8,897
Views
41
CrossRef citations to date
0
Altmetric
Articles

SARS-CoV-2 spike produced in insect cells elicits high neutralization titres in non-human primates

, ORCID Icon, , , , , , , , , , , , , , , , , , , ORCID Icon, , , ORCID Icon, ORCID Icon & ORCID Icon show all
Pages 2076-2090 | Received 23 Jul 2020, Accepted 06 Sep 2020, Published online: 24 Sep 2020

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Jeroen Pollet, Wen-Hsiang Chen, Leroy Versteeg, Brian Keegan, Bin Zhan, Junfei Wei, Zhuyun Liu, Jungsoon Lee, Rahki Kundu, Rakesh Adhikari, Cristina Poveda, Maria Jose Villar, Ana Carolina de Araujo Leao, Joanne Altieri Rivera, Zoha Momin, Portia M. Gillespie, Jason T. Kimata, Ulrich Strych, Peter J. Hotez & Maria Elena Bottazzi. (2021) SARS‑CoV-2 RBD219-N1C1: A yeast-expressed SARS-CoV-2 recombinant receptor-binding domain candidate vaccine stimulates virus neutralizing antibodies and T-cell immunity in mice. Human Vaccines & Immunotherapeutics 17:8, pages 2356-2366.
Read now

Articles from other publishers (40)

Mohamed Boumaiza, Ameni Chaabene, Ines Akrouti, Meriem Ben Zakour, Hana Askri, Said Salhi, Wafa Ben Hamouda, Soumaya Marzouki, Chaouki Benabdessalem, Melika Ben Ahmed, Khaled Trabelsi & Samia Rourou. (2023) Development of an Optimized Process for Functional Recombinant SARS-CoV-2 Spike S1 Receptor-Binding Domain Protein Produced in the Baculovirus Expression Vector System. Tropical Medicine and Infectious Disease 8:11, pages 501.
Crossref
Federico Carrión, Florencia Rammauro, Natalia Olivero‐Deibe, Martín Fló, María Magdalena Portela, Analía Lima, Rosario Durán, Otto Pritsch & Sergio Bianchi. (2023) Soluble SARS‐CoV ‐2 RBD and human ACE2 peptidase domain produced in Drosophila S2 cells show functions evoking virus–cell interface . Protein Science 32:8.
Crossref
Qiaonan Hong, Jian Liu, Yuquan Wei & Xiawei Wei. (2023) Application of Baculovirus Expression Vector System (BEVS) in Vaccine Development. Vaccines 11:7, pages 1218.
Crossref
Diego G. Noseda, Cecilia D’Alessio, Javier Santos, Tommy Idrovo-Hidalgo, Florencia Pignataro, Diana E. Wetzler, Hernán Gentili, Alejandro D. Nadra, Ernesto Roman, Carlos Paván & Lucas A. M. Ruberto. (2023) Development of a Cost-Effective Process for the Heterologous Production of SARS-CoV-2 Spike Receptor Binding Domain Using Pichia pastoris in Stirred-Tank Bioreactor. Fermentation 9:6, pages 497.
Crossref
Fajun Li, Junping Hong, Chaoheng Guan, Kaiyun Chen, Yinong Xie, Qian Wu, Junjie Chen, Baichang Deng, Jiaqing Shen, Xueying Liu, Rongsheng Hu, Yulong Zhang, Yixin Chen & Jinfeng Zhu. (2023) Affinity Exploration of SARS-CoV-2 RBD Variants to mAb-Functionalized Plasmonic Metasurfaces for Label-Free Immunoassay Boosting. ACS Nano 17:4, pages 3383-3393.
Crossref
Aboagye Kwarteng Dofuor, Naa Kwarley-Aba Quartey, Angelina Fathia Osabutey, Belinda Obenewa Boateng, Hanif Lutuf, Joseph Harold Nyarko Osei, Selina Mawunyo Ayivi-Tosuh, Albert Fynn Aiduenu, William Ekloh, Seyram Kofi Loh, Maxwell Jnr Opoku & Owusu Fordjour Aidoo. (2023) The Global Impact of COVID-19: Historical Development, Molecular Characterization, Drug Discovery and Future Directions. Clinical Pathology 16.
Crossref
Ysrafil Ysrafil, Sari Eka Pratiwi & Emmanuel Cornillot. 2023. Omics approaches and technologies in COVID-19. Omics approaches and technologies in COVID-19 219 237 .
