5,237
Views
77
CrossRef citations to date
0
Altmetric
Review

Tumor-derived exosomes: the next generation of promising cell-free vaccines in cancer immunotherapy

, , , &
Article: 1779991 | Received 27 Jan 2020, Accepted 03 Jun 2020, Published online: 16 Jun 2020

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Adriana Petrazzuolo, M. Chiara Maiuri, Laurence Zitvogel, Guido Kroemer & Oliver Kepp. (2022) Trial Watch: combination of tyrosine kinase inhibitors (TKIs) and immunotherapy. OncoImmunology 11:1.
Read now
Yongqin Deng, Yujie Cao, Liuqian Wang & Dong Ye. (2021) The Role and Application of Salivary Exosomes in Malignant Neoplasms. Cancer Management and Research 13, pages 5813-5820.
Read now
Amrita Das & Nahid Ali. (2021) Nanovaccine: an emerging strategy. Expert Review of Vaccines 20:10, pages 1273-1290.
Read now

Articles from other publishers (74)

Jinyu Guo, Changhua Liu, Zhaoyang Qi, Ting Qiu, Jin Zhang & Huanghao Yang. (2024) Engineering customized nanovaccines for enhanced cancer immunotherapy. Bioactive Materials 36, pages 330-357.
Crossref
Xiao Cheng, Brian S. Henick & Ke Cheng. (2024) Anticancer Therapy Targeting Cancer-Derived Extracellular Vesicles. ACS Nano 18:9, pages 6748-6765.
Crossref
Nils Piernitzki & Oskar Staufer. (2023) From Theory to Therapy: The Advancements of Extracellular Vesicles in Immunotherapy. Advanced Therapeutics 7:3.
Crossref
Gulixian Tuluwengjiang, Irodakhon Rasulova, Shamim Ahmed, Bahman Abedi Kiasari, Ioan Sârbu, Carmen Iulia Ciongradi, Thabit Moath Omar, Farah Hussain, Mahmood Jasem Jawad, Roxana Yolanda Castillo-Acobo, Thamer Hani, Natrayan Lakshmaiya & Severo Simeón Calderón Samaniego. (2024) Dendritic cell-derived exosomes (Dex): Underlying the role of exosomes derived from diverse DC subtypes in cancer pathogenesis. Pathology - Research and Practice 254, pages 155097.
Crossref
Xinyi Zhang, Mengya Zhang, Hengqing Cui, Tinglin Zhang, Lili Wu, Can Xu, Chuan Yin & Jie Gao. (2024) Autophagy-modulating biomembrane nanostructures: A robust anticancer weapon by modulating the inner and outer cancer environment. Journal of Controlled Release 366, pages 85-103.
Crossref
Fei Tan, Xuran Li, Zhao Wang, Jiaojiao Li, Khawar Shahzad & Jialin Zheng. (2024) Clinical applications of stem cell-derived exosomes. Signal Transduction and Targeted Therapy 9:1.
Crossref
Sangiliyandi Gurunathan, Pratheep Thangaraj, Lin Wang, Qilong Cao & Jin-Hoi Kim. (2024) Nanovaccines: An effective therapeutic approach for cancer therapy. Biomedicine & Pharmacotherapy 170, pages 115992.
Crossref
Haoyang Zheng, Ning Su, Guoquan Yan, Mengran Li, Huimin Chu, Jin Zhang, Bing Li, Jiandong Zhao, Jiaxi Wang, Mingxia Gao & Xiangmin Zhang. (2024) Immunomagnetic capture and traceless release of native tumor-derived exosomes from human plasma for exploring interaction with recipient cells by aptamer-functionalized nanoflowers. Analytica Chimica Acta 1287, pages 342109.
Crossref
Ali Al-Jipouri, Àuria Eritja & Milica Bozic. (2023) Unraveling the Multifaceted Roles of Extracellular Vesicles: Insights into Biology, Pharmacology, and Pharmaceutical Applications for Drug Delivery. International Journal of Molecular Sciences 25:1, pages 485.
Crossref
Can Liu, Cong Xia & Chenglai Xia. (2023) Biology and function of exosomes in tumor immunotherapy. Biomedicine & Pharmacotherapy 169, pages 115853.
Crossref
Laura Dietz, Jennifer Oberländer, Ana Mateos‐Maroto, Jenny Schunke, Michael Fichter, Eva‐Maria Krämer‐Albers, Katharina Landfester & Volker Mailänder. (2023) Uptake of extracellular vesicles into immune cells is enhanced by the protein corona. Journal of Extracellular Vesicles 12:12.
