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OncoImmunology Volume 9, 2020 - Issue 1
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Research Article

Clinical and immune responses to anti-CD3 x anti-EGFR bispecific antibody armed activated T cells (EGFR BATs) in pancreatic cancer patients

Lawrence G. Luma Stem Cell Transplantation Program, Division of Oncology/Hematology, Department of Medicine, University of Virginia Cancer Center, Charlottesville, VA, USACorrespondence[email protected]
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,
Archana Thakura Stem Cell Transplantation Program, Division of Oncology/Hematology, Department of Medicine, University of Virginia Cancer Center, Charlottesville, VA, USACorrespondence[email protected]
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,
Minsig Choib Department of Oncology, Stony Brook University, Stony Brook, NY, USAView further author information
,
Abhinav Deolc Department of Oncology, Barbara Ann Karmanos Cancer Institute and Wayne State University, Detroit, MI, USAView further author information
,
Vidya Kondadasulac Department of Oncology, Barbara Ann Karmanos Cancer Institute and Wayne State University, Detroit, MI, USAView further author information
,
Dana Schalka Stem Cell Transplantation Program, Division of Oncology/Hematology, Department of Medicine, University of Virginia Cancer Center, Charlottesville, VA, USAView further author information
,
Kristie Fieldsc Department of Oncology, Barbara Ann Karmanos Cancer Institute and Wayne State University, Detroit, MI, USAView further author information
,
Melissa Dufrensec Department of Oncology, Barbara Ann Karmanos Cancer Institute and Wayne State University, Detroit, MI, USAView further author information
,
Philip Philipc Department of Oncology, Barbara Ann Karmanos Cancer Institute and Wayne State University, Detroit, MI, USAView further author information
,
Gregory Dysonc Department of Oncology, Barbara Ann Karmanos Cancer Institute and Wayne State University, Detroit, MI, USAView further author information
,
Hussein D. Aond Department of Radiology, Barbara Ann Karmanos Cancer Institute and Wayne State University, Detroit, MI, USAView further author information
&
Anthony F. Shieldsc Department of Oncology, Barbara Ann Karmanos Cancer Institute and Wayne State University, Detroit, MI, USAView further author information
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Article: 1773201 | Received 18 Nov 2019, Accepted 15 May 2020, Published online: 10 Jun 2020

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Read on this site (4)

Manley T. F. Huang, Vikram Sharma, Andrew Mendelsohn, Qisheng Wei, Jinjing Li, Bo Yu, James W. Larrick & Lawrence G. Lum. (2022) Broad reactivity and enhanced potency of recombinant anti-EGFR × anti-CD3 bispecific antibody-armed activated T cells against solid tumours. Annals of Medicine 54:1, pages 1047-1057.
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Meixiao Long, Alice S. Mims & Zihai Li. (2022) Factors Affecting the Cancer Immunotherapeutic Efficacy of T Cell Bispecific Antibodies and Strategies for Improvement. Immunological Investigations 51:8, pages 2176-2214.
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Klara Dorman, Volker Heinemann, Sebastian Kobold, Michael von Bergwelt-Baildon & Stefan Boeck. (2022) Novel systemic treatment approaches for metastatic pancreatic cancer. Expert Opinion on Investigational Drugs 31:3, pages 249-262.
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Archana Thakur, Johnson Ung, Elyse N. Tomaszewski, Amy Schienschang, Timothy M. LaBrie, Dana L. Schalk & Lawrence G. Lum. (2021) Priming of pancreatic cancer cells with bispecific antibody armed activated T cells sensitizes tumors for enhanced chemoresponsiveness. OncoImmunology 10:1.
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Articles from other publishers (27)

