OncoImmunology, Volume 8, Issue 11 (2019)

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OncoImmunology, Volume 8, Issue 11 (2019)

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Author's View

Opinion
Pre-surgical oncolytic virotherapy improves breast cancer outcomes
Victor Mullins-Dansereau, Grégory Petrazzo, Karen Geoffroy, Delphine Béland & Marie-Claude Bourgeois-Daigneault
Article: e1655363
Published online: 19 Aug 2019
AbstractforPre-surgical oncolytic virotherapy improves breast cancer outcomes | Full Text | References | PDF (1.2 MB) | EPUB
  • 1700 Views
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Opinion
Apoptotic caspases cut down the immunogenicity of radiation
Aitziber Buqué, Maria Esperanza Rodriguez-Ruiz, Jitka Fucikova & Lorenzo Galluzzi
Article: e1655364
Published online: 20 Aug 2019
AbstractforApoptotic caspases cut down the immunogenicity of radiation | Full Text | References | PDF (509 KB) | EPUB
  • 1333 Views
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Opinion
Extracellular vesicles released by ovarian carcinoma contain arginase 1 that mitigates antitumor immune response
Anna Sosnowska, Malgorzata Czystowska-Kuzmicz & Jakub Golab
Article: e1655370
Published online: 20 Aug 2019
AbstractforExtracellular vesicles released by ovarian carcinoma contain arginase 1 that mitigates antitumor immune response | Full Text | References | PDF (1.1 MB) | EPUB
  • 1505 Views
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Open Access

Brief Report

Brief Report
Staphylococcal alpha-toxin tilts the balance between malignant and non-malignant CD4+ T cells in cutaneous T-cell lymphoma
Edda Blümel, Andreas Willerslev-Olsen, Maria Gluud, Lise M. Lindahl, Simon Fredholm, Claudia Nastasi, Thorbjørn Krejsgaard, Bas G. J. Surewaard, Sergei B. Koralov, Tengpeng Hu, Jenny L. Persson, Charlotte Menné Bonefeld, Carsten Geisler, Lars Iversen, Jürgen C. Becker, Mads Hald Andersen, Anders Woetmann, Terkild Brink Buus & Niels Ødum
Article: e1641387
Published online: 17 Jul 2019
AbstractforStaphylococcal alpha-toxin tilts the balance between malignant and non-malignant CD4+ T cells in cutaneous T-cell lymphoma | Full Text | References | PDF (3.7 MB) | EPUB | Supplemental
  • 2123 Views
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Open Access

