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OncoImmunology Volume 6, 2017 - Issue 5
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Original Research

Transcriptional factor EB regulates macrophage polarization in the tumor microenvironment

Liang FangDepartment of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC, USA;Department of Immunology, Fourth Military Medical University, Xi'an, China
,
Johnie HodgeDepartment of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC, USA
,
Fatma SaaoudDepartment of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC, USA
,
Junfeng WangDepartment of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC, USA
,
Stephen IwanowyczDepartment of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC, USA
,
Yuzhen WangDepartment of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC, USA
,
Yvonne HuiDepartment of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC, USA
,
Trent D. EvansCardiovascular Division, Department of Medicine and Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA
,
Babak RazaniCardiovascular Division, Department of Medicine and Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA
&
Daping FanDepartment of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC, USACorrespondence[email protected]
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Article: e1312042 | Received 02 Nov 2016, Accepted 23 Mar 2017, Published online: 08 May 2017

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Konrad Gabrusiewicz, Xu Li, Jun Wei, Yuuri Hashimoto, Anantha L. Marisetty, Martina Ott, Fei Wang, David Hawke, John Yu, Luke M. Healy, Anwar Hossain, Johnny C. Akers, Sourindra N. Maiti, Shinji Yamashita, Yuzaburo Shimizu, Kenneth Dunner, M. Anna Zal, Jared K. Burks, Joy Gumin, Felix Nwajei, Aras Rezavanian, Shouhao Zhou, Ganesh Rao, Raymond Sawaya, Gregory N. Fuller, Jason T. Huse, Jack P. Antel, Shulin Li, Laurence Cooper, Erik P. Sulman, Clark Chen, Changiz Geula, Raghu Kalluri, Tomasz Zal & Amy B. Heimberger. (2018) Glioblastoma stem cell-derived exosomes induce M2 macrophages and PD-L1 expression on human monocytes. OncoImmunology 7:4.
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Articles from other publishers (34)

