OncoImmunology, Volume 8, Issue 2 (2019)

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OncoImmunology, Volume 8, Issue 2 (2019)

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Original Research

Article
Affinity-enhanced T-cell receptors for adoptive T-cell therapy targeting MAGE-A10: strategy for selection of an optimal candidate
Ellen C. Border, Joseph P. Sanderson, Thomas Weissensteiner, Andrew B. Gerry & Nicholas J. Pumphrey
Article: e1532759
Published online: 20 Nov 2018
AbstractforAffinity-enhanced T-cell receptors for adoptive T-cell therapy targeting MAGE-A10: strategy for selection of an optimal candidate | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 7039 Views
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Open Access
Article
IL-33 increases ST2+ Tregs and promotes metastatic tumour growth in the lungs in an amphiregulin-dependent manner
E.C. Halvorsen, S.E. Franks, B.J. Wadsworth, B.T. Harbourne, R.A. Cederberg, C.A. Steer, I. Martinez-Gonzalez, J. Calder, W.W. Lockwood & K.L. Bennewith
Article: e1527497
Published online: 16 Oct 2018
AbstractforIL-33 increases ST2+ Tregs and promotes metastatic tumour growth in the lungs in an amphiregulin-dependent manner | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
  • 2071 Views
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Free Access
Article
Retrospective analysis of the efficacy of adjuvant CIK cell therapy in epithelial ovarian cancer patients who received postoperative chemotherapy
Yun Zhou, Chang-long Chen, Sen-wei Jiang, Yanling Feng, Linjing Yuan, Ping Chen, Lan Zhang, Shuting Huang, Jundong Li, Jian-Chuan Xia & Min Zheng
Article: e1528411
Published online: 11 Nov 2018
AbstractforRetrospective analysis of the efficacy of adjuvant CIK cell therapy in epithelial ovarian cancer patients who received postoperative chemotherapy | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
  • 1803 Views
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Open Access
Article
Circulating NKp46+ Natural Killer cells have a potential regulatory property and predict distinct survival in Non-Small Cell Lung Cancer
Emilie Picard, Yann Godet, Caroline Laheurte, Magalie Dosset, Jeanne Galaine, Laurent Beziaud, Romain Loyon, Laura Boullerot, Elodie Lauret Marie Joseph, Laurie Spehner, Marion Jacquin, Guillaume Eberst, Béatrice Gaugler, Françoise Le pimpec-Barthes, Elizabeth Fabre, Virginie Westeel, Anne Caignard, Christophe Borg & Olivier Adotévi
Article: e1527498
Published online: 19 Oct 2018
AbstractforCirculating NKp46+ Natural Killer cells have a potential regulatory property and predict distinct survival in Non-Small Cell Lung Cancer | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
  • 1574 Views
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Free Access
Article
Mannan-binding lectin suppresses growth of hepatocellular carcinoma by regulating hepatic stellate cell activation via the ERK/COX-2/PGE2 pathway
Junru Li, Huifang Li, Yu Yu, Yan Liu, Yunzhi Liu, Qiang Ma, Liyun Zhang, Xiao Lu, Xiang-yang Wang, Zhengliang Chen, Daming Zuo & Jia Zhou
Article: e1527650
Published online: 10 Oct 2018
AbstractforMannan-binding lectin suppresses growth of hepatocellular carcinoma by regulating hepatic stellate cell activation via the ERK/COX-2/PGE2 pathway | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
  • 1640 Views
  • 17 CrossRef citations
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Free Access
Article
Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells
Fiamma Salerno, Aurelie Guislain, Julian J. Freen-Van Heeren, Benoit P. Nicolet, Howard A. Young & Monika C. Wolkers
Article: e1532762
Published online: 22 Oct 2018
AbstractforCritical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
  • 2198 Views
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Free Access
Article
Combination of immunogenic oncolytic adenovirus ONCOS-102 with anti-PD-1 pembrolizumab exhibits synergistic antitumor effect in humanized A2058 melanoma huNOG mouse model
Lukasz Kuryk, Anne-Sophie W. Møller & Magnus Jaderberg
Article: e1532763
Published online: 29 Oct 2018
AbstractforCombination of immunogenic oncolytic adenovirus ONCOS-102 with anti-PD-1 pembrolizumab exhibits synergistic antitumor effect in humanized A2058 melanoma huNOG mouse model | Full Text | References | PDF (2 MB) | EPUB | Supplemental
  • 4655 Views
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Open Access
Article
Bortezomib sensitizes multiple myeloma to NK cells via ER-stress-induced suppression of HLA-E and upregulation of DR5
Mattias Carlsten, Ali Namazi, Robert Reger, Emily Levy, Maria Berg, Cynthia St. Hilaire & Richard W. Childs
Article: e1534664
Published online: 02 Nov 2018
AbstractforBortezomib sensitizes multiple myeloma to NK cells via ER-stress-induced suppression of HLA-E and upregulation of DR5 | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
