2,237
Views
28
CrossRef citations to date
0
Altmetric
Original Research

The inhibitory checkpoint, PD-L2, is a target for effector T cells: Novel possibilities for immune therapy

, , ORCID Icon, , , , ORCID Icon, , , , , , & show all
Article: e1390641 | Received 17 Aug 2017, Accepted 05 Oct 2017, Published online: 01 Nov 2017

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Simone Kloch Bendtsen, Maria Perez-Penco, Mie Linder Hübbe, Evelina Martinenaite, Morten Orebo Holmström, Stine Emilie Weis-Banke, Nicolai Grønne Dahlager Jørgensen, Mia Aaboe Jørgensen, Shamaila Munir Ahmad, Kasper Mølgaard Jensen, Christina Friese, Mia Thorup Lundsager, Astrid Zedlitz Johansen, Marco Carretta, Niels Ødum, Özcan Met, Inge Marie Svane, Daniel Hargbøl Madsen & Mads Hald Andersen. (2022) Peptide vaccination activating Galectin-3-specific T cells offers a novel means to target Galectin-3-expressing cells in the tumor microenvironment. OncoImmunology 11:1.
Read now
Uffe Klausen, Nicolai Grønne Dahlager Jørgensen, Jacob Handlos Grauslund, Shamaila Munir Ahmad, Anne Ortved Gang, Evelina Martinenaite, Stine Emilie Weis-Banke, Marie Fredslund Breinholt, Guy Wayne Novotny, Julie Westerlin Kjeldsen, Morten Orebo Holmström, Lone Bredo Pedersen, Christian Bjørn Poulsen, Per Boye Hansen, Özcan Met, Inge Marie Svane, Carsten Utoft Niemann, Lars Møller Pedersen & Mads Hald Andersen. (2021) An immunogenic first-in-human immune modulatory vaccine with PD-L1 and PD-L2 peptides is feasible and shows early signs of efficacy in follicular lymphoma. OncoImmunology 10:1.
Read now

Articles from other publishers (26)