Crossref
Donatella Lucchetti, Filomena Colella, Giulia Artemi, Shafiul Haque, Alessandro Sgambato, Rinaldo Pellicano & Sharmila Fagoonee. (2023) Smart nano-sized extracellular vesicles for cancer therapy: Potential theranostic applications in gastrointestinal tumors. Critical Reviews in Oncology/Hematology 191, pages 104121.
Crossref
Sajad Najafi, Jamal Majidpoor & Keywan Mortezaee. (2023) Extracellular vesicle–based drug delivery in cancer immunotherapy. Drug Delivery and Translational Research 13:11, pages 2790-2806.
Crossref
Rasanpreet Kaur, Alok Bhardwaj & Saurabh Gupta. (2023) Cancer treatment therapies: traditional to modern approaches to combat cancers. Molecular Biology Reports 50:11, pages 9663-9676.
Crossref
Xiwei Wang, Yanmei Zhang, Yuet Chung, Chloe Ran Tu, Wenyue Zhang, Xiaofeng Mu, Manni Wang, Godfrey Chi‐Fung Chan, Wing‐Hang Leung, Yu‐Lung Lau, Yinping Liu & Wenwei Tu. (2023) Tumor vaccine based on extracellular vesicles derived from γδ‐T cells exerts dual antitumor activities. Journal of Extracellular Vesicles 12:9.
Crossref
Naushad Ahmad Khan, Mohammad Asim, Kabir H. Biswas, Amani N Alansari, Harman Saman, Mohammad Zahid Sarwar, Kudaibergen Osmonaliev & Shahab Uddin. (2023) Exosome nanovesicles as potential biomarkers and immune checkpoint signaling modulators in lung cancer microenvironment: recent advances and emerging concepts. Journal of Experimental & Clinical Cancer Research 42:1.
Crossref
Kyu-Won Lee, Judy Wai Ping Yam & Xiaowen Mao. (2023) Dendritic Cell Vaccines: A Shift from Conventional Approach to New Generations. Cells 12:17, pages 2147.
Crossref
Yiming Wu, Zhe Zhang, Yuquan Wei, Zhiyong Qian & Xiawei Wei. (2023) Nanovaccines for cancer immunotherapy: Current knowledge and future perspectives. Chinese Chemical Letters 34:8, pages 108098.
Crossref
Joonsu Han, Rimsha Bhatta & Hua Wang. (2023) Bio-adhesive Macroporous Hydrogels for In Situ Recruitment and Modulation of Dendritic Cells. Cellular and Molecular Bioengineering 16:4, pages 355-367.
Crossref
Quentin Roux, Robin Boiy, Felix De Vuyst, Mercedes Tkach, Claudio Pinheiro, Sofie de Geyter, Ilkka Miinalainen, Clotilde Théry, Olivier De Wever & An Hendrix. (2023) Depletion of soluble cytokines unlocks the immunomodulatory bioactivity of extracellular vesicles. Journal of Extracellular Vesicles 12:8.
Crossref
Jianmei Guo, Lin Tang, Kelin Li, Qingxin Ma, Shuda Luo, Ruoyu Cheng & Chaoyong Liu. (2023) Application of Nanotechnology in Therapeutic Cancer Vaccines. Advanced NanoBiomed Research 3:7.
Crossref
Ana Macedo-Pereira, Cláudia Martins, Jorge Lima & Bruno Sarmento. (2023) Digging the intercellular crosstalk via extracellular vesicles: May exosomes be the drug delivery solution for target glioblastoma?. Journal of Controlled Release 358, pages 98-115.
Crossref
Chenchao Feng, Peng Tan, Guangjun Nie & Motao Zhu. (2023) Biomimetic and bioinspired nano‐platforms for cancer vaccine development. Exploration 3:3.
Crossref
David W. Greening, Rong Xu, Anukreity Ale, Christoph E. Hagemeyer & Weisan Chen. (2023) Extracellular vesicles as next generation immunotherapeutics. Seminars in Cancer Biology 90, pages 73-100.
Crossref
Xinyi Zhang, Hengqing Cui, Wenjun Zhang, Zhaoshen Li & Jie Gao. (2023) Engineered tumor cell-derived vaccines against cancer: The art of combating poison with poison. Bioactive Materials 22, pages 491-517.
Crossref
Ali Karimi Sisakht, Mohammad Malekan, Farbod Ghobadinezhad, Seyedeh Negar Mousavi Firouzabadi, Ameneh Jafari, Seyed Mohammad Ali Mirazimi, Banafshe Abadi, Rana Shafabakhsh & Hamed Mirzaei. (2022) Cellular Conversations in Glioblastoma Progression, Diagnosis and Treatment. Cellular and Molecular Neurobiology 43:2, pages 585-603.