  • 2762 Views
  • 21 CrossRef citations
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Open Access
Article
ISG20 promotes local tumor immunity and contributes to poor survival in human glioma
Mengqi Gao, Yi Lin, Xing Liu, Yiming Li, Chuanbao Zhang, Zheng Wang, Zhiliang Wang, Yulin Wang & Zongze Guo
Article: e1534038
Published online: 31 Oct 2018
AbstractforISG20 promotes local tumor immunity and contributes to poor survival in human glioma | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
  • 3157 Views
  • 29 CrossRef citations
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Open Access
Article
Immune profiling and identification of prognostic immune-related risk factors in human ovarian cancer
Emelie Rådestad, Charlotte Klynning, Arwen Stikvoort, Ole Mogensen, Silvia Nava, Isabelle Magalhaes & Michael Uhlin
Article: e1535730
Published online: 16 Nov 2018
AbstractforImmune profiling and identification of prognostic immune-related risk factors in human ovarian cancer | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
  • 3577 Views
  • 42 CrossRef citations
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Open Access
Article
Integrated molecular and immunophenotypic analysis of NK cells in anti-PD-1 treated metastatic melanoma patients
Hansol Lee, Camelia Quek, Ines Silva, Annie Tasker, Marcel Batten, Helen Rizos, Su Yin Lim, Tuba Nur Gide, Ping Shang, Grace H. Attrill, Jason Madore, Jarem Edwards, Matteo S. Carlino, Alexander Guminski, Robyn P.M. Saw, John F. Thompson, Peter M. Ferguson, Umaimainthan Palendira, Alexander M. Menzies, Georgina V. Long, Richard A. Scolyer & James S. Wilmott
Article: e1537581
Published online: 31 Oct 2018
AbstractforIntegrated molecular and immunophenotypic analysis of NK cells in anti-PD-1 treated metastatic melanoma patients | Full Text | References | PDF (3 MB) | EPUB | Supplemental
  • 2739 Views
  • 46 CrossRef citations
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Free Access
Article
Versican modulates tumor-associated macrophage properties to stimulate mesothelioma growth
Apostolos G. Pappas, Sophia Magkouta, Ioannis S. Pateras, Ioannis Skianis, Charalampos Moschos, Maria Eleni Vazakidou, Katherina Psarra, Vassilis G. Gorgoulis & Ioannis Kalomenidis
Article: e1537427
Published online: 02 Nov 2018
AbstractforVersican modulates tumor-associated macrophage properties to stimulate mesothelioma growth | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 2496 Views
  • 21 CrossRef citations
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Free Access
Article
Immunological differences between colorectal cancer and normal mucosa uncover a prognostically relevant immune cell profile
Katharina Strasser, Hanna Birnleitner, Andrea Beer, Dietmar Pils, Marlene C. Gerner, Klaus G. Schmetterer, Thomas Bachleitner-Hofmann, Anton Stift, Michael Bergmann & Rudolf Oehler
Article: e1537693
Published online: 05 Nov 2018
AbstractforImmunological differences between colorectal cancer and normal mucosa uncover a prognostically relevant immune cell profile | Full Text | References | PDF (3.7 MB) | EPUB | Supplemental
  • 4837 Views
  • 36 CrossRef citations
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Open Access
Article
Noninvasive profiling of serum cytokines in breast cancer patients and clinicopathological characteristics
Shakila Jabeen, Jaime A. Espinoza, Lilly Anne Torland, Manuela Zucknick, Surendra Kumar, Vilde D. Haakensen, Torben Lüders, Olav Engebraaten, Anne-Lise Børresen-Dale, Jon Amund Kyte, Pavel Gromov, Bjørn Naume, Vessela Kristensen, Irina Gromova & Xavier Tekpli
Article: e1537691
Published online: 05 Nov 2018
AbstractforNoninvasive profiling of serum cytokines in breast cancer patients and clinicopathological characteristics | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
  • 2699 Views
  • 19 CrossRef citations
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Open Access
Article
Genomic and transcriptional Profiling of tumor infiltrated CD8+ T cells revealed functional heterogeneity of antitumor immunity in hepatocellular carcinoma
Zhenli Li, Geng Chen, Zhixiong Cai, Xiuqing Dong, Liman Qiu, Haipo Xu, Yongyi Zeng, Xiaolong Liu & Jingfeng Liu
Article: e1538436
Published online: 10 Nov 2018
AbstractforGenomic and transcriptional Profiling of tumor infiltrated CD8+ T cells revealed functional heterogeneity of antitumor immunity in hepatocellular carcinoma | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
  • 1336 Views
  • 13 CrossRef citations
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Free Access
Article
CD28H expression identifies resident memory CD8 + T cells with less cytotoxicity in human peripheral tissues and cancers
Yu Tian, Yi Sun, Fan Gao, Michelle R. Koenig, Alexander Sunderland, Yuki Fujiwara, Robert J. Torphy, Lieping Chen, Barish H. Edil, Richard D. Schulick & Yuwen Zhu
