1,751
Views
40
CrossRef citations to date
0
Altmetric
Original Research

Analysis of the immune infiltrate in undifferentiated pleomorphic sarcoma of the extremity and trunk in response to radiotherapy: Rationale for combination neoadjuvant immune checkpoint inhibition and radiotherapy

, MD, , MD, , MD, , MD, MPH, , MD, , MD, MPH, , MD, PhDORCID Icon, , MBBS, , MD, , MD, , MD, PhDORCID Icon, , MD & , MD show all
Article: e1385689 | Received 18 Jul 2017, Accepted 24 Sep 2017, Published online: 31 Oct 2017

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Jiaqiang Wang, Hong Ge & Zhichao Tian. (2023) Immunotherapy Plus Radiotherapy for the Treatment of Sarcomas: Is There a Potential for Synergism?. OncoTargets and Therapy 16, pages 385-397.
Read now
Giacomo G Baldi, Alessandro Gronchi, Marcella Tazzari & Silvia Stacchiotti. (2022) Immunotherapy in soft tissue sarcoma: current evidence and future perspectives in a variegated family of different tumor. Expert Review of Anticancer Therapy 22:5, pages 491-503.
Read now
Xiaojie Ang, Junjun Zhang, Zekun Xu, Zhiyu Zhang, Zhixin Ling, Feng Zhou & Weiguo Chen. (2021) Inflammatory undifferentiated pleomorphic sarcoma of the kidney with obstinate cough and fever as the first symptom: a case report and literature review. All Life 14:1, pages 220-225.
Read now
Isaure Vanmeerbeek, Jenny Sprooten, Dirk De Ruysscher, Sabine Tejpar, Peter Vandenberghe, Jitka Fucikova, Radek Spisek, Laurence Zitvogel, Guido Kroemer, Lorenzo Galluzzi & Abhishek D. Garg. (2020) Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology. OncoImmunology 9:1.
Read now
Wenli Zuo & Lingdi Zhao. (2019) Recent advances and application of PD-1 blockade in sarcoma. OncoTargets and Therapy 12, pages 6887-6896.
Read now

Articles from other publishers (34)

Enar Jumaniyazova, Anastasiya Lokhonina, Dzhuliia Dzhalilova, Anna Kosyreva & Timur Fatkhudinov. (2023) Immune Cells in the Tumor Microenvironment of Soft Tissue Sarcomas. Cancers 15:24, pages 5760.
Crossref
Seung Hyuck Jeon, Changhoon Song, Keun-Yong Eom, In Ah Kim & Jae-Sung Kim. (2023) Modulation of CD8+ T Cell Responses by Radiotherapy—Current Evidence and Rationale for Combination with Immune Checkpoint Inhibitors. International Journal of Molecular Sciences 24:23, pages 16691.
Crossref
Li-Fang Shen, Zi-Ming Fu & Shui-Hong Zhou. (2023) The role of radiotherapy in tumor immunity and the potential of PET/CT in detecting the expression of PD-1/PD-L1. Japanese Journal of Radiology.
Crossref
Maria Danieli, Francesco Barretta, Stefano Radaelli, Marco Fiore, Claudia Sangalli, Marta Barisella, Elena Palassini, Rosalba Miceli, Anna Maria Frezza, Dario Callegaro, Paola Collini, Paolo Giovanni Casali, Silvia Stacchiotti & Alessandro Gronchi. (2023) Pathological and radiological response following neoadjuvant treatments in primary localized resectable myxofibrosarcoma and undifferentiated pleomorphic sarcoma of the extremities and trunk wall. Cancer.
Crossref
Kai Yu, Lan Wang, Fan Bu, Jingxuan Zhang, Yubin Hai, Rui Hu, Ji Lu & Xiaoju Shi. (2023) Retroperitoneal undifferentiated pleomorphic sarcoma with total nephrectomy: a case report and literature review. Frontiers in Surgery 10.
Crossref
Luise Rupp, Antonia Resag, Vlatko Potkrajcic, Verena Warm, Rebekka Wehner, Korinna Jöhrens, Hans Bösmüller, Franziska Eckert & Marc Schmitz. (2023) Prognostic impact of the post-treatment T cell composition and spatial organization in soft tissue sarcoma patients treated with neoadjuvant hyperthermic radio(chemo)therapy. Frontiers in Immunology 14.
