6,587
Views
45
CrossRef citations to date
0
Altmetric
Original Research

Complimentary mechanisms of dual checkpoint blockade expand unique T-cell repertoires and activate adaptive anti-tumor immunity in triple-negative breast tumors

ORCID Icon, , , , , , ORCID Icon, ORCID Icon, , , , ORCID Icon & show all
Article: e1421891 | Received 06 Nov 2017, Accepted 19 Dec 2017, Published online: 19 Jan 2018

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Simone Kloch Bendtsen, Maria Perez-Penco, Mie Linder Hübbe, Evelina Martinenaite, Morten Orebo Holmström, Stine Emilie Weis-Banke, Nicolai Grønne Dahlager Jørgensen, Mia Aaboe Jørgensen, Shamaila Munir Ahmad, Kasper Mølgaard Jensen, Christina Friese, Mia Thorup Lundsager, Astrid Zedlitz Johansen, Marco Carretta, Niels Ødum, Özcan Met, Inge Marie Svane, Daniel Hargbøl Madsen & Mads Hald Andersen. (2022) Peptide vaccination activating Galectin-3-specific T cells offers a novel means to target Galectin-3-expressing cells in the tumor microenvironment. OncoImmunology 11:1.
Read now
Zhaoxue Hu, Yifei Yang, Lincheng Fang, Jinpei Zhou & Huibin Zhang. (2021) Insight into the dichotomous regulation of STING activation in immunotherapy. Immunopharmacology and Immunotoxicology 43:2, pages 126-137.
Read now
Christopher D. Zahm, Jena E Moseman, Lauren E. Delmastro & Douglas G. Mcneel. (2021) PD-1 and LAG-3 blockade improve anti-tumor vaccine efficacy. OncoImmunology 10:1.
Read now
Julie Le Naour, Laurence Zitvogel, Lorenzo Galluzzi, Erika Vacchelli & Guido Kroemer. (2020) Trial watch: STING agonists in cancer therapy. OncoImmunology 9:1.
Read now
Shyambabu Chaurasiya, Annie Yang, Seonah Kang, Jianming Lu, Sang-In Kim, Anthony K. Park, Venkatesh Sivanandam, Zhifang Zhang, Yanghee Woo, Susanne G. Warner & Yuman Fong. (2020) Oncolytic poxvirus CF33-hNIS-ΔF14.5 favorably modulates tumor immune microenvironment and works synergistically with anti-PD-L1 antibody in a triple-negative breast cancer model. OncoImmunology 9:1.
Read now
Melody Smith, Elena García-Martínez, Michael R. Pitter, Jitka Fucikova, Radek Spisek, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi. (2018) Trial Watch: Toll-like receptor agonists in cancer immunotherapy. OncoImmunology 7:12.
Read now

Articles from other publishers (39)

Nada H. Eisa, Vincent M. Crowley, Asif Elahi, Vamsi Krishna Kommalapati, Michael A. Serwetnyk, Taoufik Llbiyi, Sumin Lu, Kashish Kainth, Yasmeen Jilani, Daniela Marasco, Abdeljabar El Andaloussi, Sukyeong Lee, Francis T.F. Tsai, Paulo C. Rodriguez, David Munn, Esteban Celis, Hasan Korkaya, Abdessamad Debbab, Brian Blagg & Ahmed Chadli. (2023) Enniatin A inhibits the chaperone Hsp90 and unleashes the immune system against triple-negative breast cancer. iScience 26:12, pages 108308.
Crossref
Timothy N. Trotter, Carina E. Dagotto, Delila Serra, Tao Wang, Xiao Yang, Chaitanya R. Acharya, Junping Wei, Gangjun Lei, H. Kim Lyerly & Zachary C. Hartman. (2023) Dormant tumors circumvent tumor-specific adaptive immunity by establishing a Treg-dominated niche via DKK3. JCI Insight 8:22.
Crossref
Dia Roy, Cassandra Gilmour, Sachin Patnaik & Li Lily Wang. (2023) Combinatorial blockade for cancer immunotherapy: targeting emerging immune checkpoint receptors. Frontiers in Immunology 14.