Original Research

Article
Enhancing direct cytotoxicity and response to immune checkpoint blockade following ionizing radiation with Wee1 kinase inhibition
Priya Patel, Lily Sun, Yvette Robbins, Paul E. Clavijo, Jay Friedman, Christopher Silvin, Carter Van Waes, John Cook, James Mitchell & Clint Allen
Article: e1638207
Published online: 19 Jul 2019
AbstractforEnhancing direct cytotoxicity and response to immune checkpoint blockade following ionizing radiation with Wee1 kinase inhibition | Full Text | References | PDF (4.8 MB) | EPUB | Supplemental
  • 2018 Views
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Free Access
Article
Dexamethasone differentially depletes tumour and peripheral blood lymphocytes and can impact the efficacy of chemotherapy/checkpoint blockade combination treatment
Wayne J. Aston, Danika E. Hope, Alistair M. Cook, Louis Boon, Ian Dick, Anna K. Nowak, Richard A. Lake & W. Joost Lesterhuis
Article: e1641390
Published online: 13 Jul 2019
AbstractforDexamethasone differentially depletes tumour and peripheral blood lymphocytes and can impact the efficacy of chemotherapy/checkpoint blockade combination treatment | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
  • 4870 Views
  • 19 CrossRef citations
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Open Access
Article
Sepsis inhibits tumor growth in mice with cancer through Toll-like receptor 4-associated enhanced Natural Killer cell activity
Clara Vigneron, Adrien Mirouse, Hamid Merdji, Christophe Rousseau, Clément Cousin, Fanny Alby-Laurent, Jean-Paul Mira, Jean-Daniel Chiche, Jean-François Llitjos & Frédéric Pène
Article: e1641391
Published online: 19 Jul 2019
AbstractforSepsis inhibits tumor growth in mice with cancer through Toll-like receptor 4-associated enhanced Natural Killer cell activity | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
  • 1633 Views
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Article
Anti-tumoral potential of a human granulysin-based, CEA-targeted cytolytic immunotoxin
Raquel Ibáñez-Pérez, Patricia Guerrero-Ochoa, Sameer Al-Wasaby, Rocío Navarro, Antonio Tapia-Galisteo, Diego De Miguel, Oscar Gonzalo, Blanca Conde, Luis Martínez-Lostao, Ramón Hurtado-Guerrero, Laura Sanz & Alberto Anel
Article: 1641392
Published online: 22 Jul 2019
AbstractforAnti-tumoral potential of a human granulysin-based, CEA-targeted cytolytic immunotoxin | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
  • 1725 Views
  • 10 CrossRef citations
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Free Access
Article
T cell receptor next-generation sequencing reveals cancer-associated repertoire metrics and reconstitution after chemotherapy in patients with hematological and solid tumors
Donjete Simnica, Nuray Akyüz, Simon Schliffke, Malte Mohme, Lisa v.Wenserski, Thorben Mährle, Lorenzo F. Fanchi, Katrin Lamszus & Mascha Binder
Article: e1644110
Published online: 25 Jul 2019
AbstractforT cell receptor next-generation sequencing reveals cancer-associated repertoire metrics and reconstitution after chemotherapy in patients with hematological and solid tumors | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
  • 7421 Views
  • 35 CrossRef citations
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Article
Clinical impact of T cells, B cells and the PD-1/PD-L1 pathway in muscle invasive bladder cancer: a comparative study of transurethral resection and cystectomy specimens
Sara Wahlin, Björn Nodin, Karin Leandersson, Karolina Boman & Karin Jirström
Article: e1644108
Published online: 03 Aug 2019
AbstractforClinical impact of T cells, B cells and the PD-1/PD-L1 pathway in muscle invasive bladder cancer: a comparative study of transurethral resection and cystectomy specimens | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
  • 2860 Views
  • 26 CrossRef citations
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Open Access
Article
Contribution of annexin A1 to anticancer immunosurveillance
Elisa Elena Baracco, Gautier Stoll, Peter Van Endert, Laurence Zitvogel, Erika Vacchelli & Guido Kroemer
Article: e1647760
Published online: 14 Aug 2019
AbstractforContribution of annexin A1 to anticancer immunosurveillance | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
  • 2180 Views
  • 21 CrossRef citations
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Free Access
Article
Polyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profile
Rosa De Groot, Marleen M. Van Loenen, Aurélie Guislain, Benoît P. Nicolet, Julian J. Freen-Van Heeren, Onno J.H.M. Verhagen, Michel M. Van Den Heuvel, Jeroen De Jong, Patrick Burger, C.Ellen Van Der Schoot, Robbert M. Spaapen, Derk Amsen, John B. A. G. Haanen, Kim Monkhorst, Koen J. Hartemink & Monika C. Wolkers
