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Original Research

Impaired NK cell recognition of vemurafenib-treated melanoma cells is overcome by simultaneous application of histone deacetylase inhibitors

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Article: e1392426 | Received 12 Jun 2017, Accepted 11 Oct 2017, Published online: 06 Nov 2017

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Kristin C. Hicks, Massimo Fantini, Renee N. Donahue, Angie Schwab, Karin M. Knudson, Sarah R. Tritsch, Caroline Jochems, Paul E. Clavijo, Clint T. Allen, James W. Hodge, Kwong Y. Tsang, Jeffrey Schlom & Sofia R. Gameiro. (2018) Epigenetic priming of both tumor and NK cells augments antibody-dependent cellular cytotoxicity elicited by the anti-PD-L1 antibody avelumab against multiple carcinoma cell types. OncoImmunology 7:11.
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Silvia López-Borrego, Carmen Campos-Silva, Amaia Sandúa, Tamara Camino, Lucía Téllez-Pérez, Estibaliz Alegre, Alexandra Beneitez, Ricardo Jara-Acevedo, Annette Paschen, María Pardo, Álvaro González & Mar Valés-Gómez. (2023) MAPK inhibitors dynamically affect melanoma release of immune NKG2D-ligands, as soluble protein and extracellular vesicle-associated. Frontiers in Cell and Developmental Biology 10.
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Carmen Campos-Silva, Yaiza Cáceres-Martell, Estela Sánchez-Herrero, Amaia Sandúa, Alexandra Beneitez-Martínez, Álvaro González, Mariano Provencio, Atocha Romero, Ricardo Jara-Acevedo, María Yáñez-Mó & Mar Valés‐Gómez. (2022) A simple immunoassay for extracellular vesicle liquid biopsy in microliters of non-processed plasma. Journal of Nanobiotechnology 20:1.
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Yu-Fan Liu, Yun Chiang, Feng-Ming Hsu, Chiao-Ling Tsai & Jason Chia-Hsien Cheng. (2022) Radiosensitization effect by HDAC inhibition improves NKG2D-dependent natural killer cytotoxicity in hepatocellular carcinoma. Frontiers in Oncology 12.
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Tiancheng Zhang, Chenhao Zhang, Zile Fu & Qiang Gao. (2022) Immune Modulatory Effects of Molecularly Targeted Therapy and Its Repurposed Usage in Cancer Immunotherapy. Pharmaceutics 14:9, pages 1768.
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Adriana Celesia, Antonietta Notaro, Marzia Franzò, Marianna Lauricella, Antonella D’Anneo, Daniela Carlisi, Michela Giuliano & Sonia Emanuele. (2022) The Histone Deacetylase Inhibitor ITF2357 (Givinostat) Targets Oncogenic BRAF in Melanoma Cells and Promotes a Switch from Pro-Survival Autophagy to Apoptosis. Biomedicines 10:8, pages 1994.
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Chuqiao Wang, Zeqi Wang, Tengteng Yao, Jibo Zhou & Zhaoyang Wang. (2022) The immune-related role of beta-2-microglobulin in melanoma. Frontiers in Oncology 12.
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Estela Sánchez-Herrero, Carmen Campos-Silva, Yaiza Cáceres-Martell, Lucía Robado de Lope, Sandra Sanz-Moreno, Roberto Serna-Blasco, Alejandro Rodríguez-Festa, Dunixe Ares Trotta, Paloma Martín-Acosta, Cristina Patiño, María José Coronado, Alexandra Beneitez, Ricardo Jara, Nerea Lago-Baameiro, Tamara Camino, Alberto Cruz-Bermúdez, María Pardo, Víctor González-Rumayor, Mar Valés-Gómez, Mariano Provencio & Atocha Romero. (2022) ALK -Fusion Transcripts Can Be Detected in Extracellular Vesicles (EVs) from Nonsmall Cell Lung Cancer Cell Lines and Patient Plasma: Toward EV-Based Noninvasive Testing . Clinical Chemistry 68:5, pages 668-679.
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Amber B. Jones, Abbey Rocco, Lawrence S. Lamb, Gregory K. Friedman & Anita B. Hjelmeland. (2022) Regulation of NKG2D Stress Ligands and Its Relevance in Cancer Progression. Cancers 14:9, pages 2339.
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Meng-Wei Ko, Kawaljit Kaur, Tahmineh Safaei, Wuyang Chen, Christine Sutanto, Paul Wong & Anahid Jewett. (2022) Defective Patient NK Function Is Reversed by AJ2 Probiotic Bacteria or Addition of Allogeneic Healthy Monocytes. Cells 11:4, pages 697.
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Reza Hosseini, Hamzeh Sarvnaz, Maedeh Arabpour, Samira Molaei Ramshe, Leila Asef-Kabiri, Hassan Yousefi, Mohammad Esmaeil Akbari & Nahid Eskandari. (2022) Cancer exosomes and natural killer cells dysfunction: biological roles, clinical significance and implications for immunotherapy. Molecular Cancer 21:1.
