Advanced search
Publication Cover
OncoImmunology Volume 8, 2019 - Issue 11
Submit an article Journal homepage
3,286
Views
23
CrossRef citations to date
0
Altmetric
Original Research

A theranostic PSMA ligand for PET imaging and retargeting of T cells expressing the universal chimeric antigen receptor UniCAR

Claudia ArndtDepartment of Radioimmunology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany
,
Anja FeldmannDepartment of Radioimmunology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany
,
Stefanie KoristkaDepartment of Radioimmunology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany
,
Martin SchäferDivision of Radiopharmaceutical Chemistry, German Cancer Research Center (DKFZ), Heidelberg, Germany
,
Ralf BergmannDepartment of Radioimmunology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, GermanyORCID Iconhttps://orcid.org/0000-0002-8733-4286
ORCID Icon,
Nicola MitwasiDepartment of Radioimmunology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany
,
Nicole BerndtDepartment of Radioimmunology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany
,
Dominik BachmannUniversityCancerCenter (UCC), Tumor Immunology, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany
,
Alexandra KeglerDepartment of Radioimmunology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany
,
Marc SchmitzInstitute of Immunology, Medical Faculty Carl Gustav Carus, TU Dresden, Dresden, Germany
,
Edinson Puentes-CalaCorporación para la Investigación de la Corrosión (CIC), Piedecuesta, Colombia
,
Javier Andrés SotoUniversidad de Santander, Cúcuta, Colombia
,
Gerhard EhningerGEMoaB Monoclonals GmbH, Dresden, Germany
,
Jens PietzschDepartment of Radioimmunology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany;Department of Chemistry and Food Chemistry, School of Science, TU Dresden, Dresden, GermanyORCID Iconhttps://orcid.org/0000-0002-1610-1493
ORCID Icon,
Christos LioliosDivision of Radiopharmaceutical Chemistry, German Cancer Research Center (DKFZ), Heidelberg, Germany
,
Gerd WunderlichDepartment of Nuclear Medicine, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany
,
Jörg KotzerkeDepartment of Radioimmunology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany;Department of Nuclear Medicine, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany;National Center for Tumor Diseases (NCT), partner site Dresden, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany
,
Klaus KopkaDivision of Radiopharmaceutical Chemistry, German Cancer Research Center (DKFZ), Heidelberg, Germany;German Cancer Consortium (DKTK), Heidelberg, Germany
&
Michael BachmannDepartment of Radioimmunology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany;UniversityCancerCenter (UCC), Tumor Immunology, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany;German Cancer Consortium (DKTK), Heidelberg, Germany;German Cancer Consortium (DKTK), partner site Dresden and German Cancer Research Center (DKFZ), Heidelberg, GermanyCorrespondence[email protected]
 show all
Article: 1659095 | Received 07 Jun 2019, Accepted 18 Aug 2019, Published online: 07 Sep 2019

Citations (23)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Anja Feldmann, Anja Hoffmann, Ralf Bergmann, Stefanie Koristka, Nicole Berndt, Claudia Arndt, Liliana Rodrigues Loureiro, Enrico Kittel-Boselli, Nicola Mitwasi, Alexandra Kegler, Chris Lamprecht, Karla Elizabeth González Soto & Michael Bachmann. (2020) Versatile chimeric antigen receptor platform for controllable and combinatorial T cell therapy. OncoImmunology 9:1.
Read now
Claudia Arndt, Liliana R. Loureiro, Anja Feldmann, Justyna Jureczek, Ralf Bergmann, Domokos Máthé, Nikolett Hegedüs, Nicole Berndt, Stefanie Koristka, Nicola Mitwasi, Frederick Fasslrinner, Chris Lamprecht, Alexandra Kegler, Anja Hoffmann, Tabea Bartsch, Ayşe Sedef Köseer, Gary Egan, Marc Schmitz, Vaclav Hořejší, Mechthild Krause, Anna Dubrovska & Michael Bachmann. (2020) UniCAR T cell immunotherapy enables efficient elimination of radioresistant cancer cells. OncoImmunology 9:1.
Read now

Articles from other publishers (21)

