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OncoImmunology Volume 8, 2019 - Issue 2
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Original Research

The multi-functionality of N-809, a novel fusion protein encompassing anti-PD-L1 and the IL-15 superagonist fusion complex

Caroline JochemsLaboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USAORCID Iconhttp://orcid.org/0000-0002-9000-9855View further author information
ORCID Icon,
Sarah R. TritschLaboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USAView further author information
,
Karin M. KnudsonLaboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USAView further author information
,
Sofia R. GameiroLaboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USAView further author information
,
Claire Smalley RumfieldLaboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USAView further author information
,
Samuel T. PellomLaboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USAView further author information
,
Y. Maurice Morillon llLaboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USAView further author information
,
Robby NewmanNantWorks, LLC, Culver City, CA, USAView further author information
,
Warren MarcusNantWorks, LLC, Culver City, CA, USAView further author information
,
Christopher SzetoNantOmics, LLC, Culver City, CA, USAView further author information
,
Shahrooz RabizadehNantOmics, LLC, Culver City, CA, USAView further author information
,
Hing C. WongNantWorks, LLC, Culver City, CA, USAView further author information
,
Patrick Soon-ShiongNantWorks, LLC, Culver City, CA, USAView further author information
&
Jeffrey SchlomLaboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USACorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0001-7932-4072View further author information
ORCID Icon show all
Article: e1532764 | Received 23 Jul 2018, Accepted 26 Sep 2018, Published online: 27 Nov 2018

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Karin M. Knudson, James W. Hodge, Jeffrey Schlom & Sofia R. Gameiro. (2020) Rationale for IL-15 superagonists in cancer immunotherapy. Expert Opinion on Biological Therapy 20:7, pages 705-709.
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Articles from other publishers (24)

