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Artificial Cells, Nanomedicine, and Biotechnology
An International Journal
Volume 46, 2018 - Issue 8
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L-Carnitine-conjugated nanoparticles to promote permeation across blood–brain barrier and to target glioma cells for drug delivery via the novel organic cation/carnitine transporter OCTN2

Longfa KouMunicipal Key Laboratory of Biopharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, China; ;Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX, USA; View further author information
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Yanxian HouMunicipal Key Laboratory of Biopharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, China; View further author information
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Qing YaoMunicipal Key Laboratory of Biopharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, China; View further author information
,
Weiling GuoMunicipal Key Laboratory of Biopharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, China; View further author information
,
Gang WangMunicipal Key Laboratory of Biopharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, China; View further author information
,
Menglin WangMunicipal Key Laboratory of Biopharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, China; View further author information
,
Qiang FuMunicipal Key Laboratory of Biopharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, China; View further author information
,
Zhonggui HeDepartment of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, ChinaView further author information
,
Vadivel GanapathyDepartment of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX, USA; Correspondence[email protected] [email protected]
View further author information
&
Jin SunMunicipal Key Laboratory of Biopharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, China; Correspondence[email protected] [email protected]
View further author information
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Pages 1605-1616 | Received 10 Aug 2017, Accepted 20 Sep 2017, Published online: 03 Oct 2017

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Yunchun Zhao, Shuya Ye, Yao Zhu, Yue Chen, Shan Yang, Fengmei Wang, Rong Wang, Dongxu Qin, Dongli Sun & Caihong Zheng. (2023) Advancement in transporter-oriented nanoplatforms for cancer therapy. Journal of Drug Targeting 31:5, pages 456-470.
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Jonathan Zaslavsky, Pauric Bannigan & Christine Allen. (2023) Re-envisioning the design of nanomedicines: harnessing automation and artificial intelligence. Expert Opinion on Drug Delivery 20:2, pages 241-257.
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Xiaowei Wang, Yuhan Qiu, Mengyan Wang, Conghui Zhang, Tianshu Zhang, Huimin Zhou, Wenxia Zhao, Wuli Zhao, Guimin Xia & Rongguang Shao. (2020) Endocytosis and Organelle Targeting of Nanomedicines in Cancer Therapy. International Journal of Nanomedicine 15, pages 9447-9467.
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Longfa Kou, Huirong Huang, Xinlu Lin, Xinyu Jiang, Yi Wang, Qiuhua Luo, Jin Sun, Qing Yao, Vadivel Ganapathy & Ruijie Chen. (2020) Endocytosis of ATB0,+(SLC6A14)-targeted liposomes for drug delivery and its therapeutic application for pancreatic cancer. Expert Opinion on Drug Delivery 17:3, pages 395-405.
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Xue Jiang, Ya-Wen Zheng, Shihui Bao, Hailin Zhang, Ruijie Chen, Qing Yao & Longfa Kou. (2020) Drug discovery and formulation development for acute pancreatitis. Drug Delivery 27:1, pages 1562-1580.
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Tan Yang, Jianfang Feng, Qian Zhang, Wei Wu, Hailan Mo, Lanzhen Huang & Wei Zhang. (2020) l-Carnitine conjugated chitosan-stearic acid polymeric micelles for improving the oral bioavailability of paclitaxel. Drug Delivery 27:1, pages 575-584.
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Longfa Kou, Shuyi Xiao, Rui Sun, Shihui Bao, Qing Yao & Ruijie Chen. (2019) Biomaterial-engineered intra-articular drug delivery systems for osteoarthritis therapy. Drug Delivery 26:1, pages 870-885.
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Qiuhua Luo, Mingyan Jiang, Longfa Kou, Ling Zhang, Guyue Li, Qing Yao, Lei Shang & Ying Chen. (2018) Ascorbate-conjugated nanoparticles for promoted oral delivery of therapeutic drugs via sodium-dependent vitamin C transporter 1 (SVCT1). Artificial Cells, Nanomedicine, and Biotechnology 46:sup1, pages 198-208.
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Longfa Kou, Rui Sun, Vadivel Ganapathy, Qing Yao & Ruijie Chen. (2018) Recent advances in drug delivery via the organic cation/carnitine transporter 2 (OCTN2/SLC22A5). Expert Opinion on Therapeutic Targets 22:8, pages 715-726.
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Articles from other publishers (19)