Crossref
Víctor Albarrán, María Luisa Villamayor, Javier Pozas, Jesús Chamorro, Diana Isabel Rosero, María San Román, Patricia Guerrero, Patricia Pérez de Aguado, Juan Carlos Calvo, Coral García de Quevedo, Carlos González & María Ángeles Vaz. (2023) Current Landscape of Immunotherapy for Advanced Sarcoma. Cancers 15:8, pages 2287.
Crossref
Areeba Saif, Emily A. Verbus, Amber Leila Sarvestani, Martha E. Teke, Jacob Lambdin, Jonathan M. Hernandez & David G. Kirsch. (2022) A Randomized Trial of Pembrolizumab & Radiotherapy Versus Radiotherapy in High-Risk Soft Tissue Sarcoma of the Extremity (SU2C-SARC032). Annals of Surgical Oncology 30:2, pages 683-685.
Crossref
Emily Z. Keung, Kate J. Krause, Jessica Maxwell, Carol D. Morris, Aimee M. Crago, Matthew T. Houdek, John Kane, Valerae Lewis, Dario Callegaro, Benjamin Miller, Alexander J. Lazar, Rebecca Gladdy, Chandrajit P. Raut, Nicola Fabbri, Waddah Al-Refaie, Mark Fairweather, Sandra L. Wong & Christina L. Roland. (2022) Sentinel Lymph Node Biopsy for Extremity and Truncal Soft Tissue Sarcomas: A Systematic Review of the Literature. Annals of Surgical Oncology 30:2, pages 958-967.
Crossref
Lars Erik Podleska, Sebastian Bauer, Christoph Pöttgen, Arne Streitbürger, Jendrik Hardes & Georg Täger. (2023) Lokalisierte WeichgewebesarkomeLocalized soft tissue sarcoma. best practice onkologie 18:1-2, pages 44-58.
Crossref
Rossana Lazcano, Carmelia M. Barreto, Ruth Salazar, Fernando Carapeto, Raymond S. Traweek, Cheuk H. Leung, Swati Gite, Jay Mehta, Davis R. Ingram, Khalida M. Wani, Kim-Anh T. Vu, Edwin R. Parra, Wei Lu, Jianling Zhou, Russell G. Witt, Brandon Cope, Prapassorn Thirasastr, Heather Y. Lin, Christopher P. Scally, Anthony P. Conley, Ravin Ratan, J. Andrew Livingston, Alexandra M. Zarzour, Joseph Ludwig, Dejka Araujo, Vinod Ravi, Shreyaskumar Patel, Robert Benjamin, Jennifer Wargo, Ignacio I. Wistuba, Neeta Somaiah, Christina L. Roland, Emily Z. Keung, Luisa Solis, Wei-Lien Wang, Alexander J. Lazar & Elise F. Nassif. (2022) The immune landscape of undifferentiated pleomorphic sarcoma. Frontiers in Oncology 12.
Crossref
Antonia Resag, Giulia Toffanin, Iva Benešová, Luise Müller, Vlatko Potkrajcic, Andrej Ozaniak, Robert Lischke, Jirina Bartunkova, Antonio Rosato, Korinna Jöhrens, Franziska Eckert, Zuzana Strizova & Marc Schmitz. (2022) The Immune Contexture of Liposarcoma and Its Clinical Implications. Cancers 14:19, pages 4578.
Crossref
Taro Akiyama, Yuki Yoshimatsu, Rei Noguchi, Yooksil Sin, Ryuto Tsuchiya, Takuya Ono, Jun Sugaya, Eisuke Kobayashi, Akihiko Yoshida, Seiji Ohtori, Akira Kawai & Tadashi Kondo. (2022) Establishment and characterization of NCC-PS1-C1: a novel cell line of pleomorphic sarcoma from a patient after neoadjuvant radiotherapy. Human Cell 35:6, pages 2011-2019.
Crossref
Fei Wang, Juan Bi, Chunxia Yi, Yuan Zhang, Yu Zhang & Qingfang Yue. (2022) Relationship between Prognosis, Immune Infiltration Level, and Differential Expression of PARVG Gene in Uterine Corpus Endometrial Carcinoma. Contrast Media & Molecular Imaging 2022, pages 1-9.
