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Artificial Cells, Blood Substitutes, and Biotechnology Volume 31, 2003 - Issue 3
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Original

Analysis of Polyethylene‐glycol‐polylactide Nano‐Dimension Artificial Red Blood Cells in Maintaining Systemic Hemoglobin Levels and Prevention of Methemoglobin Formation

Thomas M. S. Chang Artificial Cells and Organs Research Centre and MSSS‐FRSQ Research Group (equipe) on Blood Substitutes in Transfusion Medicine, Faculty of Medicine, McGill University, Montreal, Quebec, Canada, H3G 1Y6
, F.R.S.C. , O.C. , M.D. , Ph.D. , F.R.C.P.C.,
Douglas Powanda Artificial Cells and Organs Research Centre and MSSS‐FRSQ Research Group (equipe) on Blood Substitutes in Transfusion Medicine, Faculty of Medicine, McGill University, Montreal, Quebec, Canada, H3G 1Y6
, M.Sc. &
W. P. Yu Artificial Cells and Organs Research Centre and MSSS‐FRSQ Research Group (equipe) on Blood Substitutes in Transfusion Medicine, Faculty of Medicine, McGill University, Montreal, Quebec, Canada, H3G 1Y6
, Ph.D.
Pages 231-247 | Published online: 11 Jul 2009

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Thomas Ming Swi Chang. (2019) ARTIFICIAL CELL evolves into nanomedicine, biotherapeutics, blood substitutes, drug delivery, enzyme/gene therapy, cancer therapy, cell/stem cell therapy, nanoparticles, liposomes, bioencapsulation, replicating synthetic cells, cell encapsulation/scaffold, biosorbent/immunosorbent haemoperfusion/plasmapheresis, regenerative medicine, encapsulated microbe, nanobiotechnology, nanotechnology. Artificial Cells, Nanomedicine, and Biotechnology 47:1, pages 997-1013.
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Katja B. Ferenz, Indra N. Waack, Christian Mayer, Herbert de Groot & Michael Kirsch. (2013) Long-circulating poly(ethylene glycol)-coated poly(lactid-co-glycolid) microcapsules as potential carriers for intravenously administered drugs. Journal of Microencapsulation 30:7, pages 632-642.
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Wei Gao, Yuzhu Bian & Thomas M.S. Chang. (2013) Novel Nanodimension artificial red blood cells that act as O2 and CO2 carrier with enhanced antioxidant activity: PLA-PEG nanoencapsulated PolySFHb-superoxide dismutase-catalase-carbonic anhydrase. Artificial Cells, Nanomedicine, and Biotechnology 41:4, pages 232-239.
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Vibhudutta Awasthi, Vivek R. Yadav, Beth Goins & William T. Phillips. (2013) Modulation of oxidative stability of haemoglobin inside liposome-encapsulated haemoglobin. Journal of Microencapsulation 30:5, pages 471-478.
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Kazuaki Taguchi, Toru Maruyama & Masaki Otagiri. (2011) Pharmacokinetic properties of hemoglobin vesicles as a substitute for red blood cells. Drug Metabolism Reviews 43:3, pages 362-373.
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Sevil Dinçer, Mustafa Türk, Ayşe Karagöz & Gürhan Uzunalan. (2011) Potential c-myc Antisense Oligonucleotide Carriers: PCl/PEG/PEI and PLL/PEG/PEI. Artificial Cells, Blood Substitutes, and Biotechnology 39:3, pages 143-154.
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Zun Chang Liu & Thomas M.S. Chang. (2008) Long-term Effects on the Histology and Function of Livers and Spleens in Rats after 33% Toploading of PEG-PLA-nano Artificial Red Blood Cells. Artificial Cells, Blood Substitutes, and Biotechnology 36:6, pages 513-524.
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Zun Chang Liu & Thomas M.S. Chang. (2008) Effects of PEG-PLA-nano Artificial Cells Containing Hemoglobin on Kidney Function and Renal Histology in Rats. Artificial Cells, Blood Substitutes, and Biotechnology 36:5, pages 421-430.
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Bong Geun Chung, Lifeng Kang & Ali Khademhosseini. (2007) Micro- and nanoscale technologies for tissue engineering and drug discovery applications. Expert Opinion on Drug Discovery 2:12, pages 1653-1668.
