OncoImmunology, Volume 6, Issue 10 (2017)

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OncoImmunology, Volume 6, Issue 10 (2017)

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Author's View

Opinion
Tumor cell death by pattern-sensing of exogenous RNA: Tumor cell TLR3 directly induces necroptosis by poly(I:C) in vivo, independent of immune effector-mediated tumor shrinkage
Hiromi Takaki, Hiroaki Shime, Misako Matsumoto & Tsukasa Seya
Article: e1078968
Published online: 14 Sep 2017
AbstractforTumor cell death by pattern-sensing of exogenous RNA: Tumor cell TLR3 directly induces necroptosis by poly(I:C) in vivo, independent of immune effector-mediated tumor shrinkage | Full Text | References | PDF (335.4 KB)
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Brief Report

Brief Report
Blocking C5aR signaling promotes the anti-tumor efficacy of PD-1/PD-L1 blockade
Haoran Zha, Xiao Han, Ying Zhu, Fei Yang, Yongsheng Li, Qijing Li, Bo Guo & Bo Zhu
Article: e1349587
Published online: 11 Aug 2017
AbstractforBlocking C5aR signaling promotes the anti-tumor efficacy of PD-1/PD-L1 blockade | Full Text | References | PDF (1 MB) | Supplemental
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Editorial

Editorial
Soluble NKG2D ligands limit the efficacy of immune checkpoint blockade
Alejandro López-Soto, Segundo Gonzalez & Lorenzo Galluzzi
Article: e1346766
Published online: 03 Aug 2017
CitationforSoluble NKG2D ligands limit the efficacy of immune checkpoint blockade | Full Text | References | PDF (326.2 KB)
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Original Research

