286
Views
60
CrossRef citations to date
0
Altmetric
Research Article

Development of Hollow Microspheres as Floating Controlled-Release Systems for Cardiovascular Drugs: Preparation and Release Characteristics

, &
Pages 507-515 | Published online: 31 May 2001

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (21)

Umar Farooq, Samiullah Khan, Shahid Nawaz, Nazar Mohammad Ranjha, Malik Salman Haider, Muhammad Muzamil Khan, Eshwa Dar & Ahmad Nawaz. (2017) Enhanced gastric retention and drug release via development of novel floating microspheres based on Eudragit E100 and polycaprolactone: synthesis and in vitro evaluation. Designed Monomers and Polymers 20:1, pages 419-433.
Read now
Yu Huang, Yumeng Wei, Hongru Yang, Chao Pi, Hao Liu, Yun Ye & Ling Zhao. (2016) A 5-fluorouracil-loaded floating gastroretentive hollow microsphere: development, pharmacokinetic in rabbits, and biodistribution in tumor-bearing mice. Drug Design, Development and Therapy 10, pages 997-1008.
Read now
Huiming Jiang, Rui Tian, Wenjing Hu, Yuntao Jia, Pei Yuan, Jiayu Wang & Liangke Zhang. (2015) Formulation and evaluation of gastroretentive floating drug delivery system of dipyridamole. Drug Development and Industrial Pharmacy 41:4, pages 674-680.
Read now
ForamS. Patel, RaghavendraV. Kulkarni & H.M. Nanjappaiah. (2014) Multiparticulate Drug Delivery System for the Treatment of Diabetes Mellitus: In Vitro and In Vivo Evaluation. Particulate Science and Technology 32:5, pages 477-485.
Read now
Priyanka Bhadouriya, Manish Kumar & Kamla Pathak. (2013) Formulation and in vitro evaluation of prolonged release floating microspheres of atenolol using multicompartment dissolution apparatus. Drug Development and Industrial Pharmacy 39:11, pages 1663-1671.
Read now
Suryakanta Swain, Upali A. Behera, Sarwar Beg, J. Sruti, Ch. Niranjan Patro, S. C. Dinda & M. E. B. Rao. (2013) Design and characterization of enteric-coated controlled release mucoadhesive microcapsules of Rabeprazole sodium. Drug Development and Industrial Pharmacy 39:4, pages 548-560.
Read now
B. R. Rane, N. A. Gujarathi & J. K. Patel. (2012) Biodegradable anionic acrylic resin based hollow microspheres of moderately water soluble drug Rosiglitazone Maleate: preparation and in vitro characterization. Drug Development and Industrial Pharmacy 38:12, pages 1460-1469.
Read now
Atmaram P. Pawar, Makarand R. Shelake, Chellampillai Bothiraja & Ravindra N. Kamble. (2012) Development of photostable gastro retentive formulation for nifedipine using low-density polypropylene microporous particles. Journal of Microencapsulation 29:5, pages 409-416.
Read now
Pankaj Goyal, S. Gill, U. D. Gupta, Goutam Rath, Raj K. Narang & Amit K. Goyal. (2011) Development and Characterization of Rifampicin Loaded Floating Microspheres. Artificial Cells, Blood Substitutes, and Biotechnology 39:5, pages 330-334.
Read now
Khosro Adibkia, Sanaz Hamedeyazdan & Yousef Javadzadeh. (2011) Drug release kinetics and physicochemical characteristics of floating drug delivery systems. Expert Opinion on Drug Delivery 8:7, pages 891-903.
Read now
Vivek K. Pawar, Shaswat Kansal, Garima Garg, Rajendra Awasthi, Deepak Singodia & Giriraj T. Kulkarni. (2011) Gastroretentive dosage forms: A review with special emphasis on floating drug delivery systems. Drug Delivery 18:2, pages 97-110.
Read now
Krassimira Yoncheva, Nikolai Lambov & Stoian Miloshev. (2009) Modification of Biodegradable Poly(Malate) and Poly(Lactic-co-Glycolic Acid) Microparticles with Low Molecular Polyethylene Glycol. Drug Development and Industrial Pharmacy 35:4, pages 449-454.
Read now
A. Srinatha & Jayanta K. Pandit. (2008) Multi-Unit Floating Alginate System: Effect of Additives on Ciprofloxacin Release. Drug Delivery 15:7, pages 471-476.
Read now
Varaporn Buraphacheep Junyaprasert & Supaporn Pornsuwannapha. (2008) Floating Properties and Release Characteristics of Hollow Microspheres of Acyclovir. Drug Delivery 15:5, pages 331-341.
