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Research Article

Hepatotoxicity in Acute Iron Poisoning

Pages 721-726 | Published online: 31 Dec 2001

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Rana Biary, Li Li & Robert S. Hoffman. (2019) Intravenous iron overdose: treat the patient not the number. Toxicology Communications 3:1, pages 37-39.
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Daniela Rodrigues, Marisa Freitas, Vera Marisa Costa, Manuel Arturo Lopez-Quintela, José Rivas, Paulo Freitas, Félix Carvalho, Eduarda Fernandes & Paula Silva. (2017) Quantitative histochemistry for macrophage biodistribution on mice liver and spleen after the administration of a pharmacological-relevant dose of polyacrylic acid-coated iron oxide nanoparticles. Nanotoxicology 11:2, pages 256-266.
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Sudip Bhattacharyya, Jyotirmoy Ghosh & Parames C. Sil. (2012) Iron induces hepatocytes death via MAPK activation and mitochondria-dependent apoptotic pathway: Beneficial role of glycine. Free Radical Research 46:10, pages 1296-1307.
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Sarit Weinbaum, Eran Kozer, Sandra Evans, Adina Bar-Haim, Yehudit Zandback, Eli Lahat, Irena Petrov, Yoav Alkan, Yariv Siman-Tov, Moshe Rechavi, LeeH. Goldstein & Matitiahu Berkovitch. (2008) Depletion of Glutathione System Enzymes of the Liver and Erythrocytes in a Rat Model of Acute Iron Poisoning. Toxicology Mechanisms and Methods 18:8, pages 623-626.
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Ainhoa Fernández-Yunquera, Aranzazu Caballero-Marcos, Isabel Peligros & Magdalena Salcedo Plaza. (2023) Liver Transplantation for Fulminant Hepatic Failure in a Young Woman. American Journal of Transplantation 23:5, pages 682-685.
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N. Ramaswamy, Sathish K.Bhawana Ashok Badhe. (2023) An autopsy report with a diagnostic clinical profile on fatal overdose of life-saving iron supplement. Forensic Science, Medicine and Pathology.
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Bahar ÜRÜN UNAL, Duygu İlke YILDIRIM, Sevil ŞEN & Alaaddin YORULMAZ. (2022) Evaluation of Children Presenting to the Emergency Department with Iron IntoxicationAcil Servise Demir Zehirlenmesi İle Başvuran Çocuk Vakalarının Değerlendirilmesi. Pediatric Practice and Research 10:3, pages 108-112.
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Anita Mudan, Jacob A. Lebin, Alan H.B. Wu & Zhanna Livshits. (2022) Serum iron concentrations in non-iron induced acute liver injury. Clinica Chimica Acta 525, pages 12-14.
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Ravindra V. Badhe, Obakanyin Akinfosile, Divya Bijukumar, Mark Barba & Mathew T. Mathew. (2021) Systemic toxicity eliciting metal ion levels from metallic implants and orthopedic devices – A mini review. Toxicology Letters 350, pages 213-224.
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Fatma Irem Yesiler. (2018) Acute Iron Poisoning: A Case Report. MOJ Clinical & Medical Case Reports 8:1.
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Joanne Lai, Jaime Chu & Ronen Arnon. (2017) Pediatric liver transplantation for fulminant hepatic failure secondary to intentional iron overdose. Pediatric Transplantation 21:6, pages e12994.
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Rawan Eid, Nagla T.T. Arab & Michael T. Greenwood. (2017) Iron mediated toxicity and programmed cell death: A review and a re-examination of existing paradigms. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1864:2, pages 399-430.
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Sean M. Bryant & Jerrold B. Leikin. 2017. Critical Care Toxicology. Critical Care Toxicology 1313 1324 .
Sean M. Bryant & Jerrold B. Leikin. 2016. Critical Care Toxicology. Critical Care Toxicology 1 12 .
Dan Wan, Xihong Zhou, Chunyan Xie, Xugang Shu, Xin Wu & Yulong Yin. (2015) Toxicological evaluation of ferrous N-carbamylglycinate chelate: Acute, Sub-acute toxicity and mutagenicity. Regulatory Toxicology and Pharmacology 73:2, pages 644-651.
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Sohail Ejaz, Gerry Amor Camer, Khaleeq Anwar & Muhammad Ashraf. (2014) Monitoring impacts of air pollution: PIXE analysis and histopathological modalities in evaluating relative risks of elemental contamination. Ecotoxicology 23:3, pages 357-369.