Crossref
Benson Chellakkan Selvanesan, Alvaro de Mingo Pulido, Sheelu Varghese, Deepak Rohila, Daniel Hupalo, Yuriy Gusev, Sara Contente, Matthew D. Wilkerson, Clifton L. Dalgard & Geeta Upadhyay. (2023) NSC243928 Treatment Induces Anti-Tumor Immune Response in Mouse Mammary Tumor Models. Cancers 15:5, pages 1468.
Crossref
Jiazheng Li, Chao Yang & Yongbin Zheng. (2023) Identification of a tissue resident memory CD8 T cell-related risk score signature for colorectal cancer, the association with TME landscapes and therapeutic responses. Frontiers in Genetics 13.
Crossref
Sean H. Colligan, Andrea M. Amitrano, Robert A. Zollo, Jennifer Peresie, Elliot D. Kramer, Brian Morreale, Joseph Barbi, Prashant K. Singh, Han Yu, Jianmin Wang, Mateusz Opyrchal, David B. Sykes, Michael J. Nemeth & Scott I. Abrams. (2022) Inhibiting the biogenesis of myeloid-derived suppressor cells enhances immunotherapy efficacy against mammary tumor progression. Journal of Clinical Investigation 132:23.
Crossref
David Otohinoyi, Aditi Kuchi, Jiande Wu & Chindo Hicks. (2022) Integrating Genomic Information with Tumor-Immune Microenvironment in Triple-Negative Breast Cancer. International Journal of Environmental Research and Public Health 19:21, pages 13901.
Crossref
Margaret P Manspeaker, Meghan J O'Melia & Susan N Thomas. (2022) Elicitation of stem-like CD8 + T cell responses via lymph node-targeted chemoimmunotherapy evokes systemic tumor control . Journal for ImmunoTherapy of Cancer 10:9, pages e005079.
Crossref
Peibin Yue, Yinsong Zhu, Christine Brotherton-Pleiss, Wenzhen Fu, Nagendra Verma, Jasmine Chen, Kayo Nakamura, Weiliang Chen, Yue Chen, Felix Alonso-Valenteen, Simoun Mikhael, Lali Medina-Kauwe, Kathleen M. Kershaw, Maria Celeridad, Songqin Pan, Allison S. Limpert, Douglas J. Sheffler, Nicholas D.P. Cosford, Stephen L. Shiao, Marcus A. Tius, Francisco Lopez-Tapia & James Turkson. (2022) Novel potent azetidine-based compounds irreversibly inhibit Stat3 activation and induce antitumor response against human breast tumor growth in vivo. Cancer Letters 534, pages 215613.
Crossref
Bin-Jin Hwang, Li-Chung Tsao, Chaitanya R Acharya, Timothy Trotter, Pankaj Agarwal, Junping Wei, Tao Wang, Xiao-Yi Yang, Gangjun Lei, Takuya Osada, Herbert Kim Lyerly, Michael A Morse & Zachary Conrad Hartman. (2022) Sensitizing immune unresponsive colorectal cancers to immune checkpoint inhibitors through MAVS overexpression. Journal for ImmunoTherapy of Cancer 10:3, pages e003721.
Crossref
Manzoor A. Mir, Shazia Sofi & Hina Qayoom. 2022. Combinational Therapy in Triple Negative Breast Cancer. Combinational Therapy in Triple Negative Breast Cancer 121 148 .
Yanqi Ye, Chun Xu, Fengqian Chen, Qi Liu & Ning Cheng. (2021) Targeting Innate Immunity in Breast Cancer Therapy: A Narrative Review. Frontiers in Immunology 12.
Crossref
Xupeng Bai, Jie Ni, Julia Beretov, Peter Graham & Yong Li. (2021) Immunotherapy for triple-negative breast cancer: A molecular insight into the microenvironment, treatment, and resistance. Journal of the National Cancer Center 1:3, pages 75-87.
