OncoImmunology, Volume 7, Issue 3 (2018)

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OncoImmunology, Volume 7, Issue 3 (2018)

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Brief Report

Brief Report
Pro-inflammatory allogeneic DCs promote activation of bystander immune cells and thereby license antigen-specific T-cell responses
Grammatiki Fotaki, Chuan Jin, Mohanraj Ramachandran, Iliana Kyriaki Kerzeli, Alex Karlsson-Parra, Di Yu & Magnus Essand
Article: e1395126
Published online: 27 Nov 2017
AbstractforPro-inflammatory allogeneic DCs promote activation of bystander immune cells and thereby license antigen-specific T-cell responses | Full Text | References | PDF (862.7 KB) | Supplemental
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Brief Report
Genomic landscape of advanced basal cell carcinoma: Implications for precision treatment with targeted and immune therapies
Aaron M. Goodman, Shumei Kato, Philip R. Cohen, Amélie Boichard, Garrett Frampton, Vincent Miller, Philip J. Stephens, Gregory A. Daniels & Razelle Kurzrock
Article: e1404217
Published online: 22 Dec 2017
AbstractforGenomic landscape of advanced basal cell carcinoma: Implications for precision treatment with targeted and immune therapies | Full Text | References | PDF (617.7 KB) | Supplemental
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Brief Report
Deep sequencing of the T cell receptor visualizes reconstitution of T cell immunity in mogamulizumab-treated adult T cell leukemia
Takero Shindo, Kazutaka Kitaura, Hiroshi Ureshino, Kazuharu Kamachi, Masaharu Miyahara, Kazuko Doi, Tatsuro Watanabe, Eisaburo Sueoka, Tadasu Shin-I, Ryuji Suzuki & Shinya Kimura
Article: e1405204
Published online: 11 Dec 2017
AbstractforDeep sequencing of the T cell receptor visualizes reconstitution of T cell immunity in mogamulizumab-treated adult T cell leukemia | Full Text | References | PDF (736.4 KB) | Supplemental
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Brief Report
Beta blocker use correlates with better overall survival in metastatic melanoma patients and improves the efficacy of immunotherapies in mice
Kathleen M. Kokolus, Ying Zhang, Jeffrey M. Sivik, Carla Schmeck, Junjia Zhu, Elizabeth A. Repasky, Joseph J. Drabick & Todd. D. Schell
Article: e1405205
Published online: 21 Dec 2017
AbstractforBeta blocker use correlates with better overall survival in metastatic melanoma patients and improves the efficacy of immunotherapies in mice | Full Text | References | PDF (936.1 KB) | Supplemental
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Original Research

Article
Analysis of PD1, PDL1, PDL2 expression and T cells infiltration in 1014 gastric cancer patients
Xiaofang Xing, Jianping Guo, Guangyu Ding, Bo Li, Bin Dong, Qin Feng, Shen Li, Jian Zhang, Xiaomin Ying, Xiaojing Cheng, Ting Guo, Hong Du, Ying Hu, Tao Zhou, Xiaohong Wang, Lin Li, Qingda Li, Meng Xie, Liting Li, Xiangyu Gao, Fei Shan, Ziyu Li, Shuqin Jia, Xianzi Wen, Jiping Wang & Jiafu Ji
Article: e1356144
Published online: 21 Dec 2017
AbstractforAnalysis of PD1, PDL1, PDL2 expression and T cells infiltration in 1014 gastric cancer patients | Full Text | References | PDF (1.1 MB) | Supplemental
  • 5739 Views
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Article
T cells specific for a TAP-independent self-peptide remain naïve in tumor-bearing mice and are fully exploitable for therapy
Elien M. Doorduijn, Marjolein Sluijter, Koen A. Marijt, Bianca J. Querido, Sjoerd H. van der Burg & Thorbald van Hall
Article: e1382793
Published online: 20 Nov 2017
AbstractforT cells specific for a TAP-independent self-peptide remain naïve in tumor-bearing mice and are fully exploitable for therapy | Full Text | References | PDF (890.4 KB) | Supplemental
  • 1769 Views
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Article
PD-L1 and PD-1 and characterization of tumor-infiltrating lymphocytes in high grade sarcomas of soft tissue – prognostic implications and rationale for immunotherapy
