+ and CD4+ T-cell responses with multiple specificities including a novel DR7-restricted epitope
P. Baumgaertner, C. Costa Nunes, A. Cachot, H. Maby-El Hajjami, L. Cagnon, M. Braun, L. Derré, J.-P. Rivals, D. Rimoldi, S. Gnjatic, S. Abed Maillard, P. Marcos Mondéjar, M. P. Protti, E. Romano, O. Michielin, P. Romero, D. E. Speiser & C. Jandus
Article: e1216290
Published online: 27 Sep 2016
AbstractforVaccination of stage III/IV melanoma patients with long NY-ESO-1 peptide and CpG-B elicits robust CD8+ and CD4+ T-cell responses with multiple specificities including a novel DR7-restricted epitope | Full Text | References | PDF (1.4 MB) | Supplemental
  • 1671 Views
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Article
Natural killer cell recognition of in vivo drug-induced senescent multiple myeloma cells
Fabrizio Antonangeli, Alessandra Soriani, Biancamaria Ricci, Andrea Ponzetta, Giorgia Benigni, Stefania Morrone, Giovanni Bernardini & Angela Santoni
Article: e1218105
Published online: 27 Sep 2016
AbstractforNatural killer cell recognition of in vivo drug-induced senescent multiple myeloma cells | Full Text | References | PDF (1 MB) | Supplemental
  • 1811 Views
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Article
High-throughput T cell receptor sequencing reveals distinct repertoires between tumor and adjacent non-tumor tissues in HBV-associated HCC
Yunqing Chen, Ying Xu, Miaoxian Zhao, Yu Liu, Mingxing Gong, Cantao Xie, Hongkai Wu & Zhanhui Wang
Article: e1219010
Published online: 27 Sep 2016
AbstractforHigh-throughput T cell receptor sequencing reveals distinct repertoires between tumor and adjacent non-tumor tissues in HBV-associated HCC | Full Text | References | PDF (1.2 MB) | Supplemental
  • 2705 Views
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Article
Melanomas prevent endothelial cell death under restrictive culture conditions by signaling through AKT and p38 MAPK/ ERK-1/2 cascades
Asha M. Das, Mario Pescatori, Cindy E. Vermeulen, Joost A. P. Rens, Ann L. B. Seynhaeve, Gerben A. Koning, Alexander M. M. Eggermont & Timo L. M. ten Hagen
Article: e1219826
Published online: 27 Sep 2016
AbstractforMelanomas prevent endothelial cell death under restrictive culture conditions by signaling through AKT and p38 MAPK/ ERK-1/2 cascades | Full Text | References | PDF (2.5 MB) | Supplemental
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Article
Promoter methylation of the immune checkpoint receptor PD-1 (PDCD1) is an independent prognostic biomarker for biochemical recurrence-free survival in prostate cancer patients following radical prostatectomy
Diane Goltz, Heidrun Gevensleben, Jörn Dietrich, Jörg Ellinger, Jennifer Landsberg, Glen Kristiansen & Dimo Dietrich
Article: e1221555
Published online: 27 Sep 2016
AbstractforPromoter methylation of the immune checkpoint receptor PD-1 (PDCD1) is an independent prognostic biomarker for biochemical recurrence-free survival in prostate cancer patients following radical prostatectomy | Full Text | References | PDF (590.9 KB)
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Article
Mini-intronic plasmid vaccination elicits tolerant LAG3+ CD8+ T cells and inferior antitumor responses
Viswa Teja Colluru, Christopher D. Zahm & Douglas G. McNeel
Article: e1223002
Published online: 27 Sep 2016
AbstractforMini-intronic plasmid vaccination elicits tolerant LAG3+ CD8+ T cells and inferior antitumor responses | Full Text | References | PDF (1.2 MB) | Supplemental
  • 1092 Views
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Article
Impaired functional responses in follicular lymphoma CD8+TIM-3+ T lymphocytes following TCR engagement
Pauline Gravelle, Catherine Do, Camille Franchet, Sabina Mueller, Lucie Oberic, Loïc Ysebaert, Luigi Maria Larocca, Stefan Hohaus, Marie-Noëlle Calmels, François-Xavier Frenois, Robert Kridel, Randy D. Gascoyne, Guy Laurent, Pierre Brousset, Salvatore Valitutti & Camille Laurent
Article: e1224044
Published online: 07 Oct 2016
AbstractforImpaired functional responses in follicular lymphoma CD8+TIM-3+ T lymphocytes following TCR engagement | Full Text | References | PDF (1.7 MB) | Supplemental
  • 1123 Views
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Article
Tumor-infiltrating Tim-3+ T cells proliferate avidly except when PD-1 is co-expressed: Evidence for intracellular cross talk
Jing Li, Gulidanna Shayan, Lyndsay Avery, Hyun-Bae Jie, Neil Gildener-Leapman, Nicole Schmitt, Bin Feng Lu, Lawrence P. Kane & Robert L. Ferris