Rajeswara Babu MythriM.R. Aishwarya. (2023) BIOPOLYMERS AS PROMISING VEHICLES FOR DRUG DELIVERY TO THE BRAIN. Drug Metabolism Reviews, pages 1-40.
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Raheleh Farahzadi, Mohammad Saeid Hejazi, Ommoleila Molavi, Elahe Pishgahzadeh, Soheila Montazersaheb & Sevda Jafari. (2023) Clinical Significance of Carnitine in the Treatment of Cancer: From Traffic to the Regulation. Oxidative Medicine and Cellular Longevity 2023, pages 1-15.
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Ksenia Mitusova, Oleksii O. Peltek, Timofey E. Karpov, Albert R. Muslimov, Mikhail V. Zyuzin & Alexander S. Timin. (2022) Overcoming the blood–brain barrier for the therapy of malignant brain tumor: current status and prospects of drug delivery approaches. Journal of Nanobiotechnology 20:1.
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Buddolla Anantha Lakshmi & Young-Joon Kim. (2022) Modernistic and Emerging Developments of Nanotechnology in Glioblastoma-Targeted Theranostic Applications. International Journal of Molecular Sciences 23:3, pages 1641.
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Bijuli Rabha, Kaushik Kumar Bharadwaj, Siddhartha Pati, Bhabesh Kumar Choudhury, Tanmay Sarkar, Zulhisyam Abdul Kari, Hisham Atan Edinur, Debabrat Baishya & Leonard Ionut Atanase. (2021) Development of Polymer-Based Nanoformulations for Glioblastoma Brain Cancer Therapy and Diagnosis: An Update. Polymers 13:23, pages 4114.
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Longfa Kou, Qing Yao, Hailin Zhang, Maoping Chu, Yangzom D. Bhutia, Ruijie Chen & Vadivel Ganapathy. (2020) Transporter-Targeted Nano-Sized Vehicles for Enhanced and Site-Specific Drug Delivery. Cancers 12:10, pages 2837.
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Nicolas Anuku, John David Obayemi, Olushola S. Odusanya, Karen A. Malatesta & Wole Soboyejo. 2020. Bioinspired Structures and Design. Bioinspired Structures and Design 212 232 .
. 2020. Bioinspired Structures and Design. Bioinspired Structures and Design.
Emilie Darrigues, Zeid A. Nima, Robert J. Griffin, James M. Anderson, Alexandru S. Biris & Analiz Rodriguez. (2020) 3D cultures for modeling nanomaterial-based photothermal therapy. Nanoscale Horizons 5:3, pages 400-430.
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Marco Tjakra, Yeqi Wang, Vicki Vania, Zhengjun Hou, Colm Durkan, Nan Wang & Guixue Wang. (2020) Overview of Crosstalk Between Multiple Factor of Transcytosis in Blood Brain Barrier. Frontiers in Neuroscience 13.
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Shahryar Shakeri, Milad Ashrafizadeh, Ali Zarrabi, Rasoul Roghanian, Elham Ghasemipour Afshar, Abbas Pardakhty, Reza Mohammadinejad, Anuj Kumar & Vijay Kumar Thakur. (2020) Multifunctional Polymeric Nanoplatforms for Brain Diseases Diagnosis, Therapy and Theranostics. Biomedicines 8:1, pages 13.
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Nila Mary Varghese & Senthil Venkatachalam. 2020. Nanoengineered Biomaterials for Advanced Drug Delivery. Nanoengineered Biomaterials for Advanced Drug Delivery 449 472 .
Taha Umair Wani, Syed Naiem Raza, Nisar Ahmad Khan & Faheem A. Sheikh. 2020. Application of Nanotechnology in Biomedical Sciences. Application of Nanotechnology in Biomedical Sciences 119 148 .
Lorena Pochini, Michele Galluccio, Mariafrancesca Scalise, Lara Console & Cesare Indiveri. (2019) OCTN: A Small Transporter Subfamily with Great Relevance to Human Pathophysiology, Drug Discovery, and Diagnostics. SLAS Discovery 24:2, pages 89-110.
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Hongyan Su, Yan Wang, Shuo Liu, Yue Wang, Qian Liu, Guangxuan Liu & Qin Chen. (2019) Emerging transporter-targeted nanoparticulate drug delivery systems. Acta Pharmaceutica Sinica B 9:1, pages 49-58.
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Naveed Ullah Khan, Tongtong Miao, Xiufeng Ju, Qian Guo & Liang Han. 2019. Brain Targeted Drug Delivery System. Brain Targeted Drug Delivery System 129 158 .
Sunita Lahkar & Malay K. Das. 2019. Surface Modification of Nanoparticles for Targeted Drug Delivery. Surface Modification of Nanoparticles for Targeted Drug Delivery 277 310 .
Qian Lu, Xiaoli Cai, Xian Zhang, Suiqiong Li, Yang Song, Dan Du, Prashanta Dutta & Yuehe Lin. (2018) Synthetic Polymer Nanoparticles Functionalized with Different Ligands for Receptor-Mediated Transcytosis across the Blood–Brain Barrier. ACS Applied Bio Materials 1:5, pages 1687-1694.
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Longfa Kou, Yangzom D. Bhutia, Qing Yao, Zhonggui He, Jin Sun & Vadivel Ganapathy. (2018) Transporter-Guided Delivery of Nanoparticles to Improve Drug Permeation across Cellular Barriers and Drug Exposure to Selective Cell Types. Frontiers in Pharmacology 9.
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