Advanced search
Publication Cover
OncoImmunology Volume 6, 2017 - Issue 10
Submit an article Journal homepage
1,487
Views
28
CrossRef citations to date
0
Altmetric
Original Research

Mutations in JAK2 and Calreticulin genes are associated with specific alterations of the immune system in myelofibrosis

Marco RomanoDepartment of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology “L. e A. Seràgnoli,”University of Bologna, Bologna, Italy;Immunoregulation Laboratory, Division of Transplantation Immunology & Mucosal Biology, MRC Centre for Transplantation, King's College London, Guy's Hospital, UK
,
Daria SollazzoDepartment of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology “L. e A. Seràgnoli,”University of Bologna, Bologna, Italy
,
Sara TrabanelliLudwig Center for Cancer Research, University of Lausanne, Lausanne, Switzerland
,
Martina BaroneDepartment of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology “L. e A. Seràgnoli,”University of Bologna, Bologna, Italy
,
Nicola PolverelliDepartment of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology “L. e A. Seràgnoli,”University of Bologna, Bologna, Italy
,
Margherita PerriconeDepartment of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology “L. e A. Seràgnoli,”University of Bologna, Bologna, Italy
,
Dorian ForteDepartment of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology “L. e A. Seràgnoli,”University of Bologna, Bologna, Italy
,
Simona LuattiDepartment of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology “L. e A. Seràgnoli,”University of Bologna, Bologna, Italy
,
Michele CavoDepartment of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology “L. e A. Seràgnoli,”University of Bologna, Bologna, Italy
,
Nicola VianelliDepartment of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology “L. e A. Seràgnoli,”University of Bologna, Bologna, Italy
,
Camilla JandusLudwig Center for Cancer Research, University of Lausanne, Lausanne, Switzerland
,
Francesca PalandriDepartment of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology “L. e A. Seràgnoli,”University of Bologna, Bologna, Italy
&
Lucia CataniDepartment of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology “L. e A. Seràgnoli,”University of Bologna, Bologna, ItalyCorrespondence[email protected]
 show all
Article: e1345402 | Received 17 Feb 2017, Accepted 19 Jun 2017, Published online: 11 Aug 2017

Citations (28)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Yizhou Peng, Li Meng, Xuemei Hu, Zhiqiang Han & Zhenya Hong. (2020) Tuberculosis in Patients with Primary Myelofibrosis During Ruxolitinib Therapy: Case Series and Literature Review. Infection and Drug Resistance 13, pages 3309-3316.
Read now
Martina Barone, Lucia Catani, Francesca Ricci, Marco Romano, Dorian Forte, Giuseppe Auteri, Daniela Bartoletti, Emanuela Ottaviani, Pier Luigi Tazzari, Nicola Vianelli, Michele Cavo & Francesca Palandri. (2020) The role of circulating monocytes and JAK inhibition in the infectious-driven inflammatory response of myelofibrosis. OncoImmunology 9:1.
Read now

Articles from other publishers (26)

