Advanced search
Publication Cover
OncoImmunology Volume 7, 2018 - Issue 7
Submit an article Journal homepage
1,880
Views
48
CrossRef citations to date
0
Altmetric
Original Research

Efficacy of combined hypo-fractionated radiotherapy and anti-PD-1 monotherapy in difficult-to-treat advanced melanoma patients

Anissa RogerDepartment of General and Oncologic Dermatology, Ambroise-Paré hospital, APHP, & EA 4340 “Biomarkers in cancerology and hemato-oncology”, UVSQ, Université Paris-Saclay, Boulogne-Billancourt, France
,
Adeline FinetDepartment of General and Oncologic Dermatology, Ambroise-Paré hospital, APHP, & EA 4340 “Biomarkers in cancerology and hemato-oncology”, UVSQ, Université Paris-Saclay, Boulogne-Billancourt, France
,
Blandine BoruDepartment of Radiology, Ambroise-Paré hospital, APHP, Boulogne-Billancourt, France
,
Alain BeauchetDepartment of Public Health, Ambroise Paré Hospital, APHP & UVSQ, Université Paris-Saclay, Boulogne-Billancourt, France
,
Jean-Jacques MazeronDepartment of Oncology-Radiotherapy, Pitié-Salpetrière hospital, APHP, Paris, France
,
Yves OtzmeguineOncology centre, Porte de Saint-Cloud Clinic, Boulogne-Billancourt, France
,
Astrid BlomDepartment of General and Oncologic Dermatology, Ambroise-Paré hospital, APHP, & EA 4340 “Biomarkers in cancerology and hemato-oncology”, UVSQ, Université Paris-Saclay, Boulogne-Billancourt, France
,
Christine LongvertDepartment of General and Oncologic Dermatology, Ambroise-Paré hospital, APHP, & EA 4340 “Biomarkers in cancerology and hemato-oncology”, UVSQ, Université Paris-Saclay, Boulogne-Billancourt, France
,
Marie-Florence de MaleissyeDepartment of General and Oncologic Dermatology, Ambroise-Paré hospital, APHP, & EA 4340 “Biomarkers in cancerology and hemato-oncology”, UVSQ, Université Paris-Saclay, Boulogne-Billancourt, France
,
Magali FortDepartment of General and Oncologic Dermatology, Ambroise-Paré hospital, APHP, & EA 4340 “Biomarkers in cancerology and hemato-oncology”, UVSQ, Université Paris-Saclay, Boulogne-Billancourt, France
,
Elisa Funck-BrentanoDepartment of General and Oncologic Dermatology, Ambroise-Paré hospital, APHP, & EA 4340 “Biomarkers in cancerology and hemato-oncology”, UVSQ, Université Paris-Saclay, Boulogne-Billancourt, FranceORCID Iconhttp://orcid.org/0000-0002-1092-0789
ORCID Icon &
Philippe SaiagDepartment of General and Oncologic Dermatology, Ambroise-Paré hospital, APHP, & EA 4340 “Biomarkers in cancerology and hemato-oncology”, UVSQ, Université Paris-Saclay, Boulogne-Billancourt, FranceCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-6500-3507
ORCID Icon show all
Article: e1442166 | Received 20 Nov 2017, Accepted 14 Feb 2018, Published online: 13 Mar 2018

Citations (48)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

Ellen Backlund, Muyi Yang, Vitali Grozman, Giuseppe Masucci, Johan Falkenius, Hanna Eriksson, Braslav Jovanovic, Katarina Hammarlund, Ulf Isacsson, Calin Radu, Edvard Abel, Kristin Karlsson, Ricardo Palanco Zamora, Peter Wersäll, Ulrika Edbäck, Stina Wickström, Eva Darai Ramqvist, Suzanne Egyhazi Brage, Rolf Kiessling, Kristina Viktorsson, Bo Franzén, Rolf Lewensohn, Roger Olofsson Bagge, Gustav J. Ullenhag, Lars Ny, Karin Lindberg & Hildur Helgadottir. (2022) Precision radiation of immune checkpoint therapy resistant melanoma metastases (PROMMEL study): study protocol for a phase II open-label multicenter trial. Acta Oncologica 61:7, pages 869-873.
Read now
Gabriella Aitcheson, Amit Mahipal & Binu V John. (2021) Targeting FGFR in intrahepatic cholangiocarcinoma [iCCA]: leading the way for precision medicine in biliary tract cancer [BTC]?. Expert Opinion on Investigational Drugs 30:4, pages 463-477.
