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OncoImmunology Volume 8, 2019 - Issue 2
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Original Research

Blockade of TGF-β signaling with novel synthetic antibodies limits immune exclusion and improves chemotherapy response in metastatic ovarian cancer models

Daniel NewstedDepartment of Biomedical and Molecular Sciences, Queen’s University; Cancer Biology & Genetics division, Queen’s Cancer Research Institute, Kingston, ON, CanadaView further author information
,
Sunandan BanerjeeThe Donnelly Centre, University of Toronto, Toronto, ON, CanadaView further author information
,
Kathleen WattDepartment of Biomedical and Molecular Sciences, Queen’s University; Cancer Biology & Genetics division, Queen’s Cancer Research Institute, Kingston, ON, CanadaView further author information
,
Sarah NersesianDepartment of Biomedical and Molecular Sciences, Queen’s University; Cancer Biology & Genetics division, Queen’s Cancer Research Institute, Kingston, ON, CanadaView further author information
,
Peter TruesdellDepartment of Biomedical and Molecular Sciences, Queen’s University; Cancer Biology & Genetics division, Queen’s Cancer Research Institute, Kingston, ON, CanadaView further author information
,
Levi L. BlazerThe Donnelly Centre, University of Toronto, Toronto, ON, CanadaORCID Iconhttp://orcid.org/0000-0001-9594-4642View further author information
ORCID Icon,
Lia CardarelliThe Donnelly Centre, University of Toronto, Toronto, ON, CanadaView further author information
,
Jarrett J. AdamsThe Donnelly Centre, University of Toronto, Toronto, ON, CanadaORCID Iconhttp://orcid.org/0000-0002-0182-922XView further author information
ORCID Icon,
Sachdev S. SidhuThe Donnelly Centre, University of Toronto, Toronto, ON, CanadaView further author information
&
Andrew W. CraigDepartment of Biomedical and Molecular Sciences, Queen’s University; Cancer Biology & Genetics division, Queen’s Cancer Research Institute, Kingston, ON, CanadaCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-2039-2393View further author information
ORCID Icon show all
Article: e1539613 | Received 11 Jun 2018, Accepted 04 Oct 2018, Published online: 20 Nov 2018

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Na He, Linbiao Xiang, Lei Chen, Haobin Tong, Keshen Wang, Jie Zhao, Feixue Song, Hanteng Yang, Xinyuan Wei & Zuoyi Jiao. (2022) The role of long non-coding RNA FGD5-AS1 in cancer. Bioengineered 13:4, pages 11026-11041.
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Wan Liu, Wenjing Wang, Ning Zhang & Wen Di. (2020) The Role of CCL20-CCR6 Axis in Ovarian Cancer Metastasis. OncoTargets and Therapy 13, pages 12739-12750.
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Articles from other publishers (25)