Article: e1538440
Published online: 05 Nov 2018
AbstractforCD28H expression identifies resident memory CD8 + T cells with less cytotoxicity in human peripheral tissues and cancers | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 1799 Views
  • 10 CrossRef citations
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Free Access
Article
Blockade of TGF-β signaling with novel synthetic antibodies limits immune exclusion and improves chemotherapy response in metastatic ovarian cancer models
Daniel Newsted, Sunandan Banerjee, Kathleen Watt, Sarah Nersesian, Peter Truesdell, Levi L. Blazer, Lia Cardarelli, Jarrett J. Adams, Sachdev S. Sidhu & Andrew W. Craig
Article: e1539613
Published online: 20 Nov 2018
AbstractforBlockade of TGF-β signaling with novel synthetic antibodies limits immune exclusion and improves chemotherapy response in metastatic ovarian cancer models | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 2904 Views
  • 27 CrossRef citations
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Free Access
Article
Schweinfurthin natural products induce regression of murine melanoma and pair with anti-PD-1 therapy to facilitate durable tumor immunity
Kathleen M. Kokolus, Jeremy S. Haley, Emily J. Koubek, Raghavendra Gowda, Saketh S. Dinavahi, Arati Sharma, David F. Claxton, Klaus F. Helm, Joseph J. Drabick, Gavin P. Robertson, Jeffrey D. Neighbors, Raymond J. Hohl & Todd D. Schell
Article: e1539614
Published online: 11 Nov 2018
AbstractforSchweinfurthin natural products induce regression of murine melanoma and pair with anti-PD-1 therapy to facilitate durable tumor immunity | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
  • 1982 Views
  • 15 CrossRef citations
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Free Access
Article
Pre-clinical development of Listeria-based nanovaccines as immunotherapies for solid tumours: insights from melanoma
Hector Terán-Navarro, Ricardo Calderon-Gonzalez, David Salcines-Cuevas, Isabel García, Marco Marradi, Javier Freire, Erwan Salmon, Mar Portillo-Gonzalez, Elisabet Frande-Cabanes, Almudena García-Castaño, Virginia Martinez-Callejo, Javier Gomez-Roman, Raquel Tobes, Fernando Rivera, Sonsoles Yañez-Diaz & Carmen Álvarez-Domínguez
Article: e1541534
Published online: 10 Nov 2018
AbstractforPre-clinical development of Listeria-based nanovaccines as immunotherapies for solid tumours: insights from melanoma | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 1468 Views
  • 14 CrossRef citations
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Free Access
Article
PD-L2 expression is correlated with the molecular and clinical features of glioma, and acts as an unfavorable prognostic factor
Zhi-liang Wang, Guan-zhang Li, Qiang-wei Wang, Zhao-shi Bao, Zheng Wang, Chuan-bao Zhang & Tao Jiang
Article: e1541535
Published online: 20 Nov 2018
AbstractforPD-L2 expression is correlated with the molecular and clinical features of glioma, and acts as an unfavorable prognostic factor | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 2328 Views
  • 27 CrossRef citations
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Open Access
Article
DNA methylation of immune checkpoints in the peripheral blood of breast and colorectal cancer patients
Asma A. Elashi, Varun Sasidharan Nair, Rowaida Z. Taha, Hibah Shaath & Eyad Elkord
Article: e1542918
Published online: 10 Nov 2018
AbstractforDNA methylation of immune checkpoints in the peripheral blood of breast and colorectal cancer patients | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 2618 Views
  • 42 CrossRef citations
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Free Access
Article
Beneficial effects of sunitinib on tumor microenvironment and immunotherapy targeting death receptor5
Yoko Tsukita, Tatsuma Okazaki, Satoru Ebihara, Riyo Komatsu, Mayumi Nihei, Makoto Kobayashi, Taizou Hirano, Hisatoshi Sugiura, Tsutomu Tamada, Nobuyuki Tanaka, Yasufumi Sato, Hideo Yagita & Masakazu Ichinose
Article: e1543526
Published online: 13 Nov 2018
AbstractforBeneficial effects of sunitinib on tumor microenvironment and immunotherapy targeting death receptor5 | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
  • 1596 Views
  • 14 CrossRef citations
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Free Access
Article
PD-L1 and immune infiltrates are differentially expressed in distinct subgroups of gastric cancer
H. K. Angell, J. Lee, K-M. Kim, K. Kim, S-T. Kim, S. H. Park, W. K. Kang, A. Sharpe, J. Ogden, A. Davenport, D. R. Hodgson, J. C. Barrett & E. Kilgour
Article: e1544442
Published online: 10 Dec 2018
AbstractforPD-L1 and immune infiltrates are differentially expressed in distinct subgroups of gastric cancer | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 3191 Views
  • 33 CrossRef citations
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Open Access

