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Short Report

A high ratio of IC31® adjuvant to antigen is necessary for H4 TB vaccine immunomodulation

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Pages 1449-1455 | Received 04 Nov 2014, Accepted 22 Feb 2015, Published online: 18 Jun 2015

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Li Zhuang, Zhaoyang Ye, Linsheng Li, Ling Yang & Wenping Gong. (2023) Next-Generation TB Vaccines: Progress, Challenges, and Prospects. Vaccines 11:8, pages 1304.
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Amber Troy, Sandra C. Esparza-Gonzalez, Alicia Bartek, Elizabeth Creissen, Linda Izzo & Angelo A. Izzo. (2020) Pulmonary mucosal immunity mediated through CpG provides adequate protection against pulmonary Mycobacterium tuberculosis infection in the mouse model. A role for type I interferon. Tuberculosis 123, pages 101949.
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Silvia Moreno-Mendieta, Alejandra Barrera-Rosales, Dulce Mata-Espinosa, Jorge Barrios-Payán, Sergio Sánchez, Rogelio Hernández-Pando & Romina Rodríguez-Sanoja. (2019) Raw starch microparticles as BCG adjuvant: Their efficacy depends on the virulence of the infection strains. Vaccine 37:38, pages 5731-5737.
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Acep R. Wijayadikusumah, Weiguang Zeng, Hayley A. McQuilten, Chinn Yi Wong, David C. Jackson & Brendon Y. Chua. (2019) Geometry of a TLR2-Agonist-Based Adjuvant Can Affect the Resulting Antigen-Specific Immune Response. Molecular Pharmaceutics 16:5, pages 2037-2047.
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Sasmit S. Deshmukh, Federico Webster Magcalas, Kristen N. Kalbfleisch, Bruce W. Carpick & Marina D. Kirkitadze. (2018) Tuberculosis vaccine candidate: Characterization of H4-IC31 formulation and H4 antigen conformation. Journal of Pharmaceutical and Biomedical Analysis 157, pages 235-243.
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Liwei He, Jin Su, Marin Ming, Lidice Bernardo, Tricia Chen, Lucy Gisonni-Lex & Beata Gajewska. (2018) Flow cytometry: An efficient method for antigenicity measurement and particle characterization on an adjuvanted vaccine candidate H4-IC31 for tuberculosis. Journal of Immunological Methods 452, pages 39-45.
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Jalil Hakimi, Sepideh Aboutorabian, Frederick To, Salvador F. Ausar, Nausheen Rahman & Roger H. Brookes. 2017. Vaccine Adjuvants. Vaccine Adjuvants 295 304 .