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Thomas Ming Swi Chang. (2006) Evolution of Artificial Cells Using Nanobiotechnology of Hemoglobin Based RBC Blood Substitute as an Example. Artificial Cells, Blood Substitutes, and Biotechnology 34:6, pages 551-566.
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Thomas Ming Swi Chang. (2004) Artificial Cell Bioencapsulation in Macro, Micro, Nano, and Molecular Dimensions: Keynote Lecture. Artificial Cells, Blood Substitutes, and Biotechnology 32:1, pages 1-23.
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Articles from other publishers (53)

Thomas Ming Swi Chang. (2023) Editorial: Innovative medical technology based on artificial cells, including its different configurations. Frontiers in Medical Technology 5.
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Maria Alice de Oliveira, Raquel Silva Araújo & Vanessa Carla Furtado Mosqueira. (2023) PEGylated and functionalized polylactide-based nanocapsules: An overview. International Journal of Pharmaceutics 636, pages 122760.
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Wentao Jiang, Ziyu Wu, Zheng Gao, Mimi Wan, Min Zhou, Chun Mao & Jian Shen. (2022) Artificial Cells: Past, Present and Future. ACS Nano 16:10, pages 15705-15733.
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Violet V. Sheffey, Emily B. Siew, Eden E. L. Tanner & Omolola Eniola‐Adefeso. (2022) PLGA's Plight and the Role of Stealth Surface Modification Strategies in Its Use for Intravenous Particulate Drug Delivery. Advanced Healthcare Materials 11:8, pages 2101536.
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Thomas Ming Swi Chang. 2022. Blood Substitutes and Oxygen Biotherapeutics. Blood Substitutes and Oxygen Biotherapeutics 99 115 .
Flávia Castro, Cláudia Martins, Maria José Silveira, Rui Pedro Moura, Catarina Leite Pereira & Bruno Sarmento. (2021) Advances on erythrocyte-mimicking nanovehicles to overcome barriers in biological microenvironments. Advanced Drug Delivery Reviews 170, pages 312-339.
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Clara Coll-Satue, Shahana Bishnoi, Jiantao Chen & Leticia Hosta-Rigau. (2021) Stepping stones to the future of haemoglobin-based blood products: clinical, preclinical and innovative examples. Biomaterials Science 9:4, pages 1135-1152.
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梦媛 姜. (2021) Research Progress Based on Hemoglobin Oxygen Carrier. Advances in Analytical Chemistry 11:03, pages 144-152.
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Ge Li, Menghui Zhao, Fei Xu, Bo Yang, Xiangyu Li, Xiangxue Meng, Lesheng Teng, Fengying Sun & Youxin Li. (2020) Synthesis and Biological Application of Polylactic Acid. Molecules 25:21, pages 5023.
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Andre Francis Palmer & Donald Andrew Belcher. 2020. Principles of Tissue Engineering. Principles of Tissue Engineering 785 801 .
Igor Meerovich & Alekha K. Dash. 2019. Materials for Biomedical Engineering. Materials for Biomedical Engineering 269 309 .
Hong Su, Yafei Wang, Yuanliang Gu, Linda Bowman, Jinshun Zhao & Min Ding. (2018) Potential applications and human biosafety of nanomaterials used in nanomedicine. Journal of Applied Toxicology 38:1, pages 3-24.
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Quan Wang, Ruirui Zhang, Mingzi Lu, Guoxing You, Ying Wang, Gan Chen, Caiyan Zhao, Zhen Wang, Xiang Song, Yan Wu, Lian Zhao & Hong Zhou. (2017) Bioinspired Polydopamine-Coated Hemoglobin as Potential Oxygen Carrier with Antioxidant Properties. Biomacromolecules 18:4, pages 1333-1341.
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Samira MoradiAli Jahanian-NajafabadiMehryar Habibi Roudkenar. (2016) Artificial Blood Substitutes: First Steps on the Long Route to Clinical Utility. Clinical Medicine Insights: Blood Disorders 9, pages CMBD.S38461.