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Pablo S. Contreras, Pablo J. Tapia, Eutteum Jeong, Sourish Ghosh, Nihal Altan-Bonnet & Rosa Puertollano. (2023) Beta-coronaviruses exploit cellular stress responses by modulating TFEB and TFE3 activity. iScience 26:3, pages 106169.
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Alemu Gebrie. (2023) Transcription factor EB as a key molecular factor in human health and its implication in diseases. SAGE Open Medicine 11, pages 205031212311572.
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Jun Ding, Yewen Xie, Xiao Sun, Fang Shao, Jie Pan, Jie Chen, Zhichao Zhu & Chunjian Qi. (2022) Inhibition of TFEB promotes tumor-educated dendritic cells activation to enhance antitumor immune responses. Molecular Immunology 147, pages 30-39.
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Jian Chu, Xing-Chi Hu, Chang-Chun Li, Tang-Ya Li, Hui-Wen Fan & Guo-Qin Jiang. (2022) KLF14 alleviated breast cancer invasion and M2 macrophages polarization through modulating SOCS3/RhoA/Rock/STAT3 signaling. Cellular Signalling 92, pages 110242.
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Sheng-yu Zhu, Ren-qi Yao, Yu-xuan Li, Peng-yue Zhao, Chao Ren, Xiao-hui Du & Yong-ming Yao. (2021) The Role and Regulatory Mechanism of Transcription Factor EB in Health and Diseases. Frontiers in Cell and Developmental Biology 9.
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Jing Zhang, Chuan-Rui Ma, Yun-Qing Hua, Lan Li, Jing-Yu Ni, Yu-Ting Huang, Sophia Esi Duncan, Sheng Li, Shan Gao & Guan-Wei Fan. (2021) Contradictory regulation of macrophages on atherosclerosis based on polarization, death and autophagy. Life Sciences 276, pages 118957.
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Seongryong Kim, Hyun-Sup Song, Jihyun Yu & You-Me Kim. (2021) MiT Family Transcriptional Factors in Immune Cell Functions. Molecules and Cells 44:5, pages 342-355.
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Xiaotong Chen, Yetong Guan, Yi Zhang, Yufeng Jia, Wen Li, Chun Guo, Yuan Li, Xiaoyan Wang, Yongyu Shi, Qun Wang, Faliang Zhu, Yan Li & Lining Zhang. (2020) Programmed cell death 4 modulates lysosomal function by inhibiting TFEB translation. Cell Death & Differentiation 28:4, pages 1237-1250.
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Chunyan Zhang, Huan Yang, Liwei Pan, Guangfu Zhao, Ruofei Zhang, Tianci Zhang, Zhixiong Xiao, Ying Tong, Yi Zhang, Richard Hu, Stephen Pandol & Yuan-Ping Han. (2021) Hepatitis B Virus X Protein (HBx) Suppresses Transcription Factor EB (TFEB) Resulting in Stabilization of Integrin Beta 1 (ITGB1) in Hepatocellular Carcinoma Cells. Cancers 13:5, pages 1181.
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Elena Astanina, Federico Bussolino & Gabriella Doronzo. (2020) Multifaceted activities of transcription factor EB in cancer onset and progression. Molecular Oncology 15:2, pages 327-346.
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Haocheng Lu, Jinjian Sun, Milton H. Hamblin, Y. Eugene Chen & Yanbo Fan. (2021) Transcription factor EB regulates cardiovascular homeostasis. EBioMedicine 63, pages 103207.
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Haocheng LuJinjian SunWenying LiangZiyi ChangOren RomYang ZhaoGuizhen ZhaoWenhao XiongHuilun WangTianqing ZhuYanhong GuoLin ChangMinerva T. Garcia-BarrioJifeng ZhangY. Eugene ChenYanbo Fan. (2020) Cyclodextrin Prevents Abdominal Aortic Aneurysm via Activation of Vascular Smooth Muscle Cell Transcription Factor EB. Circulation 142:5, pages 483-498.
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Yong Li, Johnie Hodge, Qing Liu, Junfeng Wang, Yuzhen Wang, Trent D Evans, Diego Altomare, Yongzhong Yao, E Angela Murphy, Babak Razani & Daping Fan. (2020) TFEB is a master regulator of tumor-associated macrophages in breast cancer. Journal for ImmunoTherapy of Cancer 8:1, pages e000543.
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Irina Larionova, Elena Kazakova, Marina Patysheva & Julia Kzhyshkowska. (2020) Transcriptional, Epigenetic and Metabolic Programming of Tumor-Associated Macrophages. Cancers 12:6, pages 1411.
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Shenglan Yu, Zhengtao Wang, Lili Ding & Li Yang. (2020) The regulation of TFEB in lipid homeostasis of non-alcoholic fatty liver disease: Molecular mechanism and promising therapeutic targets. Life Sciences 246, pages 117418.
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Lokman Varisli, Osman Cen & Spiros Vlahopoulos. (2019) Dissecting pharmacological effects of chloroquine in cancer treatment: interference with inflammatory signaling pathways. Immunology 159:3, pages 257-278.
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Afsane Bahrami, Vanessa Bianconi, Matteo Pirro, Hossein M. Orafai & Amirhossein Sahebkar. (2020) The role of TFEB in tumor cell autophagy: Diagnostic and therapeutic opportunities. Life Sciences 244, pages 117341.
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Jun-Kai Kao, Shih-Chung Wang, Li-Wei Ho, Shi-Wei Huang, Cheng-Han Lee, Ming-Sheng Lee, Rei-Cheng Yang & Jeng-Jer Shieh. (2020) M2-like polarization of THP-1 monocyte-derived macrophages under chronic iron overload. Annals of Hematology 99:3, pages 431-441.
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Javier E. Irazoqui. (2020) Key Roles of MiT Transcription Factors in Innate Immunity and Inflammation. Trends in Immunology 41:2, pages 157-171.
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Ruizhi He, Min Wang, Chunle Zhao, Ming Shen, Yahong Yu, Li He, Yan Zhao, Hua Chen, Xiuhui Shi, Min Zhou, Shutao Pan, Yuhui Liu, Xingjun Guo, Xu Li & Renyi Qin. (2019) TFEB-driven autophagy potentiates TGF-β induced migration in pancreatic cancer cells. Journal of Experimental & Clinical Cancer Research 38:1.
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Trent D. Evans, Xiangyu ZhangSe-Jin Jeong, Anyuan HeEric SongSomashubhra BhattacharyaKaryn B. HollowayIrfan J. Lodhi & Babak Razani. (2019) TFEB drives PGC-1α expression in adipocytes to protect against diet-induced metabolic dysfunction. Science Signaling 12:606.
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Davide Pellacani, Susanna Tan, Sylvain Lefort & Connie J Eaves. (2019) Transcriptional regulation of normal human mammary cell heterogeneity and its perturbation in breast cancer. The EMBO Journal 38:14.
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Xiaoqin Jia, Xiangyu Hu, Sen Han, Xin Miao, Hao Liu, Xiaomin Li, Zhijie Lin, Zhengbing Wang & Weijuan Gong. (2018) Increased M1 macrophages in young miR-15a/16 −/− mice with tumour grafts or dextran sulphate sodium-induced colitis . Scandinavian Journal of Immunology 88:3, pages e12703.
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Jingyi Jin, Ying Wang, Qianli Ma, Ning Wang, Wenwei Guo, Boquan Jin, Liang Fang & Lihua Chen. (2018) LAIR-1 activation inhibits inflammatory macrophage phenotype in vitro. Cellular Immunology 331, pages 78-84.
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Lara Campana, Philip J. Starkey Lewis, Antonella Pellicoro, Rebecca L. Aucott, Janet Man, Eoghan O’Duibhir, Sarah E. Mok, Sofia Ferreira-Gonzalez, Eilidh Livingstone, Stephen N. Greenhalgh, Katherine L. Hull, Timothy J. Kendall, Douglas Vernimmen, Neil C. Henderson, Luke Boulter, Christopher D. Gregory, Yi Feng, Stephen M. Anderton, Stuart J. Forbes & John P. Iredale. (2018) The STAT3–IL-10–IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury. The Journal of Immunology 200:3, pages 1169-1187.
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Takamitsu Miyayama, Kota Fujiki & Masato Matsuoka. (2018) Silver nanoparticles induce lysosomal-autophagic defects and decreased expression of transcription factor EB in A549 human lung adenocarcinoma cells. Toxicology in Vitro 46, pages 148-154.
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