Article: e1200778
Published online: 11 Oct 2016
AbstractforTumor-infiltrating Tim-3+ T cells proliferate avidly except when PD-1 is co-expressed: Evidence for intracellular cross talk | Full Text | References | PDF (1.2 MB) | Supplemental
  • 2473 Views
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Article
The ratio of CD8+/FOXP3 T lymphocytes infiltrating breast tissues predicts the relapse of ductal carcinoma in situ
Michaela Semeraro, Julien Adam, Gautier Stoll, Emilie Louvet, Kariman Chaba, Vichnou Poirier-Colame, Allan Sauvat, Laura Senovilla, Erika Vacchelli, Norma Bloy, Juliette Humeau, Aitziber Buque, Oliver Kepp, Laurence Zitvogel, Fabrice André, Marie-Christine Mathieu, Suzette Delaloge & Guido Kroemer
Article: e1218106
Published online: 11 Oct 2016
AbstractforThe ratio of CD8+/FOXP3 T lymphocytes infiltrating breast tissues predicts the relapse of ductal carcinoma in situ | Full Text | References | PDF (1.6 MB) | Supplemental
  • 1255 Views
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Article
RIG-I activation induces the release of extracellular vesicles with antitumor activity
Juliane Daßler-Plenker, Katrin S. Reiners, Jasper G. van den Boorn, Hinrich P. Hansen, Bastian Putschli, Sabine Barnert, Christine Schuberth-Wagner, Rolf Schubert, Thomas Tüting, Michael Hallek, Martin Schlee, Gunther Hartmann, Elke Pogge von Strandmann & Christoph Coch
Article: e1219827
Published online: 11 Oct 2016
AbstractforRIG-I activation induces the release of extracellular vesicles with antitumor activity | Full Text | References | PDF (1.2 MB) | Supplemental
  • 2286 Views
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Article
Peritumoral stromal neutrophils are essential for c-Met-elicited metastasis in human hepatocellular carcinoma
Min He, Anping Peng, Xian-Zhang Huang, Dai-Chao Shi, Jun-Cheng Wang, Qiyi Zhao, Haibiao Lin, Dong-Ming Kuang, Pei-Feng Ke & Xiang-Ming Lao
Article: e1219828
Published online: 11 Oct 2016
AbstractforPeritumoral stromal neutrophils are essential for c-Met-elicited metastasis in human hepatocellular carcinoma | Full Text | References | PDF (1.2 MB) | Supplemental
  • 1866 Views
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Article
Vectorization in an oncolytic vaccinia virus of an antibody, a Fab and a scFv against programmed cell death -1 (PD-1) allows their intratumoral delivery and an improved tumor-growth inhibition
Patricia Kleinpeter, Laetitia Fend, Christine Thioudellet, Michel Geist, Nathalie Sfrontato, Véronique Koerper, Catherine Fahrner, Doris Schmitt, Murielle Gantzer, Christelle Remy-Ziller, Renée Brandely, Dominique Villeval, Karola Rittner, Nathalie Silvestre, Philippe Erbs, Laurence Zitvogel, Eric Quéméneur, Xavier Préville & Jean-Baptiste Marchand
Article: e1220467
Published online: 11 Oct 2016
AbstractforVectorization in an oncolytic vaccinia virus of an antibody, a Fab and a scFv against programmed cell death -1 (PD-1) allows their intratumoral delivery and an improved tumor-growth inhibition | Full Text | References | PDF (1.3 MB) | Supplemental
  • 4138 Views
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Article
Hepatocellular carcinoma is accelerated by NASH involving M2 macrophage polarization mediated by hif-1αinduced IL-10
Aditya Ambade, Abhishek Satishchandran, Banishree Saha, Benedek Gyongyosi, Patrick Lowe, Karen Kodys, Donna Catalano & Gyongyi Szabo
Article: e1221557
Published online: 11 Oct 2016
AbstractforHepatocellular carcinoma is accelerated by NASH involving M2 macrophage polarization mediated by hif-1αinduced IL-10 | Full Text | References | PDF (1.8 MB) | Supplemental
  • 3498 Views
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Article
Endothelial progenitor cell number and ERK phosphorylation serve as predictive and prognostic biomarkers in advanced hepatocellular carcinoma patients treated with sorafenib
Suresh Gopi Kalathil, Amit Anand Lugade, Renuka Iyer, Austin Miller & Yasmin Thanavala
Article: e1226718
Published online: 11 Oct 2016
AbstractforEndothelial progenitor cell number and ERK phosphorylation serve as predictive and prognostic biomarkers in advanced hepatocellular carcinoma patients treated with sorafenib | Full Text | References | PDF (752.8 KB) | Supplemental
  • 821 Views
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Article
