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OncoImmunology Volume 7, 2018 - Issue 2
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Original Research

Neoadjuvant radiochemotherapy decreases the total amount of tumor infiltrating lymphocytes, but increases the number of CD8+/Granzyme B+ (GrzB) cytotoxic T-cells in rectal cancer

Armin JaroschInstitute of Pathology, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Germany;National Center for Tumor Diseases (NCT) partner site Dresden
,
Ulrich SommerInstitute of Pathology, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Germany;National Center for Tumor Diseases (NCT) partner site Dresden
,
Andreas BognerDepartment for Visceral, Thoracic and Vascular Surgery, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Germany;National Center for Tumor Diseases (NCT) partner site Dresden
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Christoph ReißfelderDepartment for Visceral, Thoracic and Vascular Surgery, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Germany;National Center for Tumor Diseases (NCT) partner site Dresden;German Cancer Research Center (DKFZ), Heidelberg and German Cancer Consortium (DKTK), Dresden, Germany
,
Jürgen WeitzInstitute of Pathology, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Germany;National Center for Tumor Diseases (NCT) partner site Dresden;German Cancer Research Center (DKFZ), Heidelberg and German Cancer Consortium (DKTK), Dresden, Germany
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Mechthild KrauseNational Center for Tumor Diseases (NCT) partner site Dresden;Department of Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden;German Cancer Research Center (DKFZ), Heidelberg and German Cancer Consortium (DKTK), Dresden, Germany;OncoRay – National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany;Helmholtz-Zentrum Dresden – Rossendorf, Institute of Radiooncology, Dresden, Germany
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Gunnar FolprechtMedical Department I, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Germany;National Center for Tumor Diseases (NCT) partner site Dresden;German Cancer Research Center (DKFZ), Heidelberg and German Cancer Consortium (DKTK), Dresden, Germany
,
Gustavo B. BarettonInstitute of Pathology, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Germany;National Center for Tumor Diseases (NCT) partner site Dresden;German Cancer Research Center (DKFZ), Heidelberg and German Cancer Consortium (DKTK), Dresden, Germany;Tumor and normal tissue bank of Universitäts KrebsCentrum (UCC), University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Germany
&
Daniela E. AustInstitute of Pathology, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Germany;National Center for Tumor Diseases (NCT) partner site Dresden;German Cancer Research Center (DKFZ), Heidelberg and German Cancer Consortium (DKTK), Dresden, Germany;Tumor and normal tissue bank of Universitäts KrebsCentrum (UCC), University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, GermanyCorrespondence[email protected]
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Article: e1393133 | Received 06 Sep 2017, Accepted 11 Oct 2017, Published online: 07 Nov 2017

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Azar Rezapour, Daniel Rydbeck, Fabian Byvald, Viktor Tasselius, Gustaf Danielsson, Eva Angenete & Ulf Yrlid. (2023) A type I interferon footprint in pre-operative biopsies is an independent biomarker that in combination with CD8+ T cell quantification can improve the prediction of response to neoadjuvant treatment of rectal adenocarcinoma. OncoImmunology 12:1.
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Xiaofang Xing, Shuqin Jia, Yuxin Leng, Qian Wang, Zhongwu Li, Bin Dong, Ting Guo, Xiaojing Cheng, Hong Du, Ying Hu, Qin Feng, Shenyi Lian, Fengming Luan, Xiaoxiao Ma, Zhe Li, Ming Ni, Ziyu Li & Jiafu Ji. (2020) An integrated classifier improves prognostic accuracy in non-metastatic gastric cancer. OncoImmunology 9:1.
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Isaure Vanmeerbeek, Jenny Sprooten, Dirk De Ruysscher, Sabine Tejpar, Peter Vandenberghe, Jitka Fucikova, Radek Spisek, Laurence Zitvogel, Guido Kroemer, Lorenzo Galluzzi & Abhishek D. Garg. (2020) Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology. OncoImmunology 9:1.
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Articles from other publishers (13)