Read now
V. S. Mastiholimath, P. M. Dandagi, A. P. Gadad, Rashmi Mathews & A. R. Kulkarni. (2008) and evaluation of ranitidine hydrochloride ethyl cellulose floating microparticles. Journal of Microencapsulation 25:5, pages 307-314.
Read now
S. K. Bajpai & Seema Dubey. (2007) Dynamic Release of Vitamin B2 from Floating Barium Alginate Beads for Gastric Delivery. Journal of Macromolecular Science, Part A 44:9, pages 1005-1011.
Read now
Viral F. Patel & Natavarlal M. Patel. (2007) Statistical Evaluation of Influence of Xanthan Gum and Guar Gum Blends on Dipyridamole Release from Floating Matrix Tablets. Drug Development and Industrial Pharmacy 33:3, pages 327-334.
Read now
A. Peter Morello$suffix/text()$suffix/text(), Roxanne Burrill & Edith Mathiowitz. (2007) Preparation and characterization of poly(methyl methacrylate)—iron (III) oxide microparticles using a modified solvent evaporation method. Journal of Microencapsulation 24:5, pages 476-491.
Read now
J. Varshosaz, M. Tabbakhian & M. Zahrooni. (2007) Development and characterization of floating microballoons for oral delivery of cinnarizine by a factorial design. Journal of Microencapsulation 24:3, pages 253-262.
Read now
Alexander Streubel, Juergen Siepmann & Roland Bodmeier. (2006) Gastroretentive drug delivery systems. Expert Opinion on Drug Delivery 3:2, pages 217-233.
Read now

Articles from other publishers (39)

Vita D'Amico, Ilaria Arduino, Mirco Vacca, Rosa Maria Iacobazzi, Davide Altamura, Antonio Lopalco, Rosanna Rizzi, Annalisa Cutrignelli, Valentino Laquintana, Franco Massimo, Maria De Angelis, Nunzio Denora & Angela Assunta Lopedota. (2023) Colonic budesonide delivery by multistimuli alginate/Eudragit® FS 30D/inulin-based microspheres as a paediatric formulation. Carbohydrate Polymers 302, pages 120422.
Crossref
Arun Kumar, Silpi Chanda, Shriya Agarwal, Manisha Singh, Saurabh Sharma, Gunjan Vasant Bonde & Raj Kumar Tiwari. (2023) Formulation and evaluation of gastro-retentive Tinidazole loaded floating microsphere for sustained release. Materials Today: Proceedings 80, pages 1810-1815.
Crossref
Shazia Akram Ghumman, Arshad Mahmood, Sobia Noreen, Mavra Rana, Huma Hameed, Bushra Ijaz, Sara Hasan, Afeefa Aslam & Muhammad Fayyaz ur Rehman. (2022) Formulation and evaluation of quince seeds mucilage – sodium alginate microspheres for sustained delivery of cefixime and its toxicological studies. Arabian Journal of Chemistry 15:6, pages 103811.
Crossref
Ana C. G. Moreira, Yaidelin A. Manrique, Isabel M. Martins, M. G. Simões, A. S. Carreira, Pedro N. Simões, Alírio E. Rodrigues, José C. B. Lopes & Madalena M. Dias. (2022) Continuous production of cellulose acetate microspheres for textile impregnation using a mesostructured reactor. Cellulose 29:6, pages 3595-3612.
Crossref
Ajeet SinghRanjit Singh. (2021) Development and Characterization of Repaglinide Loaded Floating Microparticles. Research Journal of Pharmacy and Technology, pages 6573-6578.
Crossref
Amit Kumar PatelManoj Kumar MishraJitendra GuptaSaurav GhoshalReena GuptaKrishna Kushwaha. (2021) Guar Gum-Based Floating Microspheres of Repaglinide Using 3 2 Factorial Design: Fabrication, Optimization, Characterization, and In Vivo Buoyancy Behavior in Albino Rats . ASSAY and Drug Development Technologies 19:2, pages 63-74.
Crossref
Manoj Bansal, Ravinder Verma, Vineet Mittal & Deepak Kaushik. (2021) Central Composite Design for the Development and Evaluation of Floating-mucoadhesive Tablets of Gliclazide. Current Drug Therapy 16:1, pages 113-123.
Crossref
Michael B. Lowinger, Esther Y. Maier, Robert O. WilliamsIIIIII & Feng Zhang. (2020) Hydrophilic Poly(urethanes) Are an Effective Tool for Gastric Retention Independent of Drug Release Rate. Journal of Pharmaceutical Sciences 109:6, pages 1967-1977.