Review

Review
Acute myeloid leukemia and NK cells: two warriors confront each other
Aroa Baragaño Raneros, Carlos López-Larrea & Beatriz Suárez-Álvarez
Article: e1539617
Published online: 31 Oct 2018
AbstractforAcute myeloid leukemia and NK cells: two warriors confront each other | Full Text | References | PDF (1.2 MB) | EPUB
  • 2518 Views
  • 25 CrossRef citations
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Free Access

Original Research

Article
The multi-functionality of N-809, a novel fusion protein encompassing anti-PD-L1 and the IL-15 superagonist fusion complex
Caroline Jochems, Sarah R. Tritsch, Karin M. Knudson, Sofia R. Gameiro, Claire Smalley Rumfield, Samuel T. Pellom, Y. Maurice Morillon ll, Robby Newman, Warren Marcus, Christopher Szeto, Shahrooz Rabizadeh, Hing C. Wong, Patrick Soon-Shiong & Jeffrey Schlom
Article: e1532764
Published online: 27 Nov 2018
AbstractforThe multi-functionality of N-809, a novel fusion protein encompassing anti-PD-L1 and the IL-15 superagonist fusion complex | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
  • 4719 Views
  • 25 CrossRef citations
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Open Access
Article
Tumor-infiltrating T cells and PD-L1 expression in childhood malignant extracranial germ-cell tumors
Renata Boldrini, Maria Debora De Pasquale, Ombretta Melaiu, Marco Chierici, Giuseppe Jurman, Maria Chiara Benedetti, Nunzio C. Salfi, Aurora Castellano, Paola Collini, Cesare Furlanello, Vito Pistoia, Loredana Cifaldi, Monica Terenziani & Doriana Fruci
Article: e1542245
Published online: 13 Dec 2018
AbstractforTumor-infiltrating T cells and PD-L1 expression in childhood malignant extracranial germ-cell tumors | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
  • 1214 Views
  • 13 CrossRef citations
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Free Access
Article
Batf3+ DCs and type I IFN are critical for the efficacy of neoadjuvant cancer immunotherapy
Jing Liu, Elisa A. Rozeman, Jake S. O’Donnell, Stacey Allen, Lorenzo Fanchi, Mark J. Smyth, Christian U. Blank & Michele W.L. Teng
Article: e1546068
Published online: 22 Nov 2018
AbstractforBatf3+ DCs and type I IFN are critical for the efficacy of neoadjuvant cancer immunotherapy | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 2270 Views
  • 37 CrossRef citations
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Free Access
Article
The novel agonistic iNKT-cell antibody NKT14m induces a therapeutic antitumor response against B-cell lymphoma
Laura Escribà-Garcia, Carmen Alvarez-Fernández, Ana Carolina Caballero, Robert Schaub, Jorge Sierra & Javier Briones
Article: e1546543
Published online: 26 Nov 2018
AbstractforThe novel agonistic iNKT-cell antibody NKT14m induces a therapeutic antitumor response against B-cell lymphoma | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 1004 Views
  • 3 CrossRef citations
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Free Access
Article
Pomalidomide increases immune surface marker expression and immune recognition of oncovirus-infected cells
David A. Davis, Prabha Shrestha, Ashley I. Aisabor, Alexandra Stream, Veronica Galli, Cynthia A. Pise-Masison, Takanobu Tagawa, Joseph M. Ziegelbauer, Genoveffa Franchini & Robert Yarchoan
Article: e1546544
Published online: 05 Dec 2018
AbstractforPomalidomide increases immune surface marker expression and immune recognition of oncovirus-infected cells | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 2603 Views
  • 23 CrossRef citations
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Open Access

Correction

Correction
Correction
Article: e1534569
Published online: 13 Dec 2018
CitationforCorrection | Full Text | PDF (84.8 KB) | EPUB
  • 1611 Views
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