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Victor Raj Mohan Chandrasekaran, Dur-Zong Hsu & Ming-Yie Liu. (2013) Beneficial Effect of Sesame Oil on Heavy Metal Toxicity. Journal of Parenteral and Enteral Nutrition 38:2, pages 179-185.
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J. Jonathan Arul & Divya Bala. (2013) Fatal overdose of iron tablets in adults. Indian Journal of Critical Care Medicine 17:5, pages 311-313.
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Sudip Bhattacharyya, Pabitra Bikash Pal & Parames C. Sil. (2013) A 35kD Phyllanthus niruri protein modulates iron mediated oxidative impairment to hepatocytes via the inhibition of ERKs, p38 MAPKs and activation of PI3k/Akt pathway. Food and Chemical Toxicology 56, pages 119-130.
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Vinod K. Audimoolam, Julia Wendon, William Bernal, Nigel Heaton, John O?Grady & Georg Auzinger. (2011) Iron and acetaminophen a fatal combination?. Transplant International 24:10, pages e85-e88.
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Todd Pou-Yen Chang & Cyrus Rangan. (2011) Iron Poisoning. Pediatric Emergency Care 27:10, pages 978-985.
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Matthew R. Pincus & Naif Z. AbrahamJr.Jr.. 2011. Henry's Clinical Diagnosis and Management by Laboratory Methods. Henry's Clinical Diagnosis and Management by Laboratory Methods 329 364 .
Victor Raj Mohan Chandrasekaran, Ilayaraja Muthaiyan, Po-Chang Huang & Ming-Yie Liu. (2010) Using iron precipitants to remove arsenic from water: Is it safe?. Water Research 44:19, pages 5823-5827.
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Swaran J.S. Flora & Vidhu Pachauri. (2010) Chelation in Metal Intoxication. International Journal of Environmental Research and Public Health 7:7, pages 2745-2788.
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Ibrahim Abu-Kishk, Eran Kozer, Lee H. Goldstein, Sarit Weinbaum, Adina Bar-Haim, Yoav Alkan, Irena Petrov, Sandra Evans, Yariv Siman-Tov & Matitiahu Berkovitch. (2010) Oral N-acetylcysteine has a deleterious effect in acute iron intoxication in rats. The American Journal of Emergency Medicine 28:1, pages 8-12.
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Eyal Ben-Assa, Ilan Youngster, Eran Kozer, Ibrahim Abu-Kishk, Adina Bar-Haim, Benjamin Bar-Oz & Matitiahu Berkovitch. (2009) Changes in serum hepcidin levels in acute iron intoxication in a rat model. Toxicology Letters 189:3, pages 242-247.
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F. Flesch, C. Tournoud, I. Thaon & E. Benhassine. (2007) Intoxications par le fer. EMC - Pathologie professionnelle et de l 'environnement 2:1, pages 1-6.
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ALISON L. JONES & PAUL I. DARGAN. 2007. Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose. Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose 223 247 .
Taj Madiwale & Erica Liebelt. (2006) Iron: not a benign therapeutic drug. Current Opinion in Pediatrics 18:2, pages 174-179.
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Thomas D. Schiano & Kristel Hunt. 2006. Zakim and Boyer's Hepatology. Zakim and Boyer's Hepatology 561 577 .
A Robertson & M Tenenbein. (2016) Hepatotoxicity in acute iron poisoning. Human & Experimental Toxicology 24:11, pages 559-562.
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David Michael Wood, Alison H Thomson, Matthew Lawes, Alison Linda Jones & Paul Ivor Dargan. (2005) Hepatocellular Damage Following Therapeutic Intravenous Iron Sucrose Infusion in a Child. Therapeutic Drug Monitoring 27:4, pages 405-408.
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S. Eliza Halcomb, Marco L.A. Sivilotti, Anil Goklaney & Michael E. Mullins. (2005) Pharmacokinetic Effects of Diphenhydramine or Oxycodone in Simulated Acetaminophen Overdose. Academic Emergency Medicine 12:2, pages 169-172.
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Sumanth R. Daram & Paul H. Hayashi. (2005) Acute Liver Failure Due to Iron Overdose in an Adult. Southern Medical Journal 98:2, pages 241-244.
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Victoria C. Cogger, Michael Muller, Robin Fraser, Allan J. McLean, Jameel Khan & David G. Le Couteur. (2004) The effects of oxidative stress on the liver sieve. Journal of Hepatology 41:3, pages 370-376.
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