Article: e1648170
Published online: 15 Aug 2019
AbstractforPolyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profile | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
  • 3935 Views
  • 28 CrossRef citations
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Open Access
Article
Blockade of ErbB2 and PD-L1 using a bispecific antibody to improve targeted anti-ErbB2 therapy
Deepak Mittal, Dipti Vijayan, Joost Neijssen, Joost Kreijtz, Maurice M. J. M. Habraken, Hans Van Eenennaam, Andrea Van Elsas & Mark J. Smyth
Article: e1648171
Published online: 26 Aug 2019
AbstractforBlockade of ErbB2 and PD-L1 using a bispecific antibody to improve targeted anti-ErbB2 therapy | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 3385 Views
  • 29 CrossRef citations
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Article
Docking protein-1 promotes inflammatory macrophage signaling in gastric cancer
Tong Li, Beifang Li, Asgharpour Sara, Christine Ay, Wing Yan Leung, Yanquan Zhang, Yujuan Dong, Qiaoyi Liang, Xiang Zhang, Philip Weidner, Tobias Gutting, Hans-Michael Behrens, Christoph Röcken, Joseph JY Sung, Matthias P. Ebert, Jun Yu & Elke Burgermeister
Article: e1649961
Published online: 21 Aug 2019
AbstractforDocking protein-1 promotes inflammatory macrophage signaling in gastric cancer | Full Text | References | PDF (7.9 MB) | EPUB | Supplemental
  • 2676 Views
  • 13 CrossRef citations
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Free Access
Article
Combined chemotherapy and allogeneic human Vγ9Vδ2 T lymphocyte-immunotherapies efficiently control the development of human epithelial ovarian cancer cells in vivo
Noémie Joalland, Laura Lafrance, Thibauld Oullier, Séverine Marionneau-Lambot, Delphine Loussouarn, Ulrich Jarry & Emmanuel Scotet
Article: e1649971
Published online: 28 Aug 2019
AbstractforCombined chemotherapy and allogeneic human Vγ9Vδ2 T lymphocyte-immunotherapies efficiently control the development of human epithelial ovarian cancer cells in vivo | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
  • 1659 Views
  • 6 CrossRef citations
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Open Access
Article
Irreversible electroporation of locally advanced pancreatic cancer transiently alleviates immune suppression and creates a window for antitumor T cell activation
Hester J. Scheffer, Anita G.M. Stam, Bart Geboers, Laurien G.P.H. Vroomen, Alette Ruarus, Beaunelle de Bruijn, M. Petrousjka van den Tol, Geert Kazemier, Martijn R. Meijerink & Tanja D. de Gruijl
Article: 1652532
Published online: 28 Aug 2019
AbstractforIrreversible electroporation of locally advanced pancreatic cancer transiently alleviates immune suppression and creates a window for antitumor T cell activation | Full Text | References | PDF (970.8 KB) | EPUB | Supplemental
  • 3275 Views
  • 60 CrossRef citations
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Open Access
Article
The impact of CTLA-4 blockade and interferon-α on clonality of T-cell repertoire in the tumor microenvironment and peripheral blood of metastatic melanoma patients
Arjun Khunger, Julie A. Rytlewski, Paul Fields, Erik C. Yusko & Ahmad A. Tarhini
Article: e1652538
Published online: 20 Aug 2019
AbstractforThe impact of CTLA-4 blockade and interferon-α on clonality of T-cell repertoire in the tumor microenvironment and peripheral blood of metastatic melanoma patients | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 2255 Views
  • 16 CrossRef citations
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Free Access
Article
A poly-neoantigen DNA vaccine synergizes with PD-1 blockade to induce T cell-mediated tumor control
Elena Tondini, Tsolere Arakelian, Koen Oosterhuis, Marcel Camps, Suzanne van Duikeren, Wanda Han, Ramon Arens, Gerben Zondag, Jeroen van Bergen & Ferry Ossendorp
Article: 1652539
Published online: 02 Sep 2019
AbstractforA poly-neoantigen DNA vaccine synergizes with PD-1 blockade to induce T cell-mediated tumor control | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
  • 5371 Views
  • 39 CrossRef citations
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Open Access
Article
Macrophages induce CD47 upregulation via IL-6 and correlate with poor survival in hepatocellular carcinoma patients
Jing Chen, Dan-Xue Zheng, Xing-Juan Yu, Hong-Wei Sun, Yi-Tuo Xu, Yao-Jun Zhang & Jing Xu
Article: e1652540
Published online: 15 Aug 2019
AbstractforMacrophages induce CD47 upregulation via IL-6 and correlate with poor survival in hepatocellular carcinoma patients | Full Text | References | PDF (5.4 MB) | EPUB | Supplemental
  • 3357 Views
  • 48 CrossRef citations
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Original research