Crossref
Yun Lv, Xiaobo Du, Wenqiang Tang, Qian Yang & Feng Gao. (2023) Exosomes: The Role in Tumor Tolerance and the Potential Strategy for Tumor Therapy. Pharmaceutics 15:2, pages 462.
Crossref
Fangyuan Xie, Yueying Huang, Yangyang Zhan & Leilei Bao. (2023) Exosomes as drug delivery system in gastrointestinal cancer. Frontiers in Oncology 12.
Crossref
Guixiu Xiao, Zihan Xu & Feng Luo. (2023) Combinational antitumor strategies of exosomes as drug carriers: Mini review. Frontiers in Pharmacology 13.
Crossref
Hye-Ran Kim, Jeong-Su Park, Won-Chang Soh, Na-Young Kim, Hyun-Yoong Moon, Ji-Su LeeChang-Duk Jun. (2023) T Cell Microvilli: Finger-Shaped External Structures Linked to the Fate of T Cells. Immune Network 23:1.
Crossref
Ajay Prakash, Travis Gates, Xianda Zhao, Dechen Wangmo & Subbaya Subramanian. (2023) Tumor-derived extracellular vesicles in the colorectal cancer immune environment and immunotherapy. Pharmacology & Therapeutics 241, pages 108332.
Crossref
Xintong Zhou, Qi Liu, Xiaomin Wang, Xiaoyu Yao, Baogang Zhang, Jibiao Wu & Changgang Sun. (2023) Exosomal ncRNAs facilitate interactive ‘dialogue’ between tumor cells and tumor-associated macrophages. Cancer Letters 552, pages 215975.
Crossref
Shubhankhi Dey & Gajendra B. Singh. 2023. Nanovaccinology. Nanovaccinology 281 299 .
Jian Gao, Xiaodong Zhang, Lei Jiang, Yan Li & Qianqian Zheng. (2022) Tumor endothelial cell-derived extracellular vesicles contribute to tumor microenvironment remodeling. Cell Communication and Signaling 20:1.
Crossref
Seyedeh Alia Moosavian, Maryam Hashemi, Leila Etemad, Sara Daneshmand & Zahra Salmasi. (2022) Melanoma-derived exosomes: Versatile extracellular vesicles for diagnosis, metastasis, immune modulation, and treatment of melanoma. International Immunopharmacology 113, pages 109320.
Crossref
Ling Zhang, Mengchi Sun, Zhonggui He, Jin Sun, Heran Li & Qiuhua Luo. (2022) Multi-functional extracellular vesicles: Potentials in cancer immunotherapy. Cancer Letters 551, pages 215934.
Crossref
Julie Joseph, Benjamin Rahmani, Yonesha Cole, Neha Puttagunta, Edward Lin, Zafar K. Khan & Pooja Jain. (2021) Can Soluble Immune Checkpoint Molecules on Exosomes Mediate Inflammation?. Journal of Neuroimmune Pharmacology 17:3-4, pages 381-397.
Crossref
Jiaqi Li, Fang Huang, Yan Jiang, Jie Zhao, Jiangbo Wan & Siguo Hao. (2022) A novel costimulatory molecule gene-modified leukemia cell-derived exosome-targeted CD4+ T cell vaccine efficiently enhances anti-leukemia immunity. Frontiers in Immunology 13.
Crossref
Mathilde Regimbeau, Jimena Abrey, Valentin Vautrot, Sebastien Causse, Jessica Gobbo & Carmen Garrido. (2022) Heat shock proteins and exosomes in cancer theranostics. Seminars in Cancer Biology 86, pages 46-57.
Crossref
Yen N. Diep, Tae Jin Kim, Hansang Cho & Luke P. Lee. (2022) Nanomedicine for advanced cancer immunotherapy. Journal of Controlled Release 351, pages 1017-1037.
Crossref
Xing Huang, Gang Zhang, Tian-Yu Tang, Xiang Gao & Ting-Bo Liang. (2022) Personalized pancreatic cancer therapy: from the perspective of mRNA vaccine. Military Medical Research 9:1.
Crossref
Man Li, Hongzhen Cai, Ruiyi Deng, Jin Cheng & Yanyan Shi. (2022) Effects of exosomes on tumor immunomodulation and their potential clinical applications (Review). International Journal of Oncology 61:6.