Jie Zhou, Zezhong Liu, Guangxu Zhang, Wei Xu, Lixiao Xing, Lu Lu, Qian Wang & Shibo Jiang. (2022) Development of variant‐proof severe acute respiratory syndrome coronavirus 2, pan‐sarbecovirus, and pan‐β‐coronavirus vaccines. Journal of Medical Virology 95:1.
Crossref
Ram Nechooshtan, Sharon Ehrlich, Marika Vitikainen, Arik Makovitzki, Eyal Dor, Hadar Marcus, Idan Hefetz, Shani Pitel, Marilyn Wiebe, Anne Huuskonen, Lilach Cherry, Edith Lupu, Yehuda Sapir, Tzvi Holtzman, Moshe Aftalion, David Gur, Hadas Tamir, Yfat Yahalom-Ronen, Yuval Ramot, Noam Kronfeld, David Zarling, Anne Vallerga, Ronen Tchelet, Abraham Nyska, Markku Saloheimo, Mark Emalfarb & Yakir Ophir. (2022) Thermophilic Filamentous Fungus C1-Cell-Cloned SARS-CoV-2-Spike-RBD-Subunit-Vaccine Adjuvanted with Aldydrogel®85 Protects K18-hACE2 Mice against Lethal Virus Challenge. Vaccines 10:12, pages 2119.
Crossref
Muhammad Azharuddin Azali, Salmah Mohamed, Azian Harun, Faezahtul Arbaeyah Hussain, Shaharum Shamsuddin & Muhammad Farid Johan. (2022) Application of Baculovirus Expression Vector system (BEV) for COVID-19 diagnostics and therapeutics: a review. Journal of Genetic Engineering and Biotechnology 20:1, pages 98.
Crossref
Shi‐Jian Song, Heeyeon Kim, Eun Young Jang, Hyungmin Jeon, Hai‐Ping Diao, Md Rezaul Islam Khan, Mi‐Seon Lee, Young Jae Lee, Jeong‐hyun Nam, Seong‐Ryeol Kim, Young‐Jin Kim, Eun‐Ju Sohn, Inhwan Hwang & Jang‐Hoon Choi. (2022) SARS‐CoV ‐2 spike trimer vaccine expressed in Nicotiana benthamiana adjuvanted with Alum elicits protective immune responses in mice . Plant Biotechnology Journal 20:12, pages 2298-2312.
Crossref
Yapeng Hou, Tong Yu, Tingyu Wang, Yan Ding, Yong Cui & Hongguang Nie. (2022) Competitive cleavage of SARS-CoV-2 spike protein and epithelial sodium channel by plasmin as a potential mechanism for COVID-19 infection. American Journal of Physiology-Lung Cellular and Molecular Physiology 323:5, pages L569-L577.
Crossref
Tingting Deng, Tingting Li, Gege Chen, Yuhe Zhu, Lang Xu, Yanlin Lin, Hui Sun, Hui Zhang, Qianjiao Fang, Junping Hong, Dinghui Wu, Shuangquan Gao, Shaoyong Li, Yingbin Wang, Tianying Zhang, Yixin Chen, Quan Yuan, Qingbing Zheng, Hai Yu, Qinjian Zhao, Jun Zhang, Shaowei Li, Ningshao Xia & Ying Gu. (2022) Characterization and immunogenicity of SARS-CoV-2 spike proteins with varied glycosylation. Vaccine 40:47, pages 6839-6848.
Crossref
Yotaro Yamamoto, Hiroyuki Kajiura, Takahiro Nishibu & Kazuhito Fujiyama. (2022) Mamestra brassicae NIAS-Mb-32 cell strain 2g2 enables high-yield recombinant protein production in baculovirus-free and baculovirus-based insect cell expression. Journal of Bioscience and Bioengineering 134:5, pages 432-440.
Crossref
Panchanan SahooJyotirmayee DeySoumya Ranjan MahapatraArpan GhoshAryan JaiswalSantwana PadhiSamudyata C. PrabhuswamimathNamrata Misra & Mrutyunjay Suar. (2022) Nanotechnology and COVID-19 Convergence: Toward New Planetary Health Interventions Against the Pandemic. OMICS: A Journal of Integrative Biology 26:9, pages 473-488.
Crossref
Himanshi Chawla, Elisa Fadda & Max Crispin. (2022) Principles of SARS-CoV-2 glycosylation. Current Opinion in Structural Biology 75, pages 102402.