Dorothée Sartorius, Moritz Leander Blume, Johannes Robert Fleischer, Michael Ghadimi, Lena-Christin Conradi & Tiago De Oliveira. (2023) Implications of Rectal Cancer Radiotherapy on the Immune Microenvironment: Allies and Foes to Therapy Resistance and Patients’ Outcome. Cancers 15:21, pages 5124.
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Ioannis M. Koukourakis, Vassilis Kouloulias, Dina Tiniakos, Ioannis Georgakopoulos & Anna Zygogianni. (2023) Current status of locally advanced rectal cancer therapy and future prospects. Critical Reviews in Oncology/Hematology 186, pages 103992.
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Ioannis M. Koukourakis, Kalliopi Platoni, Dina Tiniakos, Vassilis Kouloulias & Anna Zygogianni. (2023) Immune Response and Immune Checkpoint Molecules in Patients with Rectal Cancer Undergoing Neoadjuvant Chemoradiotherapy: A Review. Current Issues in Molecular Biology 45:5, pages 4495-4517.
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Chao Liu, Xiaohui Li, Qingyu Huang, Min Zhang, Tianyu Lei, Fuhao Wang, Wenxue Zou, Rui Huang, Xiaoyu Hu, Cong Wang, Xiaoling Zhang, Bing Sun, Ligang Xing, Jinbo Yue & Jinming Yu. (2023) Single-cell RNA-sequencing reveals radiochemotherapy-induced innate immune activation and MHC-II upregulation in cervical cancer. Signal Transduction and Targeted Therapy 8:1.
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Hsin-Hua Lee, Chien-Hung Chen, Yu-Hsiang Huang, Cheng-Han Chiang & Ming-Yii Huang. (2022) Biomarkers of Favorable vs. Unfavorable Responses in Locally Advanced Rectal Cancer Patients Receiving Neoadjuvant Concurrent Chemoradiotherapy. Cells 11:10, pages 1611.
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Francesco Sclafani, Claudia Corrò & Thibaud Koessler. (2021) Debating Pros and Cons of Total Neoadjuvant Therapy in Rectal Cancer. Cancers 13:24, pages 6361.
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Aylin Alkan, Tobias Hofving, Eva Angenete & Ulf Yrlid. (2021) Biomarkers and cell-based models to predict the outcome of neoadjuvant therapy for rectal cancer patients. Biomarker Research 9:1.
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Claudia Corrò, Valérie Dutoit & Thibaud Koessler. (2021) Emerging Trends for Radio-Immunotherapy in Rectal Cancer. Cancers 13:6, pages 1374.
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Alberto Farolfi, Elisabetta Petracci, Luigi Serra, Alessandra Ravaioli, Sara Bravaccini, Sara Ravaioli, Maria Maddalena Tumedei, Paola Ulivi, Matteo Canale, Maurizio Puccetti, Fabio Falcini, Secondo Folli, Annalisa Curcio & Andrea Rocca. (2020) Tumor-Infiltrating Lymphocytes (TILs) and Risk of a Second Breast Event After a Ductal Carcinoma in situ. Frontiers in Oncology 10.
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Tom van den Ende, Héctor G. van den Boorn, Nadine M. Hoonhout, Faridi S. van Etten-Jamaludin, Sybren L. Meijer, Sarah Derks, Tanja D. de Gruijl, Maarten F. Bijlsma, Martijn G.H. van Oijen & Hanneke W.M. van Laarhoven. (2020) Priming the tumor immune microenvironment with chemo(radio)therapy: A systematic review across tumor types. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1874:1, pages 188386.
Crossref
Svenja Wagener-Ryczek, Max Schoemmel, Max Kraemer, Christiane Bruns, Wolfgang Schroeder, Thomas Zander, Florian Gebauer, Hakan Alakus, Sabine Merkelbach-Bruse, Reinhard Buettner, Heike Loeser, Martin Thelen, Hans A. Schlößer & Alexander Quaas. (2020) Immune profile and immunosurveillance in treatment-naive and neoadjuvantly treated esophageal adenocarcinoma. Cancer Immunology, Immunotherapy 69:4, pages 523-533.
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Markus Renninger, Omar Fahmy, Tina Schubert, Manuel Alexander Schmid, Fahmy Hassan, Arnulf Stenzl & Georgios Gakis. (2019) The prognostic impact of hexaminolevulinate-based bladder tumor resection in patients with primary non-muscle invasive bladder cancer treated with radical cystectomy. World Journal of Urology 38:2, pages 397-406.
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Felix Wagner, Ulrike Hölig, Friederike Wilczkowski, Ioana Plesca, Ulrich Sommer, Rebekka Wehner, Maximilian Kießler, Armin Jarosch, Katharina Flecke, Maia Arsova, Antje Tunger, Andreas Bogner, Christoph Reißfelder, Jürgen Weitz, Knut Schäkel, Esther G. C. Troost, Mechthild Krause, Gunnar Folprecht, Martin Bornhäuser, Michael P. Bachmann, Daniela Aust, Gustavo Baretton & Marc Schmitz. (2019) Neoadjuvant Radiochemotherapy Significantly Alters the Phenotype of Plasmacytoid Dendritic Cells and 6-Sulfo LacNAc+ Monocytes in Rectal Cancer. Frontiers in Immunology 10.
Crossref

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