Crossref
Stephen L. Shiao, Kathleen M. Kershaw, Jose J. Limon, Sungyong You, Junhee Yoon, Emily Y. Ko, Jlenia Guarnerio, Alka A. Potdar, Dermot P.B. McGovern, Shikha Bose, Tahir B. Dar, Paul Noe, Jung Lee, Yuzu Kubota, Viviana I. Maymi, Madison J. Davis, Regina M. Henson, Rachel Y. Choi, Wensha Yang, Jie Tang, Matthew Gargus, Alexander D. Prince, Zachary S. Zumsteg & David M. Underhill. (2021) Commensal bacteria and fungi differentially regulate tumor responses to radiation therapy. Cancer Cell 39:9, pages 1202-1213.e6.
Crossref
Meghan J. O’Melia, Margaret P. Manspeaker & Susan N. Thomas. (2021) Tumor-draining lymph nodes are survival niches that support T cell priming against lymphatic transported tumor antigen and effects of immune checkpoint blockade in TNBC. Cancer Immunology, Immunotherapy 70:8, pages 2179-2195.
Crossref
Ye Li, Jiaqian Wang, Liangliang Wu, Xiaoting Li, Xiaoyun Zhang, Guoqing Zhang, Shengqiang Xu, Shengjie Sun & Shunchang Jiao. (2021) Diversity of Dominant Peripheral T Cell Receptor Clone and Soluble Immune Checkpoint Proteins Associated With Clinical Outcomes Following Immune Checkpoint Inhibitor Treatment in Advanced Cancers. Frontiers in Immunology 12.
Crossref
Nimi Vashi & Samuel F. Bakhoum. (2021) The Evolution of STING Signaling and Its Involvement in Cancer. Trends in Biochemical Sciences 46:6, pages 446-460.
Crossref
Linda A. Buss, Gabi U. Dachs, Liping Goddard, Abel D. Ang, Bridget A. Robinson, Margaret J. Currie & Barry Hock. (2021) Is the immunogenicity of PD-1 blocking antibodies a confounding variable in murine studies?. Immunology Letters 234, pages 13-15.
Crossref
Ajeeth K. Pingili, Mehdi Chaib, Laura M. Sipe, Emily J. Miller, Bin Teng, Rahul Sharma, Johnathan R. Yarbro, Sarah Asemota, Qusai Al Abdallah, Tahliyah S. Mims, Tony N. Marion, Deidre Daria, Radhika Sekhri, Alina M. Hamilton, Melissa A. Troester, Heejoon Jo, Hyo Young Choi, D. Neil Hayes, Katherine L. Cook, Ramesh Narayanan, Joseph F. Pierre & Liza Makowski. (2021) Immune checkpoint blockade reprograms systemic immune landscape and tumor microenvironment in obesity-associated breast cancer. Cell Reports 35:12, pages 109285.
Crossref
Lauryn R Werner, Katelin A Gibson, Merit L Goodman, Dominika E Helm, Katherine R Walter, Sean M Holloran, Gloria M Trinca, Richard C Hastings, Howard H Yang, Ying Hu, Junping Wei, Gangjun Lei, Xiao-Yi Yang, Rashna Madan, Alfredo A Molinolo, Mary A Markiewicz, Prabhakar Chalise, Margaret L Axelrod, Justin M Balko, Kent W Hunter, Zachary C Hartman, Carol A Lange & Christy R Hagan. (2021) Progesterone promotes immunomodulation and tumor development in the murine mammary gland. Journal for ImmunoTherapy of Cancer 9:5, pages e001710.
Crossref
Máté Kiss, Lieselotte Vande Walle, Pedro H.V. Saavedra, Els Lebegge, Helena Van Damme, Aleksandar Murgaski, Junbin Qian, Manuel Ehling, Samantha Pretto, Evangelia Bolli, Jiri Keirsse, Pauline M.R. Bardet, Sana M. Arnouk, Yvon Elkrim, Maryse Schmoetten, Jan Brughmans, Ayla Debraekeleer, Amelie Fossoul, Louis Boon, Geert Raes, Geert van Loo, Diether Lambrechts, Massimiliano Mazzone, Alain Beschin, Andy Wullaert, Mohamed Lamkanfi, Jo A. Van Ginderachter & Damya Laoui. (2021) IL1β Promotes Immune Suppression in the Tumor Microenvironment Independent of the Inflammasome and Gasdermin D. Cancer Immunology Research 9:3, pages 309-323.
