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OncoImmunology Volume 8, 2019 - Issue 11
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Original research

Suppression of tumor antigen presentation during aneuploid tumor evolution contributes to immune evasion

Reshmi TripathiDivision of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USAView further author information
,
Vishnu ModurDivision of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USAView further author information
,
Laura SenovillaEquipe labellisée par la Ligue contre le cancer, Université Paris Descartes, Université Sorbonne Paris Cité, Université Paris Diderot, Université Sorbonne Université, INSERM U1138, Centre de Recherche des Cordeliers, Paris, France;Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, FranceView further author information
,
Guido KroemerEquipe labellisée par la Ligue contre le cancer, Université Paris Descartes, Université Sorbonne Paris Cité, Université Paris Diderot, Université Sorbonne Université, INSERM U1138, Centre de Recherche des Cordeliers, Paris, France;Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France;Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France;Suzhou Institute for Systems Biology, Chinese Academy of Sciences, Suzhou, China;Department of Women’s and Children’s Health, Karolinska Institute, Karolinska University Hospital, Stockholm, SwedenORCID Iconhttps://orcid.org/0000-0002-9334-4405View further author information
ORCID Icon &
Kakajan KomurovDivision of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA;Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA;Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA;Department of Pediatrics, University of Cincinnati, Cincinnati, OH, USA;Oncology Research and Development, Pfizer Inc, Pearl River, NY, USACorrespondence[email protected]
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Article: 1657374 | Received 11 Feb 2019, Accepted 15 Aug 2019, Published online: 06 Sep 2019

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Urbain Weyemi & Lorenzo Galluzzi. 2021. Chromatin and Genomic Instability in Cancer. Chromatin and Genomic Instability in Cancer ix xvii .
Renzo G DiNatale, A Ari Hakimi & Timothy A Chan. (2020) Genomics-based immuno-oncology: bridging the gap between immunology and tumor biology. Human Molecular Genetics 29:R2, pages R214-R225.
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