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Artificial Cells, Blood Substitutes, and Biotechnology Volume 30, 2002 - Issue 1
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CROSS-LINKED POLYHEMOGLOBIN-SUPEROXIDE DISMUTASE-CATALASE SUPPLIES OXYGEN WITHOUT CAUSING BLOOD BRAIN BARRIER DISRUPTION OR BRAIN EDEMA IN A RAT MODEL OF TRANSIENT GLOBAL BRAIN ISCHEMIA-REPERFUSION

D. Douglas Powanda Artificial Cells and Organs Research Centre, Faculty of Medicine, McGill University, 3655 Drummond Street, Room 1006, Montreal, Quebec, H3G 1Y6, Canada
&
Thomas M.S. Chang Artificial Cells and Organs Research Centre, Faculty of Medicine, McGill University, 3655 Drummond Street, Room 1006, Montreal, Quebec, H3G 1Y6, Canada
Pages 23-37 | Published online: 11 Jul 2009

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Thomas Ming Swi Chang. (2022) The role of artificial cells in the fight against COVID-19: deliver vaccine, hemoperfusion removes toxic cytokines, nanobiotherapeutics lower free radicals and pCO2 and replenish blood supply. Artificial Cells, Nanomedicine, and Biotechnology 50:1, pages 240-251.
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Thomas Ming Swi Chang. (2019) ARTIFICIAL CELL evolves into nanomedicine, biotherapeutics, blood substitutes, drug delivery, enzyme/gene therapy, cancer therapy, cell/stem cell therapy, nanoparticles, liposomes, bioencapsulation, replicating synthetic cells, cell encapsulation/scaffold, biosorbent/immunosorbent haemoperfusion/plasmapheresis, regenerative medicine, encapsulated microbe, nanobiotechnology, nanotechnology. Artificial Cells, Nanomedicine, and Biotechnology 47:1, pages 997-1013.
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Chen Guo & Thomas Ming Swi Chang. (2018) Long term safety and immunological effects of a nanobiotherapeutic, bovine poly-[hemoglobin-catalase-superoxide dismutase-carbonic anhydrase], after four weekly 5% blood volume top-loading followed by a challenge of 30% exchange transfusion. Artificial Cells, Nanomedicine, and Biotechnology 46:7, pages 1349-1363.
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Laura Terraneo, Paola Bianciardi, Ashok Malavalli, Gnel Mkrtchyan, Stephanie N. Spann, Jeff Lohman, Michele Samaja & Kim D. Vandegriff. (2017) Hemoglobin extravasation in the brain of rats exchange-transfused with hemoglobin-based oxygen carriers. Artificial Cells, Nanomedicine, and Biotechnology 45:4, pages 710-716.
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Wenhua Jiang, Yuzhu Bian, Zhenghui Wang & Thomas Ming Swi Chang. (2017) Hepatoprotective effects of Poly-[hemoglobin-superoxide dismutase-catalase-carbonic anhydrase] on alcohol-damaged primary rat hepatocyte culture in vitro. Artificial Cells, Nanomedicine, and Biotechnology 45:1, pages 46-50.
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Y. Z. Bian, C. Guo & T. M. S. Chang. (2016) Temperature stability of Poly-[hemoglobin-superoxide dismutase-catalase-carbonic anhydrase] in the form of a solution or in the lyophilized form during storage at −80 °C, 4 °C, 25 °C and 37 °C or pasteurization at 70 °C. Artificial Cells, Nanomedicine, and Biotechnology 44:1, pages 41-47.
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Thomas Ming Swi Chang. (2015) Red blood cell replacement, or nanobiotherapeutics with enhanced red blood cell functions?. Artificial Cells, Nanomedicine, and Biotechnology 43:3, pages 145-147.
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Zhilan Xie, Lijun Liu, Wenjin Zhu, Huifang Liu, Li Wang, Jia Zhang, Chao Chen & Hongli Zhu. (2015) The protective effect of polymerized porcine hemoglobin (pPolyHb) on transient focal cerebral ischemia/reperfusion injury. Artificial Cells, Nanomedicine, and Biotechnology 43:3, pages 180-185.
