Clinical care and therapeutic trials in PLS

Mary Kay Floeter1 National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA

Deborah Warden2 Departments of Neurology and Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD, USA

Dale Lange3 Department of Neurology, Hospital for Special Surgery, Weill Cornell School of Medicine, New York, NY, USA

James Wymer4 Department of Neurology, University of Florida, Gainesville, FL, USA

Sabrina Paganoni5 Healey Center for ALS at Mass General, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA, and

Hiroshi Mitsumoto6 Department of Neurology, Columbia University Irving Medical Center, New York, NY, USACorrespondence[email protected]

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Hiroshi Mitsumoto, Grace Jang, Ikjae Lee, Zachary Simmons, Alexander V. Sherman, Daragh Heitzman, Eric Sorenson, Ken Cheung, Jinsy Andrews, Matthew Harms, Neil A. Shneider, Regina Santella, Sabrina Paganoni, Senda Ajroud-Driss, J. Americo M. Fernandes, Katherine M. Burke, Kelly Gwathmey, Ali A. Habib, Nicholas J. Maragakis, David Walk, Christina Fournier, Terry Heiman-Patterson, James Wymer, Frank Diaz, Stephen N. Scelsa, Lauren Elman, Angela Genge, Stephen A. Goutman, Ghazala Hayat, Omar Jawdat, Wendy S. Johnston, Nanette C. Joyce, Edward J. Kasarskis, Yaz Y. Kisanuki, Catherine Lomen-Hoerth, Michael T. Pulley, Jaimin S. Shah, Christen Shoesmith & Lorne Zinman. (2023) Primary lateral sclerosis natural history study – planning, designing, and early enrollment. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 24:5-6, pages 394-404.
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Eoin Finegan, We Fong Siah, Stacey Li Hi Shing, Rangariroyashe H. Chipika, Orla Hardiman & Peter Bede. (2022) Cerebellar degeneration in primary lateral sclerosis: an under-recognized facet of PLS. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 23:7-8, pages 542-553.
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Sina Marzoughi, Gerald Pfeffer & Neil Cashman. 2023. Motor System Disorders, Part II: Spinal Cord, Neurodegenerative, and Cerebral Disorders and Treatment. Motor System Disorders, Part II: Spinal Cord, Neurodegenerative, and Cerebral Disorders and Treatment 89 99 .

Juntan Wang, Haihua Zhu, Huiyi Shang, Bishan Guo, Mengxue Zhang, Fayun Wang, Lipan Zhang, Jun Xu & Hui Wang. (2022) Development of a thiostrepton-free system for stable production of PLD in Streptomyces lividans SBT5. Microbial Cell Factories 21:1.
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Clinical care and therapeutic trials in PLS

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Clinical care and therapeutic trials in PLS

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