Morten Orebo Holmström, Morten Andersen, Sofie Traynor, Shamaila Munir Ahmad, Thomas Landkildehus Lisle, Jacob Handlos Grauslund, Vibe Skov, Lasse Kjær, Johnny T. Ottesen, Morten Frier Gjerstorff, Hans Carl Hasselbalch & Mads Hald Andersen. (2023) Therapeutic cancer vaccination against mutant calreticulin in myeloproliferative neoplasms induces expansion of specific T cells in the periphery but specific T cells fail to enrich in the bone marrow. Frontiers in Immunology 14.
Crossref
Giorgia Fanelli, Marco Romano, Giovanna Lombardi & Steven H. Sacks. (2023) Soluble Collectin 11 (CL-11) Acts as an Immunosuppressive Molecule Potentially Used by Stem Cell-Derived Retinal Epithelial Cells to Modulate T Cell Response. Cells 12:13, pages 1805.
Crossref
Arturo Bonometti, Oscar Borsani, Elisa Rumi, Virginia Valeria Ferretti, Claudia Dioli, Elena Lucato, Marco Paulli & Emanuela Boveri. (2022) Arginase‐1+ bone marrow myeloid cells are reduced in myeloproliferative neoplasms and correlate with clinical phenotype, fibrosis, and molecular driver. Cancer Medicine 12:7, pages 7815-7822.
Crossref
Alessandro Allegra, Marco Casciaro, Elena Lo Presti, Caterina Musolino & Sebastiano Gangemi. (2022) Harnessing Unconventional T Cells and Innate Lymphoid Cells to Prevent and Treat Hematological Malignancies: Prospects for New Immunotherapy. Biomolecules 12:6, pages 754.
Crossref
Jen-Chin Wang & Lishi Sun. (2022) PD-1/PD-L1, MDSC Pathways, and Checkpoint Inhibitor Therapy in Ph(-) Myeloproliferative Neoplasm: A Review. International Journal of Molecular Sciences 23:10, pages 5837.
Crossref
Marie Strickland, Lynn Quek & Bethan Psaila. (2021) The immune landscape in BCR‐ABL negative myeloproliferative neoplasms: inflammation, infections and opportunities for immunotherapy. British Journal of Haematology 196:5, pages 1149-1158.
Crossref
Mingzhong Li, Liang Wan, Man-Kay Law, Li Meng, Yanwei Jia, Pui-In Mak & Rui P. Martins. (2022) One-shot high-resolution melting curve analysis for KRAS point-mutation discrimination on a digital microfluidics platform . Lab on a Chip 22:3, pages 537-549.
Crossref
Dorian Forte, Martina Barone, Cristina Morsiani, Giorgia Simonetti, Francesco Fabbri, Samantha Bruno, Erika Bandini, Daria Sollazzo, Salvatore Collura, Maria Chiara Deregibus, Giuseppe Auteri, Emanuela Ottaviani, Nicola Vianelli, Giovanni Camussi, Claudio Franceschi, Miriam Capri, Francesca Palandri, Michele Cavo & Lucia Catani. (2021) Distinct profile of CD34+ cells and plasma-derived extracellular vesicles from triple-negative patients with Myelofibrosis reveals potential markers of aggressive disease. Journal of Experimental & Clinical Cancer Research 40:1.
Crossref
Stefania Roma, Laura Carpen, Alessandro Raveane & Francesco Bertolini. (2021) The Dual Role of Innate Lymphoid and Natural Killer Cells in Cancer. from Phenotype to Single-Cell Transcriptomics, Functions and Clinical Uses. Cancers 13:20, pages 5042.
Crossref
Nicola Polverelli, Elena M. Elli, Elisabetta Abruzzese, Giuseppe A. Palumbo, Giulia Benevolo, Mario Tiribelli, Massimiliano Bonifacio, Alessia Tieghi, Giovanni Caocci, Mariella D'Adda, Micaela Bergamaschi, Gianni Binotto, Florian H. Heidel, Francesco Cavazzini, Monica Crugnola, Novella Pugliese, Costanza Bosi, Alessandro Isidori, Daniela Bartoletti, Giuseppe Auteri, Roberto Latagliata, Lisa Gandolfi, Bruno Martino, Luigi Scaffidi, Daniele Cattaneo, Fabio D’Amore, Malgorzata M. Trawinska, Rossella Stella, Uros Markovic, Lucia Catani, Fabrizio Pane, Antonio Cuneo, Mauro Krampera, Gianpietro Semenzato, Roberto M. Lemoli, Nicola Vianelli, Massimo Breccia, Domenico Russo, Michele Cavo, Alessandra Iurlo & Francesca Palandri. (2020) Second primary malignancy in myelofibrosis patients treated with ruxolitinib. British Journal of Haematology 193:2, pages 356-368.
Crossref
Jacob Handlos Grauslund, Morten Orebo Holmström, Nicolai Grønne Jørgensen, Uffe Klausen, Stine Emilie Weis-Banke, Daniel El Fassi, Claudia Schöllkopf, Mette Borg Clausen, Lise Mette Rahbek Gjerdrum, Marie Fredslund Breinholt, Julie Westerlin Kjeldsen, Morten Hansen, Steffen Koschmieder, Nicolas Chatain, Guy Wayne Novotny, Jesper Petersen, Lasse Kjær, Vibe Skov, Özcan Met, Inge Marie Svane, Hans Carl Hasselbalch & Mads Hald Andersen. (2021) Therapeutic Cancer Vaccination With a Peptide Derived From the Calreticulin Exon 9 Mutations Induces Strong Cellular Immune Responses in Patients With CALR-Mutant Chronic Myeloproliferative Neoplasms. Frontiers in Oncology 11.
Crossref
