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OncoImmunology Volume 7, 2018 - Issue 3
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Original Research

PD-1 blockade reverses adaptive immune resistance induced by high-dose hypofractionated but not low-dose daily fractionated radiation

Megan MorisadaTranslational Tumor Immunology Program, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA
, BS,
Paul E. ClavijoTranslational Tumor Immunology Program, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA
, PhD,
Ellen MooreTranslational Tumor Immunology Program, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA
, BS,
Lillian SunTranslational Tumor Immunology Program, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA
,
Michael ChamberlinDepartment of Radiation Oncology, Walter Reed National Military Medical Center, Bethesda, MD, USA
, MD,
Carter Van WaesHead and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA
, MD, PhD,
James W. HodgeLaboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
, PhD, MBA,
James B. MitchellRadiation Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
, PhD,
Jay FriedmanTranslational Tumor Immunology Program, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA
, PhD &
Clint T. AllenTranslational Tumor Immunology Program, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA;Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA;Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USACorrespondence[email protected]
, MD show all
Article: e1395996 | Received 27 Sep 2017, Accepted 19 Oct 2017, Published online: 27 Nov 2017

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Roy Xiao, Clint T. Allen, Linda Tran, Priya Patel, So-Jin Park, Zhong Chen, Carter Van Waes & Nicole C. Schmitt. (2018) Antagonist of cIAP1/2 and XIAP enhances anti-tumor immunity when combined with radiation and PD-1 blockade in a syngeneic model of head and neck cancer. OncoImmunology 7:9.
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Udo S. Gaipl, Anca L. Grosu, Benjamin Frey, Michael Rückert, Henning Schäfer & Ilinca Popp. 2020. Kompendium Internistische Onkologie. Kompendium Internistische Onkologie 1 20 .
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Sergey V. Kozin. (2022) Vascular damage in tumors: a key player in stereotactic radiation therapy?. Trends in Cancer 8:10, pages 806-819.
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Danyi Zhai, Dandan An, Chao Wan & Kunyu Yang. (2022) Radiotherapy: Brightness and darkness in the era of immunotherapy. Translational Oncology 19, pages 101366.
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Kenneth C.W. Wong, David Johnson, Edwin P. Hui, Rachel C.T. Lam, Brigette B.Y. Ma & Anthony T.C. Chan. (2022) Opportunities and challenges in combining immunotherapy and radiotherapy in head and neck cancers. Cancer Treatment Reviews 105, pages 102361.
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Vicky Mengfei Qin, Nicole M. Haynes, Criselle D’Souza, Paul J. Neeson & Joe Jiang Zhu. (2022) CAR-T Plus Radiotherapy: A Promising Combination for Immunosuppressive Tumors. Frontiers in Immunology 12.
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Laura A. Huppert, Michael D. Green, Luke Kim, Christine Chow, Yan Leyfman, Adil I. Daud & James C. Lee. (2021) Tissue-specific Tregs in cancer metastasis: opportunities for precision immunotherapy. Cellular & Molecular Immunology 19:1, pages 33-45.
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Kewen He, Ugur Selek, Hampartsoum B. Barsoumian, Duygu Sezen, Matthew S. Ning, Nahum Puebla-Osorio, Jonathan E. Schoenhals, Dawei Chen, Carola Leuschner, Maria Angelica Cortez & James W. Welsh. 2023. Advances in Radiation Oncology in Lung Cancer. Advances in Radiation Oncology in Lung Cancer 399 414 .
Nicole C. Schmitt, Brendan L. C. Kinney & Robert L. Ferris. 2022.
Yuhei Miyasaka, Hiro Sato, Naoko Okano, Nobuteru Kubo, Hidemasa Kawamura & Tatsuya Ohno. (2021) A Promising Treatment Strategy for Lung Cancer: A Combination of Radiotherapy and Immunotherapy. Cancers 14:1, pages 203.
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M. Hecht, U. S. Gaipl & R. Fietkau. (2021) RadioimmuntherapieRadioimmunotherapy. Der Onkologe 27:11, pages 1094-1100.
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Crossref
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Karl-Göran Tranberg. (2021) Local Destruction of Tumors and Systemic Immune Effects. Frontiers in Oncology 11.
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Yang Li, Wenfang Miao, Doudou He, Siqi Wang, Jianjuan Lou, Yanni Jiang & Shouju Wang. (2021) Recent Progress on Immunotherapy for Breast Cancer: Tumor Microenvironment, Nanotechnology and More. Frontiers in Bioengineering and Biotechnology 9.
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Chen Zhang, Zhenzhen Liang, Shumei Ma & Xiaodong Liu. (2021) Radiotherapy and Cytokine Storm: Risk and Mechanism. Frontiers in Oncology 11.
Crossref
Timothy P. Lippert & Roger A. Greenberg. (2021) The abscopal effect: a sense of DNA damage is in the air. Journal of Clinical Investigation 131:9.
