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OncoImmunology Volume 6, 2017 - Issue 7
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Original Research

IL-32α-induced inflammation constitutes a link between obesity and colon cancer

Victoria CatalánMetabolic Research Laboratory, Clínica Universidad de Navarra, Pamplona, Spain;CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Pamplona, Spain;Obesity and Adipobiology Group, Instituto de Investigación Sanitaria de Navarra (IdiSNA)Pamplona, SpainCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-7513-7509
ORCID Icon,
Javier Gómez-AmbrosiMetabolic Research Laboratory, Clínica Universidad de Navarra, Pamplona, Spain;CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Pamplona, Spain;Obesity and Adipobiology Group, Instituto de Investigación Sanitaria de Navarra (IdiSNA)Pamplona, SpainORCID Iconhttp://orcid.org/0000-0001-5601-1604
ORCID Icon,
Amaia RodríguezMetabolic Research Laboratory, Clínica Universidad de Navarra, Pamplona, Spain;CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Pamplona, Spain;Obesity and Adipobiology Group, Instituto de Investigación Sanitaria de Navarra (IdiSNA)Pamplona, Spain
,
Beatriz RamírezMetabolic Research Laboratory, Clínica Universidad de Navarra, Pamplona, Spain;CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Pamplona, Spain;Obesity and Adipobiology Group, Instituto de Investigación Sanitaria de Navarra (IdiSNA)Pamplona, Spain
,
Victor A. OrtegaMetabolic Research Laboratory, Clínica Universidad de Navarra, Pamplona, SpainORCID Iconhttp://orcid.org/0000-0002-5282-7486
ORCID Icon,
José Luis Hernández-LizoainDepartment of Surgery, Clínica Universidad de Navarra, Pamplona, Spain
,
Jorge BaixauliDepartment of Surgery, Clínica Universidad de Navarra, Pamplona, Spain
,
Sara BecerrilMetabolic Research Laboratory, Clínica Universidad de Navarra, Pamplona, Spain;CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Pamplona, Spain;Obesity and Adipobiology Group, Instituto de Investigación Sanitaria de Navarra (IdiSNA)Pamplona, Spain
,
Fernando RotellarCIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Pamplona, Spain;Department of Surgery, Clínica Universidad de Navarra, Pamplona, Spain
,
Víctor ValentíCIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Pamplona, Spain;Obesity and Adipobiology Group, Instituto de Investigación Sanitaria de Navarra (IdiSNA)Pamplona, Spain;Department of Surgery, Clínica Universidad de Navarra, Pamplona, Spain
,
Rafael MoncadaCIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Pamplona, Spain;Obesity and Adipobiology Group, Instituto de Investigación Sanitaria de Navarra (IdiSNA)Pamplona, Spain;Department of Anesthesia, Clínica Universidad de Navarra, Pamplona, Spain
,
Camilo SilvaCIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Pamplona, Spain;Obesity and Adipobiology Group, Instituto de Investigación Sanitaria de Navarra (IdiSNA)Pamplona, Spain;Department of Endocrinology & Nutrition, Clínica Universidad de Navarra, Pamplona, Spain
,
Javier SalvadorCIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Pamplona, Spain;Department of Endocrinology & Nutrition, Clínica Universidad de Navarra, Pamplona, SpainORCID Iconhttp://orcid.org/0000-0002-3393-8156
ORCID Icon &
Gema FrühbeckMetabolic Research Laboratory, Clínica Universidad de Navarra, Pamplona, Spain;CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Pamplona, Spain;Obesity and Adipobiology Group, Instituto de Investigación Sanitaria de Navarra (IdiSNA)Pamplona, Spain;Department of Endocrinology & Nutrition, Clínica Universidad de Navarra, Pamplona, Spain
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Article: e1328338 | Received 27 Feb 2017, Accepted 05 May 2017, Published online: 28 Jun 2017

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Gema Frühbeck, Amaia Mentxaka, Patricia Ahechu, Javier Gómez-Ambrosi, Beatriz Ramírez, Sara Becerril, Amaia Rodríguez, Xabier Unamuno, Javier A Cienfuegos, Marcos Casado, María A Burrell, Marina Martín, Jorge Baixauli, Victor Valentí, Rafael Moncada, Gabriel Reina, Camilo Silva & Victoria Catalán. (2021) The Differential Expression of the Inflammasomes in Adipose Tissue and Colon Influences the Development of Colon Cancer in a Context of Obesity by Regulating Intestinal Inflammation. Journal of Inflammation Research 14, pages 6431-6446.