Zhe Geng, Xinxing Pan, Juan Xu & Xuemei Jia. (2022) Friend and foe: the regulation network of ascites components in ovarian cancer progression. Journal of Cell Communication and Signaling 17:3, pages 391-407.
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Hongchao Liu, Zhihao Wei, Yu Zhang, Kangke Shi & Jiaqiong Li. (2023) TGF-β based risk model to predict the prognosis and immune features in glioblastoma. Frontiers in Neurology 14.
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Yazmin Brown, Susan Hua & Pradeep S. Tanwar. (2023) Extracellular matrix in high-grade serous ovarian cancer: Advances in understanding of carcinogenesis and cancer biology. Matrix Biology 118, pages 16-46.
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Ruveyda Ayasun, Turcin Saridogan, Ola Gaber & Ibrahim Halil Sahin. (2023) Systemic Therapy for Patients With Pancreatic Cancer: Current Approaches and Opportunities for Novel Avenues Toward Precision Medicine. Clinical Colorectal Cancer 22:1, pages 2-11.
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Satoru Matsuda, Ajinkya Revandkar, Taronish D. Dubash, Arvind Ravi, Ben S. Wittner, Maoxuan Lin, Robert Morris, Risa Burr, Hongshan Guo, Karsen Seeger, Annamaria Szabolcs, Dante Che, Linda Nieman, Gad A. Getz, David T. Ting, Michael S. Lawrence, Justin Gainor, Daniel A. Haber & Shyamala Maheswaran. (2023) TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state. Cell Reports 42:3, pages 112129.
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Alicja Rajtak, Marta Ostrowska-Leśko, Klaudia Żak, Rafał Tarkowski, Jan Kotarski & Karolina Okła. (2022) Integration of local and systemic immunity in ovarian cancer: Implications for immunotherapy. Frontiers in Immunology 13.
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Robert Pomponio, Qi Tang, Anthony Mei, Anne Caron, Bema Coulibaly, Joachim Theilhaber, Maximilian Rogers-Grazado, Michele Sanicola-Nadel, Souad Naimi, Reza Olfati-Saber, Cecile Combeau, Jack Pollard, Tun Tun Lin & Rui Wang. (2022) An integrative approach of digital image analysis and transcriptome profiling to explore potential predictive biomarkers for TGFβ blockade therapy. Acta Pharmaceutica Sinica B 12:9, pages 3594-3601.
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Mariana Nunes & Sara Ricardo. 2022. Ovarian Cancer. Ovarian Cancer 27 42 .
Daryl Kai Ann Chia, Yong Xiang Gwee & Raghav Sundar. (2022) Resistance to systemic immune checkpoint inhibition in the peritoneal niche. Journal for ImmunoTherapy of Cancer 10:6, pages e004749.
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Jitka Fucikova, Lenka Palova-Jelinkova, Vanessa Klapp, Peter Holicek, Tereza Lanickova, Lenka Kasikova, Jana Drozenova, David Cibula, Beatriz Álvarez-Abril, Elena García-Martínez, Radek Spisek & Lorenzo Galluzzi. (2022) Immunological control of ovarian carcinoma by chemotherapy and targeted anticancer agents. Trends in Cancer 8:5, pages 426-444.
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Dolly Dhaliwal & Trevor G. Shepherd. (2021) Molecular and cellular mechanisms controlling integrin-mediated cell adhesion and tumor progression in ovarian cancer metastasis: a review. Clinical & Experimental Metastasis 39:2, pages 291-301.
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Christian Secchi, Paola Benaglio, Francesca Mulas, Martina Belli, Dwayne Stupack & Shunichi Shimasaki. (2021) FOXO1 mitigates the SMAD3/FOXL2C134W transcriptomic effect in a model of human adult granulosa cell tumor. Journal of Translational Medicine 19:1.
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Chia-Hsin Hsu, Hirotaka Tomiyasu, Chi-Hsun Liao & Chen-Si Lin. (2021) Genome-wide DNA methylation and RNA-seq analyses identify genes and pathways associated with doxorubicin resistance in a canine diffuse large B-cell lymphoma cell line. PLOS ONE 16:5, pages e0250013.
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Asha Kumari, Zainab Shonibare, Mehri Monavarian, Rebecca C. Arend, Nam Y. Lee, Gareth J. Inman & Karthikeyan Mythreye. (2021) TGFβ signaling networks in ovarian cancer progression and plasticity. Clinical & Experimental Metastasis 38:2, pages 139-161.
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Na Li, Biao Li & Xianquan Zhan. (2021) Comprehensive Analysis of Tumor Microenvironment Identified Prognostic Immune-Related Gene Signature in Ovarian Cancer. Frontiers in Genetics 12.
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Laudine Communal, Mauricio Medrano, Fabrice Sircoulomb, Joshua Paterson, Martin Köbel, Kurosh Rahimi, Paul Hoskins, Dongsheng Tu, Stephanie Lheureux, Amit Oza, Laurie Ailles, Diane Provencher, Robert Rottapel & Anne-Marie Mes-Masson. (2020) Low junctional adhesion molecule-A expression is associated with an epithelial to mesenchymal transition and poorer outcomes in high-grade serous carcinoma of uterine adnexa. Modern Pathology 33:11, pages 2361-2377.
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Maite Alvarez, Cordelia Dunai, Lam T. Khuat, Ethan G. Aguilar, Isabel Barao & William J. Murphy. (2020) IL-2 and Anti-TGF-β Promote NK Cell Reconstitution and Anti-tumor Effects after Syngeneic Hematopoietic Stem Cell Transplantation. Cancers 12:11, pages 3189.
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Caroline Elizabeth Ford, Bonnita Werner, Neville Frederick Hacker & Kristina Warton. (2020) The untapped potential of ascites in ovarian cancer research and treatment. British Journal of Cancer 123:1, pages 9-16.
Crossref
Souvik Mukherjee, Pratham Phadte, Megha Mehrotra & Pritha Ray. (2020) Plasticity in Ovarian Cancer: The Molecular Underpinnings and Phenotypic Heterogeneity. Journal of the Indian Institute of Science 100:3, pages 537-553.
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Qiang Xie, Fengzhou Li, Lei Fang, Wenzhi Liu & Chundong Gu. (2020) The Antitumor Efficacy of β -Elemene by Changing Tumor Inflammatory Environment and Tumor Microenvironment . BioMed Research International 2020, pages 1-13.
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Sara Gagno, Elena Poletto, Michele Bartoletti, Luca Quartuccio, Chiara Romualdi, Marica Garziera, Simona Scalone, Roberto Sorio, Eva Dreussi, Chiara Zanusso, Elena De Mattia, Rossana Roncato, Erika Cecchin, Giorgio Giorda, Salvatore De Vita, Michele Dal Bo, Fabio Puglisi & Giuseppe Toffoli. (2020) A TGF-β associated genetic score to define prognosis and platinum sensitivity in advanced epithelial ovarian cancer. Gynecologic Oncology 156:1, pages 233-242.
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Mariya Lazarova & Alexander Steinle. (2019) Impairment of NKG2D-Mediated Tumor Immunity by TGF-β. Frontiers in Immunology 10.
Crossref
Nele Loret, Hannelore Denys, Philippe Tummers & Geert Berx. (2019) The Role of Epithelial-to-Mesenchymal Plasticity in Ovarian Cancer Progression and Therapy Resistance. Cancers 11:6, pages 838.
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Jiajing Cai, Qi Qi, Xuemeng Qian, Jia Han, Xinfang Zhu, Qi Zhang & Rong Xia. (2019) The role of PD-1/PD-L1 axis and macrophage in the progression and treatment of cancer. Journal of Cancer Research and Clinical Oncology 145:6, pages 1377-1385.
Crossref
Brandon M. Roane, Rebecca C. Arend & Michael J. Birrer. (2019) Review: Targeting the Transforming Growth Factor-Beta Pathway in Ovarian Cancer. Cancers 11:5, pages 668.
Crossref

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