Crossref
Peter H. Goff, Laura Riolobos, Bonnie J. LaFleur, Matthew B. Spraker, Y. David Seo, Kimberly S. Smythe, Jean S. Campbell, Robert H. Pierce, Yuzheng ZhangQianchuan HeEdward Y. Kim, Stephanie K. Schaub, Gabrielle M. Kane, Jose G. Mantilla, Eleanor Y. Chen, Robert Ricciotti, Matthew J. Thompson, Lee D. CranmerMichael J. WagnerElizabeth T. Loggers, Robin L. Jones, Erin MurphyWendy M. BlumenscheinTerrill K. McClanahanJon EarlsKevin C. FlanaganNatalie A. LaFranzoTeresa S. Kim & Seth M. Pollack. (2022) Neoadjuvant Therapy Induces a Potent Immune Response to Sarcoma, Dominated by Myeloid and B Cells. Clinical Cancer Research 28:8, pages 1701-1711.
Crossref
Yifan Zhang, Yi Chen, Andri Papakonstantinou, Panagiotis Tsagkozis, Christina Linder-Stragliotto & Felix Haglund. (2022) Evaluation of PD-L1 Expression in Undifferentiated Pleomorphic Sarcomas, Liposarcomas and Chondrosarcomas. Biomolecules 12:2, pages 292.
Crossref
Matthieu Roulleaux Dugage, Elise F. Nassif, Antoine Italiano & Rastislav Bahleda. (2021) Improving Immunotherapy Efficacy in Soft-Tissue Sarcomas: A Biomarker Driven and Histotype Tailored Review. Frontiers in Immunology 12.
Crossref
Fan Tang, Yan Tie, Yu-Quan Wei, Chong-Qi Tu & Xia-Wei Wei. (2021) Targeted and immuno-based therapies in sarcoma: mechanisms and advances in clinical trials. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1876:2, pages 188606.
Crossref
Siddh van Oost, Debora M. Meijer, Marieke L. Kuijjer, Judith V. M. G. Bovée & Noel F. C. C. de Miranda. (2021) Linking Immunity with Genomics in Sarcomas: Is Genomic Complexity an Immunogenic Trigger?. Biomedicines 9:8, pages 1048.
Crossref
Luana Madalena Sousa, Jani Sofia Almeida, Tânia Fortes-Andrade, Manuel Santos-Rosa, Paulo Freitas-Tavares, José Manuel Casanova & Paulo Rodrigues-Santos. (2021) Tumor and Peripheral Immune Status in Soft Tissue Sarcoma: Implications for Immunotherapy. Cancers 13:15, pages 3885.
Crossref
Andrej Ozaniak, Jiri VachtenheimJr.Jr., Robert Lischke, Jirina Bartunkova & Zuzana Strizova. (2021) Novel Insights into the Immunotherapy of Soft Tissue Sarcomas: Do We Need a Change of Perspective?. Biomedicines 9:8, pages 935.
Crossref
Richard Miallot, Franck Galland, Virginie Millet, Jean-Yves Blay & Philippe Naquet. (2021) Metabolic landscapes in sarcomas. Journal of Hematology & Oncology 14:1.
Crossref
Laurene S Cheung, Lingling Chen, Teniola F Oke, Thomas B Schaffer, Karim Boudadi, Jillian T Ngo, John McMahon Gross, Holly Kemberling, Luis A Diaz, Evan Lipson, John-WIlliam Sidhom, Janis Taube, Robert Anders, Drew M Pardoll, Dung T Le, Christian F Meyer & Nicolas Llosa. (2021) Anti-PD-1 elicits regression of undifferentiated pleomorphic sarcomas with UV-mutation signatures. Journal for ImmunoTherapy of Cancer 9:6, pages e002345.
Crossref
Larisa LehmerFranchesca ChoiChristina KrausJessica ShiuSebastien de Feraudy & Ashley Elsensohn. (2021) Histopathologic PD-L1 Tumor Expression and Prognostic Significance in Nonmelanoma Skin Cancers: A Systematic Review. The American Journal of Dermatopathology 43:5, pages 321-330.