Article
Human Mesenchymal glioblastomas are characterized by an increased immune cell presence compared to Proneural and Classical tumors
Ioannis Kaffes, Frank Szulzewsky, Zhihong Chen, Cameron J. Herting, Ben Gabanic, José E. Velázquez Vega, Jennifer Shelton, Jeffrey M. Switchenko, James L. Ross, Leon F. McSwain, Jason T. Huse, Bengt Westermark, Sven Nelander, Karin Forsberg-Nilsson, Lene Uhrbom, Naga Prathyusha Maturi, Patrick. J. Cimino, Eric C. Holland, Helmut Kettenmann, Cameron W. Brennan, Daniel J. Brat & Dolores Hambardzumyan
Article: e1655360
Published online: 22 Aug 2019
AbstractforHuman Mesenchymal glioblastomas are characterized by an increased immune cell presence compared to Proneural and Classical tumors | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
  • 6205 Views
  • 60 CrossRef citations
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Open Access

Original Research

Article
PDL1 expression is associated with longer postoperative, survival in adrenocortical carcinoma
Emilien Billon, Pascal Finetti, Alexandre Bertucci, Patricia Niccoli, Daniel Birnbaum, Emilie Mamessier & François Bertucci
Article: e1655362
Published online: 28 Aug 2019
AbstractforPDL1 expression is associated with longer postoperative, survival in adrenocortical carcinoma | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 2075 Views
  • 20 CrossRef citations
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Free Access
Article
Apoptotic caspases inhibit abscopal responses to radiation and identify a new prognostic biomarker for breast cancer patients
Maria Esperanza Rodriguez-Ruiz, Aitziber Buqué, Michal Hensler, Jonathan Chen, Norma Bloy, Giulia Petroni, Ai Sato, Takahiro Yamazaki, Jitka Fucikova & Lorenzo Galluzzi
Article: e1655964
Published online: 26 Aug 2019
AbstractforApoptotic caspases inhibit abscopal responses to radiation and identify a new prognostic biomarker for breast cancer patients | Full Text | References | PDF (6.9 MB) | EPUB | Supplemental
  • 4004 Views
  • 89 CrossRef citations
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Article
Lurbinectedin synergizes with immune checkpoint blockade to generate anticancer immunity
Wei Xie, Sabrina Forveille, Kristina Iribarren, Allan Sauvat, Laura Senovilla, Yan Wang, Juliette Humeau, Maria Perez-Lanzon, Heng Zhou, Juan F. Martínez-Leal, Guido Kroemer & Oliver Kepp
Article: e1656502
Published online: 05 Sep 2019
AbstractforLurbinectedin synergizes with immune checkpoint blockade to generate anticancer immunity | Full Text | References | PDF (1.5 MB) | EPUB
  • 3184 Views
  • 40 CrossRef citations
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Original research

Article
Suppression of tumor antigen presentation during aneuploid tumor evolution contributes to immune evasion
Reshmi Tripathi, Vishnu Modur, Laura Senovilla, Guido Kroemer & Kakajan Komurov
Article: 1657374
Published online: 06 Sep 2019
AbstractforSuppression of tumor antigen presentation during aneuploid tumor evolution contributes to immune evasion | Full Text | References | PDF (2 MB) | EPUB | Supplemental
  • 3039 Views
  • 31 CrossRef citations
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Open Access

