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OncoImmunology Volume 10, 2021 - Issue 1
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Research Article

Novel adapter CAR-T cell technology for precisely controllable multiplex cancer targeting

Christian M. Seitza Department of General Pediatrics, Hematology and Oncology, University Children’s Hospital Tuebingen, GermanyORCID Iconhttps://orcid.org/0000-0002-0520-7866View further author information
ORCID Icon,
Joerg Mittelstaetb R&D Department, Miltenyi Biotec GmbH, Bergisch Gladbach, GermanyView further author information
,
Daniel Atara Department of General Pediatrics, Hematology and Oncology, University Children’s Hospital Tuebingen, GermanyView further author information
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Jana Haua Department of General Pediatrics, Hematology and Oncology, University Children’s Hospital Tuebingen, GermanyView further author information
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Selina Reitera Department of General Pediatrics, Hematology and Oncology, University Children’s Hospital Tuebingen, GermanyView further author information
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Clara Illia Department of General Pediatrics, Hematology and Oncology, University Children’s Hospital Tuebingen, GermanyView further author information
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Verena Kieblea Department of General Pediatrics, Hematology and Oncology, University Children’s Hospital Tuebingen, GermanyView further author information
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Fabian Engertb R&D Department, Miltenyi Biotec GmbH, Bergisch Gladbach, GermanyView further author information
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Britta Dreesb R&D Department, Miltenyi Biotec GmbH, Bergisch Gladbach, GermanyView further author information
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Giulia Bendera Department of General Pediatrics, Hematology and Oncology, University Children’s Hospital Tuebingen, GermanyView further author information
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Ann-Christin Krahla Department of General Pediatrics, Hematology and Oncology, University Children’s Hospital Tuebingen, GermanyView further author information
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Philipp Knopfc Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen, GermanyView further author information
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Sarah Schroedera Department of General Pediatrics, Hematology and Oncology, University Children’s Hospital Tuebingen, GermanyView further author information
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Nikolas Paulsena Department of General Pediatrics, Hematology and Oncology, University Children’s Hospital Tuebingen, GermanyView further author information
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Alexander Rokhvarguera Department of General Pediatrics, Hematology and Oncology, University Children’s Hospital Tuebingen, GermanyView further author information
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Sophia Scheuermanna Department of General Pediatrics, Hematology and Oncology, University Children’s Hospital Tuebingen, GermanyView further author information
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Elena Rappa Department of General Pediatrics, Hematology and Oncology, University Children’s Hospital Tuebingen, GermanyView further author information
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Anna-Sophia Masta Department of General Pediatrics, Hematology and Oncology, University Children’s Hospital Tuebingen, GermanyView further author information
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Armin Rabsteyna Department of General Pediatrics, Hematology and Oncology, University Children’s Hospital Tuebingen, Germany;d Cluster of Excellence iFIT (Exc 2180) “Image-guided and Functionally Instructed Tumor Therapies”, University of Tuebingen, GermanyView further author information
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Sabine Schleichera Department of General Pediatrics, Hematology and Oncology, University Children’s Hospital Tuebingen, GermanyView further author information
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Stefan Grotea Department of General Pediatrics, Hematology and Oncology, University Children’s Hospital Tuebingen, GermanyView further author information
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Karin Schilbacha Department of General Pediatrics, Hematology and Oncology, University Children’s Hospital Tuebingen, GermanyView further author information
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Manfred Kneillingc Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen, Germany;d Cluster of Excellence iFIT (Exc 2180) “Image-guided and Functionally Instructed Tumor Therapies”, University of Tuebingen, GermanyView further author information
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Bernd Pichlerc Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen, Germany;d Cluster of Excellence iFIT (Exc 2180) “Image-guided and Functionally Instructed Tumor Therapies”, University of Tuebingen, GermanyView further author information
,
Dominik Lockb R&D Department, Miltenyi Biotec GmbH, Bergisch Gladbach, GermanyView further author information
,
Bettina Kotterb R&D Department, Miltenyi Biotec GmbH, Bergisch Gladbach, GermanyView further author information
,
Sandra Dapab R&D Department, Miltenyi Biotec GmbH, Bergisch Gladbach, GermanyView further author information
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Stefan Miltenyib R&D Department, Miltenyi Biotec GmbH, Bergisch Gladbach, GermanyView further author information
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Andrew Kaiserb R&D Department, Miltenyi Biotec GmbH, Bergisch Gladbach, GermanyView further author information
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Peter Langa Department of General Pediatrics, Hematology and Oncology, University Children’s Hospital Tuebingen, Germany;d Cluster of Excellence iFIT (Exc 2180) “Image-guided and Functionally Instructed Tumor Therapies”, University of Tuebingen, GermanyView further author information
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Rupert Handgretingera Department of General Pediatrics, Hematology and Oncology, University Children’s Hospital Tuebingen, Germany;d Cluster of Excellence iFIT (Exc 2180) “Image-guided and Functionally Instructed Tumor Therapies”, University of Tuebingen, GermanyView further author information
&
Patrick Schlegela Department of General Pediatrics, Hematology and Oncology, University Children’s Hospital Tuebingen, Germany;d Cluster of Excellence iFIT (Exc 2180) “Image-guided and Functionally Instructed Tumor Therapies”, University of Tuebingen, Germany;e School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, Australia;f Cellular Cancer Therapeutics Unit, Children’s Medical Research Institute, Westmead, Australia;g Department of Pediatric Hematology and Oncology, Westmead Children’s Hospital, Westmead, AustraliaCorrespondence[email protected]
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Article: 2003532 | Received 22 Jun 2021, Accepted 03 Nov 2021, Published online: 02 Dec 2021

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Niels Werchau, Bettina Kotter, Elvira Criado-Moronati, Andre Gosselink, Nicole Cordes, Dominik Lock, Simon Lennartz, Carolin Kolbe, Nora Winter, Karin Teppert, Fabian Engert, Brian Webster, Joerg Mittelstaet, Daniel Schaefer, Peter Mallmann, Michael R. Mallmann, Dominik Ratiu, Mario Assenmacher, Thomas Schaser, Michael von Bergwelt-Baildon, Pierre Abramowski & Andrew D. Kaiser. (2022) Combined targeting of soluble latent TGF-ß and a solid tumor-associated antigen with adapter CAR T cells. OncoImmunology 11:1.
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Nicole Cordes, Nora Winter, Carolin Kolbe, Bettina Kotter, Joerg Mittelstaet, Mario Assenmacher, Toni Cathomen, Andrew Kaiser & Thomas Schaser. (2022) Adapter-Mediated Transduction with Lentiviral Vectors: A Novel Tool for Cell-Type-Specific Gene Transfer. Viruses 14:10, pages 2157.
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