Melanie Boxberg, Katja Steiger, Ulrich Lenze, Hans Rechl, Rüdiger von Eisenhart-Rothe, Klaus Wörtler, Wilko Weichert, Rupert Langer & Katja Specht
Article: e1389366
Published online: 20 Nov 2017
AbstractforPD-L1 and PD-1 and characterization of tumor-infiltrating lymphocytes in high grade sarcomas of soft tissue – prognostic implications and rationale for immunotherapy | Full Text | References | PDF (1.1 MB) | Supplemental
  • 2195 Views
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Free Access
Article
CCL3 augments tumor rejection and enhances CD8+ T cell infiltration through NK and CD103+ dendritic cell recruitment via IFNγ
Frederick Allen, Iuliana D. Bobanga, Peter Rauhe, Deborah Barkauskas, Nathan Teich, Caryn Tong, Jay Myers & Alex Y. Huang
Article: e1393598
Published online: 20 Nov 2017
AbstractforCCL3 augments tumor rejection and enhances CD8+ T cell infiltration through NK and CD103+ dendritic cell recruitment via IFNγ | Full Text | References | PDF (1 MB) | Supplemental
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Article
Dendritic cell vaccine induces antigen-specific CD8+ T cells that are metabolically distinct from those of peptide vaccine and is well-combined with PD-1 checkpoint blockade
Koji Nagaoka, Akihiro Hosoi, Tamaki Iino, Yasuyuki Morishita, Hirokazu Matsushita & Kazuhiro Kakimi
Article: e1395124
Published online: 20 Nov 2017
AbstractforDendritic cell vaccine induces antigen-specific CD8+ T cells that are metabolically distinct from those of peptide vaccine and is well-combined with PD-1 checkpoint blockade | Full Text | References | PDF (1.8 MB) | Supplemental
  • 2575 Views
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Article
PD-1 blockade reverses adaptive immune resistance induced by high-dose hypofractionated but not low-dose daily fractionated radiation
Megan Morisada BS, Paul E. Clavijo PhD, Ellen Moore BS, Lillian Sun, Michael Chamberlin MD, Carter Van Waes MD, PhD, James W. Hodge PhD, MBA, James B. Mitchell PhD, Jay Friedman PhD & Clint T. Allen MD
Article: e1395996
Published online: 27 Nov 2017
AbstractforPD-1 blockade reverses adaptive immune resistance induced by high-dose hypofractionated but not low-dose daily fractionated radiation | Full Text | References | PDF (1 MB) | Supplemental
  • 2450 Views
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Article
Intra-tumoral delivery of CXCL11 via a vaccinia virus, but not by modified T cells, enhances the efficacy of adoptive T cell therapy and vaccines
Edmund K. Moon, Liang-Chuan S. Wang, Kheng Bekdache, Rachel C. Lynn, Albert Lo, Stephen H. Thorne & Steven M. Albelda
Article: e1395997
Published online: 09 Jan 2018
AbstractforIntra-tumoral delivery of CXCL11 via a vaccinia virus, but not by modified T cells, enhances the efficacy of adoptive T cell therapy and vaccines | Full Text | References | PDF (815.7 KB) | Supplemental
  • 3043 Views
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Article
Tumor lymphocyte immune response to preoperative radiotherapy in locally advanced rectal cancer: The LYMPHOREC study
C. Mirjolet, C. Charon-Barra, S. Ladoire, F. Arbez-Gindre, A. Bertaut, F. Ghiringhelli, A. Leroux, D. Peiffert, C. Borg, J. F. Bosset & G. Créhange MD, PhD
Article: e1396402
Published online: 27 Nov 2017
AbstractforTumor lymphocyte immune response to preoperative radiotherapy in locally advanced rectal cancer: The LYMPHOREC study | Full Text | References | PDF (647.3 KB) | Supplemental
  • 1041 Views
  • 27 CrossRef citations
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Article
Serine protease inhibitor 6 protects alloreactive T cells from Granzyme B-mediated mitochondrial damage without affecting graft-versus-tumor effect
Wei Du, Hemn Mohammadpour, Rachel E. O'Neill, Sandeep Kumar, Chuan Chen, Michelle Qiu, Lin Mei, Jingxin Qiu, Philip L. McCarthy, Kelvin P. Lee & Xuefang Cao
Article: e1397247
Published online: 16 Nov 2017
