150
Views
32
CrossRef citations to date
0
Altmetric
Original

Telomerase and Telomeres: From Basic Biology to Cancer Treatment

, Ph.D., , Ph.D. & , M.D
Pages 82-101 | Published online: 22 Apr 2002

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Weiguo Zhang, Qiang Tong, Qingming Wu, Shengbao Li, Xiaohu Wang & Qiang Wang. (2009) Upregulated p27kip1 can Downregulate Survivin Expression and Inhibit Telomerase Activity in Gastric Carcinoma Cells. Cancer Investigation 27:9, pages 898-900.
Read now

Articles from other publishers (31)

. 2013. Withrow and MacEwen's Small Animal Clinical Oncology. Withrow and MacEwen's Small Animal Clinical Oncology 215 244 .
Valery Andrushchenko, Dimiter Tsankov, Maria Krasteva, Helmut Wieser & Petr Bouř. (2011) Spectroscopic Detection of DNA Quadruplexes by Vibrational Circular Dichroism. Journal of the American Chemical Society 133:38, pages 15055-15064.
Crossref
Nihar Ranjan, Katrine F. Andreasen, Sunil Kumar, David Hyde-Volpe & Dev P. Arya. (2010) Aminoglycoside Binding to Oxytricha nova Telomeric DNA . Biochemistry 49:45, pages 9891-9903.
Crossref
Wei Wang, Bin Jin, Wei Li, Chun-Xiao Xu, Fu-Ai Cui, Bin Liu, Yun-Fei Yan, Xian-Xi Liu & Xiu-Li Wang. (2009) Targeted antitumor effect induced by hTERT promoter mediated ODC antisense adenovirus. Molecular Biology Reports 37:7, pages 3239-3247.
Crossref
L. Hayflick. (2010) Unlike ageing, longevity is sexually transmitted. Médecine & Longévité 2:3, pages 114-128.
Crossref
Yan Jin, Hongyan Li & Ping Liu. (2010) Label-free electrochemical selection of G-quadruplex-binding ligands based on structure switching. Biosensors and Bioelectronics 25:12, pages 2669-2674.
Crossref
Meng Dong, Thomas E. Mürdter & Ulrich Klotz. (2009) Telomeres and telomerase as novel drug targets: reflections on the 2009 Nobel Prize in Physiology or Medicine. European Journal of Clinical Pharmacology 66:1, pages 1-3.
Crossref
Alan E. Bilsland, Stacey Hoare, Katrina Stevenson, Jane Plumb, Natividad Gomez-Roman, Claire Cairney, Sharon Burns, Kyle Lafferty-Whyte, Jon Roffey, Tim Hammonds & W. Nicol Keith. (2009) Dynamic Telomerase Gene Suppression via Network Effects of GSK3 Inhibition. PLoS ONE 4:7, pages e6459.
Crossref
M NATARAJAN, S MOHAN, R KONOPINSKI, R A OTTO & T S HERMAN. (2008) Induced telomerase activity in primary aortic endothelial cells by low-LET γ-radiation is mediated through NF-κB activation. The British Journal of Radiology 81:969, pages 711-720.
Crossref
Daniel S. Pilch, Christopher M. Barbieri, Suzanne G. Rzuczek, Edmond J. LaVoie & Joseph E. Rice. (2008) Targeting human telomeric G-quadruplex DNA with oxazole-containing macrocyclic compounds. Biochimie 90:8, pages 1233-1249.
Crossref
Ellie Shihng Meir Chu, Thomas Kwok Shing Wong & Christine Miu Ngan Yow. (2008) Photodynamic effect in medulloblastoma: downregulation of matrix metalloproteinases and human telomerase reverse transcriptase expressions. Photochemical & Photobiological Sciences 7:1, pages 76-83.
Crossref
Jonathan D. Schwartz & Josep M. Llovet. 2008. Molecular Targeting in Oncology. Molecular Targeting in Oncology 165 210 .
Christopher M. Barbieri, Annankoil R. Srinivasan, Suzanne G. Rzuczek, Joseph E. Rice, Edmond J. LaVoie & Daniel S. Pilch. (2007) Defining the mode, energetics and specificity with which a macrocyclic hexaoxazole binds to human telomeric G-quadruplex DNA. Nucleic Acids Research 35:10, pages 3272-3286.
Crossref
Huang-Hsu Chen, Chuan-Hang Yu, Jeng-Tzung Wang, Bu-Yuan Liu, Yi-Ping Wang, Andy Sun, Tung-Chieh Tsai & Chun-Pin Chiang. (2007) Expression of human telomerase reverse transcriptase (hTERT) protein is significantly associated with the progression, recurrence and prognosis of oral squamous cell carcinoma in Taiwan. Oral Oncology 43:2, pages 122-129.
Crossref
Tao Xu, Yaojian Rao, Wentao Zhu & Fengjin Guo. (2006) Inhibition of cell growth and telomerase activity in osteosarcoma cells by DN-hTERT. Journal of Huazhong University of Science and Technology 26:5, pages 601-603.
Crossref
