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Artificial Cells, Blood Substitutes, and Biotechnology Volume 30, 2002 - Issue 4
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EFFECT OF DIASPIRIN CROSSLINKED HEMOGLOBIN (DCLHb HemAssist™) DURING HIGH BLOOD LOSS SURGERY ON SELECTED INDICES OF ORGAN FUNCTION *

Armin Schubert Department of General Anesthesiology, Cleveland Clinic Foundation Health Science Center of the Ohio State University, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, U.S.A.
, M.D.,
Jerome F. O'Hara Department of General Anesthesiology, Cleveland Clinic Foundation Health Science Center of the Ohio State University, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, U.S.A.
, Jr., M.D.,
Robert J. Przybelski Hemoglobin Therapeutics Division, Baxter Healthcare Corporation, Deerfield, Illinois, U.S.A.
, M.D.,
John E. Tetzlaff Cleveland Clinic Foundation Health Science Center of the Ohio State University, Department of General Anesthesiology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, U.S.A.
, M.D.,
Kenneth E. Marks Department of Orthopedic Surgery, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, U.S.A.
, M.D.,
Edward Mascha Department of Biostatistics and Epidemiolog, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, U.S.A.
, M.S. &
Andrew C. Novick Urological Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, U.S.A.
, M.D. show all
Pages 259-283 | Published online: 11 Jul 2009

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Timothy N. Estep. (2015) Pharmacokinetics and mechanisms of plasma removal of hemoglobin-based oxygen carriers. Artificial Cells, Nanomedicine, and Biotechnology 43:3, pages 203-215.
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Jan Simoni, Grace Simoni, John F. Moeller, James P. Tsikouris & Donald E. Wesson. (2007) Evaluation of Angiotensin Converting Enzyme (ACE)-Like Activity of Acellular Hemoglobin. Artificial Cells, Blood Substitutes, and Biotechnology 35:2, pages 191-210.
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Giovanni Melioli & Giuseppe D’Onofrio. (2006) Blood doping: present procedures and detection techniques. Expert Review of Endocrinology & Metabolism 1:6, pages 793-800.
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Articles from other publishers (24)