Article
Targeting IL-5Rα with antibody-conjugates reveals a strategy for imaging and therapy for invasive bladder cancer
Michel Paquette, Luis-Guillermo Vilera-Perez, Simon Beaudoin, Nadia Ekindi-Ndongo, Pierre-Luc Boudreaut, Marc-Andre Bonin, Marie-Claude Battista, M'hamed Bentourkia, Angel F. Lopez, Roger Lecomte, Eric Marsault, Brigitte Guérin, Robert Sabbagh & Jeffrey V. Leyton
Article: e1331195
Published online: 14 Sep 2017
AbstractforTargeting IL-5Rα with antibody-conjugates reveals a strategy for imaging and therapy for invasive bladder cancer | Full Text | References | PDF (1.3 MB) | Supplemental
  • 1415 Views
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Article
Characterization of a switchable chimeric antigen receptor platform in a pre-clinical solid tumor model
Elham Pishali Bejestani, Marc Cartellieri, Ralf Bergmann, Armin Ehninger, Simon Loff, Michael Kramer, Johannes Spehr, Antje Dietrich, Anja Feldmann, Susann Albert, Martin Wermke, Michael Baumann, Mechthild Krause, Martin Bornhäuser, Gerhard Ehninger, Michael Bachmann & Malte von Bonin
Article: e1342909
Published online: 21 Jul 2017
AbstractforCharacterization of a switchable chimeric antigen receptor platform in a pre-clinical solid tumor model | Full Text | References | PDF (1.1 MB) | Supplemental
  • 1852 Views
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Article
PD-1 blockade augments anti-neuroblastoma immune response induced by anti-GD2 antibody ch14.18/CHO
Nikolai Siebert, Maxi Zumpe, Madlen Jüttner, Sascha Troschke-Meurer & Holger N. Lode
Article: e1343775
Published online: 28 Jul 2017
AbstractforPD-1 blockade augments anti-neuroblastoma immune response induced by anti-GD2 antibody ch14.18/CHO | Full Text | References | PDF (1.2 MB)
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Article
Exogenous lipid uptake induces metabolic and functional reprogramming of tumor-associated myeloid-derived suppressor cells
Amir A. Al-Khami, Liqin Zheng, Luis Del Valle, Fokhrul Hossain, Dorota Wyczechowska, Jovanny Zabaleta, Maria D. Sanchez, Matthew J. Dean, Paulo C. Rodriguez & Augusto C. Ochoa
Article: e1344804
Published online: 03 Aug 2017
AbstractforExogenous lipid uptake induces metabolic and functional reprogramming of tumor-associated myeloid-derived suppressor cells | Full Text | References | PDF (1.4 MB) | Supplemental
  • 5018 Views
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Article
Mutations in JAK2 and Calreticulin genes are associated with specific alterations of the immune system in myelofibrosis
Marco Romano, Daria Sollazzo, Sara Trabanelli, Martina Barone, Nicola Polverelli, Margherita Perricone, Dorian Forte, Simona Luatti, Michele Cavo, Nicola Vianelli, Camilla Jandus, Francesca Palandri & Lucia Catani
Article: e1345402
Published online: 11 Aug 2017
AbstractforMutations in JAK2 and Calreticulin genes are associated with specific alterations of the immune system in myelofibrosis | Full Text | References | PDF (907.7 KB) | Supplemental
  • 1487 Views
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Article
Incidence of immune checkpoint inhibitor-related colitis in solid tumor patients: A systematic review and meta-analysis
Daniel Y. Wang, Fei Ye, Shilin Zhao & Douglas B. Johnson
Article: e1344805
Published online: 14 Aug 2017
AbstractforIncidence of immune checkpoint inhibitor-related colitis in solid tumor patients: A systematic review and meta-analysis | Full Text | References | PDF (831 KB) | Supplemental
  • 3342 Views
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Article
Expression of CD94 by ex vivo-differentiated NK cells correlates with the in vitro and in vivo acquisition of cytotoxic features
Meriem Hasmim, Nadine Khalife, Yanyan Zhang, Manale Doldur, Geralidne Visentin, Stéphane Terry, Julien Giron-Michel, Ruoping Tang, François Delhommeau, Nicolas Dulphy, Jean-Henri Bourhis, Fawzia Louache & Salem Chouaib
Article: e1346763
Published online: 21 Sep 2017
AbstractforExpression of CD94 by ex vivo-differentiated NK cells correlates with the in vitro and in vivo acquisition of cytotoxic features | Full Text | References | PDF (1.3 MB)
  • 974 Views
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Article
Immunological efficacy of glypican-3 peptide vaccine in patients with advanced hepatocellular carcinoma
Nobuhiro Tsuchiya, Toshiaki Yoshikawa, Norihiro Fujinami, Keigo Saito, Shoichi Mizuno, Yu Sawada, Itaru Endo & Tetsuya Nakatsura
Article: e1346764
Published online: 02 Aug 2017
AbstractforImmunological efficacy of glypican-3 peptide vaccine in patients with advanced hepatocellular carcinoma | Full Text | References | PDF (993.5 KB) | Supplemental
  • 2237 Views
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Open Access
Article
The STING agonist DMXAA triggers a cooperation between T lymphocytes and myeloid cells that leads to tumor regression
Julia M. Weiss, Marion V. Guérin, Fabienne Regnier, Gilles Renault, Isabelle Galy-Fauroux, Lene Vimeux, Vincent Feuillet, Elisa Peranzoni, Maxime Thoreau, Alain Trautmann & Nadège Bercovici
Article: e1346765
Published online: 03 Aug 2017
AbstractforThe STING agonist DMXAA triggers a cooperation between T lymphocytes and myeloid cells that leads to tumor regression | Full Text | References | PDF (1.7 MB) | Supplemental
  • 4745 Views
  • 66 CrossRef citations
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Open Access
Article
Distinctive features of tumor-infiltrating γδ T lymphocytes in human colorectal cancer
S. Meraviglia, E. Lo Presti, M. Tosolini, C. La Mendola, V. Orlando, M. Todaro, V. Catalano, G. Stassi, G. Cicero, S. Vieni, J. J. Fourniè & F. Dieli
Article: e1347742
Published online: 11 Aug 2017
AbstractforDistinctive features of tumor-infiltrating γδ T lymphocytes in human colorectal cancer | Full Text | References | PDF (1.3 MB)
  • 3106 Views
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Article
A novel bifunctional anti-PD-L1/TGF-β Trap fusion protein (M7824) efficiently reverts mesenchymalization of human lung cancer cells
Justin M. David, Charli Dominguez, Kristen K. McCampbell, James L. Gulley, Jeffrey Schlom & Claudia Palena
Article: e1349589
Published online: 11 Aug 2017
AbstractforA novel bifunctional anti-PD-L1/TGF-β Trap fusion protein (M7824) efficiently reverts mesenchymalization of human lung cancer cells | Full Text | References | PDF (2.1 MB) | Supplemental
  • 7117 Views
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Article
Ig-like transcript 2 (ILT2) suppresses T cell function in chronic lymphocytic leukemia
Mónica Villa-Álvarez, Seila Lorenzo-Herrero, Ana P. Gonzalez-Rodriguez, Alejandro López-Soto, Angel R. Payer, Esther Gonzalez-Garcia, Leticia Huergo-Zapico & Segundo Gonzalez
Article: e1353856
Published online: 22 Aug 2017
AbstractforIg-like transcript 2 (ILT2) suppresses T cell function in chronic lymphocytic leukemia | Full Text | References | PDF (1.1 MB) | Supplemental
  • 1239 Views
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Article
PD-1 blockade at the time of tumor escape potentiates the immune-mediated antitumor effects of a melanoma-targeting monoclonal antibody
Laetitia They, Henri-Alexandre Michaud, Ondine Becquart, Virginie Lafont, Bernard Guillot, Florence Boissière-Michot, Marta Jarlier, Caroline Mollevi, Jean-François Eliaou, Nathalie Bonnefoy & Laurent Gros
Article: e1353857
Published online: 25 Aug 2017
AbstractforPD-1 blockade at the time of tumor escape potentiates the immune-mediated antitumor effects of a melanoma-targeting monoclonal antibody | Full Text | References | PDF (1.5 MB) | Supplemental
  • 2056 Views
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Article
Ionizing radiation sensitizes tumors to PD-L1 immune checkpoint blockade in orthotopic murine head and neck squamous cell carcinoma
Ayman Oweida, Shelby Lennon, Dylan Calame, Sean Korpela, Shilpa Bhatia, Jaspreet Sharma, Caleb Graham, David Binder, Natalie Serkova, David Raben, Lynn Heasley, Eric Clambey, Raphael Nemenoff & Sana D. Karam
Article: e1356153
Published online: 21 Aug 2017
AbstractforIonizing radiation sensitizes tumors to PD-L1 immune checkpoint blockade in orthotopic murine head and neck squamous cell carcinoma | Full Text | References | PDF (1.1 MB) | Supplemental
  • 2575 Views
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Point of View