Read now
Di Wang, Xia Zhang, Yajie Gao, Xiaonan Cui, Yanqin Yang, Weifeng Mao, Minghuan Li, Bin Zhang & Jinming Yu. (2020) Research Progress and Existing Problems for Abscopal Effect. Cancer Management and Research 12, pages 6695-6706.
Read now
Chenkai Mao, Michael-Joseph Gorbet, Akansha Singh, Ashish Ranjan & Steven Fiering. (2020) In situ vaccination with nanoparticles for cancer immunotherapy: understanding the immunology. International Journal of Hyperthermia 37:3, pages 4-17.
Read now

Articles from other publishers (44)

Lena Van Dingenen, Charlotte Segers, Shari Wouters, Mohamed Mysara, Natalie Leys, Samir Kumar-Singh, Surbhi Malhotra-Kumar & Rob Van Houdt. (2023) Dissecting the role of the gut microbiome and fecal microbiota transplantation in radio- and immunotherapy treatment of colorectal cancer. Frontiers in Cellular and Infection Microbiology 13.
Crossref
Fan Yang & Nan Xu. (2023) Letter Re: Response to checkpoint inhibition and targeted therapy in melanoma patients with concurrent haematological malignancies. European Journal of Cancer, pages 112982.
Crossref
Kazuhiro Okamoto, Kotaro Yoshio, Shinsuke Shirakawa, Kyohei Irie, Naoyuki Ida, Hirofumi Matsuoka, Junko Haraga, Chikako Ogawa, Keiichiro Nakamura, Shoji Nagao & Hisashi Masuyama. (2023) Pure abscopal effect in a patient with advanced uterine carcinosarcoma. Radiology Case Reports 18:7, pages 2447-2451.
Crossref
Alexander Chi & Nam Phong Nguyen. (2023) Mechanistic rationales for combining immunotherapy with radiotherapy. Frontiers in Immunology 14.
Crossref
Tatsuya Deguchi, Naoya Maekawa, Satoru Konnai, Ryo Owaki, Kenji Hosoya, Keitaro Morishita, Motoji Nakamura, Tomohiro Okagawa, Hiroto Takeuchi, Sangho Kim, Ryohei Kinoshita, Yurika Tachibana, Madoka Yokokawa, Satoshi Takagi, Yukinari Kato, Yasuhiko Suzuki, Shiro Murata & Kazuhiko Ohashi. (2023) Enhanced Systemic Antitumour Immunity by Hypofractionated Radiotherapy and Anti-PD-L1 Therapy in Dogs with Pulmonary Metastatic Oral Malignant Melanoma. Cancers 15:11, pages 3013.
Crossref
Jovanna A. Tracz, Brianna M. Donnelly, Sam Ngu, Morana Vojnic, A.Gabriella Wernicke & Randy S. D’Amico. (2023) The abscopal effect: inducing immunogenicity in the treatment of brain metastases secondary to lung cancer and melanoma. Journal of Neuro-Oncology 163:1, pages 1-14.
Crossref
Shuya Liu, Yin Liao, Yao Chen, Hanshan Yang, Yuru Hu, Zhuo Chen, Shaozhi Fu & Jingbo Wu. (2023) Effect of triple therapy with low-dose total body irradiation and hypo-fractionated radiation plus anti-programmed cell death protein 1 blockade on abscopal antitumor immune responses in breast cancer. International Immunopharmacology 117, pages 110026.
Crossref
Sara Del Mare, Yossi Nishri, Amit Shai, Margalit Efrati, Lisa Deutsch, Robert B. Den, Itzhak Kelson, Yona Keisari & Vered Domankevich. (2023) Diffusing Alpha-Emitters Radiation Therapy Promotes a Proimmunogenic Tumor Microenvironment and Synergizes With Programmed Cell Death Protein 1 Blockade. International Journal of Radiation Oncology*Biology*Physics 115:3, pages 707-718.
Crossref
S. Sumodhee, L. Guo, L. Bouhlel, A. Picard, J. Otto, A.O. Naghavi, Q. Richier, A. Lévy, P.-Y. Bondiau, M. Poudenx, T. Passeron, J.-P. Lacour, H. Montaudié & J. Doyen. (2022) Impact of radiotherapy schedule on survival of patients treated with immune-checkpoint inhibitors for advanced melanoma and non-small cell lung cancer. Cancer/Radiothérapie 26:8, pages 1045-1053.
