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Emerging Microbes & Infections Volume 10, 2021 - Issue 1
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Antimicrobial Agents

Novel tigecycline resistance mechanisms in Acinetobacter baumannii mediated by mutations in adeS, rpoB and rrf

Xiaoting Huaa Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China;b Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou, People’s Republic of China;c Regional Medical Center for National Institute of Respiratory Diseases, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-8215-916XView further author information
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Jintao Hea Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China;b Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou, People’s Republic of China;c Regional Medical Center for National Institute of Respiratory Diseases, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of ChinaView further author information
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Jingfen Wanga Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China;b Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou, People’s Republic of China;c Regional Medical Center for National Institute of Respiratory Diseases, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of ChinaView further author information
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Linghong Zhanga Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China;b Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou, People’s Republic of China;c Regional Medical Center for National Institute of Respiratory Diseases, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of ChinaView further author information
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Linyue Zhanga Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China;b Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou, People’s Republic of China;c Regional Medical Center for National Institute of Respiratory Diseases, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of ChinaView further author information
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Qingye Xua Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China;b Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou, People’s Republic of China;c Regional Medical Center for National Institute of Respiratory Diseases, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of ChinaView further author information
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Keren Shia Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China;b Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou, People’s Republic of China;c Regional Medical Center for National Institute of Respiratory Diseases, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of ChinaView further author information
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Sebastian Leptihna Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China;d Zhejiang University-University of Edinburgh Institute, Zhejiang University, Haining, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-4847-4622View further author information
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Yue Shie Department of Pathology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of ChinaView further author information
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Xiaoting Fuf Single-Cell Center, CAS Key Laboratory of Biofuels and Shandong Key Laboratory of Energy Genetics, Qingdao Institute of BioEnergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, People’s Republic of China;g Single-cell Center, Shandong Energy Institute, Qingdao, People’s Republic of ChinaView further author information
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Pengfei Zhuf Single-Cell Center, CAS Key Laboratory of Biofuels and Shandong Key Laboratory of Energy Genetics, Qingdao Institute of BioEnergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, People’s Republic of China;g Single-cell Center, Shandong Energy Institute, Qingdao, People’s Republic of ChinaView further author information
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Paul G. Higginsh Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany;i German Centre for Infection Research, Partner site Bonn–Cologne, Cologne, GermanyORCID Iconhttps://orcid.org/0000-0001-8677-9454View further author information
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Yunsong Yua Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China;b Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou, People’s Republic of China;c Regional Medical Center for National Institute of Respiratory Diseases, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-2903-918XView further author information
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Pages 1404-1417 | Received 26 Apr 2021, Accepted 23 Jun 2021, Published online: 08 Jul 2021

Citations (14)

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Wang Zhang, Yue Yao, Hua Zhou, Jintao He, Jingfen Wang, Li Li, Minsong Gao, Xiaochen Liu, Ya Shi, Jinzhong Lin, Jianzhao Liu, Huan Chen, Yu Feng, Zhihui Zhou, Yunsong Yu & Xiaoting Hua. (2022) Interactions between host epithelial cells and Acinetobacter baumannii promote the emergence of highly antibiotic resistant and highly mucoid strains. Emerging Microbes & Infections 11:1, pages 2556-2569.
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Articles from other publishers (13)