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C. Guo, M. Gynn & T. M. S. Chang. (2015) Extraction of superoxide dismutase, catalase, and carbonic anhydrase from stroma-free red blood cell hemolysate for the preparation of the nanobiotechnological complex of polyhemoglobin–superoxide dismutase–catalase–carbonic anhydrase. Artificial Cells, Nanomedicine, and Biotechnology 43:3, pages 157-162.
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Yuzhu Bian & Thomas Ming Swi Chang. (2015) A novel nanobiotherapeutic poly-[hemoglobin-superoxide dismutase-catalase-carbonic anhydrase] with no cardiac toxicity for the resuscitation of a rat model with 90 minutes of sustained severe hemorrhagic shock with loss of 2/3 blood volume. Artificial Cells, Nanomedicine, and Biotechnology 43:1, pages 1-9.
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Wei Gao, Yuzhu Bian & Thomas M.S. Chang. (2013) Novel Nanodimension artificial red blood cells that act as O2 and CO2 carrier with enhanced antioxidant activity: PLA-PEG nanoencapsulated PolySFHb-superoxide dismutase-catalase-carbonic anhydrase. Artificial Cells, Nanomedicine, and Biotechnology 41:4, pages 232-239.
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Vibhudutta Awasthi, Vivek R. Yadav, Beth Goins & William T. Phillips. (2013) Modulation of oxidative stability of haemoglobin inside liposome-encapsulated haemoglobin. Journal of Microencapsulation 30:5, pages 471-478.
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Yuzhu Bian, Gao Wei & Thomas M. S. Chang. (2013) Lowering of elevated tissue PCO2 in a hemorrhagic shock rat model after reinfusion of a novel nanobiotechnological polyhemoglobin-superoxide dismutase-catalase-carbonic anhydrase that is an oxygen and a carbon dioxide carrier with enhanced antioxidant properties. Artificial Cells, Nanomedicine, and Biotechnology 41:1, pages 60-68.
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Hongli Zhu, Qianqian Du, Chao Chen & Thomas Ming Swi Chang. (2010) The Immunological Properties of Stroma-free Polyhemolysate Containing Catalase and Superoxide Dismutase Activities Prepared by Polymerized Bovine Stroma-free Hemolysate. Artificial Cells, Blood Substitutes, and Biotechnology 38:2, pages 57-63.
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Wen-Hsiang Chang, Yen Chang, Yi-Chien Chen & Hsing-Wen Sung. (2004) Hemoglobin Polymerized with a Naturally Occurring Crosslinking Agent as a Blood Substitute: In Vitro and In Vivo Studies. Artificial Cells, Blood Substitutes, and Biotechnology 32:2, pages 243-262.
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Thomas Ming Swi Chang. (2004) Artificial Cell Bioencapsulation in Macro, Micro, Nano, and Molecular Dimensions: Keynote Lecture. Artificial Cells, Blood Substitutes, and Biotechnology 32:1, pages 1-23.
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Thomas Ming Swi Chang. (2003) Artificial Cells for Replacement of Metabolic Organ Functions. Artificial Cells, Blood Substitutes, and Biotechnology 31:2, pages 151-161.
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Thomas Ming Swi Chang. (2023) Editorial: Innovative medical technology based on artificial cells, including its different configurations. Frontiers in Medical Technology 5.
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Yuzhu Bian & Thomas Ming Swi Chang. (2023) Nanobiotechnological basis of an oxygen carrier with enhanced carbonic anhydrase for CO2 transport and enhanced catalase and superoxide dismutase for antioxidant function. Frontiers in Bioengineering and Biotechnology 11.
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Anirban Sen Gupta. (2017) Bio‐inspired nanomedicine strategies for artificial blood components. WIREs Nanomedicine and Nanobiotechnology 9:6.
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Felice D’Agnillo. 2013. Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics. Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics 665 682 .
Marie Grey, Khuanpiroon Ratanasopa & Leif Bülow. 2013. Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics. Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics 349 358 .
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Huimin Qiao, Lipeng Dong, Xiangjian Zhang, Chunhua Zhu, Xiaolin Zhang, Lina Wang, Zongjie Liu, Linyu Chen, Yinxue Xing, Chaohui Wang & Yanhua Li. (2012) Protective Effect of Luteolin in Experimental Ischemic Stroke: Upregulated SOD1, CAT, Bcl-2 and Claudin-5, Down-Regulated MDA and Bax Expression. Neurochemical Research 37:9, pages 2014-2024.