Crossref
Takehiro Kitabatake, Chihiro Kanno, Tetsuharu Kaneko, Manabu Endo, Morio Yamazaki, Sadanoshin Yaginuma, Tetsuo Akimoto & Hiroshi Hasegawa. (2022) A case of melanoma of the mandibular gingiva with long-term survival: Effect of nivolumab therapy and immuno-radiotherapy for cervical recurrence and nasal metastasis. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 34:5, pages 637-642.
Crossref
Philippe Saiag, Rafaele Molinier, Anissa Roger, Blandine Boru, Yves Otmezguine, Joelle Otz, Charles-Ambroise Valery, Astrid Blom, Christine Longvert, Alain Beauchet & Elisa Funck-Brentano. (2022) Efficacy of Large Use of Combined Hypofractionated Radiotherapy in a Cohort of Anti-PD-1 Monotherapy-Treated Melanoma Patients. Cancers 14:17, pages 4069.
Crossref
Tahir Bashir Dar, Fleury Augustin Nsole Biteghe, Ruchi Kakar-Bhanot, Eric Chekwebe Aniogo, Zaria Malindi, Olusiji Alex Akinrinmade, Nyangone Ekome Toung Chalomie, Arnaud John Kombe Kombe, Sophie Aboughe Angone, Jean Marc Ngome Ndong & Jean Delacroix Ndong. (2022) Synergistic effects of radiotherapy and targeted immunotherapy in improving tumor treatment efficacy: a review. Clinical and Translational Oncology 24:12, pages 2255-2271.
Crossref
Daniella Kuzmanovszki, Norbert Kiss, Béla Tóth, Tünde Kerner, Veronika Tóth, József Szakonyi, Kende Lőrincz, Judit Hársing, Eleonóra Imrédi, Alexa Pfund, Ákos Szabó, Valentin Brodszky, Fanni Rencz & Péter Holló. (2022) Anti-PD-1 Monotherapy in Advanced Melanoma—Real-World Data from a 77-Month-Long Retrospective Observational Study. Biomedicines 10:7, pages 1737.
Crossref
Gaofei Yin, Wei Guo, Zhigang Huang & Xiaohong Chen. (2022) Efficacy of radiotherapy combined with immune checkpoint inhibitors in patients with melanoma: a systemic review and meta-analysis. Melanoma Research 32:2, pages 71-78.
Crossref
Andrea Alberti & Paolo Bossi. (2022) Immunotherapy for Cutaneous Squamous Cell Carcinoma: Results and Perspectives. Frontiers in Oncology 11.
Crossref
Amir Anvari, Pegah Sasanpour & Mania Rajabzadeh Kheradmardi. (2021) Radiotherapy and immunotherapy in melanoma brain metastases. Hematology/Oncology and Stem Cell Therapy.
Crossref
Sarah Bouchereau, Louise Chaplain, Magali Fort, Alain Beauchet, Thomas Sidibé, Marie Chapalain, Leire Gonzalez-Lara, Christine Longvert, Astrid Blom, Philippe Saiag & Elisa Funck-Brentano. (2021) Impact of prior treatment with immune checkpoint inhibitors on dacarbazine efficacy in metastatic melanoma. British Journal of Cancer 125:7, pages 948-954.
Crossref
Karl-Göran Tranberg. (2021) Local Destruction of Tumors and Systemic Immune Effects. Frontiers in Oncology 11.
Crossref
Daniel J Craig, Nisha S Nanavaty, Monika Devanaboyina, Laura Stanbery, Danae Hamouda, Gerald Edelman, Lance Dworkin & John J Nemunaitis. (2021) The abscopal effect of radiation therapy. Future Oncology 17:13, pages 1683-1694.
Crossref
Damiënne Marcus, Relinde I. Y. Lieverse, Carmen Klein, Amir Abdollahi, Philippe Lambin, Ludwig J. Dubois & Ala Yaromina. (2021) Charged Particle and Conventional Radiotherapy: Current Implications as Partner for Immunotherapy. Cancers 13:6, pages 1468.
Crossref
Niall M. Byrne, Prajakta Tambe & Jonathan A. Coulter. (2021) Radiation Response in the Tumour Microenvironment: Predictive Biomarkers and Future Perspectives. Journal of Personalized Medicine 11:1, pages 53.