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Sarah Lévesque, Jonathan G. Pol, Gladys Ferrere, Lorenzo Galluzzi, Laurence Zitvogel & Guido Kroemer. (2019) Trial watch: dietary interventions for cancer therapy. OncoImmunology 8:7.
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Victoria Catalán, Paula Domench, Javier Gómez-Ambrosi, Beatriz Ramírez, Sara Becerril, Amaia Mentxaka, Amaia Rodríguez, Víctor Valentí, Rafael Moncada, Jorge Baixauli, Camilo Silva, Javier Escalada & Gema Frühbeck. (2022) Dermatopontin Influences the Development of Obesity-Associated Colon Cancer by Changes in the Expression of Extracellular Matrix Proteins. International Journal of Molecular Sciences 23:16, pages 9222.
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Michael W. Greene, Peter T. Abraham, Peyton C. Kuhlers, Elizabeth A. Lipke, Martin J. Heslin, Stanley T. Wijaya & Ifeoluwa Odeniyi. (2022) Consensus molecular subtype differences linking colon adenocarcinoma and obesity revealed by a cohort transcriptomic analysis. PLOS ONE 17:5, pages e0268436.
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Yihua Xu, Hao Wang, Tao Wang, Chunhui Chen, Ruibo Sun, Wanyu Yao, Ye Ma, Qingyuan Zhang, Liyi Wu, Shanmei Zeng & Xuegang Sun. (2022) Dahuang Fuzi Baijiang decoction restricts progenitor to terminally exhausted T cell differentiation in colorectal cancer. Cancer Science 113:5, pages 1739-1751.
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Saerok Shim, Siyoung Lee, Yasmin Hisham, Sinae Kim, Tam T. Nguyen, Afeisha S. Taitt, Jihyeong Hwang, Hyunjhung Jhun, Ho-Young Park, Youngmin Lee, Su Cheong Yeom, Sang-Yeob Kim, Yong-Gil Kim & Soohyun Kim. (2022) A Paradoxical Effect of Interleukin-32 Isoforms on Cancer. Frontiers in Immunology 13.
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Iranzu Gómez de Segura, Patricia Ahechu, Javier Gómez-Ambrosi, Amaia Rodríguez, Beatriz Ramírez, Sara Becerril, Xabier Unamuno, Amaia Mentxaka, Jorge Baixauli, Víctor Valentí, Rafael Moncada, Camilo Silva, Gema Frühbeck & Victoria Catalán. (2021) Decreased Levels of Microfibril-Associated Glycoprotein (MAGP)-1 in Patients with Colon Cancer and Obesity Are Associated with Changes in Extracellular Matrix Remodelling. International Journal of Molecular Sciences 22:16, pages 8485.
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Xin Su, Ye Cheng, Guoming Zhang & Bin Wang. (2021) Novel insights into the pathological mechanisms of metabolic related dyslipidemia. Molecular Biology Reports 48:7, pages 5675-5687.
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Joanna Olszańska, Katarzyna Pietraszek-Gremplewicz & Dorota Nowak. (2021) Melanoma Progression under Obesity: Focus on Adipokines. Cancers 13:9, pages 2281.