Timothy N. Estep. 2022. Blood Substitutes and Oxygen Biotherapeutics. Blood Substitutes and Oxygen Biotherapeutics 287 292 .
Lei Kuang, Yu Zhu, Yue Wu, Kunlun Tian, Xiaoyong Peng, Mingying Xue, Xinming Xiang, Billy Lau, Fei Chuen Tzang, Liangming Liu & Tao Li. (2021) A Novel Cross-Linked Hemoglobin-Based Oxygen Carrier, YQ23, Extended the Golden Hour for Uncontrolled Hemorrhagic Shock in Rats and Miniature Pigs. Frontiers in Pharmacology 12.
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Auns Q Al-Neami, Noor S Shalal & Khawla H Rasheed. (2020) An artificial blood, electron microscope image, support, principles, benefits, and fusion methods: a review. IOP Conference Series: Materials Science and Engineering 870:1, pages 012019.
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Nan Zhang, Ming-Yuan Wei & Qiang Ma. (2019) Nanomedicines: A Potential Treatment for Blood Disorder Diseases. Frontiers in Bioengineering and Biotechnology 7.
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Bruce D. Spiess. 2018. Hematologic Challenges in the Critically Ill. Hematologic Challenges in the Critically Ill 363 389 .
Howard L. Corwin & Lena M. Napolitano. 2015. Transfusion in the Intensive Care Unit. Transfusion in the Intensive Care Unit 77 91 .
Jacob Elmer, Andre F. Palmer & Pedro Cabrales. (2012) Oxygen delivery during extreme anemia with ultra-pure earthworm hemoglobin. Life Sciences 91:17-18, pages 852-859.
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Lena M. Napolitano. 2011. Chemistry and Biochemistry of Oxygen Therapeutics. Chemistry and Biochemistry of Oxygen Therapeutics 79 106 .
Satoshi Shono, Manabu Kinoshita, Bonpei Takase, Yashiro Nogami, Shinichi Kaneda, Masayuki Ishihara, Daizoh Saitoh, Makoto Kikuchi & Shuhji Seki. (2011) Intraosseous Transfusion With Liposome-Encapsulated Hemoglobin Improves Mouse Survival After Hypohemoglobinemic Shock Without Scavenging Nitric Oxide. Shock 35:1, pages 45-52.
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Edward P. Sloan, Max D. Koenigsberg, Nora B. Philbin & Weihua Gao. (2010) Diaspirin Cross-Linked Hemoglobin Infusion Did Not Influence Base Deficit and Lactic Acid Levels in Two Clinical Trials of Traumatic Hemorrhagic Shock Patient Resuscitation. Journal of Trauma: Injury, Infection & Critical Care 68:5, pages 1158-1171.
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Edward P. Sloan, Nora B. Philbin, Max D. Koenigsberg & Weihua Gao. (2010) THE LACK OF CONSISTENT DIASPIRIN CROSS-LINKED HEMOGLOBIN INFUSION BLOOD PRESSURE EFFECTS IN THE US AND EU TRAUMATIC HEMORRHAGIC SHOCK CLINICAL TRIALS. Shock 33:2, pages 123-133.
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Donald J. AbrahamStefano Bruno, Luca Ronda, Serena Faggiano, Stefano Bettati & Andrea Mozzarelli. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 609 660 .
Lena M. Napolitano. (2009) Hemoglobin-based Oxygen Carriers: First, Second or Third Generation? Human or Bovine? Where are we Now?. Critical Care Clinics 25:2, pages 279-301.
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Jong-Hoon Kim & Ki-Young Lee. (2009) Current Status and Future of Artificial Blood - Focusing on Red Blood Cell Substitutes. Journal of the Korean Medical Association 52:2, pages 168.
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Michael Dudkiewicz, Tracey A. Harpaul & Kenneth G. Proctor. (2008) Hemoglobin-based oxygen carrying compound-201 as salvage therapy for severe neuro- and polytrauma (Injury Severity Score = 27–41)*. Critical Care Medicine 36:10, pages 2838-2848.
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Avery B. Nathens & Ronald V. Maier. 2008. Surgery. Surgery 305 321 .
Stacy Voils. (2012) Pharmacologic Interventions for the Management of Critical Bleeding. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 27:9P2.
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Mark A. Young, Ashok Malavalli, Nancy Winslow, Kim D. Vandegriff & Robert M. Winslow. (2007) Toxicity and hemodynamic effects after single dose administration of MalPEG-hemoglobin (MP4) in rhesus monkeys. Translational Research 149:6, pages 333-342.
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Sarit Sivan & Noah Lotan. 2006. Wiley Encyclopedia of Biomedical Engineering. Wiley Encyclopedia of Biomedical Engineering.
P. Daull, A. Blouin, J. Cayer, M. Beaudoin, K. Belleville, P. Sirois, F. Nantel, T.M.S. Chang & B. Battistini. (2005) Profiling biochemical and hemodynamic markers using chronically instrumented, conscious and unrestrained rats undergoing severe, acute controlled hemorrhagic hypovolemic shock as an integrated in-vivo model system to assess new blood substitutes. Vascular Pharmacology 43:4, pages 289-301.
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David J. SingelJonathan S. Stamler. (2005) CHEMICAL PHYSIOLOGY OF BLOOD FLOW REGULATION BY RED BLOOD CELLS:. Annual Review of Physiology 67:1, pages 99-145.
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Darius Kubulus, Hauke Rensing, Markus Paxian, Jan-Tobias Thierbach, Tanja Meisel, Heinz Redl, Michael Bauer & Inge Bauer. (2005) Influence of heme-based solutions on stress protein expression and organ failure after hemorrhagic shock*. Critical Care Medicine 33:3, pages 629-637.
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A. Pape, M. Kleen, G. Kemming, F. Meisner, J. Meier & O. Habler. (2004) Fluid resuscitation from severe hemorrhagic shock using diaspirin cross-linked hemoglobin fails to improve pancreatic and renal perfusion. Acta Anaesthesiologica Scandinavica 48:10, pages 1328-1337.
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Armin Schubert, Robert J. Przybelski, John F. Eidt, Larry C. Lasky, Kenneth E. Marks, Matthew Karafa, Andrew C. Novick, Jerome F. O’HaraJr.,Jr.,, Michael E. Saunders, John W. Blue, John E. Tetzlaff & Edward Mascha. (2003) Diaspirin-Crosslinked Hemoglobin Reduces Blood Transfusion in Noncardiac Surgery: A Multicenter, Randomized, Controlled, Double-Blinded Trial. Anesthesia & Analgesia 97:2, pages 323-332.
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