Keyvan Kheyrolahzadeh, Mohammad Reza Tohidkia, Ali Tarighatnia, Parviz Shahabi, Nader D. Nader & Ayuob Aghanejad. (2023) Theranostic chimeric antigen receptor (CAR)-T cells: Insight into recent trends and challenges in solid tumors. Life Sciences 328, pages 121917.
Crossref
Franziska Striese, Christin Neuber, Sandy Gräßel, Claudia Arndt, Martin Ullrich, Jörg Steinbach, Jens Pietzsch, Ralf Bergmann, Hans-Jürgen Pietzsch, Wiebke Sihver, Marcus Frenz, Anja Feldmann & Michael P. Bachmann. (2023) Preclinical Characterization of the 177Lu-Labeled Prostate Stem Cell Antigen (PSCA)-Specific Monoclonal Antibody 7F5. International Journal of Molecular Sciences 24:11, pages 9420.
Crossref
Ayse Sedef Köseer, Simona Di Gaetano, Claudia Arndt, Michael Bachmann & Anna Dubrovska. (2023) Immunotargeting of Cancer Stem Cells. Cancers 15:5, pages 1608.
Crossref
Charles Wynter, Navya Murugesan & Arutselvan Natarajan. 2022. Handbook of Cancer and Immunology. Handbook of Cancer and Immunology 1 34 .
Chunrun Qu, Hao Zhang, Hui Cao, Lanhua Tang, Haoyang Mo, Fangkun Liu, Liyang Zhang, Zhenjie Yi, Lifu Long, Luzhe Yan, Zeyu Wang, Nan Zhang, Peng Luo, Jian Zhang, Zaoqu Liu, Weijie Ye, Zhixiong Liu & Quan Cheng. (2022) Tumor buster - where will the CAR-T cell therapy ‘missile’ go?. Molecular Cancer 21:1.
Crossref
Diana Lindner, Claudia Arndt, Liliana Rodrigues Loureiro, Anja Feldmann, Alexandra Kegler, Stefanie Koristka, Nicole Berndt, Nicola Mitwasi, Ralf Bergmann, Marcus Frenz & Michael P. Bachmann. (2022) Combining Radiation- with Immunotherapy in Prostate Cancer: Influence of Radiation on T Cells. International Journal of Molecular Sciences 23:14, pages 7922.
Crossref
Trang Anh Nguyen-Le, Tabea Bartsch, Robert Wodtke, Florian Brandt, Claudia Arndt, Anja Feldmann, Diana Isabel Sandoval Bojorquez, Arnau Perez Roig, Bergoi Ibarlucea, Seungho Lee, Chan-Ki Baek, Gianaurelio Cuniberti, Ralf Bergmann, Edinson Puentes-Cala, Javier Andrés Soto, Biji T. Kurien, Michael Bachmann & Larysa Baraban. (2022) Nanosensors in clinical development of CAR-T cell immunotherapy. Biosensors and Bioelectronics 206, pages 114124.
Crossref
Claudia Arndt, Ralf Bergmann, Franziska Striese, Keresztély Merkel, Domokos Máthé, Liliana R. Loureiro, Nicola Mitwasi, Alexandra Kegler, Frederick Fasslrinner, Karla Elizabeth González Soto, Christin Neuber, Nicole Berndt, Noemi Kovács, David Szöllősi, Nikolett Hegedűs, Gyula Tóth, Jan-Philipp Emmermann, Kuzhuvelil B. Harikumar, Tibor Kovacs, Michael Bachmann & Anja Feldmann. (2022) Development and Functional Characterization of a Versatile Radio-/Immunotheranostic Tool for Prostate Cancer Management. Cancers 14:8, pages 1996.
Crossref
Manja Kubeil, Irma Martínez, Michael Bachmann, Klaus Kopka, Kellie Tuck & Holger Stephan. (2022) Dual-Labelling Strategies for Nuclear and Fluorescence Molecular Imaging: Current Status and Future Perspectives. Pharmaceuticals 15:4, pages 432.
Crossref
David Kersting, Stephan Settelmeier, Ilektra-Antonia Mavroeidi, Ken Herrmann, Robert Seifert & Christoph Rischpler. (2022) Shining Damaged Hearts: Immunotherapy-Related Cardiotoxicity in the Spotlight of Nuclear Cardiology. International Journal of Molecular Sciences 23:7, pages 3802.
Crossref
Lydia G. White, Hannah E. Goy, Alinor J. Rose & Alexander D. McLellan. (2022) Controlling Cell Trafficking: Addressing Failures in CAR T and NK Cell Therapy of Solid Tumours. Cancers 14:4, pages 978.
Crossref