Crossref
Harsimrat Kaur Birdi, Anna Jirovec, Serena Cortés-Kaplan, Joel Werier, Carolyn Nessim, Jean-Simon Diallo & Michele Ardolino. (2021) Immunotherapy for sarcomas: new frontiers and unveiled opportunities. Journal for ImmunoTherapy of Cancer 9:2, pages e001580.
Crossref
Shalabh Arora, Sameer Rastogi, Shamim Ahmed Shamim, Adarsh Barwad & Maansi Sethi. (2020) Good and sustained response to pembrolizumab and pazopanib in advanced undifferentiated pleomorphic sarcoma: a case report. Clinical Sarcoma Research 10:1.
Crossref
Tom van den Ende, Héctor G. van den Boorn, Nadine M. Hoonhout, Faridi S. van Etten-Jamaludin, Sybren L. Meijer, Sarah Derks, Tanja D. de Gruijl, Maarten F. Bijlsma, Martijn G.H. van Oijen & Hanneke W.M. van Laarhoven. (2020) Priming the tumor immune microenvironment with chemo(radio)therapy: A systematic review across tumor types. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1874:1, pages 188386.
Crossref
Cameron M. Callaghan, Steven N. Seyedin, Imran H. Mohiuddin, Kelli L. Hawkes, Michael S. Petronek, Carryn M. Anderson, John M. Buatti, Mohammed M. Milhem, Varun Monga & Bryan G. Allen. (2020) The Effect of Concurrent Stereotactic Body Radiation and Anti-PD-1 Therapy for Recurrent Metastatic Sarcoma. Radiation Research 194:2, pages 124.
Crossref
Jin Liang, Dedian Chen, Liyao Chen, Xueke She, Hushan Zhang & Yanbin Xiao. (2020) The potentiality of immunotherapy for sarcomas: a summary of potential predictive biomarkers. Future Oncology 16:17, pages 1211-1223.
Crossref
Emily Z. Keung, Melissa Burgess, Ruth Salazar, Edwin R. Parra, Jaime Rodrigues-Canales, Vanessa Bolejack, Brian A. Van Tine, Scott M. Schuetze, Steven Attia, Richard F. Riedel, James Hu, Scott H. Okuno, Dennis A. Priebat, Sujana Movva, Lara E. Davis, Damon R. Reed, Alexandre Reuben, Christina L. Roland, Denise Reinke, Alexander J. Lazar, Wei-Lien Wang, Jennifer A. Wargo & Hussein A. Tawbi. (2020) Correlative Analyses of the SARC028 Trial Reveal an Association Between Sarcoma-Associated Immune Infiltrate and Response to Pembrolizumab. Clinical Cancer Research 26:6, pages 1258-1266.
Crossref
Antonella Borgatti, Erin B. Dickerson & Jessica Lawrence. (2019) Emerging therapeutic approaches for canine sarcomas: Pushing the boundaries beyond the conventional. Veterinary and Comparative Oncology 18:1, pages 9-24.
Crossref
Emily Z. Keung, Alexander J. Lazar, Keila E. Torres, Wei-Lien Wang, Janice N. Cormier, B. Ashleigh Guadagnolo, Andrew J. Bishop, Heather Lin, Kelly K. Hunt, Justin Bird, Valerae O. Lewis, Shreyaskumar R. Patel, Jennifer A. Wargo, Neeta Somaiah & Christina L. Roland. (2018) Phase II study of neoadjuvant checkpoint blockade in patients with surgically resectable undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma. BMC Cancer 18:1.
Crossref
Kripa Guram, Maria Nunez, John Einck, Loren K. Mell, Ezra Cohen, P. Dominick Sanders, Sayuri Miyauchi, Elizabeth Weihe, Razelle Kurzrock, Sarah Boles & Andrew B. Sharabi. (2018) Radiation Therapy Combined With Checkpoint Blockade Immunotherapy for Metastatic Undifferentiated Pleomorphic Sarcoma of the Maxillary Sinus With a Complete Response. Frontiers in Oncology 8.
Crossref
Amy J. Wisdom, Yvonne M. Mowery, Richard F. Riedel & David G. Kirsch. (2018) Rationale and emerging strategies for immune checkpoint blockade in soft tissue sarcoma. Cancer 124:19, pages 3819-3829.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.