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Jonathan Khalifa, Julien Mazieres, Carlos Gomez-Roca, Maha Ayyoub & Elizabeth Cohen-Jonathan Moyal. (2021) Radiotherapy in the Era of Immunotherapy With a Focus on Non-Small-Cell Lung Cancer: Time to Revisit Ancient Dogmas?. Frontiers in Oncology 11.
Crossref
N.E. Donlon, R. Power, C. Hayes, J.V. Reynolds & J. Lysaght. (2021) Radiotherapy, immunotherapy, and the tumour microenvironment: Turning an immunosuppressive milieu into a therapeutic opportunity. Cancer Letters 502, pages 84-96.
Crossref
Michael Rückert, Lisa Deloch, Benjamin Frey, Eberhard Schlücker, Rainer Fietkau & Udo S. Gaipl. (2021) Combinations of Radiotherapy with Vaccination and Immune Checkpoint Inhibition Differently Affect Primary and Abscopal Tumor Growth and the Tumor Microenvironment. Cancers 13:4, pages 714.
Crossref
Jack M. Qian & Jonathan D. Schoenfeld. (2021) Radiotherapy and Immunotherapy for Head and Neck Cancer: Current Evidence and Challenges. Frontiers in Oncology 10.
Crossref
Zhao Jing, Rongjin Zhou & Ni Zhang. (2021) Achievement of long-term local control after radiation and anti-PD-1 immunotherapy in locally advanced non-small cell lung cancer. Therapeutic Advances in Chronic Disease 12, pages 204062232110473.
Crossref
Natsuo Tomita, Shino Ogawa & Gosuke Aikawa. (2021) Abscopal Effect of Pelvic Intensity Modulated Radiation Therapy on Lung Metastases in a Patient With Recurrent Endometrial Cancer. Advances in Radiation Oncology 6:1, pages 100563.
Crossref
Ali Shamseddine, Youssef H. Zeidan, Malek Kreidieh, Ibrahim Khalifeh, Rim Turfa, Joseph Kattan, Deborah Mukherji, Sally Temraz, Kholoud Alqasem, Rula Amarin, Tala Al Awabdeh, Samer Deeba, Faek Jamali, Issa Mohamad, Mousa Elkhaldi, Faiez Daoud, Mahmoud Al Masri, Ali Dabous, Ahmad Hushki, Omar Jaber, Clement Khoury, Ziad El Husseini, Maya Charafeddine, Monita Al Darazi & Fady Geara. (2020) Short-course radiation followed by mFOLFOX-6 plus avelumab for locally-advanced rectal adenocarcinoma. BMC Cancer 20:1.
Crossref
Samantha S. Beauford, Anita Kumari & Charlie Garnett-Benson. (2020) Ionizing radiation modulates the phenotype and function of human CD4+ induced regulatory T cells. BMC Immunology 21:1.
Crossref
Fleury Augustin Nsole Biteghe, Nyangone Ekome Toung Chalomie, Neelakshi Mungra, Guillaume Vignaux, Nan Gao, Aurelia Vergeade, Ambrose Okem, Krupa Naran, Jean De La Croix Ndong & Stefan Barth. (2020) Antibody-Based Immunotherapy: Alternative Approaches for the Treatment of Metastatic Melanoma. Biomedicines 8:9, pages 327.
Crossref
Michael Green, Samantha J. Van Nest, Emilie Soisson, Kathryn Huber, Yixiang Liao, William McBride, Michael M. Dominello, Jay Burmeister & Michael C. Joiner. (2020) Three discipline collaborative radiation therapy (3DCRT) special debate: We should treat all cancer patients with hypofractionation. Journal of Applied Clinical Medical Physics 21:6, pages 7-14.
Crossref
Victor R. Adorno Febles, Seth Blacksburg, Jonathan A. Haas & David R. Wise. (2020) Translating the Immunobiology of SBRT to Novel Therapeutic Combinations for Advanced Prostate Cancer. Frontiers in Oncology 10.
Crossref
Maedeh Alinezhad, Mohsen Bakhshandeh, Elham Rostami, Reza Alimohamadi, Nariman Mosaffa & Seyed Amir Jalali. (2020) Synergistic effects of anti-PDL-1 with ablative radiation comparing to other regimens with same biological effect dose based on different immunogenic response. PLOS ONE 15:4, pages e0231507.
Crossref
Willemijn SME Theelen, Monique C de Jong & Paul Baas. (2020) Synergizing systemic responses by combining immunotherapy with radiotherapy in metastatic non-small cell lung cancer: The potential of the abscopal effect. Lung Cancer 142, pages 106-113.
Crossref
Jie Huang & Jian Jian Li. (2020) Cell repopulation, rewiring metabolism, and immune regulation in cancer radiotherapy. Radiation Medicine and Protection 1:1, pages 24-30.
Crossref
Harry J. Han, Yun Rose Li, Mack RoachIIIIII & Rahul Aggarwal. (2020) Dramatic response to combination pembrolizumab and radiation in metastatic castration resistant prostate cancer. Therapeutic Advances in Medical Oncology 12, pages 175883592093608.