Crossref
Weeraya Thongkum, Kanyarat Thongheang & Chatchai Tayapiwatana. (2022) The Occluded Epitope Residing in Spike Receptor-Binding Motif Is Essential for Cross-Neutralization of SARS-CoV-2 Delta Variant. Current Issues in Molecular Biology 44:7, pages 2842-2855.
Crossref
Liqin Liu, Tingting Chen, Lizhi Zhou, Jie Sun, Yuqian Li, Meifeng Nie, Hualong Xiong, Yuhe Zhu, Wenhui Xue, Yangtao Wu, Tingting Li, Tianying Zhang, Zhibo Kong, Hai Yu, Jun Zhang, Ying Gu, Qingbing Zheng, Qinjian Zhao, Ningshao Xia & Shaowei Li. (2022) A Bacterially Expressed SARS-CoV-2 Receptor Binding Domain Fused With Cross-Reacting Material 197 A-Domain Elicits High Level of Neutralizing Antibodies in Mice. Frontiers in Microbiology 13.
Crossref
Alexandra C. Willcox, Kevin Sung, Meghan E. Garrett, Jared G. Galloway, Jesse H. Erasmus, Jennifer K. Logue, David W. Hawman, Helen Y. Chu, Kim J. Hasenkrug, Deborah H. Fuller, Frederick A. Matsen IV & Julie Overbaugh. (2022) Detailed analysis of antibody responses to SARS-CoV-2 vaccination and infection in macaques. PLOS Pathogens 18:4, pages e1010155.
Crossref
Taotao Mi, Tiantian Wang, Huifang Xu, Peng Sun, Xuchen Hou, Xinwei Zhang, Qian Ke, Jiawen Liu, Shengwei Hu, Jun Wu & Bo Liu. (2022) Kappa-RBD produced by glycoengineered Pichia pastoris elicited high neutralizing antibody titers against pseudoviruses of SARS-CoV-2 variants. Virology 569, pages 56-63.
Crossref
Akitsu Masuda, Jae Man Lee, Takeshi Miyata, Hiroaki Mon, Keita Sato, Kosuke Oyama, Yasuteru Sakurai, Jiro Yasuda, Daisuke Takahashi, Tadashi Ueda, Yuri Kato, Motohiro Nishida, Noriko Karasaki, Kohei Kakino, Takeru Ebihara, Takumi Nagasato, Masato Hino, Ayaka Nakashima, Kengo Suzuki, Yoshino Tonooka, Miyu Tanaka, Takato Moriyama, Hirokazu Nakatake, Ryosuke Fujita & Takahiro Kusakabe. (2022) Optimization of SARS-CoV-2 Spike Protein Expression in the Silkworm and Induction of Efficient Protective Immunity by Inoculation With Alum Adjuvants. Frontiers in Immunology 12.
Crossref
Iuliia A. Merkuleva, Dmitry N. Shcherbakov, Mariya B. Borgoyakova, Daniil V. Shanshin, Andrey P. Rudometov, Larisa I. Karpenko, Svetlana V. Belenkaya, Anastasiya A. Isaeva, Valentina S. Nesmeyanova, Elena I. Kazachinskaia, Ekaterina A. Volosnikova, Tatiana I. Esina, Anna V. Zaykovskaya, Oleg V. Pyankov, Sophia S. Borisevich, Arseniya A. Shelemba, Anton N. Chikaev & Alexander A. Ilyichev. (2022) Comparative Immunogenicity of the Recombinant Receptor-Binding Domain of Protein S SARS-CoV-2 Obtained in Prokaryotic and Mammalian Expression Systems. Vaccines 10:1, pages 96.
Crossref
Brenda R. de Camargo, Leonardo A. da Silva, Athos S. de Oliveira & Bergmann M. Ribeiro. (2022) An easy pipeline for one-step purification of SARS-CoV-2 nucleocapsid protein from insect cell suspension culture. Journal of Virological Methods 299, pages 114341.
Crossref
Mariano Maffei, Linda Celeste Montemiglio, Grazia Vitagliano, Luigi Fedele, Shaila Sellathurai, Federica Bucci, Mirco Compagnone, Valerio Chiarini, Cécile Exertier, Alessia Muzi, Giuseppe Roscilli, Beatrice Vallone & Emanuele Marra. (2021) The Nuts and Bolts of SARS-CoV-2 Spike Receptor-Binding Domain Heterologous Expression. Biomolecules 11:12, pages 1812.
