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Bioengineered Volume 12, 2021 - Issue 1
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Research Paper

MicroRNA-21 regulate the cell apoptosis and cell proliferation of polycystic ovary syndrome (PCOS) granulosa cells through target toll like receptor TLR8

Yingying Yua Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai, China;b Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China;c Shanghai Municipal Key Clinical Specialty, Shanghai, ChinaView further author information
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Guojing Lia Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai, China;b Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China;c Shanghai Municipal Key Clinical Specialty, Shanghai, ChinaView further author information
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Xiaoying Hea Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai, China;b Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China;c Shanghai Municipal Key Clinical Specialty, Shanghai, ChinaView further author information
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Yu Lina Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai, China;b Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China;c Shanghai Municipal Key Clinical Specialty, Shanghai, ChinaView further author information
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Zheng Chena Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai, China;b Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China;c Shanghai Municipal Key Clinical Specialty, Shanghai, ChinaView further author information
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Xianhua Lina Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai, China;b Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China;c Shanghai Municipal Key Clinical Specialty, Shanghai, ChinaView further author information
&
Hong Xua Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai, China;b Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China;c Shanghai Municipal Key Clinical Specialty, Shanghai, ChinaCorrespondence[email protected]
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Pages 5789-5796 | Received 13 Jun 2021, Accepted 12 Aug 2021, Published online: 13 Sep 2021

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Xiaoyuan Xu, Xiaohua Xu, Xiaoshuang Wang & Ling Shen. (2023) Baicalin suppress the development of polycystic ovary syndrome via regulating the miR-874-3p/FOXO3 and miR-144/FOXO1 axis. Pharmaceutical Biology 61:1, pages 878-885.
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You Li, Guohui Xiong, Jun Tan, Shudi Wang, Qiongfang Wu, Lei Wan, Ziyu Zhang & Ouping Huang. (2021) Aberrant activation of the Hedgehog signaling pathway in granulosa cells from patients with polycystic ovary syndrome. Bioengineered 12:2, pages 12123-12134.
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Fang You, Xin Du, Taiwei Zhang, Yang Wang, Yuxia Lv & Li Zeng. (2021) High-frequency electroacupuncture improves endometrial receptivity via regulating cell adhesion molecules and leukemia inhibitory factor / signal transducer and activator of transcription signaling pathway. Bioengineered 12:2, pages 10470-10479.
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Articles from other publishers (14)

Liting Han, Tao Song, Xinyu Wang, Yan Luo, Chuanqi Gu, Xin Li, Jinda Wen, Zhibin Wen & Xiaolong Shi. (2024) miR-21 Responsive Nanocarrier Targeting Ovarian Cancer Cells. Computational and Structural Biotechnology Journal 24, pages 196-204.
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Hao-ru Guan, Bo Li, Ze-hua Zhang, Han-song Wu, Xing-lishang He, Ying-jie Dong, Jie Su, Gui-yuan Lv & Su-hong Chen. (2023) Integrated bioinformatics and network pharmacology to explore the therapeutic target and molecular mechanisms of Bailing capsule on polycystic ovary syndrome. BMC Complementary Medicine and Therapies 23:1.
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Ameneh Khoshvaghti & Raha Rahbari. (2023) The effect of ellagic acid on sex hormones and miRNA-21 expression in rats with polycystic ovary syndrome. Naunyn-Schmiedeberg's Archives of Pharmacology.
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Zhenghong Zhang, Congjian Shi & Zhengchao Wang. (2023) The physiological functions and therapeutic potential of exosomes during the development and treatment of polycystic ovary syndrome. Frontiers in Physiology 14.
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Sude TOPKARAOĞLU & Gulam HEKİMOĞLU. (2023) Abnormal Expression of miRNA in Women with Polycystic Ovary Syndrome (PCOS)Polikistik Over Sendromlu (PKOS) Kadınlarda Anormal MiRNA Ekspresyonu. Medical Research Reports 6:3, pages 183-191.
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Yi-Ru Tsai, Yen-Nung Liao & Hong-Yo Kang. (2023) Current Advances in Cellular Approaches for Pathophysiology and Treatment of Polycystic Ovary Syndrome. Cells 12:17, pages 2189.
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Fan-Sheng Kong, Zijing Lu, Yuan Zhou, Yinghua Lu, Chun-Yan Ren, Ruofan Jia, Beilei Zeng, Panwang Huang, Jihong Wang, Yaping Ma & Jian-Huan Chen. (2023) Transcriptome analysis identification of A-to-I RNA editing in granulosa cells associated with PCOS. Frontiers in Endocrinology 14.
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Xiaohong Chen, Hengzhen He, Bingcai Long, Binli Wei, Peng Yang, Xiaoying Huang, Qian Wang, Jing Lin & Hongliang Tang. (2023) Acupuncture regulates the apoptosis of ovarian granulosa cells in polycystic ovarian syndrome-related abnormal follicular development through LncMEG3-mediated inhibition of miR-21-3p. Biological Research 56:1.
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Maryam Jenabi, Parvin Khodarahmi, Farzaneh Tafvizi & Saeed Zaker Bostanabad. (2023) Evaluation of the potential of miR-21 as a diagnostic marker for oocyte maturity and embryo quality in women undergoing ICSI. Scientific Reports 13:1.
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Dariusz Szukiewicz, Seweryn Trojanowski, Anna Kociszewska & Grzegorz Szewczyk. (2022) Modulation of the Inflammatory Response in Polycystic Ovary Syndrome (PCOS)—Searching for Epigenetic Factors. International Journal of Molecular Sciences 23:23, pages 14663.
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Wei-hong Chen, Qiao-yi Huang, Zhi-yi Wang, Xuan-xuan Zhuang, Shu Lin & Qi-yang Shi. (2022) Therapeutic potential of exosomes/miRNAs in polycystic ovary syndrome induced by the alteration of circadian rhythms. Frontiers in Endocrinology 13.
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Giovana De Nardo Maffazioli, Edmund Chada Baracat, José Maria Soares, Kátia Cândido Carvalho & Gustavo Arantes Rosa Maciel. (2022) Evaluation of circulating microRNA profiles in Brazilian women with polycystic ovary syndrome: A preliminary study. PLOS ONE 17:10, pages e0275031.
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Qinyu Gao, Cong Ma, Shuyu Meng, Guanxiong Wang, Qiong Xing, Yuping Xu, Xiaojin He, Tianjuan Wang & Yunxia Cao. (2022) Exploration of molecular features of PCOS with different androgen levels and immune-related prognostic biomarkers associated with implantation failure. Frontiers in Endocrinology 13.
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Yi Zhai & Yanli Pang. (2022) Systemic and ovarian inflammation in women with polycystic ovary syndrome. Journal of Reproductive Immunology 151, pages 103628.
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