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Original Research

The immune checkpoint protein PD-L1 induces and maintains regulatory T cells in glioblastoma

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Article: e1448329 | Received 23 Oct 2017, Accepted 28 Feb 2018, Published online: 25 Apr 2018

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Crossref
Giuseppe Nicolò Fanelli, Dario Grassini, Valerio Ortenzi, Francesco Pasqualetti, Nicola Montemurro, Paolo Perrini, Antonio Giuseppe Naccarato & Cristian Scatena. (2021) Decipher the Glioblastoma Microenvironment: The First Milestone for New Groundbreaking Therapeutic Strategies. Genes 12:3, pages 445.
Crossref
Kuan Hu, Juanni Li, Geting Wu, Lei Zhou, Xiang Wang, Yuanliang Yan & Zhijie Xu. (2021) The novel roles of virus infection-associated gene CDKN1A in chemoresistance and immune infiltration of glioblastoma. Aging 13:5, pages 6662-6680.
Crossref
Kevin KosKarin E. de Visser. (2021) The Multifaceted Role of Regulatory T Cells in Breast Cancer. Annual Review of Cancer Biology 5:1, pages 291-310.
Crossref
Hongsheng Wang, Huangao Zhou, Jianing Xu, Yunpeng Lu, Xiaoyun Ji, Yizheng Yao, Hou Chao, Jun Zhang, Xiaochun Zhang, Shun Yao, Yinqiu Wu & Jie Wan. (2021) Different T-cell subsets in glioblastoma multiforme and targeted immunotherapy. Cancer Letters 496, pages 134-143.
Crossref
Chunxiao Li, Ping Jiang, Shuhua Wei, Xiaofei Xu & Junjie Wang. (2020) Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects. Molecular Cancer 19:1.
Crossref
Yueping Liu, Lei Zhao, Liyan Xue & Yingyong Hou. (2020) Selected updates in molecular and genomic pathology of esophageal cancer. Annals of the New York Academy of Sciences 1482:1, pages 225-235.
Crossref
Silvia M. Bacot, Taylor A. Harper, Rebecca L. Matthews, Christie Jane Fennell, Adovi Akue, Mark A. KuKuruga, Shiowjen Lee, Tao Wang & Gerald M. Feldman. (2020) Exploring the Potential Use of a PBMC-Based Functional Assay to Identify Predictive Biomarkers for Anti-PD-1 Immunotherapy. International Journal of Molecular Sciences 21:23, pages 9023.
Crossref
Yibin Miao, Liuting He, Xiaoyu Qi & Xiaoping Lin. (2020) Injecting Immunosuppressive M2 Macrophages Alleviates the Symptoms of Periodontitis in Mice. Frontiers in Molecular Biosciences 7.
Crossref
Ivana Manini, Federica Caponnetto, Emiliano Dalla, Tamara Ius, Giuseppe Maria Della Pepa, Enrico Pegolo, Anna Bartolini, Giuseppe La Rocca, Grazia Menna, Carla Di Loreto, Alessandro Olivi, Miran Skrap, Giovanni Sabatino & Daniela Cesselli. (2020) Heterogeneity Matters: Different Regions of Glioblastoma Are Characterized by Distinctive Tumor-Supporting Pathways. Cancers 12:10, pages 2960.
Crossref
M He, X Chen, M Luo, L Ouyang, L Xie, Z Huang & A Liu. (2020) Suppressor of cytokine signaling 1 inhibits the maturation of dendritic cells involving the nuclear factor kappa B signaling pathway in the glioma microenvironment. Clinical and Experimental Immunology 202:1, pages 47-59.
Crossref
A. Charlotte M. T. de Wolf, Carla A. Herberts & Marcel H. N. Hoefnagel. (2020) Dawn of Monitoring Regulatory T Cells in (Pre-)clinical Studies: Their Relevance Is Slowly Recognised. Frontiers in Medicine 7.
Crossref
Ana Rita Pombo Antunes, Isabelle Scheyltjens, Johnny Duerinck, Bart Neyns, Kiavash Movahedi & Jo A Van Ginderachter. (2020) Understanding the glioblastoma immune microenvironment as basis for the development of new immunotherapeutic strategies. eLife 9.
Crossref
William James Kelly, Amber Jin Giles & Mark Gilbert. (2020) T lymphocyte-targeted immune checkpoint modulation in glioma. Journal for ImmunoTherapy of Cancer 8:1, pages e000379.
Crossref
莹莹 张. (2020) Research Progress of Related Mechanisms about Treatment of Glioma by Medicine. Pharmacy Information 09:02, pages 78-84.
Crossref