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Thomas Chang. 2011. Nanomedicine and the Cardiovascular System. Nanomedicine and the Cardiovascular System 77 98 .
Venkatareddy NaditheYou Han Bae. (2011) Hemoglobin Conjugates with Antioxidant Enzymes (Hemoglobin-Superoxide Dismutase-Catalase) via Poly(Ethylene Glycol) Crosslinker for Protection of Pancreatic Beta RINm5F Cells in Hypoxia. Tissue Engineering Part A 17:19-20, pages 2453-2462.
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Taihang Li, Xiabin Jing & Yubin Huang. (2011) Polymer/Hemoglobin Assemblies: Biodegradable Oxygen Carriers for Artificial Red Blood Cells. Macromolecular Bioscience 11:7, pages 865-875.
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Venkatareddy Nadithe & You Han Bae. (2010) Synthesis and characterization of hemoglobin conjugates with antioxidant enzymes via poly(ethylene glycol) cross-linker (Hb–SOD–CAT) for protection from free radical stress. International Journal of Biological Macromolecules 47:5, pages 603-613.
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Thomas Ming Swi Chang. (2010) Blood replacement with nanobiotechnologically engineered hemoglobin and hemoglobin nanocapsules. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 2:4, pages 418-430.
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M.ª Soledad Asuero & Trinidad Dorado. 2010. Tratado de Medicina Transfusional Perioperatoria. Tratado de Medicina Transfusional Perioperatoria 327 339 .
Marie Grey, Sakda Yainoy, Virapong Prachayasittikul & Leif Bülow. (2009) A superoxide dismutase–human hemoglobin fusion protein showing enhanced antioxidative properties. The FEBS Journal 276:21, pages 6195-6203.
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T.M.S. Chang. (2009) Nanobiotechnology for Hemoglobin-based Blood Substitutes. Critical Care Clinics 25:2, pages 373-382.
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Jong-Hoon Kim & Ki-Young Lee. (2009) Current Status and Future of Artificial Blood - Focusing on Red Blood Cell Substitutes. Journal of the Korean Medical Association 52:2, pages 168.
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Roman Kocian & Donat R. Spahn. (2008) Haemoglobin, oxygen carriers and perioperative organ perfusion. Best Practice & Research Clinical Anaesthesiology 22:1, pages 63-80.
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Y. Smani, P. Labrude, C. Vigneron & B. Faivre. (2007) Les transporteurs d’oxygène à base d’hémoglobine et les tentatives de substituer les globules rouges. Transfusion Clinique et Biologique 14:5, pages 464-473.
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Sarit Sivan & Noah Lotan. 2006. Wiley Encyclopedia of Biomedical Engineering. Wiley Encyclopedia of Biomedical Engineering.
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Jan A. Plock, Claudio Contaldo, Hiromi Sakai, Eishun Tsuchida, Michael Leunig, Andrej Banic, Michael D. Menger & Dominique Erni. (2005) Is hemoglobin in hemoglobin vesicles infused for isovolemic hemodilution necessary to improve oxygenation in critically ischemic hamster skin?. American Journal of Physiology-Heart and Circulatory Physiology 289:6, pages H2624-H2631.
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Robert Bartlett. 2005. Transfusion‐Free Medicine and Surgery. Transfusion‐Free Medicine and Surgery 254 282 .
Jun Mohara, Irene Aguilera, Bruce I. Goldman, Carol A. Fisher, John P. Gaughan, Joseph R. Libonati, Satoshi Furukawa & Arun K. Singhal. (2005) Effects of Nutrient and Hemoglobin Enriched Cell Free Perfusates Upon Ex Vivo Isolated Rat Heart Preparation. ASAIO Journal 51:3, pages 288-295.
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Thomas Ming Swi Chang. (2005) Therapeutic applications of polymeric artificial cells. Nature Reviews Drug Discovery 4:3, pages 221-235.
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Paul W. Buehler & Abdu I. Alayash. (2004) Toxicities of hemoglobin solutions: in search of in-vitro and in-vivo model systems. Transfusion 44:10, pages 1516-1530.
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Abdu I. Alayash. (2004) Oxygen therapeutics: can we tame haemoglobin?. Nature Reviews Drug Discovery 3:2, pages 152-159.
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