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Joey H. Li & Timothy E. O’Sullivan. (2022) Back to the Future: Spatiotemporal Determinants of NK Cell Antitumor Function. Frontiers in Immunology 12.
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Carmen Campos-Silva, Silvia López-Borrego, María José Felgueres, Gloria Esteso & Mar Vales-Gomez. (2022) NKG2D Ligands in Liquid Biopsy: The Importance of Soluble and Vesicle-Bound Proteins for Immune Modulation. Critical Reviews in Immunology 42:1, pages 21-40.
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Luis Sánchez-del-Campo, Román Martí-Díaz, María F. Montenegro, Rebeca González-Guerrero, Trinidad Hernández-Caselles, Enrique Martínez-Barba, Antonio Piñero-Madrona, Juan Cabezas-Herrera, Colin R. Goding & José Neptuno Rodríguez-López. (2021) MITF induces escape from innate immunity in melanoma. Journal of Experimental & Clinical Cancer Research 40:1.
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Amanda A. van Vliet, Anna-Maria Georgoudaki, Monica Raimo, Tanja D. de Gruijl & Jan Spanholtz. (2021) Adoptive NK Cell Therapy: A Promising Treatment Prospect for Metastatic Melanoma. Cancers 13:18, pages 4722.
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Mercedes Beatriz Fuertes, Carolina Inés Domaica & Norberto Walter Zwirner. (2021) Leveraging NKG2D Ligands in Immuno-Oncology. Frontiers in Immunology 12.
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Fabrizio Marcucci & Cristiano Rumio. (2021) Depleting Tumor Cells Expressing Immune Checkpoint Ligands—A New Approach to Combat Cancer. Cells 10:4, pages 872.
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Giulia Petroni, Aitziber Buqué, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi. (2021) Immunomodulation by targeted anticancer agents. Cancer Cell 39:3, pages 310-345.
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Elisa C. Toffoli, Abdolkarim Sheikhi, Yannick D. Höppner, Pita de Kok, Mahsa Yazdanpanah-Samani, Jan Spanholtz, Henk M. W. Verheul, Hans J. van der Vliet & Tanja D. de Gruijl. (2021) Natural Killer Cells and Anti-Cancer Therapies: Reciprocal Effects on Immune Function and Therapeutic Response. Cancers 13:4, pages 711.
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Baokai Dou, Shichun Li, Luyao Wei, Lixin Wang, Shiguo Zhu, Zhengtao Wang, Zunji Ke, Kaixian Chen & Zhifei Wang. (2020) Astragaloside IV suppresses post-ischemic natural killer cell infiltration and activation in the brain: involvement of histone deacetylase inhibition. Frontiers of Medicine 15:1, pages 79-90.
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Kawaljit Kaur, Tahmineh Safaie, Meng-Wei Ko, Yuhao Wang & Anahid Jewett. (2021) ADCC against MICA/B Is Mediated against Differentiated Oral and Pancreatic and Not Stem-Like/Poorly Differentiated Tumors by the NK Cells; Loss in Cancer Patients due to Down-Modulation of CD16 Receptor. Cancers 13:2, pages 239.
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Carmen Campos-Silva, Yaiza Cáceres-Martell, Sheila López-Cobo, María Josefa Rodriguez, Ricardo Jara, María Yáñez-Mó & Mar Valés-Gómez. 2021. Melanoma. Melanoma 323 344 .
Italia Falcone, Fabiana Conciatori, Chiara Bazzichetto, Gianluigi Ferretti, Francesco Cognetti, Ludovica Ciuffreda & Michele Milella. (2020) Tumor Microenvironment: Implications in Melanoma Resistance to Targeted Therapy and Immunotherapy. Cancers 12:10, pages 2870.
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Minjeong Yeon, Youngmi Kim, Hyun Suk Jung & Dooil Jeoung. (2020) Histone Deacetylase Inhibitors to Overcome Resistance to Targeted and Immuno Therapy in Metastatic Melanoma. Frontiers in Cell and Developmental Biology 8.
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John M. Idso, Shunhua Lao, Nathan J. Schloemer, Jeffrey Knipstein, Robert Burns, Monica S. Thakar & Subramaniam Malarkannan. (2020) Entinostat augments NK cell functions via epigenetic upregulation of IFIT1-STING-STAT4 pathway. Oncotarget 11:20, pages 1799-1815.
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Chongren Ren, Xiaojing Ren, Dujuan Cao, Haichao Zhao, Zhensheng Zhai, Huiyu Li, Yanjun Li, Xifeng Fu, Jiefeng He & Haoliang Zhao. (2020) CNOT7 depletion reverses natural killer cell resistance by modulating the tumor immune microenvironment of hepatocellular carcinoma. FEBS Open Bio 10:5, pages 847-860.
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Anna L. Furfaro, Selene Ottonello, Giulia Loi, Irene Cossu, Sabrina Piras, Francesco Spagnolo, Paola Queirolo, Umberto M. Marinari, Lorenzo Moretta, Maria A. Pronzato, Maria C. Mingari, Gabriella Pietra & Mariapaola Nitti. (2019) HO‐1 downregulation favors BRAF V600 melanoma cell death induced by Vemurafenib/PLX4032 and increases NK recognition . International Journal of Cancer 146:7, pages 1950-1962.