Crossref
Minhui Chen, Anurag K. Singh & Elizabeth A. Repasky. (2020) Highlighting the Potential for Chronic Stress to Minimize Therapeutic Responses to Radiotherapy through Increased Immunosuppression and Radiation Resistance. Cancers 12:12, pages 3853.
Crossref
Ying Xiong, David M. Neskey, Joshua D. Horton, Chrystal M. Paulos, Hannah M. Knochelmann, Kent E. Armeson & M. Rita I. Young. (2020) Immunological effects of nivolumab immunotherapy in patients with oral cavity squamous cell carcinoma. BMC Cancer 20:1.
Crossref
Mackenzie E. Malo, Kevin J. H. Allen, Rubin Jiao, Connor Frank, David Rickles & Ekaterina Dadachova. (2020) Mechanistic Insights into Synergy between Melanin-Targeting Radioimmunotherapy and Immunotherapy in Experimental Melanoma. International Journal of Molecular Sciences 21:22, pages 8721.
Crossref
Yanjie Han, Xinxin Li, Jiliang Yan, Chunyan Ma, Xin Wang, Hong Pan, Xiaoli Zheng, Zhen Zhang, Biao Gao & Xin-Ying Ji. (2020) Bioinformatic Analysis Identifies Potential Key Genes in the Pathogenesis of Melanoma. Frontiers in Oncology 10.
Crossref
Jacques Rouanet, Valentin Benboubker, Hussein Akil, Ana Hennino, Philippe Auzeloux, Sophie Besse, Bruno Pereira, Solène Delorme, Sandrine Mansard, Michel D’Incan, Françoise Degoul & Paul-Olivier Rouzaire. (2020) Immune checkpoint inhibitors reverse tolerogenic mechanisms induced by melanoma targeted radionuclide therapy. Cancer Immunology, Immunotherapy 69:10, pages 2075-2088.
Crossref
B.E. Ellerin, C.G.N. Demandante & J.T. Martins. (2020) Pure abscopal effect of radiotherapy in a salivary gland carcinoma: Case report, literature review, and a search for new approaches. Cancer/Radiothérapie 24:3, pages 226-246.
Crossref
Sarah Knispel, Andreas Stang, Lisa Zimmer, Hildegard Lax, Ralf Gutzmer, Lucie Heinzerling, Carsten Weishaupt, Claudia Pföhler, Anja Gesierich, Rudolf Herbst, Katharina C Kaehler, Benjamin Weide, Carola Berking, Carmen Loquai, Jochen Utikal, Patrick Terheyden, Martin Kaatz, Max Schlaak, Alexander Kreuter, Jens Ulrich, Peter Mohr, Edgar Dippel, Elisabeth Livingstone, Jürgen C Becker, Michael Weichenthal, Eleftheria Chorti, Janine Gronewold, Dirk Schadendorf & Selma Ugurel. (2020) Impact of a preceding radiotherapy on the outcome of immune checkpoint inhibition in metastatic melanoma: a multicenter retrospective cohort study of the DeCOG. Journal for ImmunoTherapy of Cancer 8:1, pages e000395.
Crossref
Christian Sordo-Bahamonde, Massimo Vitale, Seila Lorenzo-Herrero, Alejandro López-Soto & Segundo Gonzalez. (2020) Mechanisms of Resistance to NK Cell Immunotherapy. Cancers 12:4, pages 893.
Crossref
Jun Xu, Robert Saklatvala, Sachin Mittal, Smeet Deshmukh & Adam Procopio. (2020) Recent Progress of Potentiating Immune Checkpoint Blockade with External Stimuli—an Industry Perspective. Advanced Science 7:8, pages 1903394.
Crossref
Teresa Amaral, Felix Kiecker, Sarah Schaefer, Henner Stege, Katharina Kaehler, Patrick Terheyden, Anja Gesierich, Ralf Gutzmer, Sebastian Haferkamp, Jochen Uttikal, Carola Berking, David Rafei-Shamsabadi, Lydia Reinhardt, Friedegund Meier, Ante Karoglan, Christian Posch, Thilo Gambichler, Claudia Pfoehler, Kai Thoms, Julia Tietze, Dirk Debus, Rudolf Herbst, Steffen Emmert, Carmen Loquai, Jessica C Hassel, Frank Meiss, Thomas Tueting, Vanessa Heinrich, Thomas Eigentler, Claus Garbe & Lisa Zimmer. (2020) Combined immunotherapy with nivolumab and ipilimumab with and without local therapy in patients with melanoma brain metastasis: a DeCOG* study in 380 patients. Journal for ImmunoTherapy of Cancer 8:1, pages e000333.