Crossref
Eric Z. Zeng, Isabelle Chen, Xingchi Chen & Xuegang Yuan. (2022) Exosomal MicroRNAs as Novel Cell-Free Therapeutics in Tissue Engineering and Regenerative Medicine. Biomedicines 10:10, pages 2485.
Crossref
Shan Liu, Xue Wu, Sutapa Chandra, Christopher Lyon, Bo Ning, Li jiang, Jia Fan & Tony Y. Hu. (2022) Extracellular vesicles: Emerging tools as therapeutic agent carriers. Acta Pharmaceutica Sinica B 12:10, pages 3822-3842.
Crossref
Nna-Emeka Onukwugha, Yoon-Tae Kang & Sunitha Nagrath. (2022) Emerging micro-nanotechnologies for extracellular vesicles in immuno-oncology: from target specific isolations to immunomodulation. Lab on a Chip 22:18, pages 3314-3339.
Crossref
Deepak S. Chauhan, Priyanka Mudaliar, Soumya Basu, Jyotirmoi Aich & Manash K. Paul. 2022. Extracellular Vesicles - Role in Diseases, Pathogenesis and Therapy. Extracellular Vesicles - Role in Diseases, Pathogenesis and Therapy.
Elham Zokaei, Farzaneh Darbeheshti & Nima Rezaei. (2022) Prospect of exosomal circular RNAs in breast Cancer: presents and future. Molecular Biology Reports 49:7, pages 6997-7011.
Crossref
Wenwen Guo, Tianyun Qiao, Bingwei Dong, Tian Li, Qiang Liu & Xiaofeng Xu. (2022) The Effect of Hypoxia-Induced Exosomes on Anti-Tumor Immunity and Its Implication for Immunotherapy. Frontiers in Immunology 13.
Crossref
Yanan Zheng, Mei Li, Bowen Weng, Haijiao Mao & Jiyuan Zhao. (2022) Exosome-based delivery nanoplatforms: next-generation theranostic platforms for breast cancer. Biomaterials Science 10:7, pages 1607-1625.
Crossref
Ming-Hsien Chan, Zhi-Xuan Chang, Chi-Ying F. Huang, L. James Lee, Ru-Shi Liu & Michael Hsiao. (2022) Integrated therapy platform of exosomal system: hybrid inorganic/organic nanoparticles with exosomes for cancer treatment. Nanoscale Horizons 7:4, pages 352-367.
Crossref
Md Walid Akram Hussain, Sarah Jahangir, Bikona Ghosh, Farjana Yesmin, Afnan Anis, Sabikun Nahar Satil, Faizan Anwar & Mohammad Harun Rashid. (2022) Exosomes for Regulation of Immune Responses and Immunotherapy. Journal of Nanotheranostics 3:1, pages 55-85.
Crossref
Zhouqi Meng, Yaojia Zhang, Xuanfang Zhou, Jiansong Ji & Zhuang Liu. (2022) Nanovaccines with cell-derived components for cancer immunotherapy. Advanced Drug Delivery Reviews 182, pages 114107.
Crossref
Zainuddin Quadri, Ahmed Elsherbini & Erhard Bieberich. (2022) Extracellular vesicles in pharmacology: Novel approaches in diagnostics and therapy. Pharmacological Research 175, pages 105980.
Crossref
Dixita Ishani Viswanath, Hsuan-Chen Liu, David P. Huston, Corrine Ying Xuan Chua & Alessandro Grattoni. (2022) Emerging biomaterial-based strategies for personalized therapeutic in situ cancer vaccines. Biomaterials 280, pages 121297.
Crossref
Yin Ji Piao, So-Hyun Yoon, Hoe Suk Kim, Woo Kyung Moon & Wonshik Han. (2021) Application of immunotherapy based on dendritic cells stimulated by tumor cell-derived exosomes in a syngeneic breast tumor mouse model. Biochemistry and Biophysics Reports 28, pages 101136.
Crossref
Rashmi Rana, Swati Sharma & Nirmal Kumar Ganguly. (2021) Comprehensive overview of extracellular vesicle proteomics in meningioma: future strategy. Molecular Biology Reports 48:12, pages 8061-8074.
Crossref
Shiu-Jau Chen, Shao-Cheng Wang & Yuan-Chuan Chen. (2021) The Immunotherapy for Colorectal Cancer, Lung Cancer and Pancreatic Cancer. International Journal of Molecular Sciences 22:23, pages 12836.
Crossref
Qi Chen, Yuefeng Li, Wujiang Gao, Lu Chen, Wenlin Xu & Xiaolan Zhu. (2021) Exosome-Mediated Crosstalk Between Tumor and Tumor-Associated Macrophages. Frontiers in Molecular Biosciences 8.