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Figen Öngöz Dede, Ceren Gökmenoğlu, Emre Taha Deveci, Selman Çelen, Bahattin Avci, Cankat Kara & Varol Çanakçi. (2020) Increased levels of interleukin‐32 isoforms alpha, beta, gamma, and delta in the gingival crevicular fluid and plasma of the patients with periodontitis. Journal of Periodontal Research 56:1, pages 83-92.
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Kristin Roseth Aass, Martin H Kastnes & Therese Standal. (2021) Molecular interactions and functions of IL-32. Journal of Leukocyte Biology 109:1, pages 143-159.
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Andrea J. De Micheli, Jason A. Spector, Olivier Elemento & Benjamin D. Cosgrove. (2020) A reference single-cell transcriptomic atlas of human skeletal muscle tissue reveals bifurcated muscle stem cell populations. Skeletal Muscle 10:1.
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Dorota Diakowska & Małgorzata Krzystek-Korpacka. (2020) Local and Systemic Interleukin-32 in Esophageal, Gastric, and Colorectal Cancers: Clinical and Diagnostic Significance. Diagnostics 10:10, pages 785.
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Xin Su & Daoquan Peng. (2020) Emerging functions of adipokines in linking the development of obesity and cardiovascular diseases. Molecular Biology Reports 47:10, pages 7991-8006.
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Meng Meng, Mingzhu Guo, Pei Wang, Ran Han, Jiaping Zhou & Chunling Wang. (2019) Chemopreventive effect of the polysaccharides from Grifola frondosa in colitis-associated colorectal cancer by modulating the Wnt/β-catenin/GSK-3β signaling pathway in C57BL/6 mice. Journal of Functional Foods 63, pages 103578.
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Mariam Haffa, Andreana N Holowatyj, Mario Kratz, Reka Toth, Axel Benner, Biljana Gigic, Nina Habermann, Petra Schrotz-King, Jürgen Böhm, Hermann Brenner, Martin Schneider, Alexis Ulrich, Esther Herpel, Peter Schirmacher, Beate K Straub, Johanna Nattenmüller, Hans-Ulrich Kauczor, Tengda Lin, Claudia R Ball, Cornelia M Ulrich, Hanno Glimm & Dominique Scherer. (2019) Transcriptome Profiling of Adipose Tissue Reveals Depot-Specific Metabolic Alterations Among Patients with Colorectal Cancer. The Journal of Clinical Endocrinology & Metabolism 104:11, pages 5225-5237.
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Andrew Redfern, Veenoo Agarwal & Erik W. Thompson. (2019) Hypoxia as a signal for prison breakout in cancer. Current Opinion in Clinical Nutrition & Metabolic Care 22:4, pages 250-263.
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Jeong Won Lee, Myung Jin Ban, Jae Hong Park & Sang Mi Lee. (2019) Visceral adipose tissue volume and CT‐attenuation as prognostic factors in patients with head and neck cancer. Head & Neck 41:6, pages 1605-1614.
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Luana Amorim Biondo, Alexandre Abilio S. Teixeira, Loreana S. Silveira, Camila O. Souza, Raquel G. F. Costa, Tiego A. Diniz, Francielle C. Mosele & José Cesar Rosa Neto. (2019) Tributyrin in Inflammation: Does White Adipose Tissue Affect Colorectal Cancer?. Nutrients 11:1, pages 110.
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Patricia Ahechu, Gabriel Zozaya, Pablo Martí, José Luis Hernández-Lizoáin, Jorge Baixauli, Xabier Unamuno, Gema Frühbeck & Victoria Catalán. (2018) NLRP3 Inflammasome: A Possible Link Between Obesity-Associated Low-Grade Chronic Inflammation and Colorectal Cancer Development. Frontiers in Immunology 9.
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Xabier Unamuno, Javier Gómez-Ambrosi, Amaia Rodríguez, Sara Becerril, Gema Frühbeck & Victoria Catalán. (2018) Adipokine dysregulation and adipose tissue inflammation in human obesity. European Journal of Clinical Investigation 48:9, pages e12997.
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