Crossref
Hans-Christian Kolberg, Oliver Hoffmann & René Baumann. (2020) The Abscopal Effect: Could a Phenomenon Described Decades Ago Become Key to Enhancing the Response to Immune Therapies in Breast Cancer?. Breast Care 15:5, pages 443-449.
Crossref
Xiaoliang Liu, Jianfei Yao, Lele Song, Sujing Zhang, Tanxiao Huang & Yu Li. (2019) Local and abscopal responses in advanced intrahepatic cholangiocarcinoma with low TMB, MSS, pMMR and negative PD-L1 expression following combined therapy of SBRT with PD-1 blockade. Journal for ImmunoTherapy of Cancer 7:1.
Crossref
Lingyun Wu, Qiuying Tang, Xin Yin, DanFang Yan, Mengmeng Tang, Jiaojiao Xin, Qiaoling Pan, Chiyuan Ma & Senxiang Yan. (2019) The Therapeutic Potential of Adipose Tissue-Derived Mesenchymal Stem Cells to Enhance Radiotherapy Effects on Hepatocellular Carcinoma. Frontiers in Cell and Developmental Biology 7.
Crossref
Blake Babcock, Medora Rodrigues, Donovan Kearns, Naveenraj Solomon, Mark E. Reeves, Maheswari Senthil, Carlos A. Garberoglio & Jukes P. Namm. (2020) Improved Survival with Immunotherapy but Lack of Synergistic Effect with Radiation for Stage IV Melanoma of the Head and Neck. The American Surgeon 85:10, pages 1118-1124.
Crossref
Marina Jovanovic, Nevena Gajovic, Miodrag L. Lukic, Ana Popovic & Ivan Jovanovic. (2019) Synergism of PDL/PD1 and IL33/ST2 Axis in Tumor Immunology. Serbian Journal of Experimental and Clinical Research 20:3, pages 223-228.
Crossref
Benjamín Pineda, Francisco Javier Sánchez García, Nora Karen Olascoaga, Verónica Pérez de la Cruz, Alelí Salazar, Sergio Moreno-Jiménez, Norma Hernández Pedro, Adrián Márquez-Navarro, Alma Ortiz Plata & Julio Sotelo. (2019) Malignant Glioma Therapy by Vaccination with Irradiated C6 Cell-Derived Microvesicles Promotes an Antitumoral Immune Response. Molecular Therapy 27:9, pages 1612-1620.
Crossref
Goto. (2019) Radiation as an In Situ Auto-Vaccination: Current Perspectives and Challenges. Vaccines 7:3, pages 100.
Crossref
Tiara Bunga Mayang Permata, Yoshihiko Hagiwara, Hiro Sato, Takaaki Yasuhara, Takahiro Oike, Soehartati Gondhowiardjo, Kathryn D. Held, Takashi Nakano & Atsushi Shibata. (2019) Base excision repair regulates PD-L1 expression in cancer cells. Oncogene 38:23, pages 4452-4466.
Crossref
Xinqing Lin, Tingting Lu, Zhanhong Xie, Yinyin Qin, Ming Liu, Xiaohong Xie, Shiyue Li & Chengzhi Zhou. (2019) Extracranial abscopal effect induced by combining immunotherapy with brain radiotherapy in a patient with lung adenocarcinoma: A case report and literature review. Thoracic Cancer 10:5, pages 1272-1275.
Crossref
Suzanne Ostrand-Rosenberg, Lucas A. Horn & Nicholas G. Ciavattone. (2019) Radiotherapy Both Promotes and Inhibits Myeloid-Derived Suppressor Cell Function: Novel Strategies for Preventing the Tumor-Protective Effects of Radiotherapy. Frontiers in Oncology 9.
Crossref
Maxim Shevtsov, Hiro Sato, Gabriele Multhoff & Atsushi Shibata. (2019) Novel Approaches to Improve the Efficacy of Immuno-Radiotherapy. Frontiers in Oncology 9.
Crossref
C. Longvert & P. Saiag. (2019) Actualités dans le mélanome cutané. La Revue de Médecine Interne 40:3, pages 178-183.
Crossref
Yang Liu, Yinping Dong, Li Kong, Fang Shi, Hui Zhu & Jinming Yu. (2018) Abscopal effect of radiotherapy combined with immune checkpoint inhibitors. Journal of Hematology & Oncology 11:1.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.