Robin Maximilian Awad, Yannick De Vlaeminck, Fien Meeus, Thomas Ertveldt, Katty Zeven, Hannelore Ceuppens, Cleo Goyvaerts, Magali Verdonck, Gustavo Salguero, Geert Raes, Nick Devoogdt & Karine Breckpot. (2023) In vitro modelling of local gene therapy with IL-15/IL-15Rα and a PD-L1 antagonist in melanoma reveals an interplay between NK cells and CD4+ T cells. Scientific Reports 13:1.
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Miguel Martin-Salgado, Ane Ochoa-Echeverría & Isabel Mérida. (2023) Diacylglycerol kinases: A look into the future of immunotherapy. Advances in Biological Regulation, pages 100999.
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Jonathan W. Cody, Amy L. Ellis-Connell, Shelby L. O’Connor & Elsje Pienaar. (2023) Mathematical modeling indicates that regulatory inhibition of CD8+ T cell cytotoxicity can limit efficacy of IL-15 immunotherapy in cases of high pre-treatment SIV viral load. PLOS Computational Biology 19:8, pages e1011425.
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Paola Sindaco, Hritisha Pandey, Colleen Isabelle, Nitin Chakravarti, Jonathan Edward Brammer, Pierluigi Porcu & Anjali Mishra. (2023) The role of interleukin-15 in the development and treatment of hematological malignancies. Frontiers in Immunology 14.
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Shoubao Ma, Michael A. Caligiuri & Jianhua Yu. (2022) Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy. Trends in Immunology 43:10, pages 833-847.
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Patrick G. Holder, Shion A. Lim, Christine S. Huang, Preeti Sharma, Yavuz S. Dagdas, Beyza Bulutoglu & Jonathan T. Sockolosky. (2022) Engineering interferons and interleukins for cancer immunotherapy. Advanced Drug Delivery Reviews 182, pages 114112.
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Adam J. Kleinman, Ivona Pandrea & Cristian Apetrei. (2022) So Pathogenic or So What?—A Brief Overview of SIV Pathogenesis with an Emphasis on Cure Research. Viruses 14:1, pages 135.
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Huan Xu, Mingyang Shi, Changsheng Shao, Hao Li, Jing Wu, Yin Yu, Fang Fang, Yugang Guo & Weihua Xiao. (2021) Development of IL-15/IL-15Rα sushi domain-IgG4 Fc complexes in Pichia pastoris with potent activities and prolonged half-lives. Microbial Cell Factories 20:1.
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Van Anh Do-Thi, Hayyoung Lee, Hye Jin Jeong, Jie-Oh Lee & Young Sang Kim. (2021) Protective and Therapeutic Effects of an IL-15:IL-15Rα-Secreting Cell-Based Cancer Vaccine Using a Baculovirus System. Cancers 13:16, pages 4039.
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Jonathan W. Cody, Amy L. Ellis-Connell, Shelby L. O’Connor & Elsje Pienaar. (2021) Mathematical modeling of N-803 treatment in SIV-infected non-human primates. PLOS Computational Biology 17:7, pages e1009204.
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Benjamin Wolfson & James W. Hodge. (2021) Next Generation Therapeutic Strateg‐Es: Evolving cancer immunotherapy through agents that Engage , Expand and Enable the anti‐tumor immune response . ImmunoMedicine 1:1.
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Fei-Ting Hsu, Yu-Chang Liu, Chang-Liang Tsai, Po-Fu Yueh, Chih-Hsien Chang & Keng-Li Lan. (2021) Preclinical Evaluation of Recombinant Human IL15 Protein Fused with Albumin Binding Domain on Anti-PD-L1 Immunotherapy Efficiency and Anti-Tumor Immunity in Colon Cancer and Melanoma. Cancers 13:8, pages 1789.
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Samuel T. Pellom, Claire Smalley Rumfield, Y. Maurice MorillonIIII, Nicholas Roller, Lisa K. Poppe, Douglas E. Brough, Helen Sabzevari, Jeffrey Schlom & Caroline Jochems. (2021) Characterization of recombinant gorilla adenovirus HPV therapeutic vaccine PRGN-2009. JCI Insight 6:7.
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Stella A. Martomo, Dan Lu, Zhanna Polonskaya, Xenia Luna, Zhikai Zhang, Sam Feldstein, Radovan Lumban-Tobing, Danielle K. Almstead, Faical Miyara & Jeegar Patel. (2021) Single-Dose Anti–PD-L1/IL-15 Fusion Protein KD033 Generates Synergistic Antitumor Immunity with Robust Tumor-Immune Gene Signatures and Memory Responses. Molecular Cancer Therapeutics 20:2, pages 347-356.
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Ivan Y. Filin, Valeriya V. Solovyeva, Kristina V. Kitaeva, Catrin S. Rutland & Albert A. Rizvanov. (2020) Current Trends in Cancer Immunotherapy. Biomedicines 8:12, pages 621.
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Nabila Seddiki, Florence Picard, Léa Dupaty, Yves Lévy & Véronique Godot. (2020) The Potential of Immune Modulation in Therapeutic HIV-1 Vaccination. Vaccines 8:3, pages 419.
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Y. Maurice MorillonIIII, Claire Smalley Rumfield, Samuel T. Pellom, Ariana Sabzevari, Nicholas T. Roller, Lucas A. Horn, Caroline Jochems, Claudia Palena, John W. Greiner & Jeffrey Schlom. (2020) The Use of a Humanized NSG-β2m−/− Model for Investigation of Immune and Anti-tumor Effects Mediated by the Bifunctional Immunotherapeutic Bintrafusp Alfa. Frontiers in Oncology 10.
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Karin M Knudson, Kristin C Hicks, Yohei Ozawa, Jeffrey Schlom & Sofia R Gameiro. (2020) Functional and mechanistic advantage of the use of a bifunctional anti-PD-L1/IL-15 superagonist. Journal for ImmunoTherapy of Cancer 8:1, pages e000493.
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Katarzyna Węgierek & Elżbieta Pajtasz-Piasecka. (2019) Perspectives for the application of interleukin 15 in anti-cancer therapy. Postępy Higieny i Medycyny Doświadczalnej 73, pages 850-864.
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A. R. Satvik Iyengar, Shreya Gupta, Snehal Jawalekar & Abhay H. Pande. (2019) Protein Chimerization: A New Frontier for Engineering Protein Therapeutics with Improved Pharmacokinetics. Journal of Pharmacology and Experimental Therapeutics 370:3, pages 703-714.
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