Original Research

Article
A synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice
Sarah Lévesque, Julie Le Naour, Federico Pietrocola, Juliette Paillet, Margerie Kremer, Francesca Castoldi, Elisa E. Baracco, Yan Wang, Erika Vacchelli, Gautier Stoll, Ariane Jolly, Pierre De La Grange, Laurence Zitvogel, Guido Kroemer & Jonathan G. Pol
Article: e1657375
Published online: 07 Sep 2019
AbstractforA synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice | Full Text | References | PDF (4.8 MB) | EPUB | Supplemental
  • 4839 Views
  • 51 CrossRef citations
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Open Access
Article
Aberrant upregulation of PDK1 in ovarian cancer cells impairs CD8+ T cell function and survival through elevation of PD-L1
Jing-Jing Wang, Michelle K. Siu, Yu-Xin Jiang, Thomas H. Leung, David W. Chan, Ran-Ran Cheng, Annie N. Cheung, Hextan Y. Ngan & Karen K. Chan
Article: 1659092
Published online: 05 Sep 2019
AbstractforAberrant upregulation of PDK1 in ovarian cancer cells impairs CD8+ T cell function and survival through elevation of PD-L1 | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
  • 2472 Views
  • 18 CrossRef citations
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Free Access
Article
A theranostic PSMA ligand for PET imaging and retargeting of T cells expressing the universal chimeric antigen receptor UniCAR
Claudia Arndt, Anja Feldmann, Stefanie Koristka, Martin Schäfer, Ralf Bergmann, Nicola Mitwasi, Nicole Berndt, Dominik Bachmann, Alexandra Kegler, Marc Schmitz, Edinson Puentes-Cala, Javier Andrés Soto, Gerhard Ehninger, Jens Pietzsch, Christos Liolios, Gerd Wunderlich, Jörg Kotzerke, Klaus Kopka & Michael Bachmann
Article: 1659095
Published online: 07 Sep 2019
AbstractforA theranostic PSMA ligand for PET imaging and retargeting of T cells expressing the universal chimeric antigen receptor UniCAR | Full Text | References | PDF (4.9 MB) | EPUB | Supplemental
  • 3289 Views
  • 23 CrossRef citations
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Open Access
Article
Evidence for interaction of the NLRP3 inflammasome and Bruton’s tyrosine kinase in tumor-associated macrophages: implications for myeloid cell production of interleukin-1beta
Brooke Benner, Luke Scarberry, Andrew Stiff, Megan C. Duggan, Logan Good, Gabriella Lapurga, Jonathan P. Butchar, Susheela Tridandapani & William E. Carson
Article: 1659704
Published online: 05 Sep 2019
AbstractforEvidence for interaction of the NLRP3 inflammasome and Bruton’s tyrosine kinase in tumor-associated macrophages: implications for myeloid cell production of interleukin-1beta | Full Text | References | PDF (4 MB) | EPUB | Supplemental
  • 2211 Views
  • 11 CrossRef citations
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Article
Upregulation of intratumoral HLA class I and peritumoral Mx1 in ulcerated melanomas
Daniëlle Verver, Vichnou Poirier-Colame, Gorana Tomasic, Khadija Cherif-Rebai, Dirk J. Grunhagen, Cornelis Verhoef, Stefan Suciu, Caroline Robert, Laurence Zitvogel & Alexander M.M. Eggermont
Article: e1660121
Published online: 06 Sep 2019
AbstractforUpregulation of intratumoral HLA class I and peritumoral Mx1 in ulcerated melanomas | Full Text | References | PDF (2 MB) | EPUB
  • 1146 Views
  • 4 CrossRef citations
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Free Access

Review

Review
Trial watch: dendritic cell vaccination for cancer immunotherapy
Jenny Sprooten, Jolien Ceusters, An Coosemans, Patrizia Agostinis, Steven De Vleeschouwer, Laurence Zitvogel, Guido Kroemer, Lorenzo Galluzzi & Abhishek D. Garg
Article: 1638212
Published online: 18 Jul 2019
AbstractforTrial watch: dendritic cell vaccination for cancer immunotherapy | Full Text | References | PDF (2.8 MB) | EPUB
  • 9641 Views
  • 103 CrossRef citations
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Free Access
Review
Immune checkpoint inhibitors in mCRPC - rationales, challenges and perspectives
H. Taghizadeh, M. Marhold, E. Tomasich, S. Udovica, A. Merchant & M. Krainer
Article: e1644109
Published online: 25 Jul 2019
AbstractforImmune checkpoint inhibitors in mCRPC - rationales, challenges and perspectives | Full Text | References | PDF (1.4 MB) | EPUB
  • 3184 Views
  • 19 CrossRef citations
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Open Access

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