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OncoImmunology Volume 9, 2020 - Issue 1
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Brief Report

IDH-mutant gliomas harbor fewer regulatory T cells in humans and mice

Leland G. Richardsona Translational Brain Tumor Immunology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;b Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USAView further author information
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Linda T. Niemanc Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USAView further author information
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Anat O. Stemmer-Rachamimovd Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USAView further author information
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Xijin S. Zhenga Translational Brain Tumor Immunology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;b Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USAView further author information
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Khalifa Stafforda Translational Brain Tumor Immunology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;b Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USAView further author information
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Hiroaki Nagashimab Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USAView further author information
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Julie J. Millerb Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USAView further author information
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Juri Kiyokawab Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USAView further author information
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David T. Tingc Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USAView further author information
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Hiroaki Wakimotob Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USAView further author information
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Daniel P. Cahillb Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USAView further author information
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Bryan D. Choia Translational Brain Tumor Immunology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;b Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USACorrespondence[email protected]
View further author information
&
William T. Currya Translational Brain Tumor Immunology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;b Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USACorrespondence[email protected]
View further author information
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Article: 1806662 | Received 18 May 2020, Accepted 04 Aug 2020, Published online: 20 Aug 2020

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Yingqian Ni, Peibo Shen, Xingchen Wang, He Liu, Huiyuan Luo & Xiuzhen Han. (2022) The Roles of IDH1 in Tumor Metabolism and Immunity. Future Oncology 18:35, pages 3941-3953.
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Nazareno Gonzalez, Antonela S. Asad, José Gómez Escalante, Jorge A. Peña Agudelo, Alejandro J. Nicola Candia, Matías García Fallit, Adriana Seilicovich & Marianela Candolfi. (2021) Potential of IDH mutations as immunotherapeutic targets in gliomas: a review and meta-analysis. Expert Opinion on Therapeutic Targets 25:12, pages 1045-1060.
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Dandan Fan, Qi Yue, Jian Chen, Cong Wang, Ruilin Yu, Ziyi Jin, Shujie Yin, Qinyue Wang, Luo Chen, Xueling Liao, Chengyuan Peng, Jianpin Zhang, Zhonglian Cao, Ying Mao, Ruimin Huang, Liang Chen & Cong Li. (2021) Reprogramming the immunosuppressive microenvironment of IDH1 wild-type glioblastoma by blocking Wnt signaling between microglia and cancer cells. OncoImmunology 10:1.
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Aleksei A. Stepanenko, Anastasiia O. Sosnovtseva, Marat P. Valikhov, Anastasia A. Chernysheva, Olga V. Abramova, Konstantin A. Pavlov & Vladimir P. Chekhonin. (2024) Systemic and local immunosuppression in glioblastoma and its prognostic significance. Frontiers in Immunology 15.
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Ye Zheng, Xiaoyu Ma, Shouchang Feng, Hongtao Zhu, Xin Chen, Xingjiang Yu, Kai Shu & Suojun Zhang. (2023) Dendritic cell vaccine of gliomas: challenges from bench to bed. Frontiers in Immunology 14.
