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Artificial Cells, Nanomedicine, and Biotechnology
An International Journal
Volume 47, 2019 - Issue 1
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Research Article

Characterisation of 2-HP-β-cyclodextrin-PLGA nanoparticle complexes for potential use as ocular drug delivery vehicles

Fan Lia Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China;b Guangdong Provincial Engineering Center of Topical Precise Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China;c R&D Team for Formulation Innovation, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of ChinaView further author information
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Yuqin Wena Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China;b Guangdong Provincial Engineering Center of Topical Precise Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China;c R&D Team for Formulation Innovation, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of ChinaView further author information
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Yan Zhanga Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China;b Guangdong Provincial Engineering Center of Topical Precise Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China;c R&D Team for Formulation Innovation, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of ChinaView further author information
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Kangyu Zhenga Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China;b Guangdong Provincial Engineering Center of Topical Precise Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China;c R&D Team for Formulation Innovation, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of ChinaView further author information
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Junfeng Bana Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China;b Guangdong Provincial Engineering Center of Topical Precise Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China;c R&D Team for Formulation Innovation, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of ChinaCorrespondence[email protected]
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Qingchun Xiea Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China;b Guangdong Provincial Engineering Center of Topical Precise Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China;c R&D Team for Formulation Innovation, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of ChinaView further author information
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Yifeng Wena Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China;b Guangdong Provincial Engineering Center of Topical Precise Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China;c R&D Team for Formulation Innovation, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of ChinaView further author information
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Qing Liua Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China;b Guangdong Provincial Engineering Center of Topical Precise Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China;c R&D Team for Formulation Innovation, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of ChinaView further author information
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Fohua Chena Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China;b Guangdong Provincial Engineering Center of Topical Precise Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China;c R&D Team for Formulation Innovation, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of ChinaView further author information
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Zhenjie Moa Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China;b Guangdong Provincial Engineering Center of Topical Precise Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China;c R&D Team for Formulation Innovation, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of ChinaView further author information
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Lizhong Liud Department of Hospital Pharmacy, Ningbo 7 Hospital, Ningbo, People’s Republic of ChinaView further author information
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Yanzhong Chena Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China;b Guangdong Provincial Engineering Center of Topical Precise Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China;c R&D Team for Formulation Innovation, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of ChinaCorrespondence[email protected]
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Zhufen Lua Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China;b Guangdong Provincial Engineering Center of Topical Precise Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China;c R&D Team for Formulation Innovation, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of ChinaCorrespondence[email protected]
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Pages 4097-4108 | Received 27 Jun 2019, Accepted 15 Oct 2019, Published online: 30 Oct 2019

Citations (17)