CD24 blunts oral squamous cancer development and dampens the functional expansion of myeloid-derived suppressor cells
Caroline W. Fugle, Yongliang Zhang, Feng Hong, Shaoli Sun, Caroline Westwater, Saleh Rachidi, Hong Yu, Elizabeth Garret-Mayer, Keith Kirkwood, Bei Liu & Zihai Li
Article: e1226719
Published online: 11 Oct 2016
AbstractforCD24 blunts oral squamous cancer development and dampens the functional expansion of myeloid-derived suppressor cells | Full Text | References | PDF (1.5 MB)
  • 1317 Views
  • 10 CrossRef citations
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Article
Therapeutic CD94/NKG2A blockade improves natural killer cell dysfunction in chronic lymphocytic leukemia
Emily M. McWilliams, Jennifer M. Mele, Carolyn Cheney, Elizabeth A. Timmerman, Faraz Fiazuddin, Ethan J. Strattan, Xiaokui Mo, John C. Byrd, Natarajan Muthusamy & Farrukh T. Awan
Article: e1226720
Published online: 11 Oct 2016
AbstractforTherapeutic CD94/NKG2A blockade improves natural killer cell dysfunction in chronic lymphocytic leukemia | Full Text | References | PDF (713.2 KB)
  • 3293 Views
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Article
Tumor necrosis factor links chronic obstructive pulmonary disease and K-ras mutant lung cancer through induction of an immunosuppressive pro-tumor microenvironment
Lei Gong, Mauricio da Silva Caetano, Amber M. Cumpian, Soudabeh Daliri, Alejandra Garza Flores, Seon Hee Chang, Cesar E. Ochoa, Christopher M. Evans, Zhentao Yu & Seyed Javad Moghaddam
Article: e1229724
Published online: 11 Oct 2016
AbstractforTumor necrosis factor links chronic obstructive pulmonary disease and K-ras mutant lung cancer through induction of an immunosuppressive pro-tumor microenvironment | Full Text | References | PDF (1.5 MB) | Supplemental
  • 1184 Views
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Article
BTN3A molecules considerably improve Vγ9Vδ2T cells-based immunotherapy in acute myeloid leukemia
Audrey Benyamine, Aude Le Roy, Emilie Mamessier, Julie Gertner-Dardenne, Céline Castanier, Florence Orlanducci, Laurent Pouyet, Armelle Goubard, Yves Collette, Norbert Vey, Emmanuel Scotet, Remy Castellano & Daniel Olive
Article: e1146843
Published online: 14 Oct 2016
AbstractforBTN3A molecules considerably improve Vγ9Vδ2T cells-based immunotherapy in acute myeloid leukemia | Full Text | References | PDF (1.1 MB) | Supplemental
  • 2121 Views
  • 35 CrossRef citations
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Article
GUCY2C-directed CAR-T cells oppose colorectal cancer metastases without autoimmunity
Michael S. Magee, Crystal L. Kraft, Tara S. Abraham, Trevor R. Baybutt, Glen P. Marszalowicz, Peng Li, Scott A. Waldman & Adam E. Snook
Article: e1227897
Published online: 14 Oct 2016
AbstractforGUCY2C-directed CAR-T cells oppose colorectal cancer metastases without autoimmunity | Full Text | References | PDF (1.4 MB) | Supplemental
  • 4745 Views
  • 55 CrossRef citations
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Open Access
Article
Human blood myeloid and plasmacytoid dendritic cells cross activate each other and synergize in inducing NK cell cytotoxicity
Jasper J. P. van Beek, Mark A. J. Gorris, Annette E. Sköld, Ibrahim Hatipoglu, Heleen H. Van Acker, Evelien L. Smits, I. Jolanda M. de Vries & Ghaith Bakdash
Article: e1227902
Published online: 14 Oct 2016
AbstractforHuman blood myeloid and plasmacytoid dendritic cells cross activate each other and synergize in inducing NK cell cytotoxicity | Full Text | References | PDF (1.1 MB) | Supplemental
  • 1343 Views
  • 24 CrossRef citations
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Article
Dense breast tissue in postmenopausal women is associated with a pro-inflammatory microenvironment in vivo
Annelie Abrahamsson, Anna Rzepecka, Thobias Romu, Magnus Borga, Olof Dahlqvist Leinhard, Peter Lundberg, Johan Kihlberg & Charlotta Dabrosin
Article: e1229723
Published online: 14 Oct 2016
AbstractforDense breast tissue in postmenopausal women is associated with a pro-inflammatory microenvironment in vivo | Full Text | References | PDF (988.7 KB)
  • 1178 Views
  • 15 CrossRef citations
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Review

Review
The rise and fall of central dogmas
George Klein & Eva Klein
Article: e1043071
Published online: 14 Oct 2016
AbstractforThe rise and fall of central dogmas | Full Text | References | PDF (256.8 KB)
  • 1144 Views
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