Crossref
Alison E. Ringel, Jefte M. Drijvers, Gregory J. Baker, Alessia Catozzi, Juan C. García-Cañaveras, Brandon M. Gassaway, Brian C. Miller, Vikram R. Juneja, Thao H. Nguyen, Shakchhi Joshi, Cong-Hui Yao, Haejin Yoon, Peter T. Sage, Martin W. LaFleur, Justin D. Trombley, Connor A. Jacobson, Zoltan Maliga, Steven P. Gygi, Peter K. Sorger, Joshua D. Rabinowitz, Arlene H. Sharpe & Marcia C. Haigis. (2020) Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity. Cell 183:7, pages 1848-1866.e26.
Crossref
Nicola Principe, Joel Kidman, Siting Goh, Caitlin M. Tilsed, Scott A. Fisher, Vanessa S. Fear, Catherine A. Forbes, Rachael M. Zemek, Abha Chopra, Mark Watson, Ian M. Dick, Louis Boon, Robert A. Holt, Richard A. Lake, Anna K. Nowak, Willem Joost Lesterhuis, Alison M. McDonnell & Jonathan Chee. (2020) Tumor Infiltrating Effector Memory Antigen-Specific CD8+ T Cells Predict Response to Immune Checkpoint Therapy. Frontiers in Immunology 11.
Crossref
Zilei Liu, Jie P. Li, Mingkuan Chen, Mengyao Wu, Yujie Shi, Wei Li, John R. Teijaro & Peng Wu. (2020) Detecting Tumor Antigen-Specific T Cells via Interaction-Dependent Fucosyl-Biotinylation. Cell 183:4, pages 1117-1133.e19.
Crossref
Joel Kidman, Nicola Principe, Mark Watson, Timo Lassmann, Robert A. Holt, Anna K. Nowak, Willem Joost Lesterhuis, Richard A. Lake & Jonathan Chee. (2020) Characteristics of TCR Repertoire Associated With Successful Immune Checkpoint Therapy Responses. Frontiers in Immunology 11.
Crossref
Timothy N. Trotter, Casey W. Shuptrine, Li-Chung Tsao, Robert D. Marek, Chaitanya Acharya, Jun-Ping Wei, Xiao-Yi Yang, Gangjun Lei, Tao Wang, Herbert Kim Lyerly & Zachary C. Hartman. (2020) IL26, a Noncanonical Mediator of DNA Inflammatory Stimulation, Promotes TNBC Engraftment and Progression in Association with Neutrophils. Cancer Research 80:15, pages 3088-3100.
Crossref
Natasha D Sheybani, Alexandra R Witter, Eric A Thim, Hideo Yagita, Timothy N J Bullock & Richard J Price. (2020) Combination of thermally ablative focused ultrasound with gemcitabine controls breast cancer via adaptive immunity. Journal for ImmunoTherapy of Cancer 8:2, pages e001008.
Crossref
Alan Chen Chen, Renhuan Xu, Tao Wang, Junping Wei, Xiao-Yi Yang, Cong-Xiao Liu, Gangjun Lei, Herbert Kim Lyerly, Teri Heiland & Zachary Conrad Hartman. (2020) HER2-LAMP vaccines effectively traffic to endolysosomal compartments and generate enhanced polyfunctional T cell responses that induce complete tumor regression. Journal for ImmunoTherapy of Cancer 8:1, pages e000258.
Crossref
Andreane Cartier, Tani LeighCatherine H. Liu & Timothy Hla. (2020) Endothelial sphingosine 1-phosphate receptors promote vascular normalization and antitumor therapy. Proceedings of the National Academy of Sciences 117:6, pages 3157-3166.