Crossref
Chih-Yun Lai, Albert To, Teri Ann S. Wong, Michael M. Lieberman, David E. Clements, James T. Senda, Aquena H. Ball, Laurent Pessaint, Hanne Andersen, Wakako Furuyama, Andrea Marzi, Oreola Donini & Axel T. Lehrer. (2021) Recombinant protein subunit SARS-CoV-2 vaccines formulated with CoVaccine HT™ adjuvant induce broad, Th1 biased, humoral and cellular immune responses in mice. Vaccine: X 9, pages 100126.
Crossref
Luis Ariel Espinosa, Yassel Ramos, Ivan Andújar, Enso Onill Torres, Gleysin Cabrera, Alejandro Martín, Diamilé Roche, Glay Chinea, Mónica Becquet, Isabel González, Camila Canaán-Haden, Elías Nelson, Gertrudis Rojas, Beatriz Pérez-Massón, Dayana Pérez-Martínez, Tamy Boggiano, Julio Palacio, Sum Lai Lozada Chang, Lourdes Hernández, Kathya Rashida de la Luz Hernández, Saloheimo Markku, Marika Vitikainen, Yury Valdés-Balbín, Darielys Santana-Medero, Daniel G. Rivera, Vicente Vérez-Bencomo, Mark Emalfarb, Ronen Tchelet, Gerardo Guillén, Miladys Limonta, Eulogio Pimentel, Marta Ayala, Vladimir Besada & Luis Javier González. (2021) In-solution buffer-free digestion allows full-sequence coverage and complete characterization of post-translational modifications of the receptor-binding domain of SARS-CoV-2 in a single ESI–MS spectrum. Analytical and Bioanalytical Chemistry 413:30, pages 7559-7585.
Crossref
Brandon J. Beddingfield, Nicholas J. Maness, Alyssa C. Fears, Jay Rappaport, Pyone Pyone Aye, Kasi Russell-Lodrigue, Lara A. Doyle-Meyers, Robert V. Blair, Ann M. Carias, Patrick J. Madden, Ramon Lorenzo Redondo, Hongmei Gao, David Montefiori, Thomas J. Hope & Chad J. Roy. (2021) Effective Prophylaxis of COVID-19 in Rhesus Macaques Using a Combination of Two Parenterally-Administered SARS-CoV-2 Neutralizing Antibodies. Frontiers in Cellular and Infection Microbiology 11.
Crossref
Linda van Oosten, Jort J. Altenburg, Cyrielle Fougeroux, Corinne Geertsema, Fred van den End, Wendy A. C. Evers, Adrie H. Westphal, Simon Lindhoud, Willy van den Berg, Daan C. Swarts, Laurens Deurhof, Andreas Suhrbier, Thuy T. Le, Shessy Torres Morales, Sebenzile K. Myeni, Marjolein Kikkert, Adam F. Sander, Willem Adriaan de Jongh, Robert Dagil, Morten A. Nielsen, Ali Salanti, Max Søgaard, Timo M. P. Keijzer, Dolf Weijers, Michel H. M. Eppink, René H. Wijffels, Monique M. van Oers, Dirk E. Martens & Gorben P. Pijlman. (2021) Two-Component Nanoparticle Vaccine Displaying Glycosylated Spike S1 Domain Induces Neutralizing Antibody Response against SARS-CoV-2 Variants. mBio 12:5.
Crossref
Antonina Naskalska, Agnieszka Dabrowska, Artur Szczepanski, Krzysztof P. Jasik, Beata Gromadzka & Krzysztof Pyrc. (2021) Functional Severe Acute Respiratory Syndrome Coronavirus 2 Virus-Like Particles From Insect Cells. Frontiers in Microbiology 12.
Crossref
David A. Meekins, Natasha N. Gaudreault & Juergen A. Richt. (2021) Natural and Experimental SARS-CoV-2 Infection in Domestic and Wild Animals. Viruses 13:10, pages 1993.
Crossref
Jennifer Schwestka, Julia König-Beihammer, Yun-Ji Shin, Ulrike Vavra, Nikolaus F. Kienzl, Clemens Grünwald-Gruber, Daniel Maresch, Miriam Klausberger, Elisabeth Laurent, Maria Stadler, Gabriele Manhart, Jasmin Huber, Manuela Hofner, Klemens Vierlinger, Andreas Weinhäusel, Ines Swoboda, Christoph J. Binder, Wilhelm Gerner, Florian Grebien, Friedrich Altmann, Lukas Mach, Eva Stöger & Richard Strasser. (2021) Impact of Specific N-Glycan Modifications on the Use of Plant-Produced SARS-CoV-2 Antigens in Serological Assays. Frontiers in Plant Science 12.
