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OncoImmunology Volume 7, 2018 - Issue 5
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Original Research

PPARγ-activation increases intestinal M1 macrophages and mitigates formation of serrated adenomas in mutant KRAS mice

Tobias GuttingDept. of Medicine II, University Hospital Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyORCID Iconhttp://orcid.org/0000-0002-0764-4066View further author information
ORCID Icon,
Christian A. WeberDept. of Medicine II, University Hospital Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyView further author information
,
Philip WeidnerDept. of Medicine II, University Hospital Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyORCID Iconhttp://orcid.org/0000-0002-9482-5155View further author information
ORCID Icon,
Frank HerweckDept. of Medicine II, University Hospital Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyView further author information
,
Sarah HennDept. of Medicine II, University Hospital Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyORCID Iconhttp://orcid.org/0000-0002-6358-7932View further author information
ORCID Icon,
Teresa FriedrichDept. of Medicine II, University Hospital Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyView further author information
,
Shuiping YinDept. of Innate Immunity and Tolerance, Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyView further author information
,
Julia KzhyshkowskaDept. of Innate Immunity and Tolerance, Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyView further author information
,
Timo GaiserDept. of Pathology, University Hospital Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyView further author information
,
Klaus-Peter JanssenDept. of Surgery, Klinikum rechts der Isar, Technische Universität München, Munich, GermanyView further author information
,
Wolfgang ReindlDept. of Medicine II, University Hospital Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyView further author information
,
Matthias P. A. EbertDept. of Medicine II, University Hospital Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyView further author information
&
Elke BurgermeisterDept. of Medicine II, University Hospital Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyCorrespondence[email protected]
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Article: e1423168 | Received 20 Sep 2017, Accepted 22 Dec 2017, Published online: 01 Feb 2018

Citations (10)

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Read on this site (2)

Peng Du, Ming Chen, Changcai Deng & Chonggui Zhu. (2022) microRNA-199a downregulation alleviates hyperuricemic nephropathy via the PPARγ/β-catenin axis. Journal of Receptors and Signal Transduction 42:4, pages 373-381.
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Xin Wang, Jin Deng, Chongxiang Xiong, Haishan Chen, Qin Zhou, Yue Xia, Xiaofei Shao & Hequn Zou. (2020) Treatment with a PPAR-γ Agonist Protects Against Hyperuricemic Nephropathy in a Rat Model. Drug Design, Development and Therapy 14, pages 2221-2233.
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Articles from other publishers (8)

Elke Burgermeister. (2023) Mitogen-Activated Protein Kinase and Nuclear Hormone Receptor Crosstalk in Cancer Immunotherapy. International Journal of Molecular Sciences 24:17, pages 13661.
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Mélissa Prat, Kimberley Coulson, Clément Blot, Godefroy Jacquemin, Mathilde Romano, Marie-Laure Renoud, Mohamad AlaEddine, Augustin Le Naour, Hélène Authier, Mouna Chirine Rahabi, Khaddouj Benmoussa, Marie Salon, Mélissa Parny, Jean-Pierre Delord, Gwenaël Ferron, Lise Lefèvre, Bettina Couderc & Agnès Coste. (2023) PPARγ activation modulates the balance of peritoneal macrophage populations to suppress ovarian tumor growth and tumor-induced immunosuppression. Journal for ImmunoTherapy of Cancer 11:8, pages e007031.
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Bo Li, Li Qian, Li Pi & Xianxi Meng. (2023) A therapeutic role of exosomal lncRNA H19 from adipose mesenchymal stem cells in cutaneous wound healing by triggering macrophage M2 polarization. Cytokine 165, pages 156175.
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Florian Lüke, Dennis Christoph Harrer, Pan Pantziarka, Tobias Pukrop, Lina Ghibelli, Christopher Gerner, Albrecht Reichle & Daniel Heudobler. (2022) Drug Repurposing by Tumor Tissue Editing. Frontiers in Oncology 12.
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S. Yuvaraj & B.R. Prashantha Kumar. (2022) Peroxisome Proliferator-activated Receptor-γ As A Novel and Promising Target For Treating Cancer Via Regulation of Inflammation: A Brief Review. Mini-Reviews in Medicinal Chemistry 22:1, pages 3-14.
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Begoña Alburquerque-González, Fernando F. López-Calderón, María Dolores López-Abellán, Ángel Esteban-Gil, José García-Solano & Pablo Conesa-Zamora. (2020) Biology and Therapeutic Targets of Colorectal Serrated Adenocarcinoma; Clues for a Histologically Based Treatment against an Aggressive Tumor. International Journal of Molecular Sciences 21:6, pages 1991.
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Jan Korbecki, Rafał Bobiński & Mieczysław Dutka. (2019) Self-regulation of the inflammatory response by peroxisome proliferator-activated receptors. Inflammation Research 68:6, pages 443-458.
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Tobias Gutting, Elke Burgermeister, Nicolai Härtel & Matthias P. Ebert. (2019) Checkpoints and beyond – Immunotherapy in colorectal cancer. Seminars in Cancer Biology 55, pages 78-89.
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