Co-stimulatory signaling determines tumor antigen sensitivity and persistence of CAR T cells targeting PSCA+ metastatic prostate cancer

Saul J. PricemanDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA;T Cell Therapeutics Research Laboratory, City of Hope, Duarte, CA, USA

Ethan A. GerdtsDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA

Dileshni TilakawardaneDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA

Kelly T. KennewickDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA

John P. MuradDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA

Anthony K. ParkDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA

Brook JeangDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA

Yukiko YamaguchiDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA

Xin YangDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA

https://orcid.org/0000-0003-2744-7622

Ryan UrakDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA

Lihong WengDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA

Wen-Chung ChangDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA

Sarah WrightDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA

Sumanta PalDepartment of Medical Oncology & Therapeutics Research, City of Hope, Duarte, CA, USA

Robert E. ReiterDepartment of Urology, University of California, Los Angeles, Los Angeles, CA, USA

Anna M. WuDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, USA

https://orcid.org/0000-0001-8487-823X

Christine E. BrownDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA;T Cell Therapeutics Research Laboratory, City of Hope, Duarte, CA, USA

Stephen J. FormanDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA;T Cell Therapeutics Research Laboratory, City of Hope, Duarte, CA, USACorrespondence[email protected]

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Co-stimulatory signaling determines tumor antigen sensitivity and persistence of CAR T cells targeting PSCA+ metastatic prostate cancer

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Co-stimulatory signaling determines tumor antigen sensitivity and persistence of CAR T cells targeting PSCA+ metastatic prostate cancer

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