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George Dan Mogoşanu, Alexandru Mihai Grumezescu, Ludovic Everard Bejenaru & Cornelia Bejenaru. 2016. Nanobiomaterials in Drug Delivery. Nanobiomaterials in Drug Delivery 229 284 .
Anirban Sen Gupta. 2015. Biomaterials in Regenerative Medicine and the Immune System. Biomaterials in Regenerative Medicine and the Immune System 113 137 .
Feroz Alam, Neha Yadav, Murad Ahmad & Mariyam Shadan. (2013) Blood Substitutes: Possibilities with Nanotechnology. Indian Journal of Hematology and Blood Transfusion 30:3, pages 155-162.
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Thomas Ming Swi Chang. 2014. Principles of Tissue Engineering. Principles of Tissue Engineering 1059 1073 .
Christa L. Modery-Pawlowski, Lewis L. Tian, Victor Pan & Anirban Sen Gupta. (2013) Synthetic Approaches to RBC Mimicry and Oxygen Carrier Systems. Biomacromolecules 14:4, pages 939-948.
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Hongjun Gao, Jie Xiong, Tangjian Cheng, Jinjian Liu, Liping Chu, Jianfeng Liu, Rujiang Ma & Linqi Shi. (2013) In Vivo Biodistribution of Mixed Shell Micelles with Tunable Hydrophilic/Hydrophobic Surface. Biomacromolecules 14:2, pages 460-467.
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Thomas Ming Swi Chang. 2013. Biomaterials Science. Biomaterials Science 811 827 .
Thomas Ming Swi Chang. 2013. Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics. Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics 3 26 .
Dominik Dobrunz, Adriana C. Toma, Pascal Tanner, Thomas Pfohl & Cornelia G. Palivan. (2012) Polymer Nanoreactors with Dual Functionality: Simultaneous Detoxification of Peroxynitrite and Oxygen Transport. Langmuir 28:45, pages 15889-15899.
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Yun Wang & Thomas M. S. Chang. (2012) Nanobiotechnological Nanocapsules Containing Polyhemoglobin-Tyrosinase: Effects on Murine B16F10 Melanoma Cell Proliferation and Attachment. Journal of Skin Cancer 2012, pages 1-9.
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Thomas Chang. 2011. Nanomedicine and the Cardiovascular System. Nanomedicine and the Cardiovascular System 77 98 .
Taihang Li, Xiabin Jing & Yubin Huang. (2011) Polymer/Hemoglobin Assemblies: Biodegradable Oxygen Carriers for Artificial Red Blood Cells. Macromolecular Bioscience 11:7, pages 865-875.
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Thomas Ming Swi Chang. (2010) Blood replacement with nanobiotechnologically engineered hemoglobin and hemoglobin nanocapsules. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 2:4, pages 418-430.
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James P. BertramCicely A. WilliamsRebecca RobinsonSteven S. SegalNolan T. FlynnErin B. Lavik. (2009) Intravenous Hemostat: Nanotechnology to Halt Bleeding. Science Translational Medicine 1:11.
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Jing Sun, Yubin Huang, Quan Shi, Xuesi Chen & Xiabin Jing. (2009) Oxygen Carrier Based on Hemoglobin/Poly( l -lysine)- block -poly( l -phenylalanine) Vesicles . Langmuir 25:24, pages 13726-13729.
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Yan Sheng, Changsheng Liu, Yuan Yuan, Xiaolan Zhang, Xiaoqian Shan & Feng Xu. (2009) Porosity and semipermeability of hemoglobin‐loaded polymeric nanoparticles as potential blood substitutes. Journal of Biomedical Materials Research Part B: Applied Biomaterials 91B:2, pages 631-642.
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Quan Shi, Yubin Huang, Xuesi Chen, Meng Wu, Jing Sun & Xiabin Jing. (2009) Hemoglobin conjugated micelles based on triblock biodegradable polymers as artificial oxygen carriers. Biomaterials 30:28, pages 5077-5085.
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Yan Sheng, Yuan Yuan, Changsheng Liu, Xinyi Tao, Xiaoqian Shan & Feng Xu. (2009) In vitro macrophage uptake and in vivo biodistribution of PLA–PEG nanoparticles loaded with hemoglobin as blood substitutes: effect of PEG content. Journal of Materials Science: Materials in Medicine 20:9, pages 1881-1891.