Vincenzo Nasillo, Giovanni Riva, Ambra Paolini, Fabio Forghieri, Luca Roncati, Beatrice Lusenti, Monica Maccaferri, Andrea Messerotti, Valeria Pioli, Andrea Gilioli, Francesca Bettelli, Davide Giusti, Patrizia Barozzi, Ivana Lagreca, Rossana Maffei, Roberto Marasca, Leonardo Potenza, Patrizia Comoli, Rossella Manfredini, Antonino Maiorana, Enrico Tagliafico, Mario Luppi & Tommaso Trenti. (2021) Inflammatory Microenvironment and Specific T Cells in Myeloproliferative Neoplasms: Immunopathogenesis and Novel Immunotherapies. International Journal of Molecular Sciences 22:4, pages 1906.
Crossref
Anna Ravn Landtblom, Therese M-L Andersson, Paul W Dickman, Karin E Smedby, Sandra Eloranta, Nurgul Batyrbekova, Jan Samuelsson, Magnus Björkholm & Malin Hultcrantz. (2020) Risk of infections in patients with myeloproliferative neoplasms—a population-based cohort study of 8363 patients. Leukemia 35:2, pages 476-484.
Crossref
David C. A. Molitor, Peter Boor, Andreas Buness, Rebekka K. Schneider, Lino L. Teichmann, Ruth-Miriam Körber, Gabor L. Horvath, Steffen Koschmieder & Ines Gütgemann. (2020) Macrophage frequency in the bone marrow correlates with morphologic subtype of myeloproliferative neoplasm. Annals of Hematology 100:1, pages 97-104.
Crossref
Nicolas Chatain, Steffen Koschmieder & Edgar Jost. (2020) Role of Inflammatory Factors during Disease Pathogenesis and Stem Cell Transplantation in Myeloproliferative Neoplasms. Cancers 12:8, pages 2250.
Crossref
Ivo Veletic, Sanja Prijic, Taghi Manshouri, Graciela M. Nogueras-Gonzalez, Srdan Verstovsek & Zeev Estrov. (2020) Altered T-cell subset repertoire affects treatment outcome of patients with myelofibrosis. Haematologica 106:9, pages 2384-2396.
Crossref
Morten Orebo Holmström, Hans Carl Hasselbalch & Mads Hald Andersen. (2020) Cancer Immune Therapy for Philadelphia Chromosome-Negative Chronic Myeloproliferative Neoplasms. Cancers 12:7, pages 1763.
Crossref
Ken Ogasawara, Patricia M. LoRusso, Anthony J. Olszanski, Olivier Rixe, Christine Xu, Jian Yin, Maria Palmisano & Gopal Krishna. (2020) Assessment of effects of repeated oral doses of fedratinib on inhibition of cytochrome P450 activities in patients with solid tumors using a cocktail approach. Cancer Chemotherapy and Pharmacology 86:1, pages 87-95.
Crossref
Dorian Forte, Flaminia Fanelli, Marco Mezzullo, Martina Barone, Giulia Corradi, Giuseppe Auteri, Daniela Bartoletti, Marina Martello, Emanuela Ottaviani, Carolina Terragna, Antonio Curti, Uberto Pagotto, Francesca Palandri, Michele Cavo & Lucia Catani. (2020) Disease-Specific Derangement of Circulating Endocannabinoids and N-Acylethanolamines in Myeloproliferative Neoplasms. International Journal of Molecular Sciences 21:9, pages 3399.
Crossref
Ken Ogasawara, Christine Xu, Vanaja Kanamaluru, Maria Palmisano & Gopal Krishna. (2020) Effects of repeated oral doses of ketoconazole on a sequential ascending single oral dose of fedratinib in healthy subjects. Cancer Chemotherapy and Pharmacology 85:5, pages 899-906.
Crossref
Giovanni Barosi, Rita Campanelli, Paolo Catarsi, Mara De Amici, Carlotta Abbà, Gianluca Viarengo, Laura Villani, Robert P. Gale, Vittorio Rosti & Margherita Massa. (2020) Plasma sIL-2Rα levels are associated with disease progression in myelofibrosis with JAK2V617F but not CALR mutation. Leukemia Research 90, pages 106319.
Crossref
Alejandro Schcolnik-Cabrera, Bernardo Oldak, Mandy Juárez, Mayra Cruz-Rivera, Ana Flisser & Fela Mendlovic. (2019) Calreticulin in phagocytosis and cancer: opposite roles in immune response outcomes. Apoptosis 24:3-4, pages 245-255.
Crossref
Bianca Blom, Vera van Hoeven & Mette D. Hazenberg. (2019) ILCs in hematologic malignancies: Tumor cell killers and tissue healers. Seminars in Immunology 41, pages 101279.
Crossref
Adeline Crinier, Eric Vivier & Mathieu Bléry. (2019) Helper-like innate lymphoid cells and cancer immunotherapy. Seminars in Immunology 41, pages 101274.
Crossref
Laura Chiossone, Pierre-Yves Dumas, Margaux Vienne & Eric Vivier. (2018) Natural killer cells and other innate lymphoid cells in cancer. Nature Reviews Immunology 18:11, pages 671-688.
Crossref
Nicola Polverelli, Giuseppe A. Palumbo, Gianni Binotto, Elisabetta Abruzzese, Giulia Benevolo, Micaela Bergamaschi, Alessia Tieghi, Massimiliano Bonifacio, Massimo Breccia, Lucia Catani, Mario Tiribelli, Mariella D'Adda, Nicola Sgherza, Alessandro Isidori, Francesco Cavazzini, Bruno Martino, Roberto Latagliata, Monica Crugnola, Florian Heidel, Costanza Bosi, Adalberto Ibatici, Francesco Soci, Domenico Penna, Luigi Scaffidi, Franco Aversa, Roberto M. Lemoli, Umberto Vitolo, Antonio Cuneo, Domenico Russo, Michele Cavo, Nicola Vianelli & Francesca Palandri. (2018) Epidemiology, outcome, and risk factors for infectious complications in myelofibrosis patients receiving ruxolitinib: A multicenter study on 446 patients. Hematological Oncology 36:3, pages 561-569.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.