Crossref
Nicole C. Schmitt & Robert L. Ferris. 2020. Novel Therapies in Head and Neck Cancer: Beyond the Horizon. Novel Therapies in Head and Neck Cancer: Beyond the Horizon 117 142 .
Julijan Kabiljo, Felix Harpain, Sebastian Carotta & Michael Bergmann. (2019) Radiotherapy as a Backbone for Novel Concepts in Cancer Immunotherapy. Cancers 12:1, pages 79.
Crossref
Jared M. Newton, Aurelie Hanoteau, Hsuan-Chen Liu, Angelina Gaspero, Falguni Parikh, Robyn D. Gartrell-Corrado, Thomas D. Hart, Damya Laoui, Jo A. Van Ginderachter, Neeraja Dharmaraj, William C. Spanos, Yvonne Saenger, Simon Young & Andrew G. Sikora. (2019) Immune microenvironment modulation unmasks therapeutic benefit of radiotherapy and checkpoint inhibition. Journal for ImmunoTherapy of Cancer 7:1.
Crossref
Ayman J Oweida, Laurel Darragh, Andy Phan, David Binder, Shilpa Bhatia, Adam Mueller, Benjamin Van Court, Dallin Milner, David Raben, Richard Woessner, Lynn Heasley, Raphael Nemenoff, Eric Clambey & Sana D Karam. (2019) STAT3 Modulation of Regulatory T Cells in Response to Radiation Therapy in Head and Neck Cancer. JNCI: Journal of the National Cancer Institute 111:12, pages 1339-1349.
Crossref
Vishwajith Sridharan & Jonathan D. Schoenfeld. (2019) Immunotherapy and Radiation. Hematology/Oncology Clinics of North America 33:6, pages 1057-1069.
Crossref
David B. Page, Harry Bear, Sangeetha Prabhakaran, Margaret E. Gatti-Mays, Alexandra Thomas, Erin Cobain, Heather McArthur, Justin M. Balko, Sofia R. Gameiro, Rita Nanda, James L. Gulley, Kevin Kalinsky, Julia White, Jennifer Litton, Steven J. Chmura, Mei-Yin Polley, Benjamin Vincent, David W. Cescon, Mary L. Disis, Joseph A. Sparano, Elizabeth A. Mittendorf & Sylvia Adams. (2019) Two may be better than one: PD-1/PD-L1 blockade combination approaches in metastatic breast cancer. npj Breast Cancer 5:1.
Crossref
Ryusuke Hori, Shogo Shinohara, Tsuyoshi Kojima, Hiroki Kagoshima, Morimasa Kitamura, Ichiro Tateya, Hisanobu Tamaki, Yohei Kumabe, Ryo Asato, Hiroyuki Harada, Yoshiharu Kitani, Takashi Tsujimura, Keigo Honda, Kazuyuki Ichimaru & Koichi Omori. (2019) Real-World Outcomes and Prognostic Factors in Patients Receiving Nivolumab Therapy for Recurrent or Metastatic Head and Neck Carcinoma. Cancers 11:9, pages 1317.
Crossref
Sana D Karam & David Raben. (2019) Radioimmunotherapy for the treatment of head and neck cancer. The Lancet Oncology 20:8, pages e404-e416.
Crossref
Tadanobu Nagaya, Jay Friedman, Yasuhiro Maruoka, Fusa Ogata, Shuhei Okuyama, Paul E. Clavijo, Peter L. Choyke, Clint Allen & Hisataka Kobayashi. (2019) Host Immunity Following Near-Infrared Photoimmunotherapy Is Enhanced with PD-1 Checkpoint Blockade to Eradicate Established Antigenic Tumors. Cancer Immunology Research 7:3, pages 401-413.
Crossref
Dirk De Ruysscher, Gabriele Niedermann, Neil G. Burnet, Shankar Siva, Anne W. M. Lee & Fiona Hegi-Johnson. (2019) Radiotherapy toxicity. Nature Reviews Disease Primers 5:1.
Crossref
Benjamin Frey, Michael Rückert & Udo S. Gaipl. 2019. Radiation Oncology. Radiation Oncology 1 12 .
Zachary S. Buchwald, Jacob Wynne, Tahseen H. Nasti, Simeng Zhu, Waleed F. Mourad, Weisi Yan, Seema Gupta, Samir N. Khleif & Mohammad K. Khan. (2018) Radiation, Immune Checkpoint Blockade and the Abscopal Effect: A Critical Review on Timing, Dose and Fractionation. Frontiers in Oncology 8.
Crossref
Andrew J. Gunderson & Kristina H. Young. (2018) Exploring optimal sequencing of radiation and immunotherapy combinations. Advances in Radiation Oncology 3:4, pages 494-505.
Crossref
Inigo Martinez-Zubiaurre, Anthony J. Chalmers & Turid Hellevik. (2018) Radiation-Induced Transformation of Immunoregulatory Networks in the Tumor Stroma. Frontiers in Immunology 9.
Crossref

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