Darya S Nesterova, Vishal Midya, Brad E Zacharia, Elizabeth A Proctor, Sang Y Lee, Lindsay C Stetson, Justin D Lathia, Joshua B Rubin, Kristin A Waite, Michael E Berens, Jill S Barnholtz-Sloan & James R Connor. (2020) Sexually dimorphic impact of the iron-regulating gene, HFE, on survival in glioblastoma. Neuro-Oncology Advances 2:1.
Crossref
Chiara V. Locarno, Matteo Simonelli, Claudia Carenza, Arianna Capucetti, Elisabetta Stanzani, Elena Lorenzi, Pasquale Persico, Silvia Della Bella, Lorena Passoni, Domenico Mavilio, Raffaella Bonecchi, Massimo Locati & Benedetta Savino. (2020) Role of myeloid cells in the immunosuppressive microenvironment in gliomas. Immunobiology 225:1, pages 151853.
Crossref
Kim Margolin, Michael Davies, Harriet Kluger & Hussein Tawbi. 2020. Cutaneous Melanoma. Cutaneous Melanoma 1421 1454 .
Julian Burks, Alia Fleury, Sarah Livingston & Jill P. Smith. (2019) ISG15 pathway knockdown reverses pancreatic cancer cell transformation and decreases murine pancreatic tumor growth via downregulation of PDL-1 expression. Cancer Immunology, Immunotherapy 68:12, pages 2029-2039.
Crossref
Gang Xu, Lejia Sun, Yunzhu Li, Feihu Xie, Xiaoxiang Zhou, Huayu Yang, Shunda Du, Haifeng Xu & Yilei Mao. (2019) The Clinicopathological and Prognostic Value of PD-L1 Expression in Cholangiocarcinoma: A Meta-Analysis. Frontiers in Oncology 9.
Crossref
Radhika R. Gudi, Subha Karumuthil-Melethil, Nicolas Perez, Gongbo Li & Chenthamarakshan Vasu. (2019) Engineered Dendritic Cell-Directed Concurrent Activation of Multiple T cell Inhibitory Pathways Induces Robust Immune Tolerance. Scientific Reports 9:1.
Crossref
Lahari Saikia, Trinayan Deka, Pranjal Deori, Rasmi Roy, Md Ezaz Hussain & Reema Nath. (2019) Frequencies of Regulatory Subsets of CD4+ TH Cells in Peripheral Blood in Mycobacterium Tuberculosis-Infected Individuals and Healthy Contacts in a High-Burden Setting from Assam, Northeast India. Indian Journal of Medical Microbiology 37:3, pages 370-375.
Crossref
Maria E. Mycielska, Markus T. J. Mohr, Katharina Schmidt, Konstantin Drexler, Petra Rümmele, Sebastian Haferkamp, Hans J. Schlitt, Andreas Gaumann, Jerzy Adamski & Edward K. Geissler. (2019) Potential Use of Gluconate in Cancer Therapy. Frontiers in Oncology 9.
Crossref
Kerstetter-Fogle, Shukla, Wang, Beiss, Harris, Sloan & Steinmetz. (2019) Plant Virus-Like Particle In Situ Vaccine for Intracranial Glioma Immunotherapy. Cancers 11:4, pages 515.
Crossref
Ruo Qiao Chen, Feng Liu, Xin Yao Qiu & Xiao Qian Chen. (2019) The Prognostic and Therapeutic Value of PD-L1 in Glioma. Frontiers in Pharmacology 9.
Crossref
Aras Toker & Pamela S. Ohashi. 2019. 193 261 .
Kim Margolin, Michael Davies, Harriet Kluger & Hussein Tawbi. 2019. Cutaneous Melanoma. Cutaneous Melanoma 1 34 .
John Lynes, Victoria Sanchez, Gifty Dominah, Anthony Nwankwo & Edjah Nduom. (2018) Current Options and Future Directions in Immune Therapy for Glioblastoma. Frontiers in Oncology 8.
Crossref
Christopher Chin, Emma S. Lunking, Macarena de la Fuente & Nagi G. Ayad. (2018) Immunotherapy and Epigenetic Pathway Modulation in Glioblastoma Multiforme. Frontiers in Oncology 8.
Crossref
Wen-Chao Wang, Xiao-Feng Zhang, Jian Peng, Xi-Feng Li, Ai-Li Wang, Ya-Qin Bie, Le-Hua Shi, Mou-Bin Lin & Xiao-Feng Zhang. (2018) Survival Mechanisms and Influence Factors of Circulating Tumor Cells. BioMed Research International 2018, pages 1-9.
Crossref
Diana Matias, Joana Balça-Silva, Grazielle C. da Graça, Caroline M. Wanjiru, Lucy W. Macharia, Carla Pires Nascimento, Natalia R. Roque, Juliana M. Coelho-Aguiar, Cláudia M. Pereira, Marcos F. Dos Santos, Luciana S. Pessoa, Flavia R. S. Lima, Alberto Schanaider, Valéria P. Ferrer & Vivaldo Moura-Neto. (2018) Microglia/Astrocytes–Glioblastoma Crosstalk: Crucial Molecular Mechanisms and Microenvironmental Factors. Frontiers in Cellular Neuroscience 12.
Crossref

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