M. Imai, Y. Nakamura, T. Denda, Y. Komatsu, S. Yuki, T. Nishina, Y. Hamamoto, H. Hara, T. Esaki, H. Kawakami, K. Kato, T. Satoh, N. Okano, Y. Sunakawa, H. Taniguchi, K. Yamaguchi, T. Yamada, I. Miki, M. Wakabayashi, T. Kuwata, K. Shitara & T. Yoshino. (2023) Association of PD-L1 and PD-L2 expression and tumor-infiltrating lymphocytes in BRAF V600E-mutated metastatic colorectal cancer: GI-SCREEN post-hoc analysis. ESMO Gastrointestinal Oncology 2, pages 100008.
Crossref
Ru-Yue Chen, Yun Zhu, Yun-Yan Shen, Qin-Ying Xu, Han-Yun Tang, Ning-Xun Cui, Lu Jiang, Xiao-Mei Dai, Wei-Qing Chen, Qiang Lin & Xiao-Zhong Li. (2023) The role of PD-1 signaling in health and immune-related diseases. Frontiers in Immunology 14.
Crossref
Rasmus Erik Johansson Mortensen, Morten Orebo Holmström, Thomas Landkildehus Lisle, Jane P Hasselby, Gro L Willemoe, Özcan Met, Inge Marie Svane, Julia Johansen, Dorte L Nielsen, Inna M Chen & Mads Hald Andersen. (2023) Pre-existing TGF-β-specific T-cell immunity in patients with pancreatic cancer predicts survival after checkpoint inhibitors combined with radiotherapy. Journal for ImmunoTherapy of Cancer 11:3, pages e006432.
Crossref
Mads Hald Andersen. (2022) Tumor microenvironment antigens. Seminars in Immunopathology 45:2, pages 253-264.
Crossref
Maysaa Abdulla, Christer Sundström, Cecilia Lindskog & Peter Hollander. (2023) Expression of IDO1 and PD-L2 in Patients with Benign Lymphadenopathies and Association with Autoimmune Diseases. Biomolecules 13:2, pages 240.
Crossref
Yun-Yun Tao, Yue Shi, Xue-Qin Gong, Li Li, Zu-Mao Li, Lin Yang & Xiao-Ming Zhang. (2023) Radiomic Analysis Based on Magnetic Resonance Imaging for Predicting PD-L2 Expression in Hepatocellular Carcinoma. Cancers 15:2, pages 365.
Crossref
Uffe Klausen, Jacob Handlos Grauslund, Nicolai Grønne Dahlager Jørgensen, Shamaila Munir Ahmad, Merete Jonassen, Stine Emilie Weis-Banke, Evelina Martinenaite, Lone Bredo Pedersen, Thomas Landkildehus Lisle, Anne Ortved Gang, Lisbeth Enggaard, Morten Hansen, Morten Orebo Holmström, Özcan Met, Inge Marie Svane, Carsten Utoft Niemann, Lars Møller Pedersen & Mads Hald Andersen. (2022) Anti-PD-L1/PD-L2 therapeutic vaccination in untreated chronic lymphocytic leukemia patients with unmutated IgHV. Frontiers in Oncology 12.
Crossref
Nicola Humphry. (2022) An Overview of the EORTC-CLTG 2022 Congress. EMJ Oncology.
Crossref
Piper A. Rawding, Jiyoon Bu, Jianxin Wang, Da Won Kim, Adam J. Drelich, Youngsoo Kim & Seungpyo Hong. (2021) Dendrimers for cancer immunotherapy: Avidity‐based drug delivery vehicles for effective anti‐tumor immune response. WIREs Nanomedicine and Nanobiotechnology 14:2.
Crossref
Iguaracy Pinheiro-de-Sousa, Miriam H. Fonseca-Alaniz, Samantha K. Teixeira, Mariliza V. Rodrigues & Jose E. Krieger. (2022) Uncovering emergent phenotypes in endothelial cells by clustering of surrogates of cardiovascular risk factors. Scientific Reports 12:1.
Crossref
Aoyun Wang, Han Chu, Zheng Jin, Qingzhu Jia & Bo Zhu. (2021) Programmed Cell Death Protein Ligand 2 Is a Potential Biomarker That Predicts the Efficacy of Immunotherapy. Disease Markers 2021, pages 1-10.
Crossref
Zhen-Hang Li, Yan-Lei Guan & Guo-Bin Zhang. (2021) Genomic Analysis of Glioblastoma Multiforme Reveals a Key Transcription Factor Signature Relevant to Prognosis and the Immune Processes. Frontiers in Oncology 11.
Crossref
Samantha Batman, Koji Matsuo, Paulette Mhawech-Fauceglia, Elizabeth Munro, Mercedes Weisenberger, Allison Allen, Sonali Joshi, Hiroko Machida, Shinya Matsuzaki, Tatjana Bozanovic & Tanja Pejovic. (2021) Intersection of DNA Repair Pathways and the Immune Landscape Identifies PD-L2 as a Prognostic Marker in Epithelial Ovarian Cancer. Cancers 13:8, pages 1972.
Crossref