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Baohua Li, Geng Lu, Wenbin Liu, Liqi Liao, Junfeng Ban & Zhufen Lu. (2023) Formulation and Evaluation of PLGA Nanoparticulate-Based Microneedle System for Potential Treatment of Neurological Diseases. International Journal of Nanomedicine 18, pages 3745-3760.
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Rui Wang, Yuan Gao, Anchang Liu & Guangxi Zhai. (2021) A review of nanocarrier-mediated drug delivery systems for posterior segment eye disease: challenges analysis and recent advances. Journal of Drug Targeting 29:7, pages 687-702.
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Mohammed Muqtader Ahmed, Farhat Fatima, Md. Khalid Anwer, Mohammed F. Aldawsari, Saurabh Bhatia & Ahmed Al-Harrasi. (2021) Brigatinib loaded poly(d,l-lactide-co-glycolide) nanoparticles for improved anti-tumoral activity against non-small cell lung cancer cell lines. Drug Development and Industrial Pharmacy 47:7, pages 1112-1120.
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Ge Jiang, Huanhuan Jia, Jindi Qiu, Zhenjie Mo, Yifeng Wen, Yan Zhang, Yuqin Wen, Qingchun Xie, Junfeng Ban, Zhufen Lu, Yanzhong Chen, Hao Wu, Qingchun Ni, Fohua Chen, Jiashu Lu, Zhijiong Wang, Haoting Li & Junming Chen. (2020) PLGA Nanoparticle Platform for Trans-Ocular Barrier to Enhance Drug Delivery: A Comparative Study Based on the Application of Oligosaccharides in the Outer Membrane of Carriers. International Journal of Nanomedicine 15, pages 9373-9387.
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Monireh Esmaeili Rad, Caner Soylukan, Prabir Kumar Kulabhusan, Beyza Nur Günaydın & Meral Yüce. (2023) Material and Design Toolkit for Drug Delivery: State of the Art, Trends, and Challenges. ACS Applied Materials & Interfaces 15:48, pages 55201-55231.
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Madhukiran R. Dhondale, Amritha G. Nambiar, Maan Singh, Abhishek R. Mali, Ashish K. Agrawal, Nalini R. Shastri, Pradeep Kumar & Dinesh Kumar. (2023) Current Trends in API Co-Processing: Spherical Crystallization and Co-Precipitation Techniques. Journal of Pharmaceutical Sciences 112:8, pages 2010-2028.
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Jatinder Singh, Isha Dhamija, Harmanpreet Meehenian, Neeraj Kumar, Simran Simran, Muskan Muskan, Madan L. Verma & Sandeep Kumar. (2022) Chronicle updates in cyclodextrin-based carriers for drug delivery. Bulletin of the National Research Centre 46:1.
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Xiaodong Xie, Shuqi Li, Yanling Liu, Zhigang Huang, Jun Yi, Xiaofang Li, Chongkai Gao, Fang Wu & Bohong Guo. (2022) Based on functional materials and PLGA for the florfenicol controlled release system and its antibacterial properties. Reactive and Functional Polymers 178, pages 105331.
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Nazia Tarannum, Deepak Kumar & Nitin Kumar. (2022) β‐Cyclodextrin‐Based Nanocomposite Derivatives: State of the Art in Synthesis, Characterization and Application in Molecular Recognition. ChemistrySelect 7:22.
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Cristian Peptu, Diana-Andreea Blaj, Mihaela Balan-Porcarasu & Joanna Rydz. (2022) Cyclodextrin-Oligocaprolactone Derivatives—Synthesis and Advanced Structural Characterization by MALDI Mass Spectrometry. Polymers 14:7, pages 1436.
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Aravind Roy, Venkata V. Krishna Venuganti, Shreya S. Chauhan & Prashant Garg. (2022) Polymeric Drug Delivery Devices: Role in Cornea and External Disease. Eye & Contact Lens: Science & Clinical Practice 48:3, pages 119-126.
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Farhat Fatima, Mohammed F. Aldawsari, Mohammed Muqtader Ahmed, Md. Khalid Anwer, Maimuna Naz, Mohammad Javed Ansari, Abubaker M. Hamad, Ameeduzzafar Zafar & Mohammed Jafar. (2021) Green Synthesized Silver Nanoparticles Using Tridax Procumbens for Topical Application: Excision Wound Model and Histopathological Studies. Pharmaceutics 13:11, pages 1754.
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Astrid Pany, Marie Wohlgenannt, Safoura Klopprogge, Michael Wolzt, Thomas Heuser, Harald Kotisch, Claudia Valenta & Victoria Klang. (2021) Effect of hydroxypropyl‐β‐cyclodextrin in fluid and semi‐solid submicron emulsions on physiological skin parameters during regular in vivo application. International Journal of Cosmetic Science 43:2, pages 263-268.
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Dawin Khiev, Zeinab A. Mohamed, Riddhi Vichare, Ryan Paulson, Sofia Bhatia, Subhra Mohapatra, Glenn P. Lobo, Mallika Valapala, Nagaraj Kerur, Christopher L. Passaglia, Shyam S. Mohapatra & Manas R. Biswal. (2021) Emerging Nano-Formulations and Nanomedicines Applications for Ocular Drug Delivery. Nanomaterials 11:1, pages 173.
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Rajiv R. Mohan, Lynn M. Martin & Nishant R. Sinha. (2021) Novel insights into gene therapy in the cornea. Experimental Eye Research 202, pages 108361.
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Bartłomiej Kost, Marek Brzeziński, Marta Socka, Małgorzata Baśko & Tadeusz Biela. (2020) Biocompatible Polymers Combined with Cyclodextrins: Fascinating Materials for Drug Delivery Applications. Molecules 25:15, pages 3404.
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Wan Bei, Li Jing & Nie Chen. (2020) Cardio protective role of wogonin loaded nanoparticle against isoproterenol induced myocardial infarction by moderating oxidative stress and inflammation. Colloids and Surfaces B: Biointerfaces 185, pages 110635.
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