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Laura Damele, Selene Ottonello, Maria Cristina Mingari, Gabriella Pietra & Chiara Vitale. (2020) Targeted Therapies: Friends or Foes for Patient’s NK Cell-Mediated Tumor Immune-Surveillance?. Cancers 12:4, pages 774.
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Anahid Jewett, Janko Kos, Kawaljit Kaur, Tahmineh Safaei, Christine Sutanto, Wuyang Chen, Paul Wong, Artin Keshishian Namagerdi, Changge Fang, Yuman Fong & Meng-Wei Ko. (2020) Natural Killer Cells: Diverse Functions in Tumor Immunity and Defects in Pre-neoplastic and Neoplastic Stages of Tumorigenesis. Molecular Therapy - Oncolytics 16, pages 41-52.
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Lydia Bellmann, Giuseppe Cappellano, Johanna F. Schachtl‐Riess, Anastasia Prokopi, Athanasios Seretis, Daniela Ortner, Christoph H. Tripp, Constance E. Brinckerhoff, David W. Mullins & Patrizia Stoitzner. (2019) A TLR7 agonist strengthens T and NK cell function during BRAF‐targeted therapy in a preclinical melanoma model. International Journal of Cancer 146:5, pages 1409-1420.
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Monica Marzagalli, Nancy D. Ebelt & Edwin R. Manuel. (2019) Unraveling the crosstalk between melanoma and immune cells in the tumor microenvironment. Seminars in Cancer Biology 59, pages 236-250.
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Michael Schnekenburger, Mario Dicato & Marc F. Diederich. (2019) Anticancer potential of naturally occurring immunoepigenetic modulators: A promising avenue?. Cancer 125:10, pages 1612-1628.
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Alexandra Frazao, Louise Rethacker, Meriem Messaoudene, Marie-Françoise Avril, Antoine Toubert, Nicolas Dulphy & Anne Caignard. (2019) NKG2D/NKG2-Ligand Pathway Offers New Opportunities in Cancer Treatment. Frontiers in Immunology 10.
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Iris Helfrich & Bernhard Singer. (2019) Size Matters: The Functional Role of the CEACAM1 Isoform Signature and Its Impact for NK Cell-Mediated Killing in Melanoma. Cancers 11:3, pages 356.
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Carmen Campos-Silva, Henar Suárez, Ricardo Jara-Acevedo, Estefanía Linares-Espinós, Luis Martinez-Piñeiro, María Yáñez-Mó & Mar Valés-Gómez. (2019) High sensitivity detection of extracellular vesicles immune-captured from urine by conventional flow cytometry. Scientific Reports 9:1.
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Paola Kučan Brlić, Tihana Lenac Roviš, Guy Cinamon, Pini Tsukerman, Ofer Mandelboim & Stipan Jonjić. (2018) Targeting PVR (CD155) and its receptors in anti-tumor therapy. Cellular & Molecular Immunology 16:1, pages 40-52.
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Sheila López-Cobo, Carmen Campos-Silva, Amanda Moyano, Myriam Oliveira-Rodríguez, Annette Paschen, María Yáñez-Mó, María Carmen Blanco-López & Mar Valés-Gómez. (2018) Immunoassays for scarce tumour-antigens in exosomes: detection of the human NKG2D-Ligand, MICA, in tetraspanin-containing nanovesicles from melanoma. Journal of Nanobiotechnology 16:1.
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Anahid Jewett, Janko Kos, Yuman Fong, Meng-Wei Ko, Tahmineh Safaei, Milica Perišić Nanut & Kawaljit Kaur. (2018) NK cells shape pancreatic and oral tumor microenvironments; role in inhibition of tumor growth and metastasis. Seminars in Cancer Biology 53, pages 178-188.
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Eszter Lajkó, Sarah Spring, Rózsa Hegedüs, Beáta Biri-Kovács, Sven Ingebrandt, Gábor Mező & László Kőhidai. (2018) Comparative cell biological study of in vitro antitumor and antimetastatic activity on melanoma cells of GnRH-III-containing conjugates modified with short-chain fatty acids. Beilstein Journal of Organic Chemistry 14, pages 2495-2509.
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Dominik Schmiedel & Ofer Mandelboim. (2018) NKG2D Ligands–Critical Targets for Cancer Immune Escape and Therapy. Frontiers in Immunology 9.
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C. Campos‐Silva, M. K. Kramer & M. Valés‐Gómez. (2018) NKG2D‐ligands: Putting everything under the same umbrella can be misleading. HLA 91:6, pages 489-500.
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Kawaljit Kaur, Milica Perišić Nanut, Meng-Wei Ko, Tahmineh Safaie, Janko Kos & Anahid Jewett. (2018) Natural killer cells target and differentiate cancer stem-like cells/undifferentiated tumors: strategies to optimize their growth and expansion for effective cancer immunotherapy. Current Opinion in Immunology 51, pages 170-180.
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