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Original Articles

Bioactive peptides in milk and their biological and health implications

Pages 1-16 | Published online: 03 Nov 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Muhammad Umar, Uracha Ruktanonchai, Davids Makararpong & Anil Kumar Anal. (2023) Enhancing Immunity Against Pathogens Through Glycosylated Bovine Colostrum Proteins. Food Reviews International 0:0, pages 1-18.
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Nam Su Oh, Jae Yeon Joung, Ji Young Lee, Jae Gwang Song, Sangnam Oh, Younghoon Kim, Hyung Wook Kim & Sae Hun Kim. (2020) Glycated milk protein fermented with Lactobacillus rhamnosus ameliorates the cognitive health of mice under mild-stress condition. Gut Microbes 11:6, pages 1643-1661.
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Flavio Tidona, Andrea Criscione, Anna Maria Guastella, Antonio Zuccaro, Salvatore Bordonaro & Donata Marletta. (2009) Bioactive peptides in dairy products. Italian Journal of Animal Science 8:3, pages 315-340.
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Articles from other publishers (56)

Lucía Jiménez-Montenegro, Leopoldo Alfonso, José A. Mendizabal & Olaia Urrutia. (2022) Worldwide Research Trends on Milk Containing Only A2 β-Casein: A Bibliometric Study. Animals 12:15, pages 1909.
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Anne Krog Ingerslev, Laura Rasmussen, Pan Zhou, Jan Værum Nørgaard, Peter Kappel Theil, Søren Krogh Jensen & Helle Nygaard Lærke. (2021) Effects of dairy and plant protein on growth and growth biomarkers in a piglet model. Food & Function 12:22, pages 11625-11640.
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Raju Sasikumar, Kambhampati Vivek & Amit K. Jaiswal. (2021) Effect of spray drying conditions on the physical characteristics, amino acid profile, and bioactivity of blood fruit ( Haematocarpus validus Bakh.F. Ex Forman) seed protein isolate . Journal of Food Processing and Preservation 45:6.
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Junjing Xue, Liang Xie, Bo Liu, Liyuan Zhou, Yajun Hu, Kolapo Matthew Ajuwon & Rejun Fang. (2021) Dietary Supplementation of EGF Ameliorates the Negatively Effects of LPS on Early-Weaning Piglets: From Views of Growth Performance, Nutrient Digestibility, Microelement Absorption and Possible Mechanisms. Animals 11:6, pages 1598.
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Salih ÖZDEMİR, Ezgi EDEBALİ & Cihat ÖZDEMİR. (2021) Süt ve Süt Ürünlerinde Bulunan Biyoaktif Peptitler ve İnsan Sağlığı Üzerine EtkileriBioactive Peptides in Milk and Dairy Products and Their Effects on Human Healts. Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi 11:1, pages 268-280.
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Muthu Thiruvengadam, Baskar Venkidasamy, Prabhu Thirupathi, Ill-Min Chung & Umadevi Subramanian. (2021) β-Casomorphin: A complete health perspective. Food Chemistry 337, pages 127765.
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Sajid Maqsood, Sabika Jafar & Priti Mudgil. 2021. Food biopolymers: Structural, functional and nutraceutical properties. Food biopolymers: Structural, functional and nutraceutical properties 251 267 .
Lourdes Amigo, Daniel Martínez-Maqueda & Blanca Hernández-Ledesma. (2020) In Silico and In Vitro Analysis of Multifunctionality of Animal Food-Derived Peptides. Foods 9:8, pages 991.
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Emily Mason, Lamia L’Hocine, Allaoua Achouri, Mélanie Pitre & Salwa Karboune. (2020) Health Promoting Bioactive Properties of Novel Hairless Canary Seed Flour after In Vitro Gastrointestinal Digestion. Foods 9:7, pages 932.
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Sevda Arısoy, Işık Çoban & Özlem Üstün-Aytekin. 2019. From Conventional to Innovative Approaches for Pain Treatment. From Conventional to Innovative Approaches for Pain Treatment.
Stig Purup, Søren D. Nielsen, Thao T. Le, Hans Bertelsen, John Sørensen & Lotte B. Larsen. (2018) Wound Healing Properties of Commercial Milk Hydrolysates in Intestinal Cells. International Journal of Peptide Research and Therapeutics 25:2, pages 483-491.
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W.H. Chang, A.J. Zheng, Z.M. Chen, S. Zhang, H.Y. Cai & G.H. Liu. (2019) β-Casomorphin increases fat deposition in broiler chickens by modulating expression of lipid metabolism genes. Animal 13:4, pages 777-783.
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Ryan Hazlett, Christiane Schmidmeier & James A. O'Mahony. 2019. Encyclopedia of Food Chemistry. Encyclopedia of Food Chemistry 138 147 .
Elham Nourmohammadi & Alireza Sadeghi Mahoonak. (2018) Health Implications of Bioactive Peptides: A Review. International Journal for Vitamin and Nutrition Research 88:5-6, pages 319-343.