Jerry W. Shay & Woodring E. Wright. (2006) Telomerase therapeutics for cancer: challenges and new directions. Nature Reviews Drug Discovery 5:7, pages 577-584.
Crossref
Kamilla Piotrowska, Elke Kleideiter, Thomas E Mürdter, Sebastian Taetz, Christiane Baldes, Ulrich Schaefer, Claus-Michael Lehr & Ulrich Klotz. (2005) Optimization of the TRAP assay to evaluate specificity of telomerase inhibitors. Laboratory Investigation 85:12, pages 1565-1569.
Crossref
Deborah A. Freedman & Judah Folkman. (2005) CDK2 translational down-regulation during endothelial senescence. Experimental Cell Research 307:1, pages 118-130.
Crossref
Sebastian Brandt, Hartmut Heller, Klaus-Dieter Schuster & J�rgen Grote. (2004) The tamoxifen-induced suppression of telomerase activity in the human hepatoblastoma cell line HepG2: a result of post-translational regulation. Journal of Cancer Research and Clinical Oncology 131:2, pages 120-128.
Crossref
Zuzana Sieglová, Soňa Žilovcová, Jaroslav Čermák, Hana Řı́hová, Dagmar Březinová, Renáta Dvořáková, Markéta Marková, Jacqueline Maaloufová, Jana Sajdová, Jana Březinová, Zuzana Zemanová & Kyra Michalová. (2004) Dynamics of telomere erosion and its association with genome instability in myelodysplastic syndromes (MDS) and acute myelogenous leukemia arising from MDS: a marker of disease prognosis?. Leukemia Research 28:10, pages 1013-1021.
Crossref
Charles Dudognon, Frédéric Pendino, Josette Hillion, Anne Saumet, Michel Lanotte & Evelyne Ségal-Bendirdjian. (2004) Death receptor signaling regulatory function for telomerase: hTERT abolishes TRAIL-induced apoptosis, independently of telomere maintenance. Oncogene 23:45, pages 7469-7474.
Crossref
Srdan Verstovsek, Francis J Giles, Susan O?Brien, Stefan Faderl, Hagop M Kantarjian, Michael J Keating & Maher Albitar. (2004) Telomerase activity is not a prognostic factor in chronic lymphocytic leukemia. Leukemia Research 28:7, pages 707-711.
Crossref
Lisa H. Butterfield, Stephen P. Schoenberger & Jeffrey B. Lyczak. 2004. Immunology, Infection, and Immunity. Immunology, Infection, and Immunity 573 591 .
Frédéric Pendino, Charles Dudognon, Francois Delhommeau, Tewfik Sahraoui, Maria Flexor, Annelise Bennaceur-Griscelli, Michel Lanotte & Evelyne Ségal-Bendirdjian. (2003) Retinoic acid receptor α and retinoid-X receptor-specific agonists synergistically target telomerase expression and induce tumor cell death. Oncogene 22:57, pages 9142-9150.
Crossref
Leonard Hayflick. (2003) Living forever and dying in the attempt. Experimental Gerontology 38:11-12, pages 1231-1241.
Crossref
Srdan Verstovsek, Taghi Manshouri, Franklin O. Smith, Francis J. Giles, Jorge Cortes, Elihu Estey, Hagop Kantarjian, Michael Keating, Sima Jeha & Maher Albitar. (2003) Telomerase activity is prognostic in pediatric patients with acute myeloid leukemia. Cancer 97:9, pages 2212-2217.
Crossref
Maurice Phil DeYoung, Matthew Tress & Ramaswamy Narayanan. (2003) Identification of Down's syndrome critical locus gene SIM2-s as a drug therapy target for solid tumors . Proceedings of the National Academy of Sciences 100:8, pages 4760-4765.
Crossref
E. Guilhon, P. Voisin, J. A. de Zwart, B. Quesson, R. Salomir, C. Maurange, V. Bouchaud, P. Smirnov, H. de Verneuil, A. Vekris, P. Canioni & C. T. W. Moonen. (2003) Spatial and temporal control of transgene expressionin vivo using a heat-sensitive promoter and MRI-guided focused ultrasound. The Journal of Gene Medicine 5:4, pages 333-342.
Crossref
Lisong Teng, Michelle C. Specht, Catherine B. Barden & Thomas J. FaheyIIIIII. (2003) Antisense hTERT Inhibits Thyroid Cancer Cell Growth. The Journal of Clinical Endocrinology & Metabolism 88:3, pages 1362-1366.
Crossref
Srdan Verstovsek, Hagop Kantarjian, Taghi Manshouri, Jorge Cortes, Stefan Faderl, Francis J. Giles, Michael Keating & Maher Albitar. (2003) Increased telomerase activity is associated with shorter survival in patients with chronic phase chronic myeloid leukemia. Cancer 97:5, pages 1248-1252.
Crossref
Jerry W Shay & Woodring E Wright. (2002) Telomerase: A target for cancer therapeutics. Cancer Cell 2:4, pages 257-265.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.