Crossref
Tingting Li, Wenhui Xue, Qingbing Zheng, Shuo Song, Chuanlai Yang, Hualong Xiong, Sibo Zhang, Minqing Hong, Yali Zhang, Hai Yu, Yuyun Zhang, Hui Sun, Yang Huang, Tingting Deng, Xin Chi, Jinjin Li, Shaojuan Wang, Lizhi Zhou, Tingting Chen, Yingbin Wang, Tong Cheng, Tianying Zhang, Quan Yuan, Qinjian Zhao, Jun Zhang, Jason S. McLellan, Z. Hong Zhou, Zheng Zhang, Shaowei Li, Ying Gu & Ningshao Xia. (2021) Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants. Nature Communications 12:1.
Crossref
Jintao Zou, Haiming Jing, Xiaoli Zhang, Yiheng Liu, Zhuo Zhao, Lianli Duan, Yue Yuan, Zhifu Chen, Qiang Gou, Qingshan Xiong, Sisi Li, Feng Yang, Hao Zeng, Quanming Zou & Jinyong Zhang. (2021) α-Hemolysin-Aided Oligomerization of the Spike Protein RBD Resulted in Improved Immunogenicity and Neutralization Against SARS-CoV-2 Variants. Frontiers in Immunology 12.
Crossref
Rod Chalk, William E. P. Greenland, Tiago Moreira, Jesse Coker, Shubhashish M. M. Mukhopadhyay, Eleanor Williams, Charlotte Manning, Tina Bohstedt, Rama McCrorie, Alejandra Fernandez-Cid & Nicola A. Burgess-Brown. (2021) Identification, mapping and relative quantitation of SARS-CoV-2 Spike glycopeptides by Mass-Retention Time Fingerprinting. Communications Biology 4:1.
Crossref
Ahmed O. Shalash, Waleed M. Hussein, Mariusz Skwarczynski & Istvan Toth. (2021) Key Considerations for the Development of Safe and Effective SARS‐CoV‐2 Subunit Vaccine: A Peptide‐Based Vaccine Alternative. Advanced Science 8:16.
Crossref
Sheeja Cc, Damodaran Arun & Lekha Divya. (2021) Insect in vitro System for Toxicology Studies — Current and Future Perspectives. Frontiers in Toxicology 3.
Crossref
Yury Valdes-Balbin, Darielys Santana-Mederos, Françoise Paquet, Sonsire Fernandez, Yanet Climent, Fabrizio Chiodo, Laura Rodríguez, Belinda Sanchez Ramirez, Kalet Leon, Tays Hernandez, Lila Castellanos-Serra, Raine Garrido, Guang-Wu Chen, Dagmar Garcia-Rivera, Daniel G. Rivera & Vicente Verez-Bencomo. (2021) Molecular Aspects Concerning the Use of the SARS-CoV-2 Receptor Binding Domain as a Target for Preventive Vaccines. ACS Central Science 7:5, pages 757-767.
Crossref
Martin S. Winkler, Tomasz Skirecki, Frank M. Brunkhorst, Sara Cajander, Jean-Marc Cavaillon, Ricard Ferrer, Stefanie B. Flohé, Alberto García-Salido, Evangelos J. Giamarellos-Bourboulis, Massimo Girardis, Matthijs Kox, Gunnar Lachmann, Ignacio Martin-Loeches, Mihai G. Netea, Thibaud Spinetti, Joerg C. Schefold, Antoni Torres, Florian Uhle, Fabienne Venet, Sebastian Weis, André Scherag, Ignacio Rubio & Marcin F. Osuchowski. (2021) Bridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challenge. eBioMedicine 66, pages 103291.
Crossref
Jiao Tong, Chenxi Zhu, Hanyu Lai, Chunchao Feng & Dapeng Zhou. (2021) Potent Neutralization Antibodies Induced by a Recombinant Trimeric Spike Protein Vaccine Candidate Containing PIKA Adjuvant for COVID-19. Vaccines 9:3, pages 296.
Crossref
Ahmed M. Maged El-Goly. 2021. Covid-19 Infections and Pregnancy. Covid-19 Infections and Pregnancy 63 89 .