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T.M.S. Chang. (2009) Nanobiotechnology for Hemoglobin-based Blood Substitutes. Critical Care Clinics 25:2, pages 373-382.
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Yan Sheng, Changsheng Liu, Yuan Yuan, Xinyi Tao, Fan Yang, Xiaoqian Shan, Huanjun Zhou & Feng Xu. (2009) Long-circulating polymeric nanoparticles bearing a combinatorial coating of PEG and water-soluble chitosan. Biomaterials 30:12, pages 2340-2348.
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Xiaolan Zhang, Changsheng Liu, Yuan Yuan, Xiaoqian Shan, Yan Sheng & Feng Xu. (2008) Reduction and suppression of methemoglobin loaded in the polymeric nanoparticles intended for blood substitutes. Journal of Biomedical Materials Research Part B: Applied Biomaterials 87B:2, pages 354-363.
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Thomas Ming Swi Chang. (2008) Nanobiotechnological modification of hemoglobin and enzymes from this laboratory. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1784:10, pages 1435-1440.
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DAVID R. HARRIS & ANDRE F. PALMER. (2007) Novel strategies for transporting cellular hemoglobin-based oxygen carriers in the systemic circulation. Transfusion Alternatives in Transfusion Medicine 9:4, pages 237-245.
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T M S CHANG. 2007. Artificial Cells, Cell Engineering and Therapy. Artificial Cells, Cell Engineering and Therapy 321 332 .
S PRAKASH, J R BHATHENA & H CHEN. 2007. Artificial Cells, Cell Engineering and Therapy. Artificial Cells, Cell Engineering and Therapy 3 41 .
W YU & D SU. 2007. Artificial Cells, Cell Engineering and Therapy. Artificial Cells, Cell Engineering and Therapy 103 114 .
Thomas Ming Swi Chang. 2007. Principles of Tissue Engineering. Principles of Tissue Engineering 749 758 .
Vibhudutta Awasthi, Beth Goins & William Phillips. 2006. Liposome Technology, Volume II. Liposome Technology, Volume II 63 91 .
Thomas Ming Swi Chang. (2006) Blood substitutes based on nanobiotechnology. Trends in Biotechnology 24:8, pages 372-377.
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Patrick Couvreur & Christine Vauthier. (2006) Nanotechnology: Intelligent Design to Treat Complex Disease. Pharmaceutical Research 23:7, pages 1417-1450.
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Thomas Ming Swi Chang. 2006. Blood Substitutes. Blood Substitutes 523 531 .
Thomas Ming Swi Chang. 2005. Scaffolding In Tissue Engineering. Scaffolding In Tissue Engineering 473 480 .
Dennis M. Vriezema, Marta Comellas Aragonès, Johannes A. A. W. Elemans, Jeroen J. L. M. Cornelissen, Alan E. Rowan & Roeland J. M. Nolte. (2005) Self-Assembled Nanoreactors. Chemical Reviews 105:4, pages 1445-1490.
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Thomas Ming Swi Chang. (2005) Therapeutic applications of polymeric artificial cells. Nature Reviews Drug Discovery 4:3, pages 221-235.
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Thomas Ming Swi Chang. 2005. Artificial Oxygen Carrier. Artificial Oxygen Carrier 22 33 .
R Lane Smith. 2004. Nanoscale Technology in Biological Systems. Nanoscale Technology in Biological Systems.
Hiromi Sakai, Yohei Masada, Hiroto Onuma, Shinji Takeoka & Eishun Tsuchida. (2004) Reduction of Methemoglobin via Electron Transfer from Photoreduced Flavin:  Restoration of O 2 -Binding of Concentrated Hemoglobin Solution Coencapsulated in Phospholipid Vesicles . Bioconjugate Chemistry 15:5, pages 1037-1045.
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Thomas Ming Swi Chang. (2004) Artificial Cells for Cell and Organ Replacements. Artificial Organs 28:3, pages 265-270.
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Thomas Ming Swi Chang. (2004) A new red blood cell substitute *. Critical Care Medicine 32:2, pages 612-613.
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