Crossref
Abdul Majeed, Nazar Muhammad Ranjha, Mussadique Hussain & Muhammad Fawad Rasool. (2018) Fabrication and evaluation of pH-dependent polymeric microspheres of ivabradine and their in vitro and in vivo studies. Polymer Bulletin 76:6, pages 3127-3151.
Crossref
Cheng-Yun Zhu, Jin-Yue Wang, Jin Huang, Guo-Hua Han, Yan-Yan Ji, Xiang-Rong Zhang & Dong Liang. (2019) Preparation and evaluation of gastro-floating hollow adhesive microspheres of carbomer/ethyl cellulose encapsulating dipyridamole. New Journal of Chemistry 43:15, pages 5897-5903.
Crossref
Arti Patel & Yashwant V. Pathak. 2019. Coronary and Cardiothoracic Critical Care. Coronary and Cardiothoracic Critical Care 499 508 .
Hazuki Yonashiro, Kenjirou Higashi, Chikako Morikawa, Keisuke Ueda, Tsutomu Itoh, Masataka Ito, Hyuma Masu, Shuji Noguchi & Kunikazu Moribe. (2018) Morphological and Physicochemical Evaluation of Two Distinct Glibenclamide/Hypromellose Amorphous Nanoparticles Prepared by the Antisolvent Method. Molecular Pharmaceutics 15:4, pages 1587-1597.
Crossref
Yasser Shahzad, Sidra Saeed, Muhammad Usman Ghori, Tariq Mahmood, Abid Mehmood Yousaf, Muhammad Jamshaid, Rizwan Sheikh & Syed A.A. Rizvi. (2018) Influence of polymer ratio and surfactants on controlled drug release from cellulosic microsponges. International Journal of Biological Macromolecules 109, pages 963-970.
Crossref
Abdul Majeed, Nazar Muhammad Ranjha, Muhammad Fawad Rasool & Musaddique Hussain. (2018) Development and evaluation of ivabradine microspheres for controlled release. Bioinspired, Biomimetic and Nanobiomaterials 7:1, pages 8-19.
Crossref
Arti Patel & Yashwant V. Pathak. 2017. Emerging Applications, Perspectives, and Discoveries in Cardiovascular Research. Emerging Applications, Perspectives, and Discoveries in Cardiovascular Research 245 253 .
Chungang Zhang, Jingya Tang, Dechun Liu, Xuetao Li, Lan Cheng & Xing Tang. (2016) Design and evaluation of an innovative floating and bioadhesive multiparticulate drug delivery system based on hollow structure. International Journal of Pharmaceutics 503:1-2, pages 41-55.
Crossref
Nizar Al-Zoubi, Hatim S. Alkhatib, Ghadah Alobaidi, Safwan Abdel-Rahim, Wasfy Obeidat & Stavros Malamataris. (2015) Optimization of pH-independent chronotherapeutic release of verapamil HCl from three-layer matrix tablets. International Journal of Pharmaceutics 494:1, pages 296-303.
Crossref
Adeola O Adebisi & Barbara R Conway. (2015) Modification of drug delivery to improve antibiotic targeting to the stomach. Therapeutic Delivery 6:6, pages 741-762.
Crossref
Rishikesh Gupta, Sunil Kumar Prajapati, Snigdha Pattnaik & Peeyush Bhardwaj. (2014) Formulation and evaluation of novel stomach specific floating microspheres bearing famotidine for treatment of gastric ulcer and their radiographic study. Asian Pacific Journal of Tropical Biomedicine 4:9, pages 729-735.
Crossref
Namdev B. Shelke, Roshan James, Cato T. Laurencin & Sangamesh G. Kumbar. (2014) Polysaccharide biomaterials for drug delivery and regenerative engineering. Polymers for Advanced Technologies 25:5, pages 448-460.
Crossref
J. M. Bermudez, A. G. Cid, M. V. Ramírez-Rigo, D. Quinteros, A. Simonazzi, S. Sánchez Bruni & S. Palma. (2014) Challenges and opportunities in polymer technology applied to veterinary medicine. Journal of Veterinary Pharmacology and Therapeutics 37:2, pages 105-124.
Crossref
Peeyush Bhardwaj, Deepti Chaurasia, Ranjit Singh & Anoop Swarup. (2014) Development and Characterization of Novel Site Specific Hollow Floating Microspheres Bearing 5-Fu for Stomach Targeting. The Scientific World Journal 2014, pages 1-11.
Crossref
C. A. Hanley, J. E. McCarthy, F. Purcell-Milton, V. Gerard, D. McCloskey, J. Donegan, Y. P. Rakovich & Y. K. Gun’ko. (2013) Preparation and Investigation of Quantum-Dot-Loaded Hollow Polymer Microspheres. The Journal of Physical Chemistry C 117:46, pages 24527-24536.