Xiaorong Ye, Yue Yu, Xiaohu Zheng & Hongdi Ma. (2024) Clinical immunotherapy in pancreatic cancer. Cancer Immunology, Immunotherapy 73:4.
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Ningqiang Gong, Xuexiang Han, Lulu Xue, Margaret M. Billingsley, Xisha Huang, Rakan El-Mayta, Jingya Qin, Neil C. Sheppard, Carl H. June & Michael J. Mitchell. (2024) Small-molecule-mediated control of the anti-tumour activity and off-tumour toxicity of a supramolecular bispecific T cell engager. Nature Biomedical Engineering.
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Juan Wang, Ning Zhang, Xiuping Ding, Chengrui Fu, Xiaodong Li, Baosheng Li, Jianxun Ding & Tianmeng Sun. (2024) Targeted nanostrategies eliminate pre-metastatic niche of cancer. Nano Research.
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Tine Logghe, Eke van Zwol, Benoît Immordino, Kris Van den Cruys, Marc Peeters, Elisa Giovannetti & Johannes Bogers. (2024) Hyperthermia in Combination with Emerging Targeted and Immunotherapies as a New Approach in Cancer Treatment. Cancers 16:3, pages 505.
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Camilo E. Fadul, Archana Thakur, Jungeun Kim, Jessica Kassay-McAllister, Dana Schalk, M. Beatriz Lopes, Joseph Donahue, Benjamin Purow, Patrick Dillon, Tri Le, David Schiff, Qin Liu & Lawrence G. Lum. (2024) Phase I study targeting newly diagnosed grade 4 astrocytoma with bispecific antibody armed T cells (EGFR BATs) in combination with radiation and temozolomide. Journal of Neuro-Oncology 166:2, pages 321-330.
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Akhil Raj, Amal Babu, Vinoth Kumar Kothandan, In-Kyu Park & Seung Rim Hwang. (2023) Development of nano-immunotherapy for cancer treatment: achievements and scopes. Journal of Pharmaceutical Investigation 53:6, pages 827-844.
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Mary L. Faber, Robyn A. A. Oldham, Archana Thakur, Mary Jo Rademacher, Ewa Kubicka, Theresa A. Dlugi, Steven A. Gifford, William M. McKillop, Nathan J. Schloemer, Lawrence G. Lum & Jeffrey A. Medin. (2023) Novel anti-CD30/CD3 bispecific antibodies activate human T cells and mediate potent anti-tumor activity. Frontiers in Immunology 14.
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Diana C. Simão, Kevin K. Zarrabi, José L. Mendes, Ricardo Luz, Jorge A. Garcia, William K. Kelly & Pedro C. Barata. (2023) Bispecific T-Cell Engagers Therapies in Solid Tumors: Focusing on Prostate Cancer. Cancers 15:5, pages 1412.
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Ewa Kubicka, Lawrence G. Lum, Manley Huang & Archana Thakur. (2022) Bispecific antibody-targeted T-cell therapy for acute myeloid leukemia. Frontiers in Immunology 13.
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Elena Levantini, Giorgia Maroni, Marzia Del Re & Daniel G. Tenen. (2022) EGFR signaling pathway as therapeutic target in human cancers. Seminars in Cancer Biology 85, pages 253-275.
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Wanting Hou, Biao Yang & Hong Zhu. (2022) Nanoparticle-Based Therapeutic Strategies for Enhanced Pancreatic Ductal Adenocarcinoma Immunotherapy. Pharmaceutics 14:10, pages 2033.
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Seyed Amir Sanatkar, Arash Heidari & Nima Rezaei. (2022) Cancer Immunotherapy: Diverse Approaches and Obstacles. Current Pharmaceutical Design 28:29, pages 2387-2403.
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Marie Sorbara, Pierre Cordelier & Nicolas Bery. (2022) Antibody-Based Approaches to Target Pancreatic Tumours. Antibodies 11:3, pages 47.
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Keshav Kooragayala, Johanna Lou & Young Ki Hong. (2022) Current State of Cell Therapies for Gastrointestinal Cancers. The Cancer Journal 28:4, pages 310-321.
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Evangelos Koustas, Eleni-Myrto Trifylli, Panagiotis Sarantis, Nikolaos Papadopoulos, Eleni Karapedi, Georgios Aloizos, Christos Damaskos, Nikolaos Garmpis, Anna Garmpi, Kostas A. Papavassiliou, Michalis V. Karamouzis & Athanasios G. Papavassiliou. (2022) Immunotherapy as a Therapeutic Strategy for Gastrointestinal Cancer—Current Treatment Options and Future Perspectives. International Journal of Molecular Sciences 23:12, pages 6664.
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Laura A. Huppert, Veronica Mariotti, A. Jo Chien & Hatem H. Soliman. (2021) Emerging immunotherapeutic strategies for the treatment of breast cancer. Breast Cancer Research and Treatment 191:2, pages 243-255.
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Zhaoming Wang, Chaobo Yin, Lawrence G. Lum, Andrean Simons & George J. Weiner. (2021) Bispecific antibody-activated T cells enhance NK cell-mediated antibody-dependent cellular cytotoxicity. Journal of Hematology & Oncology 14:1.
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Kirit Singh, Kelly M Hotchkiss, Aditya A Mohan, Jessica L Reedy, John H Sampson & Mustafa Khasraw. (2021) For whom the T cells troll? Bispecific T-cell engagers in glioblastoma. Journal for ImmunoTherapy of Cancer 9:11, pages e003679.
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Barbara Mandriani, Eleonora Pelle'Gaetano Pezzicoli, Jonathan Strosberg, Daniel Abate-Daga, Attilio Guarini, Mauro Cives & Camillo Porta. (2021) Adoptive T-cell immunotherapy in digestive tract malignancies: Current challenges and future perspectives. Cancer Treatment Reviews 100, pages 102288.
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Archana Thakur, John Scholler, Ewa Kubicka, Edwin T. Bliemeister, Dana L. Schalk, Carl H. June & Lawrence G. Lum. (2021) Bispecific Antibody Armed Metabolically Enhanced Headless CAR T Cells. Frontiers in Immunology 12.
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Jeong A Park, Brian H Santich, Hong Xu, Lawrence G Lum & Nai-Kong V Cheung. (2021) Potent ex vivo armed T cells using recombinant bispecific antibodies for adoptive immunotherapy with reduced cytokine release. Journal for ImmunoTherapy of Cancer 9:5, pages e002222.
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Lawrence G. Lum & Jogender Tushir-Singh. (2021) Arming “old guards” with “new dual-targeting weapons”. Cancer Cell 39:5, pages 604-606.
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James W. Smithy & Eileen M. O'Reilly. (2021) Pancreas cancer: Therapeutic trials in metastatic disease. Journal of Surgical Oncology 123:6, pages 1475-1488.
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Ajit Singh, Sundee Dees & Iqbal S. Grewal. (2021) Overcoming the challenges associated with CD3+ T-cell redirection in cancer. British Journal of Cancer 124:6, pages 1037-1048.
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Cédric Leroux & Georgia Konstantinidou. (2021) Targeted Therapies for Pancreatic Cancer: Overview of Current Treatments and New Opportunities for Personalized Oncology. Cancers 13:4, pages 799.
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Binbin Zheng-Lin & Eileen M. O’Reilly. 2023. Immune Strategies for Gastrointestinal Cancer. Immune Strategies for Gastrointestinal Cancer 221 255 .
Steven B. Maron, James Xu & Yelena Y. Janjigian. (2020) Targeting EGFR in Esophagogastric Cancer. Frontiers in Oncology 10.
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