AbstractforSerine protease inhibitor 6 protects alloreactive T cells from Granzyme B-mediated mitochondrial damage without affecting graft-versus-tumor effect | Full Text | References | PDF (1.6 MB) | Supplemental
  • 955 Views
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Article
IL-25 dampens the growth of human germinal center-derived B-cell non Hodgkin Lymphoma by curtailing neoangiogenesis
Elisa Ferretti, Emma Di Carlo, Emanuela Ognio, Giulio Fraternali-Orcioni, Anna Corcione, Beatrice Belmonte, Jean Louis Ravetti, Claudio Tripodo, Domenico Ribatti & Vito Pistoia
Article: e1397249
Published online: 27 Nov 2017
AbstractforIL-25 dampens the growth of human germinal center-derived B-cell non Hodgkin Lymphoma by curtailing neoangiogenesis | Full Text | References | PDF (1.1 MB) | Supplemental
  • 1002 Views
  • 6 CrossRef citations
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Free Access
Article
Cancer vaccine based on a combination of an infection-enhanced adenoviral vector and pro-inflammatory allogeneic DCs leads to sustained antigen-specific immune responses in three melanoma models
Grammatiki Fotaki, Chuan Jin, Iliana Kyriaki Kerzeli, Mohanraj Ramachandran, Minttu-Maria Martikainen, Alex Karlsson-Parra, Di Yu & Magnus Essand
Article: e1397250
Published online: 26 Dec 2017
AbstractforCancer vaccine based on a combination of an infection-enhanced adenoviral vector and pro-inflammatory allogeneic DCs leads to sustained antigen-specific immune responses in three melanoma models | Full Text | References | PDF (1.2 MB) | Supplemental
  • 2122 Views
  • 4 CrossRef citations
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Open Access
Article
Bromodomain inhibition exerts its therapeutic potential in malignant pleural mesothelioma by promoting immunogenic cell death and changing the tumor immune-environment
Chiara Riganti, Marcello Francesco Lingua, Iris Chiara Salaroglio, Chiara Falcomatà, Luisella Righi, Deborah Morena, Francesca Picca, Daniele Oddo, Joanna Kopecka, Monica Pradotto, Roberta Libener, Sara Orecchia, Paolo Bironzo, Valentina Comunanza, Federico Bussolino, Silvia Novello, Giorgio Vittorio Scagliotti, Federica Di Nicolantonio & Riccardo Taulli
Article: e1398874
Published online: 27 Nov 2017
AbstractforBromodomain inhibition exerts its therapeutic potential in malignant pleural mesothelioma by promoting immunogenic cell death and changing the tumor immune-environment | Full Text | References | PDF (1.5 MB) | Supplemental
  • 2419 Views
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Article
Harnessing innate lung anti-cancer effector functions with a novel bacterial-derived immunotherapy
Mark Bazett, Amanda M. Costa, Momir Bosiljcic, Rebecca M. Anderson, Matthew P. Alexander, Stephanie W. Y. Wong, Salim Dhanji, Jenny MH Chen, Jim Pankovich, Stephen Lam, Simon Sutcliffe, Hal Gunn, Shirin Kalyan & David W. Mullins
Article: e1398875
Published online: 27 Nov 2017
AbstractforHarnessing innate lung anti-cancer effector functions with a novel bacterial-derived immunotherapy | Full Text | References | PDF (1.1 MB) | Supplemental
  • 3439 Views
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Article
A safe and highly efficient tumor-targeted type I interferon immunotherapy depends on the tumor microenvironment
Anje Cauwels, Sandra Van Lint, Geneviève Garcin, Jennyfer Bultinck, Franciane Paul, Sarah Gerlo, José Van der Heyden, Yann Bordat, Dominiek Catteeuw, Lode De Cauwer, Elke Rogge, Annick Verhee, Gilles Uzé & Jan Tavernier
Article: e1398876
Published online: 27 Nov 2017
AbstractforA safe and highly efficient tumor-targeted type I interferon immunotherapy depends on the tumor microenvironment | Full Text | References | PDF (1.5 MB) | Supplemental
  • 2368 Views
  • 35 CrossRef citations
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Article
Prognostic relevance of tumor-infiltrating lymphocytes and immune checkpoints in pediatric medulloblastoma