Crossref
Yu-meng Wei, Zheng-kai Xue, Peng Wang & Ling Zhao. (2013) Formulation and pharmacokinetic evaluation of once-daily sustained-released system of nifedipine with solid dispersion and coating techniques. Archives of Pharmacal Research 36:7, pages 864-873.
Crossref
Ling Zhao, Yu-meng Wei, Yu Yu & Wen-wu Zheng. (2010) Polymer blends used to prepare nifedipine loaded hollow microspheres for a floating-type oral drug delivery system: In vitro evaluation. Archives of Pharmacal Research 33:3, pages 443-450.
Crossref
P. Phutane, V. Lotlikar, A. Ghule, S. Sutar, V. Kadam & S. Shidhaye. (2010) In vitro Evaluation of Novel Sustained Release Microspheres of Glipizide Prepared by the Emulsion Solvent Diffusion-Evaporation Method. Journal of Young Pharmacists 2:1, pages 35-41.
Crossref
Anand P. Gadad, Mrityunjaya B. Patil, Suma N. Naduvinamani, Vinayak S. Mastiholimath, Panchaxari M. Dandagi & Anandrao R. Kulkarni. (2009) Sodium alginate polymeric floating beads for the delivery of cefpodoxime proxetil. Journal of Applied Polymer Science 114:3, pages 1921-1926.
Crossref
Mitra Jelvehgari, Fatemeh Atapour & Ali Nokhodchi. (2009) Micromeritics and release behaviours of cellulose acetate butyrate microspheres containing theophylline prepared by emulsion solvent evaporation and emulsion non-solvent addition method. Archives of Pharmacal Research 32:7, pages 1019-1028.
Crossref
Sunil K. Jain & Manmohan S. Jangdey. (2008) Lectin Conjugated Gastroretentive Multiparticulate Delivery System of Clarithromycin for the Effective Treatment of Helicobacter pylori . Molecular Pharmaceutics 6:1, pages 295-304.
Crossref
Yu-meng Wei & Ling Zhao. (2008) In vitro and in vivo evaluation of ranitidine hydrochloride loaded hollow microspheres in rabbits. Archives of Pharmacal Research 31:10, pages 1369-1377.
Crossref
Ninan Ma, Lu Xu, Qifang Wang, Xiangrong Zhang, Wenji Zhang, Yang Li, Lingyu Jin & Sanming Li. (2008) Development and evaluation of new sustained-release floating microspheres. International Journal of Pharmaceutics 358:1-2, pages 82-90.
Crossref
Sunil Kumar Bajpai & Rasika Tankhiwale. (2008) Preparation, characterization and preliminary calcium release study of floating sodium alginate/dextran-based hydrogel beads: part I. Polymer International 57:1, pages 57-65.
Crossref
Ajit P. Rokhade, Sangamesh A. Patil, Anagha A. Belhekar, Shivaraj B. Halligudi & Tejraj M. Aminabhavi. (2007) Preparation and evaluation of cellulose acetate butyrate and poly(ethylene oxide) blend microspheres for gastroretentive floating delivery of repaglinide. Journal of Applied Polymer Science 105:5, pages 2764-2771.
Crossref
Kevin J. Edgar. (2006) Cellulose esters in drug delivery. Cellulose 14:1, pages 49-64.
Crossref
Sunil K. Jain, Govind P. Agrawal & Narendra K. Jain. (2006) A novel calcium silicate based microspheres of repaglinide: In vivo investigations. Journal of Controlled Release 113:2, pages 111-116.
Crossref
Kumaresh S. Soppimath, Tejraj M. Aminabhavi, Sunil A. Agnihotri, Nadagouda N. Mallikarjuna & Padmakar V. Kulkarni. (2006) Effect of coexcipients on drug release and floating property of nifedipine hollow microspheres: A novel gastro retentive drug delivery system. Journal of Applied Polymer Science 100:1, pages 486-494.
Crossref
Sunil K. Jain, A.M. Awasthi, N.K. Jain & G.P. Agrawal. (2005) Calcium silicate based microspheres of repaglinide for gastroretentive floating drug delivery: Preparation and in vitro characterization. Journal of Controlled Release 107:2, pages 300-309.
Crossref
Kinam Park & Yoon Yeo. 2003. Tissue Engineering And Novel Delivery Systems. Tissue Engineering And Novel Delivery Systems.
Ibrahim El-Gibaly. (2002) Development and in vitro evaluation of novel floating chitosan microcapsules for oral use: comparison with non-floating chitosan microspheres. International Journal of Pharmaceutics 249:1-2, pages 7-21.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.