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Tora Asledottir, Thao T. Le, Bjørn Petrat-Melin, Tove G. Devold, Lotte B. Larsen & Gerd E. Vegarud. (2017) Identification of bioactive peptides and quantification of β-casomorphin-7 from bovine β-casein A1, A2 and I after ex vivo gastrointestinal digestion. International Dairy Journal 71, pages 98-106.
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Rajeev Kapila, Suman Kapila & Rishika Vij. 2017. Nutrients in Dairy and their Implications on Health and Disease. Nutrients in Dairy and their Implications on Health and Disease 303 311 .
D.P. Mohanty, S. Mohapatra, S. Misra & P.S. Sahu. (2016) Milk derived bioactive peptides and their impact on human health – A review. Saudi Journal of Biological Sciences 23:5, pages 577-583.
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Salvatore Pisanu, Daniela Pagnozzi, Massimo Pes, Antonio Pirisi, Tonina Roggio, Sergio Uzzau & Maria Filippa Addis. (2015) Differences in the peptide profile of raw and pasteurised ovine milk cheese and implications for its bioactive potential. International Dairy Journal 42, pages 26-33.
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P. F. Fox, T. Uniacke-Lowe, P. L. H. McSweeney & J. A. O'MahonyP. F. Fox, T. Uniacke-Lowe, P. L. H. McSweeney & J. A. O’Mahony. 2015. Dairy Chemistry and Biochemistry. Dairy Chemistry and Biochemistry 415 497 .
O.A. Alhaj & A. Kanekanian. 2014. Milk and Dairy Products as Functional Foods. Milk and Dairy Products as Functional Foods 237 288 .
K. Petrotos, E. Tsakali, P. Goulas & A.G. D'Alessandro. 2014. Milk and Dairy Products as Functional Foods. Milk and Dairy Products as Functional Foods 94 146 .
M.R. Tatara, A. Brodzki, K. Pasternak, M. Szpetnar, P. Rosenbeiger, B. Tymczyna, D. Niedziela & W. Krupski. (2014) Changes of amino acid concentrations in Polish Merino sheep between 21 and 150 days of life. Veterinární medicína 59:2, pages 68-75.
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Laxmana Naik, Bimlesh Mann, Rajesh Bajaj, R. B. Sangwan & Rajan Sharma. (2013) Process Optimization for the Production of Bio-functional Whey Protein Hydrolysates: Adopting Response Surface Methodology. International Journal of Peptide Research and Therapeutics 19:3, pages 231-237.
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Nohemí Campos-Quevedo, Sergio Rosales-Mendoza, Luz María Teresita Paz-Maldonado, Luis Martínez-Salgado, Juan Carlos Guevara-Arauza & Ruth Elena Soria-Guerra. (2012) Production of milk-derived bioactive peptides as precursor chimeric proteins in chloroplasts of Chlamydomonas reinhardtii. Plant Cell, Tissue and Organ Culture (PCTOC) 113:2, pages 217-225.
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Oscar Martínez-Alvarez. 2013. Marine Proteins and Peptides. Marine Proteins and Peptides 351 367 .
Rongxin Su, Miao Liang, Wei Qi, Rui Liu, Suxia Yuan & Zhimin He. (2012) Pancreatic hydrolysis of bovine casein: Peptide release and time-dependent reaction behavior. Food Chemistry 133:3, pages 851-858.
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Akbar Nikkhah. (2012) Milk for humans: Evolving perceptions of an all-time mother science. Russian Agricultural Sciences 38:4, pages 328-336.
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A.C. Rohit, K. Sathisha & H.S. Aparna. (2012) A variant peptide of buffalo colostrum β-lactoglobulin inhibits angiotensin I-converting enzyme activity. European Journal of Medicinal Chemistry 53, pages 211-219.
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Navam Hettiarachchy, Kenji Sato, Maurice Marshall & Arvind KannanBartłomiej Dziuba, Piotr Minkiewicz & Małgorzata Darewicz. 2012. Food Proteins and Peptides. Food Proteins and Peptides 331 374 .
T.G. Tavares, M.M. Contreras, M. Amorim, P.J. Martín-Álvarez, M.E. Pintado, I. Recio & F.X. Malcata. (2011) Optimisation, by response surface methodology, of degree of hydrolysis and antioxidant and ACE-inhibitory activities of whey protein hydrolysates obtained with cardoon extract. International Dairy Journal 21:12, pages 926-933.
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Lorenzo Castigliego, Xiaoning Li, Andrea Armani, Marco Mazzi & Alessandra Guidi. (2011) An immunoenzymatic assay to measure insulin-like growth factor 1 (IGF-1) in buffalo milk with an IGF binding protein blocking pre-treatment of the sample. International Dairy Journal 21:6, pages 421-426.