Stanislav A. Petrov, Nikolay Y. Zyk, Aleksei E. Machulkin, Elena K. Beloglazkina & Alexander G. Majouga. (2021) PSMA-targeted low-molecular double conjugates for diagnostics and therapy. European Journal of Medicinal Chemistry 225, pages 113752.
Crossref
Tabea Bartsch, Claudia Arndt, Liliana R. Loureiro, Alexandra Kegler, Edinson Puentes-Cala, Javier Andrés Soto, Biji T. Kurien, Anja Feldmann, Nicole Berndt & Michael P. Bachmann. (2021) A Small Step, a Giant Leap: Somatic Hypermutation of a Single Amino Acid Leads to Anti-La Autoreactivity. International Journal of Molecular Sciences 22:21, pages 12046.
Crossref
Nicole Berndt, Claudia C. Bippes, Irene Michalk, Tabea Bartsch, Claudia Arndt, Edinson Puentes-Cala, Javier Andrés Soto, Liliana R. Loureiro, Alexandra Kegler, Dominik Bachmann, Joanne K. Gross, Tim Gross, Biji T. Kurien, R. Hal Scofield, A. Darise Farris, Judith A. James, Ralf Bergmann, Marc Schmitz, Anja Feldmann & Michael P. Bachmann. (2021) And Yet It Moves: Oxidation of the Nuclear Autoantigen La/SS-B Is the Driving Force for Nucleo-Cytoplasmic Shuttling. International Journal of Molecular Sciences 22:18, pages 9699.
Crossref
Martin WermkeSabrina KrausArmin EhningerRalf C. Bargou, Maria-Elisabeth Goebeler, Jan Moritz MiddekeCarla Kreissig, Malte von BoninJan KoedamMichael PehlMartin BornhäuserHermann EinseleGerhard EhningerMarc Cartellieri. (2021) Proof of concept for a rapidly switchable universal CAR-T platform with UniCAR-T-CD123 in relapsed/refractory AML. Blood 137:22, pages 3145-3148.
Crossref
Virginia Liberini, Riccardo Laudicella, Martina Capozza, Martin W. Huellner, Irene A. Burger, Sergio Baldari, Enzo Terreno & Désirée Deandreis. (2021) The Future of Cancer Diagnosis, Treatment and Surveillance: A Systemic Review on Immunotherapy and Immuno-PET Radiotracers. Molecules 26:8, pages 2201.
Crossref
Nicole Berndt, Claudia C. Bippes, Irene Michalk, Dominik Bachmann, Jennifer Bachmann, Edinson Puentes-Cala, Tabea Bartsch, Liliana R. Loureiro, Alexandra Kegler, Ralf Bergmann, Joanne K. Gross, Tim Gross, Biji T. Kurien, R. Hal Scofield, A. Darise Farris, Judith A. James, Marc Schmitz, Karim Fahmy, Anja Feldmann, Claudia Arndt & Michael P. Bachmann. (2021) Two Be or Not Two Be: The Nuclear Autoantigen La/SS-B Is Able to Form Dimers and Oligomers in a Redox Dependent Manner. International Journal of Molecular Sciences 22:7, pages 3377.
Crossref
Michael P. Bachmann, Tabea Bartsch, Claudia C. Bippes, Dominik Bachmann, Edinson Puentes-Cala, Jennifer Bachmann, Holger Bartsch, Claudia Arndt, Stefanie Koristka, Liliana R. Loureiro, Alexandra Kegler, Markus Laube, Joanne K. Gross, Tim Gross, Biji T. Kurien, R. Hal Scofield, A. Darise Farris, Judith A. James, Marc Schmitz & Anja Feldmann. (2021) T Cell Mediated Conversion of a Non-Anti-La Reactive B Cell to an Autoreactive Anti-La B Cell by Somatic Hypermutation. International Journal of Molecular Sciences 22:3, pages 1198.
Crossref
Ashley R. Sutherland, Madeline N. Owens & C. Ronald Geyer. (2020) Modular Chimeric Antigen Receptor Systems for Universal CAR T Cell Retargeting. International Journal of Molecular Sciences 21:19, pages 7222.
Crossref
Claudia Arndt, Frederick Fasslrinner, Liliana R. Loureiro, Stefanie Koristka, Anja Feldmann & Michael Bachmann. (2020) Adaptor CAR Platforms—Next Generation of T Cell-Based Cancer Immunotherapy. Cancers 12:5, pages 1302.
Crossref
Anja Feldmann, Claudia Arndt, Stefanie Koristka, Nicole Berndt, Ralf Bergmann & Michael P. Bachmann. (2019) Conventional CARs versus modular CARs. Cancer Immunology, Immunotherapy 68:10, pages 1713-1719.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.