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Bioengineered Volume 12, 2021 - Issue 1
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Research Paper

MicroRNA-21 regulate the cell apoptosis and cell proliferation of polycystic ovary syndrome (PCOS) granulosa cells through target toll like receptor TLR8

Yingying Yua Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai, China;b Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China;c Shanghai Municipal Key Clinical Specialty, Shanghai, ChinaView further author information
,
Guojing Lia Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai, China;b Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China;c Shanghai Municipal Key Clinical Specialty, Shanghai, ChinaView further author information
,
Xiaoying Hea Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai, China;b Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China;c Shanghai Municipal Key Clinical Specialty, Shanghai, ChinaView further author information
,
Yu Lina Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai, China;b Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China;c Shanghai Municipal Key Clinical Specialty, Shanghai, ChinaView further author information
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Zheng Chena Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai, China;b Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China;c Shanghai Municipal Key Clinical Specialty, Shanghai, ChinaView further author information
,
Xianhua Lina Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai, China;b Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China;c Shanghai Municipal Key Clinical Specialty, Shanghai, ChinaView further author information
&
Hong Xua Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai, China;b Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China;c Shanghai Municipal Key Clinical Specialty, Shanghai, ChinaCorrespondence[email protected]
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Pages 5789-5796 | Received 13 Jun 2021, Accepted 12 Aug 2021, Published online: 13 Sep 2021

References

  • Kaptein MB, Hirasing RA, Koppenaal C, et al. Endocrine features of polycystic ovary syndrome in a random population sample of 14-16 year old adolescents[J]. Hum Reprod. 1999;14(9):2223–2229.
  • Hoyt KL, Schmidt MC. Polycystic ovary(Stein-Leventha1)syn- drome: etiology, complications, and treatment [J]. Clin Lab Sci. 2004;17(3):155–163.
  • Szczuko M, Zapałowskachwyć M, Maciejewska D, et al. High glycemic index diet in PCOS patients. The analysis of IGF I and TNF-α pathways in metabolic disorders.[J]. Medical Hypotheses. 2016;96:42–47.
  • Uematsu S, Akira S. Toll-like receptors and innate immunity. J Mol Med (Berl). 2006;84(9):712–725.
  • Kawai T, Akira S. Signaling to NF-kappaB by Toll-like receptors. Trends Mol Med. 2007;13(11):460͂469.
  • Takeda K, Akira S. Microbial recognition by toll-like receptors. J Dermatol Sci. 2004(34):73–82.
  • Brunn GJ, Bungum MK, Johnson GB, et al. Conditional signaling by Toll-like receptor 4. FASEB J. 2005;19(7):872–874.
  • Bi X, Zhai Z, Wang S, et al. Identification of the key pathways and genes related to polycystic ovary syndrome using bioinformatics analysis. Gen Physiol Biophys. 2019 May;38(3):205–214.
  • Vijay K. Toll-like receptors in immunity and inflammatory diseases: Past, present, and future. Int Immunopharmacol. 2018 Jun;59:391-412.
  • Calore F, Londhe P, Fadda P, et al. The TLR7/8/9 antagonist IMO-8503 inhibits cancer-Induced Cachexia. Cancer Res. 2018 Dec;78(23):6680–6690.
  • McDonald G, Cabal N, Vannier A, et al. Female bias in systemic lupus erythematosus is associated with the differential expression of X-Linked toll-Like receptor 8. Front Immunol. 2015;6:457.
  • Bayraktar R, Bertilaccio MTS, Calin GA. The interaction between two worlds: microRNAs and toll-Like receptors. Front Immunol. 2019 May;14(10):1053.
  • Gebremedhn S, Ali A, Hossain M, et al. MicroRNA-Mediated gene regulatory mechanisms in mammalian female reproductive health. Int J Mol Sci. 2021;22(2):938.
  • Chen X, Liang H, Zhang J, et al. microRNAs are ligands of toll-like receptors. RNA. 2013 Jun;19(6):737–739.
  • Naji M, Aleyasin A, Nekoonam S, et al. Differential expression of miR-93 and miR-21 in granulosa cells and follicular fluid of polycystic ovary syndrome associating with different phenotypes. Sci Rep. 2017;7(1):14671.
  • Fabbri M, Paone A, Calore F, et al. MicroRNAs bind to toll-like receptors to induce prometastatic inflammatory response. Proceedings of the National Academy of Sciences of the United States of America. 2012;109:E2110–6.
  • Preall JB, Sontheimer EJ. RNAi: RISC gets loaded. Cell. 2005;123(4): 543–545. 10.1016/j.cell.2005.11.006.
  • Legro RS, Kunselman AR, Dunaif A, et al. Prevalence and pre- dictors of dyslipidemia in women with polycystic ovary syndrome [J]. Am J Med. 2001;111(8):607–613.
  • Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell. 2009;136(2):215–233.
  • Krol J, Loedige I, Filipowicz W. The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet. 2010;11(9):597–610.
  • Marinelli C, Di Liddo R, Facci L, et al. Ligand engagement of Toll-like receptors regulates their expression in cortical microglia and astrocytes. J Neuroinflammation. 2015;12(1):244.
  • Chen X, Liang H, Zhang J, et al. Secreted microRNAs: a new form of intercellular communication. Trends Cell Biol. 2012;22(3):125–132.
  • Chen X, Liang H, Zhang CY, et al. miRNA regulates noncoding RNA: a noncanonical function model. Trends Biochem Sci. 2012;37(11):457–459.
  • Takeda K, Akira S. Toll-like receptors. Curr Protoc Immunol. 2015;109(1):142. 1.
  • Pasare C, Medzhitov R. Toll-like receptors: linking innate and adaptive immunity[J]. Microbes & Infection. 2004;6(15):1382–1387.

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