Jeroen F. Vermeulen, Wim Van Hecke, Elisabeth J. M. Adriaansen, Mieke K. Jansen, Rianne G. Bouma, José Villacorta Hidalgo, Paul Fisch, Roel Broekhuizen, Wim G. M. Spliet, Marcel Kool & Niels Bovenschen
Article: e1398877
Published online: 27 Nov 2017
AbstractforPrognostic relevance of tumor-infiltrating lymphocytes and immune checkpoints in pediatric medulloblastoma | Full Text | References | PDF (863.8 KB)
  • 3697 Views
  • 59 CrossRef citations
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Open Access
Article
Lack of MHC class II molecules favors CD8+ T-cell infiltration into tumors associated with an increased control of tumor growth
Nada Chaoul, Alexandre Tang, Belinda Desrues, Marine Oberkampf, Catherine Fayolle, Daniel Ladant, Alexander Sainz-Perez & Claude Leclerc
Article: e1404213
Published online: 07 Dec 2017
AbstractforLack of MHC class II molecules favors CD8+ T-cell infiltration into tumors associated with an increased control of tumor growth | Full Text | References | PDF (1.7 MB) | Supplemental
  • 2407 Views
  • 11 CrossRef citations
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Article
Frequent adaptive immune responses against arginase-1
Evelina Martinenaite, Rasmus Erik Johansson Mortensen, Morten Hansen, Morten Orebo Holmström, Shamaila Munir Ahmad, Nicolai Grønne Dahlager Jørgensen, Özcan Met, Marco Donia, Inge Marie Svane & Mads Hald Andersen
Article: e1404215
Published online: 26 Dec 2017
AbstractforFrequent adaptive immune responses against arginase-1 | Full Text | References | PDF (722.9 KB) | Supplemental
  • 1545 Views
  • 5 CrossRef citations
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Article
Oncolytic viruses sensitize human tumor cells for NY-ESO-1 tumor antigen recognition by CD4+ effector T cells.
Tiphaine Delaunay, Mathilde Violland, Nicolas Boisgerault, Soizic Dutoit, Virginie Vignard, Christian Münz, Monique Gannage, Brigitte Dréno, Kristine Vaivode, Dace Pjanova, Nathalie Labarrière, Yaohe Wang, E. Antonio Chiocca, Fabrice Le Boeuf, John C. Bell, Philippe Erbs, Frédéric Tangy, Marc Grégoire & Jean-François Fonteneau
Article: e1407897
Published online: 26 Dec 2017
AbstractforOncolytic viruses sensitize human tumor cells for NY-ESO-1 tumor antigen recognition by CD4+ effector T cells. | Full Text | References | PDF (1.2 MB) | Supplemental
  • 1561 Views
  • 2 CrossRef citations
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Article
Development of chimeric antigen receptors targeting T-cell malignancies using two structurally different anti-CD5 antigen binding domains in NK and CRISPR-edited T cell lines
Sunil S. Raikar, Lauren C. Fleischer, Robert Moot, Andrew Fedanov, Na Yoon Paik, Kristopher A. Knight, Christopher B. Doering & H. Trent Spencer
Article: e1407898
Published online: 26 Dec 2017
AbstractforDevelopment of chimeric antigen receptors targeting T-cell malignancies using two structurally different anti-CD5 antigen binding domains in NK and CRISPR-edited T cell lines | Full Text | References | PDF (1.1 MB) | Supplemental
  • 3534 Views
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Article
Poly(I:C) primes primary human glioblastoma cells for an immune response invigorated by PD-L1 blockade
Jorrit De Waele, Elly Marcq, Jonas RM Van Audenaerde, Jinthe Van Loenhout, Christophe Deben, Karen Zwaenepoel, Erik Van de Kelft, David Van der Planken, Tomas Menovsky, Johan MJ Van den Bergh, Yannick Willemen, Patrick Pauwels, Zwi N Berneman, Filip Lardon, Marc Peeters, An Wouters & Evelien LJ Smits
Article: e1407899
Published online: 12 Dec 2017
AbstractforPoly(I:C) primes primary human glioblastoma cells for an immune response invigorated by PD-L1 blockade | Full Text | References | PDF (1.2 MB) | Supplemental
  • 2274 Views
  • 31 CrossRef citations
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Article
Monocytes/Macrophages promote vascular CXCR4 expression via the ERK pathway in hepatocellular carcinoma