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Chaturvedi Madhusudan, Singh Manoj, Kumar Rahul & Chugh M. Rishi. (2011) Seaweeds: A Diet with Nutritional, Medicinal and Industrial Value. Research Journal of Medicinal Plant 5:2, pages 153-157.
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A. Nikkhah. (2011) Milk Products and Postmodern Humans: Public Education Fundamentals. Food and Nutrition Sciences 02:03, pages 222-224.
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Martha Phelan & David Kerins. (2011) The potential role of milk-derived peptides in cardiovascular disease. Food & Function 2:3-4, pages 153.
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Arnis Kuksis, Gregory Dolnikowski, Jean - Luc Wolfender, Dwight Matthews, Matej Oresic, Bruce German, Claudio Corradini, Nicole Packer & Michael AffolterClaudio Corradini, Lisa Elviri & Antonella Cavazza. 2010. Mass Spectrometry and Nutrition Research. Mass Spectrometry and Nutrition Research 78 101 .
Richard Owusu-Apenten. 2010. Bioactive Peptides. Bioactive Peptides 21 57 .
S. Srinivas & V. Prakash. (2009) Bioactive Peptides from Bovine Milk α-Casein: Isolation, Characterization and Multifunctional properties. International Journal of Peptide Research and Therapeutics 16:1, pages 7-15.
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Martha Phelan, Aisling Aherne, Richard J. FitzGerald & Nora M. O'Brien. (2009) Casein-derived bioactive peptides: Biological effects, industrial uses, safety aspects and regulatory status. International Dairy Journal 19:11, pages 643-654.
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J. O’Regan, M.P. Ennis & D.M. Mulvihill. 2009. Handbook of Hydrocolloids. Handbook of Hydrocolloids 298 358 .
A. Guidi, L. Castigliego, G. Iannone, A. Armani & D. Gianfaldoni. (2007) An Immunoenzymatic Method to Measure IGF-1 in Milk. Veterinary Research Communications 31:S1, pages 373-376.
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R. Zabielski. (2007) Hormonal and neural regulation of intestinal function in pigs. Livestock Science 108:1-3, pages 32-40.
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Rainer Hartmann & Hans Meisel. (2007) Food-derived peptides with biological activity: from research to food applications. Current Opinion in Biotechnology 18:2, pages 163-169.
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Peter Van Dael, Peter Kastenmayer, Jennifer Clough, Andrée-Rose Jarret, Denis V. Barclay & Jean-Claude Maire. (2005) Substitution of Casein by β-Casein or of Whey Protein Isolate by α-Lactalbumin Does Not Affect Mineral Balance in Growing Rats. The Journal of Nutrition 135:6, pages 1438-1443.
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Sofia V. Silva & F.Xavier Malcata. (2005) Caseins as source of bioactive peptides. International Dairy Journal 15:1, pages 1-15.
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Jean Amiot, Lucie Germain, Sylvie Turgeon, Martine Lemay, Christine Ory-Salam & François A. Auger. (2004) Peptides from milk protein hydrolysates to improve the growth of human keratinocytes in culture. International Dairy Journal 14:7, pages 619-626.
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C.L Kruger & S.W Mann. (2003) Safety evaluation of functional ingredients. Food and Chemical Toxicology 41:6, pages 793-805.
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Youping Sun, Eriko Nonobe, Youko Kobayashi, Takeshi Kuraishi, Fugaku Aoki, Kazuo Yamamoto & Senkiti Sakai. (2002) Characterization and Expression of l-Amino Acid Oxidase of Mouse Milk. Journal of Biological Chemistry 277:21, pages 19080-19086.
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R.J. Xu, P.T. Sangild, Y.Q. Zhang & S.H. Zhang. 2002. Biology of the Intestine in Growing Animals. Biology of the Intestine in Growing Animals 169 192 .
Cornelly van der Ven, Harry Gruppen, Dries B.A. de Bont & Alphons G.J. Voragen. (2002) Optimisation of the angiotensin converting enzyme inhibition by whey protein hydrolysates using response surface methodology. International Dairy Journal 12:10, pages 813-820.
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G Suzzi, M.T Lanorte, F Galgano, C Andrighetto, A Lombardi, R Lanciotti & M.E Guerzoni. (2001) Proteolytic, lipolytic and molecular characterisation of Yarrowia lipolytica isolated from cheese. International Journal of Food Microbiology 69:1-2, pages 69-77.
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R.J Xu, F Wang & S.H Zhang. (2000) Postnatal adaptation of the gastrointestinal tract in neonatal pigs: a possible role of milk-borne growth factors. Livestock Production Science 66:2, pages 95-107.
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Wei-Hua Shen & Ruo-Jun Xu. (2000) Stability of Insulin-Like Growth Factor I in the Gastrointestinal Lumen in Neonatal Pigs. Journal of Pediatric Gastroenterology and Nutrition 30:3, pages 299-304.
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