Hyejin Cho, Tesalonika Sondak & Kwang-sun Kim. (2023) Characterization of Increased Extracellular Vesicle-Mediated Tigecycline Resistance in Acinetobacter baumannii. Pharmaceutics 15:4, pages 1251.
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Rubén de Dios, Chris R Proctor, Evgenia Maslova, Sindija Dzalbe, Christian J Rudolph & Ronan R McCarthy. (2022) Artificial sweeteners inhibit multidrug‐resistant pathogen growth and potentiate antibiotic activity. EMBO Molecular Medicine 15:1.
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Mehri Haeili, Yalda Shoghi, Mohaddeseh Moghimi, Arash Ghodousi, Maryam Omrani & Daniela Maria Cirillo. (2022) Genomic features of in vitro selected mutants of Escherichia coli with decreased susceptibility to tigecycline. Journal of Global Antimicrobial Resistance 31, pages 32-37.
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Razieh Dehbanipour & Zohreh Ghalavand. (2022) Acinetobacter baumannii : Pathogenesis, virulence factors, novel therapeutic options and mechanisms of resistance to antimicrobial agents with emphasis on tigecycline . Journal of Clinical Pharmacy and Therapeutics 47:11, pages 1875-1884.
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Abbas Maleki, Vahab Hassan Kaviar, Maryam Koupaei, Mohammad Hossein Haddadi, Behrooz Sadeghi Kalani, Hassan Valadbeigi, Somayeh Karamolahi, Nazanin Omidi, Marziyeh Hashemian, Nourkhoda Sadeghifard, Jasem Mohamadi, Mohsen Heidary & Saeed Khoshnood. (2022) Molecular typing and antibiotic resistance patterns among clinical isolates of Acinetobacter baumannii recovered from burn patients in Tehran, Iran. Frontiers in Microbiology 13.
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Shaqiu Zhang, Jinfeng Wen, Yuwei Wang, Mingshu Wang, Renyong Jia, Shun Chen, Mafeng Liu, Dekang Zhu, Xinxin Zhao, Ying Wu, Qiao Yang, Juan Huang, Xumin Ou, Sai Mao, Qun Gao, Di Sun, Bin Tian & Anchun Cheng. (2022) Dissemination and prevalence of plasmid-mediated high-level tigecycline resistance gene tet (X4). Frontiers in Microbiology 13.
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Manas S. Deolankar, Rachel A. Carr, Rebecca Fliorent, Sean Roh, Henry Fraimow & Valerie J. Carabetta. (2022) Evaluating the Efficacy of Eravacycline and Omadacycline against Extensively Drug-Resistant Acinetobacter baumannii Patient Isolates. Antibiotics 11:10, pages 1298.
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Bing Bai, Chengchun Chen, Yuxi Zhao, Guangjian Xu, Zhijian Yu, Vincent H Tam & Zewen Wen. (2022) In vitro activity of tigecycline and proteomic analysis of tigecycline adaptation strategies in clinical Enterococcus faecalis isolates from China. Journal of Global Antimicrobial Resistance 30, pages 66-74.
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Michelle Lowe, Ashika Singh-Moodley, Husna Ismail, Teena Thomas, Vindana Chibabhai, Trusha Nana, Warren Lowman, Arshad Ismail, Wai Yin Chan & Olga Perovic. (2022) Molecular characterisation of Acinetobacter baumannii isolates from bloodstream infections in a tertiary-level hospital in South Africa. Frontiers in Microbiology 13.
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Linyue Zhang, Ying Fu, Linghong Zhang, Qingye Xu, Yunxing Yang, Jintao He, Sebastian Leptihn, Belinda Loh, Robert A. Moran, Willem van Schaik, Mark Alexander Toleman, Qiong Chen, Lilin Liu, Yunsong Yu & Xiaoting Hua. (2022) Co‐evolutionary adaptations of Acinetobacter baumannii and a clinical carbapenemase‐encoding plasmid during carbapenem exposure . Evolutionary Applications 15:7, pages 1045-1061.
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Jun-Fang Dong, Cheng-jie Feng, Ping Wang, Ren-Qing Li & Qing-Hua Zou. (2022) Comparative genomics analysis of Acinetobacter baumannii multi-drug resistant and drug sensitive strains in China. Microbial Pathogenesis 165, pages 105492.
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Zhiren Wang, Henan Li, Jiangang Zhang, Xiaojuan Wang, Yawei Zhang & Hui Wang. (2022) Identification of a novel plasmid-mediated tigecycline resistance-related gene, tet (Y), in Acinetobacter baumannii . Journal of Antimicrobial Chemotherapy 77:1, pages 58-68.
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Xi Li, Huanhuan Ke, Wenhao Wu, Yuexing Tu, Hua Zhou & Yunsong Yu. (2021) Molecular Mechanisms Driving the In Vivo Development of KPC-71-Mediated Resistance to Ceftazidime-Avibactam during Treatment of Carbapenem-Resistant Klebsiella pneumoniae Infections . mSphere 6:6.
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