Opinion
Labeling of cell therapies: How can we get it right?
Sonia Waiczies, Thoralf Niendorf & Giovanna Lombardi
Article: e1345403
Published online: 03 Aug 2017
AbstractforLabeling of cell therapies: How can we get it right? | Full Text | References | PDF (332.6 KB)
  • 613 Views
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Review

Review
Translational nanoparticle engineering for cancer vaccines
Adam J. Grippin, Elias J. Sayour & Duane A. Mitchell
Article: e1290036
Published online: 17 Aug 2017
AbstractforTranslational nanoparticle engineering for cancer vaccines | Full Text | References | PDF (487.8 KB)
  • 2098 Views
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Open Access
Review
No patient left behind: The promise of immune priming with epigenetic agents
Corey A. Carter, Bryan T. Oronsky, Joseph Roswarski, Arnold L. Oronsky, Neil Oronsky, Jan Scicinski, Harry Lybeck, Michelle M. Kim, Michelle Lybeck & Tony R. Reid
Article: e1315486
Published online: 15 Sep 2017
AbstractforNo patient left behind: The promise of immune priming with epigenetic agents | Full Text | References | PDF (1.1 MB)
  • 1658 Views
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Review
Immune evasion mechanisms and immune checkpoint inhibition in advanced merkel cell carcinoma
Dirk Schadendorf, Paul Nghiem, Shailender Bhatia, Axel Hauschild, Philippe Saiag, Lisa Mahnke, Subramanian Hariharan & Howard L. Kaufman
Article: e1338237
Published online: 05 Sep 2017
AbstractforImmune evasion mechanisms and immune checkpoint inhibition in advanced merkel cell carcinoma | Full Text | References | PDF (972 KB)
  • 1870 Views
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Review
Mevalonate metabolism governs cancer immune surveillance
Georg Gruenbacher & Martin Thurnher
Article: e1342917
Published online: 01 Aug 2017
AbstractforMevalonate metabolism governs cancer immune surveillance | Full Text | References | PDF (1.1 MB)
  • 3602 Views
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Corrigendum

Correction
Corrigendum
Article: e1389146
Published online: 31 Oct 2017
CitationforCorrigendum | Full Text | PDF (98.9 KB)
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Correction
Corrigendum
Article: e1392418
Published online: 25 Oct 2017
CitationforCorrigendum | Full Text | PDF (101.4 KB)
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