Crossref
Filipa D. Oliveira, Miguel A. R. B. Castanho & Vera Neves. (2021) Exosomes and Brain Metastases: A Review on Their Role and Potential Applications. International Journal of Molecular Sciences 22:19, pages 10899.
Crossref
Alfredo Cappariello & Nadia Rucci. (2021) Extracellular Vesicles in Bone Tumors: How to Seed in the Surroundings Molecular Information for Malignant Transformation and Progression. Frontiers in Oncology 11.
Crossref
Nika Kučuk, Mateja Primožič, Željko Knez & Maja Leitgeb. (2021) Exosomes Engineering and Their Roles as Therapy Delivery Tools, Therapeutic Targets, and Biomarkers. International Journal of Molecular Sciences 22:17, pages 9543.
Crossref
Ghadi N. Alzhrani, Sarah T. Alanazi, Sumayyah Y. Alsharif, Amani M. Albalawi, Anwar A. Alsharif, Mohamed S. Abdel‐Maksoud & Nehal Elsherbiny. (2021) Exosomes: Isolation, characterization, and biomedical applications. Cell Biology International 45:9, pages 1807-1831.
Crossref
Yi Yao, Chunmei Fu, Li Zhou, Qing-Sheng Mi & Aimin Jiang. (2021) DC-Derived Exosomes for Cancer Immunotherapy. Cancers 13:15, pages 3667.
Crossref
Lingyun Wang, Zhichao Sun & Hongmei Wang. (2021) Extracellular vesicles and the regulation of tumor immunity: Current progress and future directions. Journal of Cellular Biochemistry 122:7, pages 760-769.
Crossref
Hai-Tao Luo, Yuan-Yuan Zheng, Jun Tang, Li-Juan Shao, Yi-Heng Mao, Wei Yang, Xiao-Fei Yang, Yang Li, Rui-Jun Tian & Fu-Rong Li. (2021) Dissecting the multi-omics atlas of the exosomes released by human lung adenocarcinoma stem-like cells. npj Genomic Medicine 6:1.
Crossref
Nafiseh Pakravan, Ardeshir Abbasi & Zuhair Mohammad Hassan. (2021) Immunotherapy Using Oxygenated Water and Tumor-Derived Exosomes Potentiates Antitumor Immune Response and Attenuates Malignancy Tendency in Mice Model of Breast Cancer. Oxidative Medicine and Cellular Longevity 2021, pages 1-15.
Crossref
Shenglong Li & Wei Wang. (2021) Extracellular Vesicles in Tumors: A Potential Mediator of Bone Metastasis. Frontiers in Cell and Developmental Biology 9.
Crossref
Marzieh Naseri, Margot Zöller, Jamshid Hadjati, Roya Ghods, Ehsan Ranaei Pirmardan, Jafar Kiani, Leila Eini, Mahmood Bozorgmehr & Zahra Madjd. (2021) Dendritic cells loaded with exosomes derived from cancer stem cell‐enriched spheroids as a potential immunotherapeutic option. Journal of Cellular and Molecular Medicine 25:7, pages 3312-3326.
Crossref
Akhil Srivastava, Shipra Rathore, Anupama Munshi & Rajagopal Ramesh. (2021) Extracellular Vesicles in Oncology: from Immune Suppression to Immunotherapy. The AAPS Journal 23:2.
Crossref
Andrés Rincón-Riveros, Liliana Lopez, E Victoria Villegas & Josefa Antonia Rodriguez. (2021) Regulation of Antitumor Immune Responses by Exosomes Derived from Tumor and Immune Cells. Cancers 13:4, pages 847.
Crossref
Zhijie Xu, Shuangshuang Zeng, Zhicheng Gong & Yuanliang Yan. (2020) Exosome-based immunotherapy: a promising approach for cancer treatment. Molecular Cancer 19:1.
Crossref
Irene Fernández-Delgado, Diego Calzada-Fraile & Francisco Sánchez-Madrid. (2020) Immune Regulation by Dendritic Cell Extracellular Vesicles in Cancer Immunotherapy and Vaccines. Cancers 12:12, pages 3558.
Crossref
Paulo Rodrigues, Catarina Melim, Francisco Veiga & Ana Figueiras. (2020) An Overview of Exosomes in Cancer Therapy: A Small Solution to a Big Problem. Processes 8:12, pages 1561.
Crossref
Chunmei Fu, Li Zhou, Qing-Sheng Mi & Aimin Jiang. (2020) DC-Based Vaccines for Cancer Immunotherapy. Vaccines 8:4, pages 706.
Crossref