Jacob Handlos Grauslund, Morten Orebo Holmström, Nicolai Grønne Jørgensen, Uffe Klausen, Stine Emilie Weis-Banke, Daniel El Fassi, Claudia Schöllkopf, Mette Borg Clausen, Lise Mette Rahbek Gjerdrum, Marie Fredslund Breinholt, Julie Westerlin Kjeldsen, Morten Hansen, Steffen Koschmieder, Nicolas Chatain, Guy Wayne Novotny, Jesper Petersen, Lasse Kjær, Vibe Skov, Özcan Met, Inge Marie Svane, Hans Carl Hasselbalch & Mads Hald Andersen. (2021) Therapeutic Cancer Vaccination With a Peptide Derived From the Calreticulin Exon 9 Mutations Induces Strong Cellular Immune Responses in Patients With CALR-Mutant Chronic Myeloproliferative Neoplasms. Frontiers in Oncology 11.
Crossref
Morten Orebo Holmström, Rasmus Erik Johansson Mortensen, Angelos Michail Pavlidis, Evelina Martinenaite, Stine Emilie Weis-Banke, Mia Aaboe-Jørgensen, Simone Kloch Bendtsen, Özcan Met, Ayako Wakatsuki Pedersen, Marco Donia, Inge Marie Svane & Mads Hald Andersen. (2021) Cytotoxic T cells isolated from healthy donors and cancer patients kill TGFβ-expressing cancer cells in a TGFβ-dependent manner. Cellular & Molecular Immunology 18:2, pages 415-426.
Crossref
Cinzia Solinas, Marco Aiello, Esdy Rozali, Matteo Lambertini, Karen Willard-Gallo & Edoardo Migliori. (2020) Programmed cell death-ligand 2: A neglected but important target in the immune response to cancer?. Translational Oncology 13:10, pages 100811.
Crossref
Yiyin Zhang, Jin Xu, Jie Hua, Jiang Liu, Chen Liang, Qingcai Meng, Miaoyan Wei, Bo Zhang, Xianjun Yu & Si Shi. (2019) A PD-L2-based immune marker signature helps to predict survival in resected pancreatic ductal adenocarcinoma. Journal for ImmunoTherapy of Cancer 7:1.
Crossref
So Mee Kwon, Anuradha Budhu, Hyun Goo Woo, Jittiporn Chaisaingmongkol, Hien Dang, Marshonna Forgues, Curtis C. Harris, Gao Zhang, Noam Auslander, Eytan Ruppin, Chulabhorn Mahidol, Mathuros Ruchirawat & Xin Wei Wang. (2019) Functional Genomic Complexity Defines Intratumor Heterogeneity and Tumor Aggressiveness in Liver Cancer. Scientific Reports 9:1.
Crossref
Marina Jovanovic, Nevena Gajovic, Miodrag L. Lukic, Ana Popovic & Ivan Jovanovic. (2019) Synergism of PDL/PD1 and IL33/ST2 Axis in Tumor Immunology. Serbian Journal of Experimental and Clinical Research 20:3, pages 223-228.
Crossref
Anne Hansen Ree, Vigdis Nygaard, Hege G. Russnes, Daniel Heinrich, Vegard Nygaard, Christin Johansen, Inger Riise Bergheim, Eivind Hovig, Klaus Beiske, Anne Negård, Anne-Lise Børresen-Dale, Kjersti Flatmark & Gunhild M. Mælandsmo. (2019) Responsiveness to PD-1 Blockade in End-Stage Colon Cancer with Gene Locus 9p24.1 Copy-Number Gain. Cancer Immunology Research 7:5, pages 701-706.
Crossref
Huayu Yang, Xiaoxiang Zhou, Lejia Sun & Yilei Mao. (2019) Correlation Between PD-L2 Expression and Clinical Outcome in Solid Cancer Patients: A Meta-Analysis. Frontiers in Oncology 9.
Crossref
Neda Yaghoubi, Arash Soltani, Kiarash Ghazvini, Seyed Mahdi Hassanian & Seyed Isaac Hashemy. (2019) PD-1/ PD-L1 blockade as a novel treatment for colorectal cancer. Biomedicine & Pharmacotherapy 110, pages 312-318.
Crossref
Mads Hald Andersen. (2018) The T-win® technology: immune-modulating vaccines. Seminars in Immunopathology 41:1, pages 87-95.
Crossref
Uffe Klausen, Staffan Holmberg, Morten Orebo Holmström, Nicolai Grønne Dahlager Jørgensen, Jacob Handlos Grauslund, Inge Marie Svane & Mads Hald Andersen. (2018) Novel Strategies for Peptide-Based Vaccines in Hematological Malignancies. Frontiers in Immunology 9.
Crossref
Elizabeth F. Wallin. (2018) T Follicular Regulatory Cells and Antibody Responses in Transplantation. Transplantation 102:10, pages 1614-1623.
Crossref
Mads Hald Andersen. (2018) The Balance Players of the Adaptive Immune System. Cancer Research 78:6, pages 1379-1382.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.