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Haiwei Wang, Xinrui Wang, Liangpu Xu & Ji Zhang. (2023) RARRES2 is Downregulated in Isocitrate Dehydrogenase 1 Mutant Glioma Patients and Served as an Unfavorable Prognostic Factor of Glioma. World Neurosurgery 176, pages e610-e622.
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Guihua Tang, Jianqiao Peng, Longwei Huo & Wen Yin. (2023) An N6-methyladenosine regulation- and mRNAsi-related prognostic index reveals the distinct immune microenvironment and immunotherapy responses in lower-grade glioma. BMC Bioinformatics 24:1.
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Antoinette van Weverwijk & Karin E. de Visser. (2023) Mechanisms driving the immunoregulatory function of cancer cells. Nature Reviews Cancer 23:4, pages 193-215.
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Yang Li, Yabo Feng, Fushu Luo, Gang Peng & Yueran Li. (2023) Positive regulators of T cell functions as predictors of prognosis and microenvironment characteristics of low-grade gliomas. Frontiers in Immunology 13.
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Quentin Richard, Alice Laurenge, Michel Mallat, Marc Sanson & Luis Jaime Castro-Vega. (2022) New insights into the Immune TME of adult-type diffuse gliomas. Current Opinion in Neurology 35:6, pages 794-802.
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Andrea Franson, Brandon L. McClellan, Maria Luisa Varela, Andrea Comba, Mohammad Faisal Syed, Kaushik Banerjee, Ziwen Zhu, Nazareno Gonzalez, Marianela Candolfi, Pedro Lowenstein & Maria Graciela Castro. (2022) Development of immunotherapy for high-grade gliomas: Overcoming the immunosuppressive tumor microenvironment. Frontiers in Medicine 9.
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Feng Tang, Zhiyong Pan, Yi Wang, Tian Lan, Mengyue Wang, Fengping Li, Wei Quan, Zhenyuan Liu, Zefen Wang & Zhiqiang Li. (2022) Advances in the Immunotherapeutic Potential of Isocitrate Dehydrogenase Mutations in Glioma. Neuroscience Bulletin 38:9, pages 1069-1084.
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Yuheng Yan, Lan Huang, Yiming Liu, Ming Yi, Qian Chu, Dechao Jiao & Kongming Wu. (2022) Metabolic profiles of regulatory T cells and their adaptations to the tumor microenvironment: implications for antitumor immunity. Journal of Hematology & Oncology 15:1.
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Chunzhao Li, Yi Wang, Lang Long, Peng Zhang, Yang Zhang & Nan Ji. (2022) gp96 Expression in Gliomas and Its Association with Tumor Malignancy and T Cell Infiltrating Level. Journal of Oncology 2022, pages 1-14.
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Dongming Yan, Weicheng Li, Qibing Liu & Kun Yang. (2022) Advances in Immune Microenvironment and Immunotherapy of Isocitrate Dehydrogenase Mutated Glioma. Frontiers in Immunology 13.
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Debo Yun, Xuya Wang, Wenbo Wang, Xiao Ren, Jiabo Li, Xisen Wang, Jianshen Liang, Jie Liu, Jikang Fan, Xiude Ren, Hao Zhang, Guanjie Shang, Jingzhang Sun, Lei Chen, Tao Li, Chen Zhang, Shengping Yu & Xuejun Yang. (2022) A Novel Prognostic Signature Based on Glioma Essential Ferroptosis-Related Genes Predicts Clinical Outcomes and Indicates Treatment in Glioma. Frontiers in Oncology 12.
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Ana Paula Candiota & Carles Arús. (2022) Establishing Imaging Biomarkers of Host Immune System Efficacy during Glioblastoma Therapy Response: Challenges, Obstacles and Future Perspectives. Metabolites 12:3, pages 243.
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Leland G. Richardson, Julie J. Miller, Yosuke Kitagawa, Hiroaki Wakimoto, Bryan D. Choi & William T. Curry. (2022) Implications of IDH mutations on immunotherapeutic strategies for malignant glioma. Neurosurgical Focus 52:2, pages E6.
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Angeliki Datsi & Rüdiger V. Sorg. (2021) Dendritic Cell Vaccination of Glioblastoma: Road to Success or Dead End. Frontiers in Immunology 12.
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Hongye Bi & Chunzhi Zhang. (2021) Extrinsic factors associated with the response to immunotherapy in glioblastoma. Cancer Letters 511, pages 47-55.
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Wanzun Lin, Xianxin Qiu, Pian Sun, Yuling Ye, Qingting Huang, Lin Kong & Jiade J. Lu. (2021) Association of IDH mutation and 1p19q co-deletion with tumor immune microenvironment in lower-grade glioma. Molecular Therapy - Oncolytics 21, pages 288-302.
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