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OncoImmunology Volume 6, 2017 - Issue 3
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Original Research

Obinutuzumab-mediated high-affinity ligation of FcγRIIIA/CD16 primes NK cells for IFNγ production

Cristina CapuanoDepartment of Experimental Medicine, Laboratorio Pasteur Italia Fondazione Cenci Bolognetti, Sapienza University, Rome, Italy
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Chiara PighiDepartment of Molecular Medicine, Laboratorio Pasteur Italia Fondazione Cenci Bolognetti, Sapienza University, Rome, Italy
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Rosa MolfettaDepartment of Molecular Medicine, Laboratorio Pasteur Italia Fondazione Cenci Bolognetti, Sapienza University, Rome, Italy
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Rossella PaoliniDepartment of Molecular Medicine, Laboratorio Pasteur Italia Fondazione Cenci Bolognetti, Sapienza University, Rome, Italy
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Simone BattellaDepartment of Molecular Medicine, Laboratorio Pasteur Italia Fondazione Cenci Bolognetti, Sapienza University, Rome, Italy
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Gabriella PalmieriDepartment of Experimental Medicine, Laboratorio Pasteur Italia Fondazione Cenci Bolognetti, Sapienza University, Rome, Italy
,
Giuseppe GianniniDepartment of Molecular Medicine, Laboratorio Pasteur Italia Fondazione Cenci Bolognetti, Sapienza University, Rome, ItalyORCID Iconhttp://orcid.org/0000-0003-0299-4056
ORCID Icon,
Francesca BelardinilliDepartment of Molecular Medicine, Laboratorio Pasteur Italia Fondazione Cenci Bolognetti, Sapienza University, Rome, ItalyORCID Iconhttp://orcid.org/0000-0003-4966-7044
ORCID Icon,
Angela SantoniDepartment of Molecular Medicine, Laboratorio Pasteur Italia Fondazione Cenci Bolognetti, Sapienza University, Rome, Italy;IRCCS Neuromed, Pozzilli, Italy
&
Ricciarda GalandriniDepartment of Experimental Medicine, Laboratorio Pasteur Italia Fondazione Cenci Bolognetti, Sapienza University, Rome, ItalyCorrespondence[email protected]
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Article: e1290037 | Received 07 Dec 2016, Accepted 26 Jan 2017, Published online: 30 Mar 2017

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Tian Huan, Bugao Guan, Hongbo Li, Xiu Tu, Chi Zhang & Bin Tang. (2023) Principles and current clinical landscape of NK cell engaging bispecific antibody against cancer. Human Vaccines & Immunotherapeutics 19:2.
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Nada S. Alakhras, Jiabin Qiu, Guilherme V. Rocha, Derrick R. Witcher, Anja Koester, Jinsam You, David A. Schaer, Rikke B. Holmgaard, Kyla Driscoll, Jeffrey A. Willy & Laurent P. Malherbe. (2018) FcγRIIIa-dependent IFN-γ release in whole blood assay is predictive of therapeutic IgG1 antibodies safety. mAbs 10:6, pages 913-921.
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Joshua K.M. Wong, Riccardo Dolcetti, Handoo Rhee, Fiona Simpson & Fernando Souza-Fonseca-Guimaraes. (2023) Weaponizing natural killer cells for solid cancer immunotherapy. Trends in Cancer 9:2, pages 111-121.
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Max Yano, John C. Byrd & Natarajan Muthusamy. (2022) Natural Killer Cells in Chronic Lymphocytic Leukemia: Functional Impairment and Therapeutic Potential. Cancers 14:23, pages 5787.
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Josée Golay, Alain E. Andrea & Irene Cattaneo. (2022) Role of Fc Core Fucosylation in the Effector Function of IgG1 Antibodies. Frontiers in Immunology 13.
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M. Eltahir, E. Fletcher, L. Dynesius, J.L. Jarblad, M. Lord, I. Laurén, M. Zekarias, X. Yu, M.S. Cragg, C. Hammarström, K.H. Levedahl, M. Höglund, G. Ullenhag, M. Mattsson & S.M. Mangsbo. (2021) Profiling of donor-specific immune effector signatures in response to rituximab in a human whole blood loop assay using blood from CLL patients. International Immunopharmacology 90, pages 107226.
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Laurie Lajoie, Nicolas Congy-Jolivet, Armelle Bolzec & Gilles Thibault. (2017) Gradual Increase of FcγRIIIa/CD16a Expression and Shift toward IFN-γ Secretion during Differentiation of CD56dim Natural Killer Cells. Frontiers in Immunology 8.
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