Ya-Ming Meng, Jing Liang, Chong Wu, Jing Xu, Dan-Ni Zeng, Xing-Juan Yu, Huiheng Ning, Li Xu & Limin Zheng
Article: e1408745
Published online: 13 Dec 2017
AbstractforMonocytes/Macrophages promote vascular CXCR4 expression via the ERK pathway in hepatocellular carcinoma | Full Text | References | PDF (1.4 MB) | Supplemental
  • 2048 Views
  • 1 CrossRef citations
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Article
A Virus-Like-Particle immunotherapy targeting Epitope-Specific anti-xCT expressed on cancer stem cell inhibits the progression of metastatic cancer in vivo
Elisabetta Bolli, John P. O'Rourke, Laura Conti, Stefania Lanzardo, Valeria Rolih, Jayne M. Christen, Giuseppina Barutello, Marco Forni, Federica Pericle & Federica Cavallo
Article: e1408746
Published online: 06 Dec 2017
AbstractforA Virus-Like-Particle immunotherapy targeting Epitope-Specific anti-xCT expressed on cancer stem cell inhibits the progression of metastatic cancer in vivo | Full Text | References | PDF (1.4 MB) | Supplemental
  • 3065 Views
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Article
Cellular vaccination of MLH1−/− mice – an immunotherapeutic proof of concept study
Claudia Maletzki, Yvonne Saara Gladbach, Mohamed Hamed, Georg Fuellen, Marie-Luise Semmler, Jan Stenzel & Michael Linnebacher
Article: e1408748
Published online: 14 Dec 2017
AbstractforCellular vaccination of MLH1−/− mice – an immunotherapeutic proof of concept study | Full Text | References | PDF (1.3 MB) | Supplemental
  • 1285 Views
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Article
Virus-like particle display of HER2 induces potent anti-cancer responses
Arianna Palladini, Susan Thrane, Christoph M. Janitzek, Jessica Pihl, Stine B. Clemmensen, Willem Adriaan de Jongh, Thomas M. Clausen, Giordano Nicoletti, Lorena Landuzzi, Manuel L. Penichet, Tania Balboni, Marianna L. Ianzano, Veronica Giusti, Thor G. Theander, Morten A. Nielsen, Ali Salanti, Pier-Luigi Lollini, Patrizia Nanni & Adam F. Sander
Article: e1408749
Published online: 05 Jan 2018
AbstractforVirus-like particle display of HER2 induces potent anti-cancer responses | Full Text | References | PDF (1.3 MB) | Supplemental
  • 5787 Views
  • 4 CrossRef citations
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Article
Melanoma induced immunosuppression is mediated by hematopoietic dysregulation
Neha Kamran, Youping Li, Maria Sierra, Mahmoud S. Alghamri, Padma Kadiyala, Henry D. Appelman, Marta Edwards, Pedro R. Lowenstein & Maria G. Castro
Article: e1408750
Published online: 14 Dec 2017
AbstractforMelanoma induced immunosuppression is mediated by hematopoietic dysregulation | Full Text | References | PDF (1.6 MB) | Supplemental
  • 1830 Views
  • 2 CrossRef citations
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Article
Macrophage-derived lipocalin-2 transports iron in the tumor microenvironment
Christina Mertens, Javier Mora, Bilge Ören, Stephan Grein, Sofia Winslow, Klaus Scholich, Andreas Weigert, Per Malmström, Carina Forsare, Mårten Fernö, Tobias Schmid, Bernhard Brüne & Michaela Jung
Article: e1408751
Published online: 22 Dec 2017
AbstractforMacrophage-derived lipocalin-2 transports iron in the tumor microenvironment | Full Text | References | PDF (1.3 MB) | Supplemental
  • 2933 Views
  • 1 CrossRef citations
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Open Access

Review

Review
Antibody structure and engineering considerations for the design and function of Antibody Drug Conjugates (ADCs)
Ricarda M. Hoffmann, Ben G. T. Coumbe, Debra H. Josephs, Silvia Mele, Kristina M. Ilieva, Anthony Cheung, Andrew N. Tutt, James F. Spicer, David E. Thurston, Silvia Crescioli & Sophia N. Karagiannis
Article: e1395127
Published online: 20 Nov 2017
AbstractforAntibody structure and engineering considerations for the design and function of Antibody Drug Conjugates (ADCs) | Full Text | References | PDF (781 KB)
  • 8759 Views
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