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Research Article

Antagonism of NK-1R using aprepitant suppresses inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes

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Pages 1628-1634 | Received 23 Oct 2018, Accepted 20 Dec 2018, Published online: 23 Apr 2019

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Janine Gross, Alfred R. Wegener, Martin Kronschläger, Carl-Ludwig Schönfeld, Frank G. Holz & Linda M. Meyer. (2021) UVR-B-induced NKR-1 Expression in Ocular Tissues is blocked by Substance P Receptor Antagonist Fosaprepitant in the Exposed as well as Unexposed Partner Eye. Ocular Immunology and Inflammation 29:5, pages 963-975.
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Xiao-nan Zhao, Zhen-zi Bai, Cheng-hua Li, Chuan-lun Sheng & Hong-yan Li. (2020) The NK-1R Antagonist Aprepitant Prevents LPS-Induced Oxidative Stress and Inflammation in RAW264.7 Macrophages. Drug Design, Development and Therapy 14, pages 1943-1952.
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Li Long, Hongmei Guo, Xixi Chen, Yan Liu, Ruyi Wang, Xiaomei Zheng, Xiaobo Huang, Qiao Zhou & Yi Wang. (2022) Advancement in understanding the role of ferroptosis in rheumatoid arthritis. Frontiers in Physiology 13.
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Safieh Ebrahimi, Abbas Alalikhan, Seyed Hamid Aghaee-Bakhtiari & Seyed Isaac Hashemy. (2022) The redox modulatory effects of SP/NK1R system: Implications for oxidative stress-associated disorders. Life Sciences 296, pages 120448.
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Hossein Javid, Atefeh Ghahremanloo, Amir R. Afshari, Roham Salek & Seyed Isaac Hashemy. (2022) The Emerging Role of Neurokinin-1 Receptor Blockade Using Aprepitant in the Redox System of Esophageal Squamous Cell Carcinoma. International Journal of Peptide Research and Therapeutics 28:3.
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Heba M. Hafez, Shaimaa Waz, Rehab Ahmed Rifaai & Mervat Z. Mohamed. (2022) Involvement of NOX-4/JAK/STAT pathway in the protective effect of aprepitant against diclofenac-induced renal toxicity. Life Sciences 294, pages 120381.
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Kyung Rae Ko, Hyunil Lee, Soo-Hong Han, Wooyeol Ahn, Do Kyung Kim, Il-Su Kim, Bo Sung Jung & Soonchul Lee. (2022) Substance P, A Promising Therapeutic Target in Musculoskeletal Disorders. International Journal of Molecular Sciences 23:5, pages 2583.
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Yang Yang, Wei Zhou, Xiuqi Xu, Xianxiu Ge, Fei Wang, Guang-Qin Zhang, Lin Miao & Xueting Deng. (2022) Aprepitant Inhibits JNK and p38/MAPK to Attenuate Inflammation and Suppresses Inflammatory Pain. Frontiers in Pharmacology 12.
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Negeen Mehrabani, Mohammad Reza Vaezi Kakhki, Hossein Javid, Safieh Ebrahimi & Seyed Isaac Hashemy. (2021) The SP/NK1R System-Mediated ROS Generation in GBM Cells through Inhibiting Glutaredoxin Protein. Neurology Research International 2021, pages 1-7.
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Lin Li, Donghai Zhou, Qiuping Liu, Dianming Li, Qiao Wang, Xiaowei Shi, Chengping Wen & Lin Huang. (2021) Network analysis indicating the pharmacological mechanism of Yunpi-Qufeng-Chushi-prescription in prophylactic treatment of rheumatoid arthritis. BMC Complementary Medicine and Therapies 21:1.
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Kentaro Noda, Bianca Dufner, Haruyasu Ito, Ken Yoshida, Gianfranco Balboni & Rainer H. Straub. (2021) Differential inflammation-mediated function of prokineticin 2 in the synovial fibroblasts of patients with rheumatoid arthritis compared with osteoarthritis. Scientific Reports 11:1.
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Duygu Kose, Harun Un, Rustem Anil Ugan, Zekai Halici, Elif Cadirci, Tugba Bal Tastan & Aysenur Kahramanlar. (2021) Aprepitant: an antiemetic drug, contributes to the prevention of acute lung injury with its anti-inflammatory and antioxidant properties. Journal of Pharmacy and Pharmacology 73:10, pages 1302-1309.
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Pan Lin Xin, Li Fan Jie, Qian Cheng, Du Yi Bin & Cheng Wen Dan. (2021) Pathogenesis and Function of Interleukin-35 in Rheumatoid Arthritis. Frontiers in Pharmacology 12.
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Rustem Anil Ugan, Harun Un, Duygu Kose, Elif Cadirci, Tugba Bal Tastan, Muhammed Yayla & Zekai Halici. (2020) Can aprepitant used for nausea and vomiting be good gastrointestinal complaints?. Naunyn-Schmiedeberg's Archives of Pharmacology 393:12, pages 2463-2472.
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Miguel Muñoz & Rafael Coveñas. (2020) The Neurokinin-1 Receptor Antagonist Aprepitant: An Intelligent Bullet against Cancer?. Cancers 12:9, pages 2682.
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Harun Un, Rustem Anil Ugan, Duygu Kose, Yasin Bayir, Elif Cadirci, Jale Selli & Zekai Halici. (2020) A novel effect of Aprepitant: Protection for cisplatin-induced nephrotoxicity and hepatotoxicity. European Journal of Pharmacology 880, pages 173168.
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Karol Wtorek, Anna Adamska-Bartłomiejczyk, Justyna Piekielna-Ciesielska, Federica Ferrari, Chiara Ruzza, Alicja Kluczyk, Joanna Piasecka-Zelga, Girolamo Calo’ & Anna Janecka. (2019) Synthesis and Pharmacological Evaluation of Hybrids Targeting Opioid and Neurokinin Receptors. Molecules 24:24, pages 4460.
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A. V. Prytkova. (2019) Interleukin-6 Dynamics as a Predictor of the Renal Dysfunction Formation and a Criterion of the Effectiveness of the Nephroprotective Strategy in Early Rheumatoid Arthritis. Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 4:4, pages 115-123.
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