Crossref
Katherine J. Carpenter, Aurore-Cecile Valfort, Nick Steinauer, Arindam Chatterjee, Suomia Abuirqeba, Shabnam Majidi, Monideepa Sengupta, Richard J. Di Paolo, Laurie P. Shornick, Jinsong Zhang & Colin A. Flaveny. (2019) LXR-inverse agonism stimulates immune-mediated tumor destruction by enhancing CD8 T-cell activity in triple negative breast cancer. Scientific Reports 9:1.
Crossref
Li-Chung Tsao, Erika J. Crosby, Timothy N. Trotter, Pankaj Agarwal, Bin-Jin Hwang, Chaitanya Acharya, Casey W. Shuptrine, Tao Wang, Junping Wei, Xiao Yang, Gangjun Lei, Cong-Xiao Liu, Christopher A. Rabiola, Lewis A. Chodosh, William J. Muller, Herbert Kim Lyerly & Zachary C. Hartman. (2019) CD47 blockade augmentation of trastuzumab antitumor efficacy dependent on antibody-dependent cellular phagocytosis. JCI Insight 4:24.
Crossref
Ang A. Tu, Todd M. Gierahn, Brinda Monian, Duncan M. Morgan, Naveen K. Mehta, Bert Ruiter, Wayne G. Shreffler, Alex K. Shalek & J. Christopher Love. (2019) TCR sequencing paired with massively parallel 3′ RNA-seq reveals clonotypic T cell signatures. Nature Immunology 20:12, pages 1692-1699.
Crossref
Casey D. Stefanski, Kaitlyn Keffler, Stephanie McClintock, Lauren Milac & Jenifer R. Prosperi. (2019) APC loss affects DNA damage repair causing doxorubicin resistance in breast cancer cells. Neoplasia 21:12, pages 1143-1150.
Crossref
Isaac Kim, Katherine Sanchez, Heather L. McArthur & David Page. (2019) Immunotherapy in Triple-Negative Breast Cancer: Present and Future. Current Breast Cancer Reports 11:4, pages 259-271.
Crossref
María José Godoy-Calderón, Eglys González-Marcano, Jeismar Carballo & Ana Federica Convit. (2019) Evaluation of a ConvitVax/anti-PD-1 combined immunotherapy for breast cancer treatment. Oncotarget 10:61, pages 6546-6560.
Crossref
Lindsey M. Kuehm, Kyle Wolf, John Zahour, Richard J. DiPaolo & Ryan M. Teague. (2019) Checkpoint blockade immunotherapy enhances the frequency and effector function of murine tumor-infiltrating T cells but does not alter TCRβ diversity. Cancer Immunology, Immunotherapy 68:7, pages 1095-1106.
Crossref
Erika J. Crosby, William Gwin, Kimberly Blackwell, Paul K. Marcom, Serena Chang, Holden T. Maecker, Gloria Broadwater, Terry Hyslop, Sungjin Kim, Andre Rogatko, Veronica Lubkov, Joshua C. Snyder, Takuya Osada, Amy C. Hobeika, Michael A. Morse, H. Kim Lyerly & Zachary C. Hartman. (2019) Vaccine-Induced Memory CD8+ T Cells Provide Clinical Benefit in HER2 Expressing Breast Cancer: A Mouse to Human Translational Study. Clinical Cancer Research 25:9, pages 2725-2736.
Crossref
Simone Nüssing, Hui‐Fern Koay, Sneha Sant, Thomas Loudovaris, Stuart I Mannering, Martha Lappas, Yves d′Udekem, Igor E Konstantinov, Stuart P Berzins, Guus F Rimmelzwaan, Stephen J Turner, E Bridie Clemens, Dale I Godfrey, Thi HO Nguyen & Katherine Kedzierska. (2019) Divergent SATB 1 expression across human life span and tissue compartments . Immunology & Cell Biology 97:5, pages 498-511.
Crossref
H. Kim Lyerly, Takuya Osada & Zachary C. Hartman. (2019) Right Time and Place for IL12: Targeted Delivery Stimulates Immune Therapy. Clinical Cancer Research 25:1, pages 9-11.
Crossref